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/test.data/contact_map/agents/~session027.test

http://github.com/kappamodeler/jkappa
Unknown | 710 lines | 710 code | 0 blank | 0 comment | 0 complexity | 6bf3d726c1ae35423bc9558b4e60cb74 MD5 | raw file
Possible License(s): LGPL-3.0, Apache-2.0

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  1<?xml version='1.0' encoding='utf-8'?>
  2<!-- Automaticaly generated by Complx 3.40..4208 -->
  3<ComplxSession Timestamp="25/2/2009 (21:53:40)" CommandLine="C:\DOCUME~1\LOPATK~1\LOCALS~1\Temp\tmp53467.exe ~kappa53549.tmp --output-xml ~session53548.tmp --memory-limit 1024 --reset-all --do-XML --do-low-res-contact-map --focus-on ~focus53547.tmp --key 07CFC00F0BEB0D5B" InputFile="~kappa53549.tmp" 
  4xsi:schemaLocation="http://plectix.synthesisstudios.com
  5KappaSession.xsd" xmlns="http://plectix.synthesisstudios.com/schemas/kappasession"
  6xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" >
  7<Log>
  8<Entry Type="INFO" Message="Compilation(simplx)                      0.062 s."/>
  9<Entry Type="INFO" Message="Second compilation(pretty printing)      0.016 s."/>
 10<Entry Type="INFO" Message="Translation                              0. s."/>
 11<Entry Type="INFO" Message="Renaming                                 0.031 s."/>
 12<Entry Type="INFO" Message="Boolean encoding of the initial system   0.125 s."/>
 13</Log>
 14<RuleSet Name="Original">
 15<Rule Id="1" Name="ErbB1_ErbB2" Data="ErbB1(C,CR,L~ext!_,N),ErbB2(C,CR,L~ext,N)->ErbB1(C,CR!0,L~ext!_,N),ErbB2(C,CR!0,L~ext,N)" ForwardRate="1" />
 16<Rule Id="2" Name="ErbB1_ErbB2_op" Data="ErbB1(C,CR!0,L~ext!_,N),ErbB2(C,CR!0,L~ext,N)->ErbB1(C,CR,L~ext!_,N),ErbB2(C,CR,L~ext,N)" ForwardRate="1" />
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 18<Rule Id="4" Name="ErbB2_ErbB3_op" Data="ErbB2(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)->ErbB2(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)" ForwardRate="1" />
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 22<Rule Id="8" Name="ErbB2_A_op" Data="ErbB2(bp!0),A(s!0)->ErbB2(bp),A(s)" ForwardRate="1" />
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 40<Rule Id="26" Name="Rule14" Data="ErbB2(C,CR!0,N),ErbB3(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB3(C!0,CR!1,N)" ForwardRate="1" />
 41<Rule Id="27" Name="Rule14_op" Data="ErbB2(C,CR!1,N!0),ErbB3(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB3(C,CR!0,N)" ForwardRate="1" />
 42<Rule Id="28" Name="Rule15" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1035~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1035~p),A(s~pp!0)" ForwardRate="1" />
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 46<Rule Id="32" Name="Rule19" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1257~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1257~p),A(s~pp!0)" ForwardRate="1" />
 47<Rule Id="33" Name="Rule20" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1270~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1270~p),A(s~pp!0)" ForwardRate="1" />
 48<Rule Id="34" Name="Rule21" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1309~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1309~p),A(s~pp!0)" ForwardRate="1" />
 49<Rule Id="35" Name="Rule22" Data="ErbB2(C,CR!0,N),ErbB4(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB4(C!0,CR!1,N)" ForwardRate="1" />
 50<Rule Id="36" Name="Rule22_op" Data="ErbB2(C,CR!1,N!0),ErbB4(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB4(C,CR!0,N)" ForwardRate="1" />
 51<Rule Id="37" Name="Rule23" Data="ErbB2(N!1,bp!0),ErbB4(C!1,Y1056~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB4(C!1,Y1056~p),A(s~pp!0)" ForwardRate="1" />
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100<Rule Id="86" Name="Rule33" Data="ErbB1(N!1,bp!0),ErbB1(C!1,Y1148~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB1(C!1,Y1148~p),A(s~pp!0)" ForwardRate="1" />
101<Rule Id="87" Name="Rule34" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y992~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y992~p),A(s~pp!0)" ForwardRate="1" />
102<Rule Id="88" Name="Rule35" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y1068~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y1068~p),A(s~pp!0)" ForwardRate="1" />
103<Rule Id="89" Name="Rule36" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y1148~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y1148~p),A(s~pp!0)" ForwardRate="1" />
104<Rule Id="90" Name="Rule37" Data="ErbB1(C,CR!0,N),ErbB3(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB3(C!0,CR!1,N)" ForwardRate="1" />
105<Rule Id="91" Name="Rule37_op" Data="ErbB1(C,CR!1,N!0),ErbB3(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB3(C,CR!0,N)" ForwardRate="1" />
106<Rule Id="92" Name="Rule38" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1035~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1035~p),A(s~pp!0)" ForwardRate="1" />
107<Rule Id="93" Name="Rule39" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1178~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1178~p),A(s~pp!0)" ForwardRate="1" />
108<Rule Id="94" Name="Rule40" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1203~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1203~p),A(s~pp!0)" ForwardRate="1" />
109<Rule Id="95" Name="Rule41" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1241~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1241~p),A(s~pp!0)" ForwardRate="1" />
110<Rule Id="96" Name="Rule42" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1257~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1257~p),A(s~pp!0)" ForwardRate="1" />
111<Rule Id="97" Name="Rule43" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1270~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1270~p),A(s~pp!0)" ForwardRate="1" />
112<Rule Id="98" Name="Rule44" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1309~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1309~p),A(s~pp!0)" ForwardRate="1" />
113<Rule Id="99" Name="Rule45" Data="ErbB1(C,CR!0,N),ErbB4(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB4(C!0,CR!1,N)" ForwardRate="1" />
114<Rule Id="100" Name="Rule45_op" Data="ErbB1(C,CR!1,N!0),ErbB4(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB4(C,CR!0,N)" ForwardRate="1" />
115<Rule Id="101" Name="Rule46" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1056~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1056~p),A(s~pp!0)" ForwardRate="1" />
116<Rule Id="102" Name="Rule47" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1188~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1188~p),A(s~pp!0)" ForwardRate="1" />
117<Rule Id="103" Name="Rule48" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1242~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1242~p),A(s~pp!0)" ForwardRate="1" />
118<Rule Id="104" Name="Rule49" Data="ErbB1(Y992~p)=>ErbB1(Y992~u),Pi()" ForwardRate="1" />
119<Rule Id="105" Name="Rule50" Data="ErbB1(Y1068~p)=>ErbB1(Y1068~u),Pi()" ForwardRate="1" />
120<Rule Id="106" Name="Rule51" Data="ErbB1(Y1148~p)=>ErbB1(Y1148~u),Pi()" ForwardRate="1" />
121<Rule Id="107" Name="Rule52" Data="ErbB3(Y1035~p)=>ErbB3(Y1035~u),Pi()" ForwardRate="1" />
122<Rule Id="108" Name="Rule53" Data="ErbB3(Y1178~p)=>ErbB3(Y1178~u),Pi()" ForwardRate="1" />
123<Rule Id="109" Name="Rule54" Data="ErbB3(Y1203~p)=>ErbB3(Y1203~u),Pi()" ForwardRate="1" />
124<Rule Id="110" Name="Rule55" Data="ErbB3(Y1241~p)=>ErbB3(Y1241~u),Pi()" ForwardRate="1" />
125<Rule Id="111" Name="Rule56" Data="ErbB3(Y1257~p)=>ErbB3(Y1257~u),Pi()" ForwardRate="1" />
126<Rule Id="112" Name="Rule57" Data="ErbB3(Y1270~p)=>ErbB3(Y1270~u),Pi()" ForwardRate="1" />
127<Rule Id="113" Name="Rule58" Data="ErbB3(Y1309~p)=>ErbB3(Y1309~u),Pi()" ForwardRate="1" />
128<Rule Id="114" Name="Rule59" Data="ErbB4(Y1056~p)=>ErbB4(Y1056~u),Pi()" ForwardRate="1" />
129<Rule Id="115" Name="Rule60" Data="ErbB4(Y1188~p)=>ErbB4(Y1188~u),Pi()" ForwardRate="1" />
130<Rule Id="116" Name="Rule61" Data="ErbB4(Y1242~p)=>ErbB4(Y1242~u),Pi()" ForwardRate="1" />
131<Rule Id="117" Name="ErbB1_RasGAP" Data="ErbB1(Y992~p),RasGAP(SH2)->ErbB1(Y992~p!0),RasGAP(SH2!0)" ForwardRate="1" />
132<Rule Id="118" Name="ErbB1_RasGAP_op" Data="ErbB1(Y992~p!0),RasGAP(SH2!0)->ErbB1(Y992~p),RasGAP(SH2)" ForwardRate="1" />
133<Rule Id="119" Name="ErbB1_Grb2" Data="ErbB1(Y1068~p),Grb2(SH2)->ErbB1(Y1068~p!0),Grb2(SH2!0)" ForwardRate="1" />
134<Rule Id="120" Name="ErbB1_Grb2_op" Data="ErbB1(Y1068~p!0),Grb2(SH2!0)->ErbB1(Y1068~p),Grb2(SH2)" ForwardRate="1" />
135<Rule Id="121" Name="ErbB1_Shc" Data="ErbB1(Y1148~p),Shc(PTB)->ErbB1(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />
136<Rule Id="122" Name="ErbB1_Shc_op" Data="ErbB1(Y1148~p!0),Shc(PTB!0)->ErbB1(Y1148~p),Shc(PTB)" ForwardRate="1" />
137<Rule Id="123" Name="ErbB3_Shc" Data="ErbB3(Y1309~p),Shc(PTB)->ErbB3(Y1309~p!0),Shc(PTB!0)" ForwardRate="1" />
138<Rule Id="124" Name="ErbB3_Shc_op" Data="ErbB3(Y1309~p!0),Shc(PTB!0)->ErbB3(Y1309~p),Shc(PTB)" ForwardRate="1" />
139<Rule Id="125" Name="Shc#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~u)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
140<Rule Id="126" Name="Shc#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~u)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
141<Rule Id="127" Name="Shc_op" Data="Shc(Y318~p)=>Shc(Y318~u),Pi()" ForwardRate="1" />
142<Rule Id="128" Name="Shc_Grb2" Data="Shc(Y318~p),Grb2(SH2)->Shc(Y318~p!0),Grb2(SH2!0)" ForwardRate="1" />
143<Rule Id="129" Name="Shc_Grb2_op" Data="Shc(Y318~p!0),Grb2(SH2!0)->Shc(Y318~p),Grb2(SH2)" ForwardRate="1" />
144<Rule Id="130" Name="Grb2_SoS" Data="Grb2(SH3),SoS(SS~u,a)->Grb2(SH3!0),SoS(SS~u,a!0)" ForwardRate="1" />
145<Rule Id="131" Name="Grb2_SoS_op" Data="Grb2(SH3!0),SoS(a!0)->Grb2(SH3),SoS(a)" ForwardRate="1" />
146<Rule Id="132" Name="long arm SoS_Ras#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
147<Rule Id="133" Name="long arm SoS_Ras#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
148<Rule Id="134" Name="short arm SoS_Ras#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b),Ras(S1S2~gdp)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b!2),Ras(S1S2~gdp!2)" ForwardRate="1" />
149<Rule Id="135" Name="Ras GTP" Data="SoS(b!0),Ras(S1S2~gdp!0)->SoS(b!0),Ras(S1S2~gtp!0)" ForwardRate="1" />
150<Rule Id="136" Name="SoS_Ras_op" Data="SoS(b!0),Ras(S1S2!0)->SoS(b),Ras(S1S2)" ForwardRate="1" />
151<Rule Id="137" Name="direct RasGAP_Ras#1" Data="ErbB1(Y992~p!0),RasGAP(SH2!0,s),Ras(S1S2~gtp)->ErbB1(Y992~p!0),RasGAP(SH2!0,s!1),Ras(S1S2~gtp!1)" ForwardRate="1" />
152<Rule Id="138" Name="Ras GDP" Data="RasGAP(s!0),Ras(S1S2~gtp!0)->RasGAP(s!0),Ras(S1S2~gdp!0)" ForwardRate="1" />
153<Rule Id="139" Name="RasGAP_Ras_op" Data="RasGAP(s!0),Ras(S1S2!0)->RasGAP(s),Ras(S1S2)" ForwardRate="1" />
154<Rule Id="140" Name="Grb2_Gab1" Data="Grb2(SH3c),Gab1(PR)->Grb2(SH3c!0),Gab1(PR!0)" ForwardRate="1" />
155<Rule Id="141" Name="Grb2_Gab1_op" Data="Grb2(SH3c!0),Gab1(PR!0)->Grb2(SH3c),Gab1(PR)" ForwardRate="1" />
156<Rule Id="142" Name="Gab1@447#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p)" ForwardRate="1" />
157<Rule Id="143" Name="Gab1@472#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p)" ForwardRate="1" />
158<Rule Id="144" Name="Gab1@619#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p)" ForwardRate="1" />
159<Rule Id="145" Name="Gab1_PI3K@447" Data="Gab1(Y447~p),PI3K(SH2)->Gab1(Y447~p!0),PI3K(SH2!0)" ForwardRate="1" />
160<Rule Id="146" Name="Gab1_PI3K@447_op" Data="Gab1(Y447~p!0),PI3K(SH2!0)->Gab1(Y447~p),PI3K(SH2)" ForwardRate="1" />
161<Rule Id="147" Name="Gab1_PI3K@472" Data="Gab1(Y472~p),PI3K(SH2)->Gab1(Y472~p!0),PI3K(SH2!0)" ForwardRate="1" />
162<Rule Id="148" Name="Gab1_PI3K@472_op" Data="Gab1(Y472~p!0),PI3K(SH2!0)->Gab1(Y472~p),PI3K(SH2)" ForwardRate="1" />
163<Rule Id="149" Name="Gab1_PI3K@619" Data="Gab1(Y619~p),PI3K(SH2)->Gab1(Y619~p!0),PI3K(SH2!0)" ForwardRate="1" />
164<Rule Id="150" Name="Gab1_PI3K@619_op" Data="Gab1(Y619~p!0),PI3K(SH2!0)->Gab1(Y619~p),PI3K(SH2)" ForwardRate="1" />
165<Rule Id="151" Name="Gab1_Shp2@447" Data="Gab1(Y447~p),Shp2(s)->Gab1(Y447~p!0),Shp2(s!0)" ForwardRate="1" />
166<Rule Id="152" Name="Gab1_Shp2@472" Data="Gab1(Y472~p),Shp2(s)->Gab1(Y472~p!0),Shp2(s!0)" ForwardRate="1" />
167<Rule Id="153" Name="Gab1_Shp2@619" Data="Gab1(Y619~p),Shp2(s)->Gab1(Y619~p!0),Shp2(s!0)" ForwardRate="1" />
168<Rule Id="154" Name="Gab1@447_op" Data="Gab1(Y447~p!0),Shp2(s!0)=>Gab1(Y447~u!0),Shp2(s!0),Pi()" ForwardRate="1" />
169<Rule Id="155" Name="Gab1@472_op" Data="Gab1(Y472~p!0),Shp2(s!0)=>Gab1(Y472~u!0),Shp2(s!0),Pi()" ForwardRate="1" />
170<Rule Id="156" Name="Gab1@619_op" Data="Gab1(Y619~p!0),Shp2(s!0)=>Gab1(Y619~u!0),Shp2(s!0),Pi()" ForwardRate="1" />
171<Rule Id="157" Name="Gab1_Shp2@447_op" Data="Gab1(Y447!0),Shp2(s!0)->Gab1(Y447),Shp2(s)" ForwardRate="1" />
172<Rule Id="158" Name="Gab1_Shp2@472_op" Data="Gab1(Y472!0),Shp2(s!0)->Gab1(Y472),Shp2(s)" ForwardRate="1" />
173<Rule Id="159" Name="Gab1_Shp2@619_op" Data="Gab1(Y619!0),Shp2(s!0)->Gab1(Y619),Shp2(s)" ForwardRate="1" />
174<Rule Id="160" Name="ErbB3_PI3K#1" Data="ErbB3(Y1035~p),PI3K(SH2)->ErbB3(Y1035~p!0),PI3K(SH2!0)" ForwardRate="1" />
175<Rule Id="161" Name="ErbB3_PI3K#1_op" Data="ErbB3(Y1035~p!0),PI3K(SH2!0)->ErbB3(Y1035~p),PI3K(SH2)" ForwardRate="1" />
176<Rule Id="162" Name="ErbB3_PI3K#2" Data="ErbB3(Y1178~p),PI3K(SH2)->ErbB3(Y1178~p!0),PI3K(SH2!0)" ForwardRate="1" />
177<Rule Id="163" Name="ErbB3_PI3K#2_op" Data="ErbB3(Y1178~p!0),PI3K(SH2!0)->ErbB3(Y1178~p),PI3K(SH2)" ForwardRate="1" />
178<Rule Id="164" Name="ErbB3_PI3K#3" Data="ErbB3(Y1203~p),PI3K(SH2)->ErbB3(Y1203~p!0),PI3K(SH2!0)" ForwardRate="1" />
179<Rule Id="165" Name="ErbB3_PI3K#3_op" Data="ErbB3(Y1203~p!0),PI3K(SH2!0)->ErbB3(Y1203~p),PI3K(SH2)" ForwardRate="1" />
180<Rule Id="166" Name="ErbB3_PI3K#4" Data="ErbB3(Y1241~p),PI3K(SH2)->ErbB3(Y1241~p!0),PI3K(SH2!0)" ForwardRate="1" />
181<Rule Id="167" Name="ErbB3_PI3K#4_op" Data="ErbB3(Y1241~p!0),PI3K(SH2!0)->ErbB3(Y1241~p),PI3K(SH2)" ForwardRate="1" />
182<Rule Id="168" Name="ErbB3_PI3K#5" Data="ErbB3(Y1257~p),PI3K(SH2)->ErbB3(Y1257~p!0),PI3K(SH2!0)" ForwardRate="1" />
183<Rule Id="169" Name="ErbB3_PI3K#5_op" Data="ErbB3(Y1257~p!0),PI3K(SH2!0)->ErbB3(Y1257~p),PI3K(SH2)" ForwardRate="1" />
184<Rule Id="170" Name="ErbB3_PI3K#6" Data="ErbB3(Y1270~p),PI3K(SH2)->ErbB3(Y1270~p!0),PI3K(SH2!0)" ForwardRate="1" />
185<Rule Id="171" Name="ErbB3_PI3K#6_op" Data="ErbB3(Y1270~p!0),PI3K(SH2!0)->ErbB3(Y1270~p),PI3K(SH2)" ForwardRate="1" />
186<Rule Id="172" Name="short arm PI3K_PI#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
187<Rule Id="173" Name="short arm PI3K_PI#2" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
188<Rule Id="174" Name="short arm PI3K_PI#3" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
189<Rule Id="175" Name="direct PI3K_PI#1" Data="ErbB3(Y1035~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1035~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
190<Rule Id="176" Name="direct PI3K_PI#2" Data="ErbB3(Y1178~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1178~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
191<Rule Id="177" Name="direct PI3K_PI#3" Data="ErbB3(Y1203~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1203~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
192<Rule Id="178" Name="direct PI3K_PI#4" Data="ErbB3(Y1241~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1241~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
193<Rule Id="179" Name="direct PI3K_PI#5" Data="ErbB3(Y1257~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1257~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
194<Rule Id="180" Name="direct PI3K_PI#6" Data="ErbB3(Y1270~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1270~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
195<Rule Id="181" Name="PI@three" Data="PI3K(s!0),PI(three~u!0)->PI3K(s!0),PI(three~p!0)" ForwardRate="1" />
196<Rule Id="182" Name="PI3K_PI_op" Data="PI3K(s!0),PI(three!0)->PI3K(s),PI(three)" ForwardRate="1" />
197<Rule Id="183" Name="PTEN_PI" Data="PTEN(s),PI(three~p)->PTEN(s!0),PI(three~p!0)" ForwardRate="1" />
198<Rule Id="184" Name="PI@three_op" Data="PTEN(s!0),PI(three~p!0)->PTEN(s!0),PI(three~u!0)" ForwardRate="1" />
199<Rule Id="185" Name="PTEN_PI_op" Data="PTEN(s!0),PI(three!0)->PTEN(s),PI(three)" ForwardRate="1" />
200<Rule Id="186" Name="PIP3_PDK1" Data="PI(five~p,four~p,three~p),PDK1(PH)->PI(five~p,four~p,three~p!0),PDK1(PH!0)" ForwardRate="1" />
201<Rule Id="187" Name="PIP3_PDK1_op" Data="PI(three!0),PDK1(PH!0)->PI(three),PDK1(PH)" ForwardRate="1" />
202<Rule Id="188" Name="PIP3_Akt" Data="PI(five~p,four~p,three~p),Akt(PH)->PI(five~p,four~p,three~p!0),Akt(PH!0)" ForwardRate="1" />
203<Rule Id="189" Name="PIP3_Akt_op" Data="PI(three!0),Akt(PH!0)->PI(three),Akt(PH)" ForwardRate="1" />
204<Rule Id="190" Name="Ras_Raf" Data="Ras(S1S2~gtp),Raf(x~u)->Ras(S1S2~gtp!0),Raf(x~u!0)" ForwardRate="1" />
205<Rule Id="191" Name="Raf" Data="Ras(S1S2~gtp!0),Raf(x~u!0)->Ras(S1S2~gtp!0),Raf(x~p!0)" ForwardRate="1" />
206<Rule Id="192" Name="Ras_Raf_op" Data="Ras(S1S2~gtp!0),Raf(x!0)->Ras(S1S2~gtp),Raf(x)" ForwardRate="1" />
207<Rule Id="193" Name="SoS_ERK" Data="SoS(SS),ERK(T185~p,Y187~p,s)->SoS(SS!0),ERK(T185~p,Y187~p,s!0)" ForwardRate="1" />
208<Rule Id="194" Name="SoS_ERK_op" Data="SoS(SS!0),ERK(T185~p,Y187~p,s!0)->SoS(SS),ERK(T185~p,Y187~p,s)" ForwardRate="1" />
209<Rule Id="195" Name="SoS@SS" Data="SoS(SS~u!0),ERK(T185~p,Y187~p,s!0)->SoS(SS~p!0),ERK(T185~p,Y187~p,s!0)" ForwardRate="1" />
210<Rule Id="196" Name="SoS@SS_op" Data="SoS(SS~p)=>SoS(SS~u),Pi()" ForwardRate="1" />
211<Rule Id="197" Name="EGFR_RasGAP" Data="EGFR(Y1016~p),RasGAP(SH2~u)=>EGFR(Y1016~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
212<Rule Id="198" Name="EGFR_RasGAP_op" Data="EGFR(Y1016~p!0),RasGAP(SH2~rec!0)=>EGFR(Y1016~p),RasGAP(SH2~u)" ForwardRate="1" />
213<Rule Id="199" Name="EGFR_Grb2" Data="EGFR(Y1092~p),Grb2(SH2~u)=>EGFR(Y1092~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
214<Rule Id="200" Name="EGFR_Grb2_op" Data="EGFR(Y1092~p!0),Grb2(SH2~rec!0)=>EGFR(Y1092~p),Grb2(SH2~u)" ForwardRate="1" />
215<Rule Id="201" Name="EGFR_Shc" Data="EGFR(Y1172~p),Shc(PTB~u)=>EGFR(Y1172~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
216<Rule Id="202" Name="EGFR_Shc_op" Data="EGFR(Y1172~p!0),Shc(PTB~rec!0)=>EGFR(Y1172~p),Shc(PTB~u)" ForwardRate="1" />
217<Rule Id="203" Name="HER2_Grb2" Data="HER2(Y1139~p),Grb2(SH2~u)=>HER2(Y1139~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
218<Rule Id="204" Name="HER2_Grb2_op" Data="HER2(Y1139~p!0),Grb2(SH2~rec!0)=>HER2(Y1139~p),Grb2(SH2~u)" ForwardRate="1" />
219<Rule Id="205" Name="HER2_Shc#1" Data="HER2(Y1196~p),Shc(PTB~u)=>HER2(Y1196~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
220<Rule Id="206" Name="HER2_Shc#1_op" Data="HER2(Y1196~p!0),Shc(PTB~rec!0)=>HER2(Y1196~p),Shc(PTB~u)" ForwardRate="1" />
221<Rule Id="207" Name="HER2_RasGAP" Data="HER2(Y1221~p),RasGAP(SH2~u)=>HER2(Y1221~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
222<Rule Id="208" Name="HER2_RasGAP_op" Data="HER2(Y1221~p!0),RasGAP(SH2~rec!0)=>HER2(Y1221~p),RasGAP(SH2~u)" ForwardRate="1" />
223<Rule Id="209" Name="HER2_Shc#2" Data="HER2(Y1221~p),Shc(PTB~u)=>HER2(Y1221~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
224<Rule Id="210" Name="HER2_Shc#2_op" Data="HER2(Y1221~p!0),Shc(PTB~rec!0)=>HER2(Y1221~p),Shc(PTB~u)" ForwardRate="1" />
225<Rule Id="211" Name="HER3_PI3K#1" Data="HER3(Y1035~p),PI3K(SH2~u)=>HER3(Y1035~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
226<Rule Id="212" Name="HER3_PI3K#1_op" Data="HER3(Y1035~p!0),PI3K(SH2~rec!0)=>HER3(Y1035~p),PI3K(SH2~u)" ForwardRate="1" />
227<Rule Id="213" Name="HER3_PI3K#2" Data="HER3(Y1178~p),PI3K(SH2~u)=>HER3(Y1178~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
228<Rule Id="214" Name="HER3_PI3K#2_op" Data="HER3(Y1178~p!0),PI3K(SH2~rec!0)=>HER3(Y1178~p),PI3K(SH2~u)" ForwardRate="1" />
229<Rule Id="215" Name="HER3_PI3K#3" Data="HER3(Y1203~p),PI3K(SH2~u)=>HER3(Y1203~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
230<Rule Id="216" Name="HER3_PI3K#3_op" Data="HER3(Y1203~p!0),PI3K(SH2~rec!0)=>HER3(Y1203~p),PI3K(SH2~u)" ForwardRate="1" />
231<Rule Id="217" Name="HER3_PI3K#4" Data="HER3(Y1241~p),PI3K(SH2~u)=>HER3(Y1241~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
232<Rule Id="218" Name="HER3_PI3K#4_op" Data="HER3(Y1241~p!0),PI3K(SH2~rec!0)=>HER3(Y1241~p),PI3K(SH2~u)" ForwardRate="1" />
233<Rule Id="219" Name="HER3_PI3K#5" Data="HER3(Y1257~p),PI3K(SH2~u)=>HER3(Y1257~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
234<Rule Id="220" Name="HER3_PI3K#5_op" Data="HER3(Y1257~p!0),PI3K(SH2~rec!0)=>HER3(Y1257~p),PI3K(SH2~u)" ForwardRate="1" />
235<Rule Id="221" Name="HER3_PI3K#6" Data="HER3(Y1270~p),PI3K(SH2~u)=>HER3(Y1270~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
236<Rule Id="222" Name="HER3_PI3K#6_op" Data="HER3(Y1270~p!0),PI3K(SH2~rec!0)=>HER3(Y1270~p),PI3K(SH2~u)" ForwardRate="1" />
237<Rule Id="223" Name="HER3_Shc" Data="HER3(Y1309~p),Shc(PTB~u)=>HER3(Y1309~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
238<Rule Id="224" Name="HER3_Shc_op" Data="HER3(Y1309~p!0),Shc(PTB~rec!0)=>HER3(Y1309~p),Shc(PTB~u)" ForwardRate="1" />
239<Rule Id="225" Name="HER4_RasGAP" Data="HER4(Y1~p),RasGAP(SH2~u)=>HER4(Y1~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
240<Rule Id="226" Name="HER4_RasGAP_op" Data="HER4(Y1~p!0),RasGAP(SH2~rec!0)=>HER4(Y1~p),RasGAP(SH2~u)" ForwardRate="1" />
241<Rule Id="227" Name="HER4_Grb2" Data="HER4(Y2~p),Grb2(SH2~u)=>HER4(Y2~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
242<Rule Id="228" Name="HER4_Grb2_op" Data="HER4(Y2~p!0),Grb2(SH2~rec!0)=>HER4(Y2~p),Grb2(SH2~u)" ForwardRate="1" />
243<Rule Id="229" Name="HER4_Shc" Data="HER4(Y3~p),Shc(PTB~u)=>HER4(Y3~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
244<Rule Id="230" Name="HER4_Shc_op" Data="HER4(Y3~p!0),Shc(PTB~rec!0)=>HER4(Y3~p),Shc(PTB~u)" ForwardRate="1" />
245<Rule Id="231" Name="Shc@Y" Data="Shc(PTB~rec!_,Y~u)->Shc(PTB~rec!_,Y~p)" ForwardRate="1" />
246<Rule Id="232" Name="Gab1@48" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48~p)" ForwardRate="1" />
247<Rule Id="233" Name="Gab1@317" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317~p)" ForwardRate="1" />
248<Rule Id="234" Name="Gab1@447" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447~p)" ForwardRate="1" />
249<Rule Id="235" Name="Gab1@472" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472~p)" ForwardRate="1" />
250<Rule Id="236" Name="Gab1@619" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619~p)" ForwardRate="1" />
251<Rule Id="237" Name="Gab1@657" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y657~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y657~p)" ForwardRate="1" />
252<Rule Id="238" Name="Gab1@689" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y689~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y689~p)" ForwardRate="1" />
253<Rule Id="239" Name="Gab1@48_op" Data="Gab1(Y48~p)->Gab1(Y48~u)" ForwardRate="1" />
254<Rule Id="240" Name="Gab1@317_op" Data="Gab1(Y317~p)->Gab1(Y317~u)" ForwardRate="1" />
255<Rule Id="241" Name="Gab1@657_op" Data="Gab1(Y657~p)->Gab1(Y657~u)" ForwardRate="1" />
256<Rule Id="242" Name="Gab1@689_op" Data="Gab1(Y689~p)->Gab1(Y689~u)" ForwardRate="1" />
257<Rule Id="243" Name="Gab1_Grb2" Data="Gab1(Y48~p),Grb2(SH2)->Gab1(Y48~p!0),Grb2(SH2!0)" ForwardRate="1" />
258<Rule Id="244" Name="Gab1_Grb2_op" Data="Gab1(Y48~p!0),Grb2(SH2!0)->Gab1(Y48~p),Grb2(SH2)" ForwardRate="1" />
259<Rule Id="245" Name="Gab1_RasGAP" Data="Gab1(Y317~p),RasGAP(SH2)->Gab1(Y317~p!0),RasGAP(SH2!0)" ForwardRate="1" />
260<Rule Id="246" Name="Gab1_RasGAP_op" Data="Gab1(Y317~p!0),RasGAP(SH2!0)->Gab1(Y317~p),RasGAP(SH2)" ForwardRate="1" />
261<Rule Id="247" Name="Gab1_PI3K@447_op" Data="Gab1(Y447!0),PI3K(SH2!0)->Gab1(Y447),PI3K(SH2)" ForwardRate="1" />
262<Rule Id="248" Name="Gab1_PI3K@472_op" Data="Gab1(Y472!0),PI3K(SH2!0)->Gab1(Y472),PI3K(SH2)" ForwardRate="1" />
263<Rule Id="249" Name="Gab1_PI3K@619_op" Data="Gab1(Y619!0),PI3K(SH2!0)->Gab1(Y619),PI3K(SH2)" ForwardRate="1" />
264<Rule Id="250" Name="Gab1_Shp2#1" Data="Gab1(Y689~p),Shp2(SH2c)->Gab1(Y689~p!0),Shp2(SH2c!0)" ForwardRate="1" />
265<Rule Id="251" Name="Gab1_Shp2#2" Data="Gab1(Y657~p,Y689!0),Shp2(SH2c!0,SH2n)->Gab1(Y657~p!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
266<Rule Id="252" Name="Gab1_Shp2_op#1" Data="Gab1(Y657!0),Shp2(SH2n!0)->Gab1(Y657),Shp2(SH2n)" ForwardRate="1" />
267<Rule Id="253" Name="Gab1_Shp2_op#2" Data="Gab1(Y689!0),Shp2(SH2c!0)->Gab1(Y689),Shp2(SH2c)" ForwardRate="1" />
268<Rule Id="254" Name="Rule62" Data="Gab1(Y317~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y317~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
269<Rule Id="255" Name="Rule63" Data="Gab1(Y447~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y447~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
270<Rule Id="256" Name="Rule64" Data="Gab1(Y472~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y472~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
271<Rule Id="257" Name="Rule65" Data="Gab1(Y619~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y619~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
272<Rule Id="258" Name="PI3K@s Rec" Data="PI3K(SH2~rec!_,s~u)->PI3K(SH2~rec!_,s~p)" ForwardRate="1" />
273<Rule Id="259" Name="PI3K@s Gab#1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
274<Rule Id="260" Name="PI3K@s Gab#2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
275<Rule Id="261" Name="PI3K@s Gab#3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
276<Rule Id="262" Name="PI3K@s_op" Data="PI3K(s~p)->PI3K(s~u)" ForwardRate="1" />
277<Rule Id="263" Name="SoS short arm" Data="Grb2(SH2~rec!_,SH3n!0),SoS(GEF,PR!0),Ras(s~gdp)->Grb2(SH2~rec!_,SH3n!0),SoS(GEF!1,PR!0),Ras(s~gdp!1)" ForwardRate="1" />
278<Rule Id="264" Name="SoS long arm" Data="Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />
279<Rule Id="265" Name="SoS vlong arm" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48!1),Grb2(SH2!1,SH3n!2),SoS(GEF,PR!2),Ras(s~gdp)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48!1),Grb2(SH2!1,SH3n!2),SoS(GEF!3,PR!2),Ras(s~gdp!3)" ForwardRate="1" />
280<Rule Id="266" Name="RasGAP no arm" Data="RasGAP(GAP,SH2~rec!_),Ras(s~gtp)->RasGAP(GAP!0,SH2~rec!_),Ras(s~gtp!0)" ForwardRate="1" />
281<Rule Id="267" Name="RasGAP long arm" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317!1),RasGAP(GAP,SH2!1),Ras(s~gtp)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317!1),RasGAP(GAP!2,SH2!1),Ras(s~gtp!2)" ForwardRate="1" />
282<Rule Id="268" Name="PI3K no arm" Data="PI3K(SH2~rec!_,s~p),PI(three~u)->PI3K(SH2~rec!_,s~p!0),PI(three~u!0)" ForwardRate="1" />
283<Rule Id="269" Name="PI3K long arm #1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
284<Rule Id="270" Name="PI3K long arm #2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
285<Rule Id="271" Name="PI3K long arm #3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
286<Rule Id="272" Name="intrinsic GDP" Data="Ras(s~gtp)->Ras(s~gdp)" ForwardRate="1" />
287<Rule Id="273" Name="PI@five" Data="PI(five~u)->PI(five~p)" ForwardRate="1" />
288<Rule Id="274" Name="PI@five_op" Data="SHIP(s!0),PI(five~p!0)->SHIP(s!0),PI(five~u!0)" ForwardRate="1" />
289<Rule Id="275" Name="Ras_PI3K no arm" Data="Ras(s~gtp),PI3K(RBD,SH2~rec!_,s~u)->Ras(s~gtp!0),PI3K(RBD!0,SH2~rec!_,s~u)" ForwardRate="1" />
290<Rule Id="276" Name="Ras_PI3K long arm #1" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
291<Rule Id="277" Name="Ras_PI3K long arm #2" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
292<Rule Id="278" Name="Ras_PI3K long arm #3" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
293<Rule Id="279" Name="Ras_PI3K_op" Data="Ras(s!0),PI3K(RBD!0)->Ras(s),PI3K(RBD)" ForwardRate="1" />
294<Rule Id="280" Name="PIP3_Gab1" Data="PI(five~p,four~p,three~p),Grb2(SH2~rec!_,SH3c!0),Gab1(PH,PR!0)->PI(five~p,four~p,three~p!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PH!0,PR!1)" ForwardRate="1" />
295<Rule Id="281" Name="PIP3_Gab1_op" Data="PI(three!0),Gab1(PH!0)->PI(three),Gab1(PH)" ForwardRate="1" />
296<Rule Id="282" Name="PI3K@s Ras" Data="PI3K(RBD!_,s~u)->PI3K(RBD!_,s~p)" ForwardRate="1" />
297<Rule Id="283" Name="RasGAP Gab arm" Data="Gab1(PH!_,Y317~p!0),RasGAP(GAP,SH2!0),Ras(s~gtp)->Gab1(PH!_,Y317~p!0),RasGAP(GAP!1,SH2!0),Ras(s~gtp!1)" ForwardRate="1" />
298<Rule Id="284" Name="SoS Gab arm #1" Data="Gab1(PH!_,Y48~p!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Gab1(PH!_,Y48~p!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />
299<Rule Id="285" Name="SoS Gab arm #2" Data="Gab1(PH!_,PR!0),Grb2(SH3c!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Gab1(PH!_,PR!0),Grb2(SH3c!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />
300<Rule Id="286" Name="PI3K Ras arm" Data="PI3K(RBD!_,s~p),PI(three~u)->PI3K(RBD!_,s~p!0),PI(three~u!0)" ForwardRate="1" />
301<Rule Id="287" Name="PI3K Gab arm #1" Data="Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
302<Rule Id="288" Name="PI3K Gab arm #2" Data="Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
303<Rule Id="289" Name="PI3K Gab arm #3" Data="Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
304<Rule Id="290" Name="ERK_SoS" Data="ERK(T~p,Y~p,s),SoS(S~u)->ERK(T~p,Y~p,s!0),SoS(S~u!0)" ForwardRate="1" />
305<Rule Id="291" Name="ERK_SoS_op" Data="ERK(s!0),SoS(S!0)->ERK(s),SoS(S)" ForwardRate="1" />
306<Rule Id="292" Name="ERK_Gab1#1" Data="ERK(T~p,Y~p,s),Gab1(S454~u)->ERK(T~p,Y~p,s!0),Gab1(S454~u!0)" ForwardRate="1" />
307<Rule Id="293" Name="ERK_Gab1#2" Data="ERK(T~p,Y~p,s),Gab1(T476~u)->ERK(T~p,Y~p,s!0),Gab1(T476~u!0)" ForwardRate="1" />
308<Rule Id="294" Name="ERK_Gab1#3" Data="ERK(T~p,Y~p,s),Gab1(S597~u)->ERK(T~p,Y~p,s!0),Gab1(S597~u!0)" ForwardRate="1" />
309<Rule Id="295" Name="ERK_Gab1#1_op" Data="ERK(s!0),Gab1(S454!0)->ERK(s),Gab1(S454)" ForwardRate="1" />
310<Rule Id="296" Name="ERK_Gab1#2_op" Data="ERK(s!0),Gab1(T476!0)->ERK(s),Gab1(T476)" ForwardRate="1" />
311<Rule Id="297" Name="ERK_Gab1#3_op" Data="ERK(s!0),Gab1(S597!0)->ERK(s),Gab1(S597)" ForwardRate="1" />
312<Rule Id="298" Name="SoS@S" Data="ERK(s!0),SoS(S~u!0)->ERK(s!0),SoS(S~p!0)" ForwardRate="1" />
313<Rule Id="299" Name="SoS@S_op" Data="SoS(S~p)->SoS(S~u)" ForwardRate="1" />
314<Rule Id="300" Name="Gab1@454" Data="ERK(s!0),Gab1(S454~u!0)->ERK(s!0),Gab1(S454~p!0)" ForwardRate="1" />
315<Rule Id="301" Name="Gab1@476" Data="ERK(s!0),Gab1(T476~u!0)->ERK(s!0),Gab1(T476~p!0)" ForwardRate="1" />
316<Rule Id="302" Name="Gab1@597" Data="ERK(s!0),Gab1(S597~u!0)->ERK(s!0),Gab1(S597~p!0)" ForwardRate="1" />
317<Rule Id="303" Name="Gab1@454_op" Data="Gab1(S454~p)->Gab1(S454~u)" ForwardRate="1" />
318<Rule Id="304" Name="Gab1@476_op" Data="Gab1(T476~p)->Gab1(T476~u)" ForwardRate="1" />
319<Rule Id="305" Name="Gab1@597_op" Data="Gab1(S597~p)->Gab1(S597~u)" ForwardRate="1" />
320<Rule Id="306" Name="EGFR_Grb2@Y1086_SH2" Data="EGFR(Y1086~p),Grb2(SH2)->EGFR(Y1086~p!0),Grb2(SH2!0)" ForwardRate="1" />
321<Rule Id="307" Name="Shc_Src@SH2_S1" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2),Src(S1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2!1),Src(S1!1)" ForwardRate="1" />
322<Rule Id="308" Name="Shc_p@Y239" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)" ForwardRate="1" />
323<Rule Id="309" Name="Shc_Src_op" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~p),Src(S1)" ForwardRate="1" />
324<Rule Id="310" Name="Shc_p@Y240" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y240~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y240~p),Src(S1!1)" ForwardRate="1" />
325<Rule Id="311" Name="EGFR_Shc@Y1173_PTB" Data="Shc(PTB),EGFR(Y1173~p)->Shc(PTB!0),EGFR(Y1173~p!0)" ForwardRate="1" />
326<Rule Id="312" Name="EGFR_Shc@Y1173_SH2" Data="Shc(SH2),EGFR(Y1173~p)->Shc(SH2!0),EGFR(Y1173~p!0)" ForwardRate="1" />
327<Rule Id="313" Name="EGFR_Shc@Y992_PTB" Data="Shc(PTB),EGFR(Y992~p)->Shc(PTB!0),EGFR(Y992~p!0)" ForwardRate="1" />
328<Rule Id="314" Name="EGFR_Shc@Y992_SH2" Data="Shc(SH2),EGFR(Y992~p)->Shc(SH2!0),EGFR(Y992~p!0)" ForwardRate="1" />
329<Rule Id="315" Name="Shc_EGFR@PTB_Y1148" Data="EGFR(Y1148~p),Shc(PTB)->EGFR(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />
330<Rule Id="316" Name="Shc_EGFR@PTB_Y1148_op" Data="EGFR(Y1148~p!0),Shc(PTB!0)->EGFR(Y1148~p),Shc(PTB)" ForwardRate="1" />
331<Rule Id="317" Name="Shc_EGFR@SH2_Y1148" Data="EGFR(Y1148~p),Shc(SH2)->EGFR(Y1148~p!0),Shc(SH2!0)" ForwardRate="1" />
332<Rule Id="318" Name="Shc_EGFR@SH2_Y1148_op" Data="EGFR(Y1148~p!0),Shc(SH2!0)->EGFR(Y1148~p),Shc(SH2)" ForwardRate="1" />
333<Rule Id="319" Name="Shc_EGFR@PTB_Y1173" Data="EGFR(Y1173~p),Shc(PTB)->EGFR(Y1173~p!0),Shc(PTB!0)" ForwardRate="1" />
334<Rule Id="320" Name="Shc_EGFR@PTB_Y1173_op" Data="EGFR(Y1173~p!0),Shc(PTB!0)->EGFR(Y1173~p),Shc(PTB)" ForwardRate="1" />
335<Rule Id="321" Name="Shc_EGFR@SH2_Y1173" Data="EGFR(Y1173~p),Shc(SH2)->EGFR(Y1173~p!0),Shc(SH2!0)" ForwardRate="1" />
336<Rule Id="322" Name="Shc_EGFR@SH2_Y1173_op" Data="EGFR(Y1173~p!0),Shc(SH2!0)->EGFR(Y1173~p),Shc(SH2)" ForwardRate="1" />
337<Rule Id="323" Name="Shc_p@Y317" Data="EGFR(Y1148~p!0),Shc(PTB!0,Y317~u)->EGFR(Y1148~p!0),Shc(PTB!0,Y317~p)" ForwardRate="1" />
338<Rule Id="324" Name="EGFR_p@Y1086" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1086~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1086~p),A(s~pp!0)" ForwardRate="1" />
339<Rule Id="325" Name="EGFR_p@Y1173" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1173~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1173~p),A(s~pp!0)" ForwardRate="1" />
340<Rule Id="326" Name="EGFR_Shc@Y1068_SH2" Data="EGFR(Y1068~p),Shc(SH2)->EGFR(Y1068~p!0),Shc(SH2!0)" ForwardRate="1" />
341<Rule Id="327" Name="EGFR_Shc@Y1068_SH2_op" Data="EGFR(Y1068~p!0),Shc(SH2!0)->EGFR(Y1068~p),Shc(SH2)" ForwardRate="1" />
342<Rule Id="328" Name="EGFR_Shc@Y1086_SH2" Data="EGFR(Y1086~p),Shc(SH2)->EGFR(Y1086~p!0),Shc(SH2!0)" ForwardRate="1" />
343<Rule Id="329" Name="EGFR_Shc@Y1086_SH2_op" Data="EGFR(Y1086~p!0),Shc(SH2!0)->EGFR(Y1086~p),Shc(SH2)" ForwardRate="1" />
344<Rule Id="330" Name="EGFR_Gab1@S1_S1" Data="Gab1(X~u),EGFR(S1)->Gab1(X~u!0),EGFR(S1!0)" ForwardRate="1" />
345<Rule Id="331" Name="Gab1_p@Y627" Data="Gab1(Y627~u!0),EGFR(S1!0)->Gab1(Y627~p!0),EGFR(S1!0)" ForwardRate="1" />
346<Rule Id="332" Name="Gab1_EGFR_op" Data="Gab1(Y627~p!0),EGFR(S1!0)->Gab1(Y627~p),EGFR(S1)" ForwardRate="1" />
347<Rule Id="333" Name="Gab1_p@Y659" Data="Gab1(Y659~u!0),EGFR(S1!0)->Gab1(Y659~p!0),EGFR(S1!0)" ForwardRate="1" />
348<Rule Id="334" Name="Gab1_PIP3@PH" Data="Gab1(PH),PI(five~p,four~p,three~p)->Gab1(PH!0),PI(five~p!0,four~p,three~p)" ForwardRate="1" />
349<Rule Id="335" Name="Gab1_SHP2@Y627_SH2n" Data="Gab1(Y627~p),SHP2(SH2n)->Gab1(Y627~p!0),SHP2(SH2n!0)" ForwardRate="1" />
350<Rule Id="336" Name="Gab1_SHP2@Y659_SH2c" Data="Gab1(Y659~p),SHP2(SH2c)->Gab1(Y659~p!0),SHP2(SH2c!0)" ForwardRate="1" />
351<Rule Id="337" Name="Gab1_u@Y659" Data="Gab1(Y659~p!0),SHP2(SH2c!0)->Gab1(Y659~u!0),SHP2(SH2c!0)" ForwardRate="1" />
352<Rule Id="338" Name="Gab1_u@Y627" Data="Gab1(Y627~p!0),SHP2(SH2c!0)->Gab1(Y627~u!0),SHP2(SH2c!0)" ForwardRate="1" />
353<Rule Id="339" Name="Gab1_PLCG1@Y307_SH2" Data="Gab1(Y307~p),PLCG1(SH2)->Gab1(Y307~p!0),PLCG1(SH2!0)" ForwardRate="1" />
354<Rule Id="340" Name="Gab1_PLCG1@Y373_SH2" Data="Gab1(Y373~p),PLCG1(SH2)->Gab1(Y373~p!0),PLCG1(SH2!0)" ForwardRate="1" />
355<Rule Id="341" Name="Gab1_PLCG1@Y407_SH2" Data="Gab1(Y407~p),PLCG1(SH2)->Gab1(Y407~p!0),PLCG1(SH2!0)" ForwardRate="1" />
356<Rule Id="342" Name="Akt_PIP2@PH" Data="Akt(PH),PI(four~p,three~p)->Akt(PH!0),PI(four~p!0,three~p)" ForwardRate="1" />
357<Rule Id="343" Name="Vav_PIP3@PH" Data="PI(five~p,four~p,three~p),Vav(PH)->PI(five~p!0,four~p,three~p),Vav(PH!0)" ForwardRate="1" />
358<Rule Id="344" Name="Vav_PIP3@PH_op" Data="PI(five~p!0,four~p,three~p),Vav(PH!0)->PI(five~p,four~p,three~p),Vav(PH)" ForwardRate="1" />
359<Rule Id="345" Name="Vav_Rac@DH_X~u" Data="PI(five~p!0,four~p,three~p),Vav(DH,PH!0,X~p),Rac(X~u)->PI(five~p!0,four~p,three~p),Vav(DH!1,PH!0,X~p),Rac(X~u!1)" ForwardRate="1" />
360<Rule Id="346" Name="Vav_Rac@DH_X~u_op" Data="PI(five~p!0,four~p,three~p),Vav(DH!1,PH!0,X~p),Rac(X~u!1)->PI(five~p!0,four~p,three~p),Vav(DH,PH!0,X~p),Rac(X~u)" ForwardRate="1" />
361<Rule Id="347" Name="Rac_p@X" Data="Rac(X~gdp!0),Vav(DH!0,PH!1,X~p),PI(five~p!1,four~p,three~p)->Rac(X~gtp!0),Vav(DH!0,PH!1,X~p),PI(five~p!1,four~p,three~p)" ForwardRate="1" />
362<Rule Id="348" Name="PIP3_Sos@PH" Data="PI(five~p,four~p,three~p),Sos(PH)->PI(five~p!0,four~p,three~p),Sos(PH!0)" ForwardRate="1" />
363<Rule Id="349" Name="Sos_Rac@DH_X~u" Data="PI(five~p!0,four~p,three~p),Sos(DH,PH!0,X~p),Rac(X~u)->PI(five~p!0,four~p,three~p),Sos(DH!1,PH!0,X~p),Rac(X~u!1)" ForwardRate="1" />
364<Rule Id="350" Name="Sos_Rac@DH_X~u_op" Data="PI(five~p!0,four~p,three~p),Sos(DH!1,PH!0,X~p),Rac(X~u!1)->PI(five~p!0,four~p,three~p),Sos(DH,PH!0,X~p),Rac(X~u)" ForwardRate="1" />
365<Rule Id="351" Name="PIP2_PLD@PH" Data="PI(five~p,four~p),PLD(PH)->PI(five~p!0,four~p),PLD(PH!0)" ForwardRate="1" />
366<Rule Id="352" Name="PIP2_PLD@PH_op" Data="PI(five~p!0,four~p),PLD(PH!0)->PI(five~p,four~p),PLD(PH)" ForwardRate="1" />
367<Rule Id="353" Name="Rom2_PI3K@PH_S1" Data="Rom2(PH),PI3K(S1)->Rom2(PH!0),PI3K(S1!0)" ForwardRate="1" />
368<Rule Id="354" Name="Rom2_PI3K@PH_S1_op" Data="Rom2(PH!0),PI3K(S1!0)->Rom2(PH),PI3K(S1)" ForwardRate="1" />
369<Rule Id="355" Name="Grb2_EGFR@SH2_Y1068" Data="Grb2(SH2),EGFR(Y1068~p)->Grb2(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />
370<Rule Id="356" Name="Pak1_Grb2@SH3_SBM" Data="Grb2(SH2!0,SH3),EGFR(Y1068~p!0),Pak1(SBM)->Grb2(SH2!1,SH3!0),EGFR(Y1068~p!1),Pak1(SBM!0)" ForwardRate="1" />
371<Rule Id="357" Name="Raf1_Ras@CR1_rafts" Data="Raf1(CR1,Y341~p),Ras(rafts)->Raf1(CR1!0,Y341~p),Ras(rafts!0)" ForwardRate="1" />
372<Rule Id="358" Name="Raf1_p@S338" Data="Raf1(CR1!0,S338~u,Y341~p),Ras(rafts!0)->Raf1(CR1!0,S338~p,Y341~p),Ras(rafts!0)" ForwardRate="1" />
373<Rule Id="359" Name="New Rule" Data="A(x~u)->A(x~p)" ForwardRate="1" />
374<Rule Id="360" Name="New Rule_op" Data="A(x~p)->A(x~u)" ForwardRate="1" />
375<Rule Id="361" Name="Rule66" Data="A(x~p),B(x1)->A(x~p!0),B(x1!0)" ForwardRate="1" />
376<Rule Id="362" Name="Rule67" Data="A(x!0),B(x1!0)->A(x),B(x1)" ForwardRate="1" />
377<Rule Id="363" Name="Rule68" Data="A(x!0),B(x1!0,y1~u)->A(x!0),B(x1!0,y1~p)" ForwardRate="1" />
378<Rule Id="364" Name="Rule69" Data="A(x~p),B(x2)->A(x~p!0),B(x2!0)" ForwardRate="1" />
379<Rule Id="365" Name="Rule70" Data="A(x!0),B(x2!0)->A(x),B(x2)" ForwardRate="1" />
380<Rule Id="366" Name="Rule71" Data="A(x!0),B(x2!0,y2~u)->A(x!0),B(x2!0,y2~p)" ForwardRate="1" />
381</RuleSet>
382<ContactMap Name="Low resolution">
383<Agent Name="Shc">
384<Site Name="PTB" CanChangeState="true" CanBeBound="true">
385<Rule Id="201"/>
386<Rule Id="202"/>
387<Rule Id="205"/>
388<Rule Id="206"/>
389<Rule Id="209"/>
390<Rule Id="210"/>
391<Rule Id="223"/>
392<Rule Id="224"/>
393<Rule Id="229"/>
394<Rule Id="230"/>
395</Site>
396<Site Name="SH2" CanChangeState="false" CanBeBound="true">
397</Site>
398<Site Name="Y" CanChangeState="true" CanBeBound="true">
399<Rule Id="231"/>
400</Site>
401<Site Name="Y239" CanChangeState="true" CanBeBound="true">
402<Rule Id="308"/>
403</Site>
404<Site Name="Y240" CanChangeState="true" CanBeBound="true">
405<Rule Id="310"/>
406</Site>
407<Site Name="Y317" CanChangeState="true" CanBeBound="true">
408<Rule Id="323"/>
409</Site>
410<Site Name="Y318" CanChangeState="true" CanBeBound="true">
411<Rule Id="51"/>
412<Rule Id="52"/>
413<Rule Id="125"/>
414<Rule Id="126"/>
415<Rule Id="127"/>
416</Site>
417</Agent>
418<Agent Name="RasGAP">
419<Site Name="GAP" CanChangeState="false" CanBeBound="true">
420</Site>
421<Site Name="SH2" CanChangeState="true" CanBeBound="true">
422<Rule Id="197"/>
423<Rule Id="198"/>
424<Rule Id="207"/>
425<Rule Id="208"/>
426<Rule Id="225"/>
427<Rule Id="226"/>
428</Site>
429<Site Name="s" CanChangeState="false" CanBeBound="true">
430</Site>
431</Agent>
432<Agent Name="Grb2">
433<Site Name="SH2" CanChangeState="true" CanBeBound="true">
434<Rule Id="199"/>
435<Rule Id="200"/>
436<Rule Id="203"/>
437<Rule Id="204"/>
438<Rule Id="227"/>
439<Rule Id="228"/>
440</Siteā€¦

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