/test.data/contact_map/agents/~session027.test

http://github.com/kappamodeler/jkappa · Unknown · 710 lines · 710 code · 0 blank · 0 comment · 0 complexity · 6bf3d726c1ae35423bc9558b4e60cb74 MD5 · raw file

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  1. <?xml version='1.0' encoding='utf-8'?>

    2. 

  2. <!-- Automaticaly generated by Complx 3.40..4208 -->

    3. 

  3. <ComplxSession Timestamp="25/2/2009 (21:53:40)" CommandLine="C:\DOCUME~1\LOPATK~1\LOCALS~1\Temp\tmp53467.exe ~kappa53549.tmp --output-xml ~session53548.tmp --memory-limit 1024 --reset-all --do-XML --do-low-res-contact-map --focus-on ~focus53547.tmp --key 07CFC00F0BEB0D5B" InputFile="~kappa53549.tmp" 

    4. 

  4. xsi:schemaLocation="http://plectix.synthesisstudios.com

    5. 

  5. KappaSession.xsd" xmlns="http://plectix.synthesisstudios.com/schemas/kappasession"

    6. 

  6. xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" >

    7. 

  7. <Log>

    8. 

  8. <Entry Type="INFO" Message="Compilation(simplx)                      0.062 s."/>

    9. 

  9. <Entry Type="INFO" Message="Second compilation(pretty printing)      0.016 s."/>

    10. 

  10. <Entry Type="INFO" Message="Translation                              0. s."/>

    11. 

  11. <Entry Type="INFO" Message="Renaming                                 0.031 s."/>

    12. 

  12. <Entry Type="INFO" Message="Boolean encoding of the initial system   0.125 s."/>

    13. 

  13. </Log>

    14. 

  14. <RuleSet Name="Original">

    15. 

  15. <Rule Id="1" Name="ErbB1_ErbB2" Data="ErbB1(C,CR,L~ext!_,N),ErbB2(C,CR,L~ext,N)->ErbB1(C,CR!0,L~ext!_,N),ErbB2(C,CR!0,L~ext,N)" ForwardRate="1" />

    16. 

  16. <Rule Id="2" Name="ErbB1_ErbB2_op" Data="ErbB1(C,CR!0,L~ext!_,N),ErbB2(C,CR!0,L~ext,N)->ErbB1(C,CR,L~ext!_,N),ErbB2(C,CR,L~ext,N)" ForwardRate="1" />

    17. 

  17. <Rule Id="3" Name="ErbB2_ErbB3" Data="ErbB2(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)->ErbB2(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    18. 

  18. <Rule Id="4" Name="ErbB2_ErbB3_op" Data="ErbB2(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)->ErbB2(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)" ForwardRate="1" />

    19. 

  19. <Rule Id="5" Name="ErbB2_ErbB4" Data="ErbB2(C,CR,L~ext,N),ErbB4(C,CR,L~ext!_,N)->ErbB2(C,CR!0,L~ext,N),ErbB4(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    20. 

  20. <Rule Id="6" Name="ErbB2_ErbB4_op" Data="ErbB2(C,CR!0,L~ext,N),ErbB4(C,CR!0,L~ext!_,N)->ErbB2(C,CR,L~ext,N),ErbB4(C,CR,L~ext!_,N)" ForwardRate="1" />

    21. 

  21. <Rule Id="7" Name="ErbB2_ATP" Data="ErbB2(bp),A(s~ppp)->ErbB2(bp!0),A(s~ppp!0)" ForwardRate="1" />

    22. 

  22. <Rule Id="8" Name="ErbB2_A_op" Data="ErbB2(bp!0),A(s!0)->ErbB2(bp),A(s)" ForwardRate="1" />

    23. 

  23. <Rule Id="9" Name="Rule1" Data="ErbB2(C,CR!0,N),ErbB1(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB1(C!0,CR!1,N)" ForwardRate="1" />

    24. 

  24. <Rule Id="10" Name="Rule1_op" Data="ErbB2(C,CR!1,N!0),ErbB1(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB1(C,CR!0,N)" ForwardRate="1" />

    25. 

  25. <Rule Id="11" Name="Rule2" Data="ErbB2(N!1,bp!0),ErbB1(C!1,Y992~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB1(C!1,Y992~p),A(s~pp!0)" ForwardRate="1" />

    26. 

  26. <Rule Id="12" Name="Rule3" Data="ErbB2(N!1,bp!0),ErbB1(C!1,Y1068~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB1(C!1,Y1068~p),A(s~pp!0)" ForwardRate="1" />

    27. 

  27. <Rule Id="13" Name="Rule4" Data="ErbB2(N!1,bp!0),ErbB1(C!1,Y1148~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB1(C!1,Y1148~p),A(s~pp!0)" ForwardRate="1" />

    28. 

  28. <Rule Id="14" Name="Rule5" Data="ErbB1(C,CR!0,N),ErbB2(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB2(C!0,CR!1,N)" ForwardRate="1" />

    29. 

  29. <Rule Id="15" Name="Rule5_op" Data="ErbB1(C,CR!1,N!0),ErbB2(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB2(C,CR!0,N)" ForwardRate="1" />

    30. 

  30. <Rule Id="16" Name="Rule6" Data="ErbB2(C,CR!0,N),ErbB2(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB2(C!0,CR!1,N)" ForwardRate="1" />

    31. 

  31. <Rule Id="17" Name="Rule6_op" Data="ErbB2(C,CR!1,N!0),ErbB2(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB2(C,CR!0,N)" ForwardRate="1" />

    32. 

  32. <Rule Id="18" Name="Rule7" Data="ErbB4(C,CR!0,N),ErbB2(C,CR!0,N)->ErbB4(C,CR!1,N!0),ErbB2(C!0,CR!1,N)" ForwardRate="1" />

    33. 

  33. <Rule Id="19" Name="Rule7_op" Data="ErbB4(C,CR!1,N!0),ErbB2(C!0,CR!1,N)->ErbB4(C,CR!0,N),ErbB2(C,CR!0,N)" ForwardRate="1" />

    34. 

  34. <Rule Id="20" Name="Rule8" Data="ErbB1(N!1,bp!0),ErbB2(C!1,Y1139~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB2(C!1,Y1139~p),A(s~pp!0)" ForwardRate="1" />

    35. 

  35. <Rule Id="21" Name="Rule9" Data="ErbB1(N!1,bp!0),ErbB2(C!1,Y1196~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB2(C!1,Y1196~p),A(s~pp!0)" ForwardRate="1" />

    36. 

  36. <Rule Id="22" Name="Rule10" Data="ErbB1(N!1,bp!0),ErbB2(C!1,Y1221~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB2(C!1,Y1221~p),A(s~pp!0)" ForwardRate="1" />

    37. 

  37. <Rule Id="23" Name="Rule11" Data="ErbB4(N!1,bp!0),ErbB2(C!1,Y1139~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB2(C!1,Y1139~p),A(s~pp!0)" ForwardRate="1" />

    38. 

  38. <Rule Id="24" Name="Rule12" Data="ErbB4(N!1,bp!0),ErbB2(C!1,Y1196~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB2(C!1,Y1196~p),A(s~pp!0)" ForwardRate="1" />

    39. 

  39. <Rule Id="25" Name="Rule13" Data="ErbB4(N!1,bp!0),ErbB2(C!1,Y1221~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB2(C!1,Y1221~p),A(s~pp!0)" ForwardRate="1" />

    40. 

  40. <Rule Id="26" Name="Rule14" Data="ErbB2(C,CR!0,N),ErbB3(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB3(C!0,CR!1,N)" ForwardRate="1" />

    41. 

  41. <Rule Id="27" Name="Rule14_op" Data="ErbB2(C,CR!1,N!0),ErbB3(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB3(C,CR!0,N)" ForwardRate="1" />

    42. 

  42. <Rule Id="28" Name="Rule15" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1035~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1035~p),A(s~pp!0)" ForwardRate="1" />

    43. 

  43. <Rule Id="29" Name="Rule16" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1178~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1178~p),A(s~pp!0)" ForwardRate="1" />

    44. 

  44. <Rule Id="30" Name="Rule17" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1203~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1203~p),A(s~pp!0)" ForwardRate="1" />

    45. 

  45. <Rule Id="31" Name="Rule18" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1241~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1241~p),A(s~pp!0)" ForwardRate="1" />

    46. 

  46. <Rule Id="32" Name="Rule19" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1257~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1257~p),A(s~pp!0)" ForwardRate="1" />

    47. 

  47. <Rule Id="33" Name="Rule20" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1270~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1270~p),A(s~pp!0)" ForwardRate="1" />

    48. 

  48. <Rule Id="34" Name="Rule21" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1309~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1309~p),A(s~pp!0)" ForwardRate="1" />

    49. 

  49. <Rule Id="35" Name="Rule22" Data="ErbB2(C,CR!0,N),ErbB4(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB4(C!0,CR!1,N)" ForwardRate="1" />

    50. 

  50. <Rule Id="36" Name="Rule22_op" Data="ErbB2(C,CR!1,N!0),ErbB4(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB4(C,CR!0,N)" ForwardRate="1" />

    51. 

  51. <Rule Id="37" Name="Rule23" Data="ErbB2(N!1,bp!0),ErbB4(C!1,Y1056~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB4(C!1,Y1056~p),A(s~pp!0)" ForwardRate="1" />

    52. 

  52. <Rule Id="38" Name="Rule24" Data="ErbB2(N!1,bp!0),ErbB4(C!1,Y1188~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB4(C!1,Y1188~p),A(s~pp!0)" ForwardRate="1" />

    53. 

  53. <Rule Id="39" Name="Rule25" Data="ErbB2(N!1,bp!0),ErbB4(C!1,Y1242~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB4(C!1,Y1242~p),A(s~pp!0)" ForwardRate="1" />

    54. 

  54. <Rule Id="40" Name="Rule26" Data="ErbB2(Y1139~p)=>ErbB2(Y1139~u),Pi()" ForwardRate="1" />

    55. 

  55. <Rule Id="41" Name="Rule27" Data="ErbB2(Y1196~p)=>ErbB2(Y1196~u),Pi()" ForwardRate="1" />

    56. 

  56. <Rule Id="42" Name="Rule28" Data="ErbB2(Y1221~p)=>ErbB2(Y1221~u),Pi()" ForwardRate="1" />

    57. 

  57. <Rule Id="43" Name="ErbB2_RasGAP" Data="ErbB2(Y1221~p),RasGAP(SH2)->ErbB2(Y1221~p!0),RasGAP(SH2!0)" ForwardRate="1" />

    58. 

  58. <Rule Id="44" Name="ErbB2_RasGAP_op" Data="ErbB2(Y1221~p!0),RasGAP(SH2!0)->ErbB2(Y1221~p),RasGAP(SH2)" ForwardRate="1" />

    59. 

  59. <Rule Id="45" Name="ErbB2_Grb2" Data="ErbB2(Y1139~p),Grb2(SH2)->ErbB2(Y1139~p!0),Grb2(SH2!0)" ForwardRate="1" />

    60. 

  60. <Rule Id="46" Name="ErbB2_Grb2_op" Data="ErbB2(Y1139~p!0),Grb2(SH2!0)->ErbB2(Y1139~p),Grb2(SH2)" ForwardRate="1" />

    61. 

  61. <Rule Id="47" Name="ErbB2_Shc#1" Data="ErbB2(Y1196~p),Shc(PTB)->ErbB2(Y1196~p!0),Shc(PTB!0)" ForwardRate="1" />

    62. 

  62. <Rule Id="48" Name="ErbB2_Shc#1_op" Data="ErbB2(Y1196~p!0),Shc(PTB!0)->ErbB2(Y1196~p),Shc(PTB)" ForwardRate="1" />

    63. 

  63. <Rule Id="49" Name="ErbB2_Shc#2" Data="ErbB2(Y1221~p),Shc(PTB)->ErbB2(Y1221~p!0),Shc(PTB!0)" ForwardRate="1" />

    64. 

  64. <Rule Id="50" Name="ErbB2_Shc#2_op" Data="ErbB2(Y1221~p!0),Shc(PTB!0)->ErbB2(Y1221~p),Shc(PTB)" ForwardRate="1" />

    65. 

  65. <Rule Id="51" Name="Shc#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />

    66. 

  66. <Rule Id="52" Name="Shc#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />

    67. 

  67. <Rule Id="53" Name="long arm SoS_Ras#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />

    68. 

  68. <Rule Id="54" Name="long arm SoS_Ras#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />

    69. 

  69. <Rule Id="55" Name="short arm SoS_Ras#2" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b),Ras(S1S2~gdp)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b!2),Ras(S1S2~gdp!2)" ForwardRate="1" />

    70. 

  70. <Rule Id="56" Name="direct RasGAP_Ras#2" Data="ErbB2(Y1221~p!0),RasGAP(SH2!0,s),Ras(S1S2~gtp)->ErbB2(Y1221~p!0),RasGAP(SH2!0,s!1),Ras(S1S2~gtp!1)" ForwardRate="1" />

    71. 

  71. <Rule Id="57" Name="Gab1@447#2" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p)" ForwardRate="1" />

    72. 

  72. <Rule Id="58" Name="Gab1@472#2" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p)" ForwardRate="1" />

    73. 

  73. <Rule Id="59" Name="Gab1@619#2" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p)" ForwardRate="1" />

    74. 

  74. <Rule Id="60" Name="short arm PI3K_PI#4" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    75. 

  75. <Rule Id="61" Name="short arm PI3K_PI#5" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    76. 

  76. <Rule Id="62" Name="short arm PI3K_PI#6" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    77. 

  77. <Rule Id="63" Name="ATP recycling" Data="A(s~pp),Pi()=>A(s~ppp)" ForwardRate="1" />

    78. 

  78. <Rule Id="64" Name="EGF_ErbB1" Data="EGF(r~ext),ErbB1(CR,L~ext)->EGF(r~ext!0),ErbB1(CR,L~ext!0)" ForwardRate="1" />

    79. 

  79. <Rule Id="65" Name="EGF_ErbB1_op" Data="EGF(r~ext!0),ErbB1(CR,L~ext!0)->EGF(r~ext),ErbB1(CR,L~ext)" ForwardRate="1" />

    80. 

  80. <Rule Id="66" Name="HRG_ErbB3" Data="HRG(r~ext),ErbB3(CR,L~ext)->HRG(r~ext!0),ErbB3(CR,L~ext!0)" ForwardRate="1" />

    81. 

  81. <Rule Id="67" Name="HRG_ErbB3_op" Data="HRG(r~ext!0),ErbB3(CR,L~ext!0)->HRG(r~ext),ErbB3(CR,L~ext)" ForwardRate="1" />

    82. 

  82. <Rule Id="68" Name="HRG_ErbB4" Data="HRG(r~ext),ErbB4(CR,L~ext)->HRG(r~ext!0),ErbB4(CR,L~ext!0)" ForwardRate="1" />

    83. 

  83. <Rule Id="69" Name="HRG_ErbB4_op" Data="HRG(r~ext!0),ErbB4(CR,L~ext!0)->HRG(r~ext),ErbB4(CR,L~ext)" ForwardRate="1" />

    84. 

  84. <Rule Id="70" Name="ErbB1_ErbB1" Data="ErbB1(C,CR,L~ext!_,N),ErbB1(C,CR,L~ext!_,N)->ErbB1(C,CR!0,L~ext!_,N),ErbB1(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    85. 

  85. <Rule Id="71" Name="ErbB1_ErbB1_op" Data="ErbB1(C,CR!0,L~ext!_,N),ErbB1(C,CR!0,L~ext!_,N)->ErbB1(C,CR,L~ext!_,N),ErbB1(C,CR,L~ext!_,N)" ForwardRate="1" />

    86. 

  86. <Rule Id="72" Name="ErbB1_ErbB3" Data="ErbB1(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)->ErbB1(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    87. 

  87. <Rule Id="73" Name="ErbB1_ErbB3_op" Data="ErbB1(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)->ErbB1(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)" ForwardRate="1" />

    88. 

  88. <Rule Id="74" Name="ErbB1_ErbB4" Data="ErbB1(C,CR,L~ext,N),ErbB4(C,CR,L~ext!_,N)->ErbB1(C,CR!0,L~ext,N),ErbB4(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    89. 

  89. <Rule Id="75" Name="ErbB1_ErbB4_op" Data="ErbB1(C,CR!0,L~ext,N),ErbB4(C,CR!0,L~ext!_,N)->ErbB1(C,CR,L~ext,N),ErbB4(C,CR,L~ext!_,N)" ForwardRate="1" />

    90. 

  90. <Rule Id="76" Name="ErbB1_ATP" Data="ErbB1(bp),A(s~ppp)->ErbB1(bp!0),A(s~ppp!0)" ForwardRate="1" />

    91. 

  91. <Rule Id="77" Name="ErbB1_A_op" Data="ErbB1(bp!0),A(s!0)->ErbB1(bp),A(s)" ForwardRate="1" />

    92. 

  92. <Rule Id="78" Name="ErbB4_ATP" Data="ErbB4(bp),A(s~ppp)->ErbB4(bp!0),A(s~ppp!0)" ForwardRate="1" />

    93. 

  93. <Rule Id="79" Name="ErbB4_A_op" Data="ErbB4(bp!0),A(s!0)->ErbB4(bp),A(s)" ForwardRate="1" />

    94. 

  94. <Rule Id="80" Name="Rule29" Data="ErbB1(C,CR!0,N),ErbB1(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB1(C!0,CR!1,N)" ForwardRate="1" />

    95. 

  95. <Rule Id="81" Name="Rule29_op" Data="ErbB1(C,CR!1,N!0),ErbB1(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB1(C,CR!0,N)" ForwardRate="1" />

    96. 

  96. <Rule Id="82" Name="Rule30" Data="ErbB4(C,CR!0,N),ErbB1(C,CR!0,N)->ErbB4(C,CR!1,N!0),ErbB1(C!0,CR!1,N)" ForwardRate="1" />

    97. 

  97. <Rule Id="83" Name="Rule30_op" Data="ErbB4(C,CR!1,N!0),ErbB1(C!0,CR!1,N)->ErbB4(C,CR!0,N),ErbB1(C,CR!0,N)" ForwardRate="1" />

    98. 

  98. <Rule Id="84" Name="Rule31" Data="ErbB1(N!1,bp!0),ErbB1(C!1,Y992~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB1(C!1,Y992~p),A(s~pp!0)" ForwardRate="1" />

    99. 

  99. <Rule Id="85" Name="Rule32" Data="ErbB1(N!1,bp!0),ErbB1(C!1,Y1068~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB1(C!1,Y1068~p),A(s~pp!0)" ForwardRate="1" />

    100. 

  100. <Rule Id="86" Name="Rule33" Data="ErbB1(N!1,bp!0),ErbB1(C!1,Y1148~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB1(C!1,Y1148~p),A(s~pp!0)" ForwardRate="1" />

    101. 

  101. <Rule Id="87" Name="Rule34" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y992~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y992~p),A(s~pp!0)" ForwardRate="1" />

    102. 

  102. <Rule Id="88" Name="Rule35" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y1068~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y1068~p),A(s~pp!0)" ForwardRate="1" />

    103. 

  103. <Rule Id="89" Name="Rule36" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y1148~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y1148~p),A(s~pp!0)" ForwardRate="1" />

    104. 

  104. <Rule Id="90" Name="Rule37" Data="ErbB1(C,CR!0,N),ErbB3(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB3(C!0,CR!1,N)" ForwardRate="1" />

    105. 

  105. <Rule Id="91" Name="Rule37_op" Data="ErbB1(C,CR!1,N!0),ErbB3(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB3(C,CR!0,N)" ForwardRate="1" />

    106. 

  106. <Rule Id="92" Name="Rule38" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1035~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1035~p),A(s~pp!0)" ForwardRate="1" />

    107. 

  107. <Rule Id="93" Name="Rule39" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1178~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1178~p),A(s~pp!0)" ForwardRate="1" />

    108. 

  108. <Rule Id="94" Name="Rule40" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1203~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1203~p),A(s~pp!0)" ForwardRate="1" />

    109. 

  109. <Rule Id="95" Name="Rule41" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1241~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1241~p),A(s~pp!0)" ForwardRate="1" />

    110. 

  110. <Rule Id="96" Name="Rule42" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1257~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1257~p),A(s~pp!0)" ForwardRate="1" />

    111. 

  111. <Rule Id="97" Name="Rule43" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1270~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1270~p),A(s~pp!0)" ForwardRate="1" />

    112. 

  112. <Rule Id="98" Name="Rule44" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1309~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1309~p),A(s~pp!0)" ForwardRate="1" />

    113. 

  113. <Rule Id="99" Name="Rule45" Data="ErbB1(C,CR!0,N),ErbB4(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB4(C!0,CR!1,N)" ForwardRate="1" />

    114. 

  114. <Rule Id="100" Name="Rule45_op" Data="ErbB1(C,CR!1,N!0),ErbB4(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB4(C,CR!0,N)" ForwardRate="1" />

    115. 

  115. <Rule Id="101" Name="Rule46" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1056~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1056~p),A(s~pp!0)" ForwardRate="1" />

    116. 

  116. <Rule Id="102" Name="Rule47" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1188~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1188~p),A(s~pp!0)" ForwardRate="1" />

    117. 

  117. <Rule Id="103" Name="Rule48" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1242~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1242~p),A(s~pp!0)" ForwardRate="1" />

    118. 

  118. <Rule Id="104" Name="Rule49" Data="ErbB1(Y992~p)=>ErbB1(Y992~u),Pi()" ForwardRate="1" />

    119. 

  119. <Rule Id="105" Name="Rule50" Data="ErbB1(Y1068~p)=>ErbB1(Y1068~u),Pi()" ForwardRate="1" />

    120. 

  120. <Rule Id="106" Name="Rule51" Data="ErbB1(Y1148~p)=>ErbB1(Y1148~u),Pi()" ForwardRate="1" />

    121. 

  121. <Rule Id="107" Name="Rule52" Data="ErbB3(Y1035~p)=>ErbB3(Y1035~u),Pi()" ForwardRate="1" />

    122. 

  122. <Rule Id="108" Name="Rule53" Data="ErbB3(Y1178~p)=>ErbB3(Y1178~u),Pi()" ForwardRate="1" />

    123. 

  123. <Rule Id="109" Name="Rule54" Data="ErbB3(Y1203~p)=>ErbB3(Y1203~u),Pi()" ForwardRate="1" />

    124. 

  124. <Rule Id="110" Name="Rule55" Data="ErbB3(Y1241~p)=>ErbB3(Y1241~u),Pi()" ForwardRate="1" />

    125. 

  125. <Rule Id="111" Name="Rule56" Data="ErbB3(Y1257~p)=>ErbB3(Y1257~u),Pi()" ForwardRate="1" />

    126. 

  126. <Rule Id="112" Name="Rule57" Data="ErbB3(Y1270~p)=>ErbB3(Y1270~u),Pi()" ForwardRate="1" />

    127. 

  127. <Rule Id="113" Name="Rule58" Data="ErbB3(Y1309~p)=>ErbB3(Y1309~u),Pi()" ForwardRate="1" />

    128. 

  128. <Rule Id="114" Name="Rule59" Data="ErbB4(Y1056~p)=>ErbB4(Y1056~u),Pi()" ForwardRate="1" />

    129. 

  129. <Rule Id="115" Name="Rule60" Data="ErbB4(Y1188~p)=>ErbB4(Y1188~u),Pi()" ForwardRate="1" />

    130. 

  130. <Rule Id="116" Name="Rule61" Data="ErbB4(Y1242~p)=>ErbB4(Y1242~u),Pi()" ForwardRate="1" />

    131. 

  131. <Rule Id="117" Name="ErbB1_RasGAP" Data="ErbB1(Y992~p),RasGAP(SH2)->ErbB1(Y992~p!0),RasGAP(SH2!0)" ForwardRate="1" />

    132. 

  132. <Rule Id="118" Name="ErbB1_RasGAP_op" Data="ErbB1(Y992~p!0),RasGAP(SH2!0)->ErbB1(Y992~p),RasGAP(SH2)" ForwardRate="1" />

    133. 

  133. <Rule Id="119" Name="ErbB1_Grb2" Data="ErbB1(Y1068~p),Grb2(SH2)->ErbB1(Y1068~p!0),Grb2(SH2!0)" ForwardRate="1" />

    134. 

  134. <Rule Id="120" Name="ErbB1_Grb2_op" Data="ErbB1(Y1068~p!0),Grb2(SH2!0)->ErbB1(Y1068~p),Grb2(SH2)" ForwardRate="1" />

    135. 

  135. <Rule Id="121" Name="ErbB1_Shc" Data="ErbB1(Y1148~p),Shc(PTB)->ErbB1(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />

    136. 

  136. <Rule Id="122" Name="ErbB1_Shc_op" Data="ErbB1(Y1148~p!0),Shc(PTB!0)->ErbB1(Y1148~p),Shc(PTB)" ForwardRate="1" />

    137. 

  137. <Rule Id="123" Name="ErbB3_Shc" Data="ErbB3(Y1309~p),Shc(PTB)->ErbB3(Y1309~p!0),Shc(PTB!0)" ForwardRate="1" />

    138. 

  138. <Rule Id="124" Name="ErbB3_Shc_op" Data="ErbB3(Y1309~p!0),Shc(PTB!0)->ErbB3(Y1309~p),Shc(PTB)" ForwardRate="1" />

    139. 

  139. <Rule Id="125" Name="Shc#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~u)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />

    140. 

  140. <Rule Id="126" Name="Shc#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~u)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />

    141. 

  141. <Rule Id="127" Name="Shc_op" Data="Shc(Y318~p)=>Shc(Y318~u),Pi()" ForwardRate="1" />

    142. 

  142. <Rule Id="128" Name="Shc_Grb2" Data="Shc(Y318~p),Grb2(SH2)->Shc(Y318~p!0),Grb2(SH2!0)" ForwardRate="1" />

    143. 

  143. <Rule Id="129" Name="Shc_Grb2_op" Data="Shc(Y318~p!0),Grb2(SH2!0)->Shc(Y318~p),Grb2(SH2)" ForwardRate="1" />

    144. 

  144. <Rule Id="130" Name="Grb2_SoS" Data="Grb2(SH3),SoS(SS~u,a)->Grb2(SH3!0),SoS(SS~u,a!0)" ForwardRate="1" />

    145. 

  145. <Rule Id="131" Name="Grb2_SoS_op" Data="Grb2(SH3!0),SoS(a!0)->Grb2(SH3),SoS(a)" ForwardRate="1" />

    146. 

  146. <Rule Id="132" Name="long arm SoS_Ras#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />

    147. 

  147. <Rule Id="133" Name="long arm SoS_Ras#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />

    148. 

  148. <Rule Id="134" Name="short arm SoS_Ras#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b),Ras(S1S2~gdp)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b!2),Ras(S1S2~gdp!2)" ForwardRate="1" />

    149. 

  149. <Rule Id="135" Name="Ras GTP" Data="SoS(b!0),Ras(S1S2~gdp!0)->SoS(b!0),Ras(S1S2~gtp!0)" ForwardRate="1" />

    150. 

  150. <Rule Id="136" Name="SoS_Ras_op" Data="SoS(b!0),Ras(S1S2!0)->SoS(b),Ras(S1S2)" ForwardRate="1" />

    151. 

  151. <Rule Id="137" Name="direct RasGAP_Ras#1" Data="ErbB1(Y992~p!0),RasGAP(SH2!0,s),Ras(S1S2~gtp)->ErbB1(Y992~p!0),RasGAP(SH2!0,s!1),Ras(S1S2~gtp!1)" ForwardRate="1" />

    152. 

  152. <Rule Id="138" Name="Ras GDP" Data="RasGAP(s!0),Ras(S1S2~gtp!0)->RasGAP(s!0),Ras(S1S2~gdp!0)" ForwardRate="1" />

    153. 

  153. <Rule Id="139" Name="RasGAP_Ras_op" Data="RasGAP(s!0),Ras(S1S2!0)->RasGAP(s),Ras(S1S2)" ForwardRate="1" />

    154. 

  154. <Rule Id="140" Name="Grb2_Gab1" Data="Grb2(SH3c),Gab1(PR)->Grb2(SH3c!0),Gab1(PR!0)" ForwardRate="1" />

    155. 

  155. <Rule Id="141" Name="Grb2_Gab1_op" Data="Grb2(SH3c!0),Gab1(PR!0)->Grb2(SH3c),Gab1(PR)" ForwardRate="1" />

    156. 

  156. <Rule Id="142" Name="Gab1@447#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p)" ForwardRate="1" />

    157. 

  157. <Rule Id="143" Name="Gab1@472#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p)" ForwardRate="1" />

    158. 

  158. <Rule Id="144" Name="Gab1@619#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p)" ForwardRate="1" />

    159. 

  159. <Rule Id="145" Name="Gab1_PI3K@447" Data="Gab1(Y447~p),PI3K(SH2)->Gab1(Y447~p!0),PI3K(SH2!0)" ForwardRate="1" />

    160. 

  160. <Rule Id="146" Name="Gab1_PI3K@447_op" Data="Gab1(Y447~p!0),PI3K(SH2!0)->Gab1(Y447~p),PI3K(SH2)" ForwardRate="1" />

    161. 

  161. <Rule Id="147" Name="Gab1_PI3K@472" Data="Gab1(Y472~p),PI3K(SH2)->Gab1(Y472~p!0),PI3K(SH2!0)" ForwardRate="1" />

    162. 

  162. <Rule Id="148" Name="Gab1_PI3K@472_op" Data="Gab1(Y472~p!0),PI3K(SH2!0)->Gab1(Y472~p),PI3K(SH2)" ForwardRate="1" />

    163. 

  163. <Rule Id="149" Name="Gab1_PI3K@619" Data="Gab1(Y619~p),PI3K(SH2)->Gab1(Y619~p!0),PI3K(SH2!0)" ForwardRate="1" />

    164. 

  164. <Rule Id="150" Name="Gab1_PI3K@619_op" Data="Gab1(Y619~p!0),PI3K(SH2!0)->Gab1(Y619~p),PI3K(SH2)" ForwardRate="1" />

    165. 

  165. <Rule Id="151" Name="Gab1_Shp2@447" Data="Gab1(Y447~p),Shp2(s)->Gab1(Y447~p!0),Shp2(s!0)" ForwardRate="1" />

    166. 

  166. <Rule Id="152" Name="Gab1_Shp2@472" Data="Gab1(Y472~p),Shp2(s)->Gab1(Y472~p!0),Shp2(s!0)" ForwardRate="1" />

    167. 

  167. <Rule Id="153" Name="Gab1_Shp2@619" Data="Gab1(Y619~p),Shp2(s)->Gab1(Y619~p!0),Shp2(s!0)" ForwardRate="1" />

    168. 

  168. <Rule Id="154" Name="Gab1@447_op" Data="Gab1(Y447~p!0),Shp2(s!0)=>Gab1(Y447~u!0),Shp2(s!0),Pi()" ForwardRate="1" />

    169. 

  169. <Rule Id="155" Name="Gab1@472_op" Data="Gab1(Y472~p!0),Shp2(s!0)=>Gab1(Y472~u!0),Shp2(s!0),Pi()" ForwardRate="1" />

    170. 

  170. <Rule Id="156" Name="Gab1@619_op" Data="Gab1(Y619~p!0),Shp2(s!0)=>Gab1(Y619~u!0),Shp2(s!0),Pi()" ForwardRate="1" />

    171. 

  171. <Rule Id="157" Name="Gab1_Shp2@447_op" Data="Gab1(Y447!0),Shp2(s!0)->Gab1(Y447),Shp2(s)" ForwardRate="1" />

    172. 

  172. <Rule Id="158" Name="Gab1_Shp2@472_op" Data="Gab1(Y472!0),Shp2(s!0)->Gab1(Y472),Shp2(s)" ForwardRate="1" />

    173. 

  173. <Rule Id="159" Name="Gab1_Shp2@619_op" Data="Gab1(Y619!0),Shp2(s!0)->Gab1(Y619),Shp2(s)" ForwardRate="1" />

    174. 

  174. <Rule Id="160" Name="ErbB3_PI3K#1" Data="ErbB3(Y1035~p),PI3K(SH2)->ErbB3(Y1035~p!0),PI3K(SH2!0)" ForwardRate="1" />

    175. 

  175. <Rule Id="161" Name="ErbB3_PI3K#1_op" Data="ErbB3(Y1035~p!0),PI3K(SH2!0)->ErbB3(Y1035~p),PI3K(SH2)" ForwardRate="1" />

    176. 

  176. <Rule Id="162" Name="ErbB3_PI3K#2" Data="ErbB3(Y1178~p),PI3K(SH2)->ErbB3(Y1178~p!0),PI3K(SH2!0)" ForwardRate="1" />

    177. 

  177. <Rule Id="163" Name="ErbB3_PI3K#2_op" Data="ErbB3(Y1178~p!0),PI3K(SH2!0)->ErbB3(Y1178~p),PI3K(SH2)" ForwardRate="1" />

    178. 

  178. <Rule Id="164" Name="ErbB3_PI3K#3" Data="ErbB3(Y1203~p),PI3K(SH2)->ErbB3(Y1203~p!0),PI3K(SH2!0)" ForwardRate="1" />

    179. 

  179. <Rule Id="165" Name="ErbB3_PI3K#3_op" Data="ErbB3(Y1203~p!0),PI3K(SH2!0)->ErbB3(Y1203~p),PI3K(SH2)" ForwardRate="1" />

    180. 

  180. <Rule Id="166" Name="ErbB3_PI3K#4" Data="ErbB3(Y1241~p),PI3K(SH2)->ErbB3(Y1241~p!0),PI3K(SH2!0)" ForwardRate="1" />

    181. 

  181. <Rule Id="167" Name="ErbB3_PI3K#4_op" Data="ErbB3(Y1241~p!0),PI3K(SH2!0)->ErbB3(Y1241~p),PI3K(SH2)" ForwardRate="1" />

    182. 

  182. <Rule Id="168" Name="ErbB3_PI3K#5" Data="ErbB3(Y1257~p),PI3K(SH2)->ErbB3(Y1257~p!0),PI3K(SH2!0)" ForwardRate="1" />

    183. 

  183. <Rule Id="169" Name="ErbB3_PI3K#5_op" Data="ErbB3(Y1257~p!0),PI3K(SH2!0)->ErbB3(Y1257~p),PI3K(SH2)" ForwardRate="1" />

    184. 

  184. <Rule Id="170" Name="ErbB3_PI3K#6" Data="ErbB3(Y1270~p),PI3K(SH2)->ErbB3(Y1270~p!0),PI3K(SH2!0)" ForwardRate="1" />

    185. 

  185. <Rule Id="171" Name="ErbB3_PI3K#6_op" Data="ErbB3(Y1270~p!0),PI3K(SH2!0)->ErbB3(Y1270~p),PI3K(SH2)" ForwardRate="1" />

    186. 

  186. <Rule Id="172" Name="short arm PI3K_PI#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    187. 

  187. <Rule Id="173" Name="short arm PI3K_PI#2" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    188. 

  188. <Rule Id="174" Name="short arm PI3K_PI#3" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    189. 

  189. <Rule Id="175" Name="direct PI3K_PI#1" Data="ErbB3(Y1035~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1035~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    190. 

  190. <Rule Id="176" Name="direct PI3K_PI#2" Data="ErbB3(Y1178~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1178~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    191. 

  191. <Rule Id="177" Name="direct PI3K_PI#3" Data="ErbB3(Y1203~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1203~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    192. 

  192. <Rule Id="178" Name="direct PI3K_PI#4" Data="ErbB3(Y1241~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1241~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    193. 

  193. <Rule Id="179" Name="direct PI3K_PI#5" Data="ErbB3(Y1257~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1257~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    194. 

  194. <Rule Id="180" Name="direct PI3K_PI#6" Data="ErbB3(Y1270~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1270~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    195. 

  195. <Rule Id="181" Name="PI@three" Data="PI3K(s!0),PI(three~u!0)->PI3K(s!0),PI(three~p!0)" ForwardRate="1" />

    196. 

  196. <Rule Id="182" Name="PI3K_PI_op" Data="PI3K(s!0),PI(three!0)->PI3K(s),PI(three)" ForwardRate="1" />

    197. 

  197. <Rule Id="183" Name="PTEN_PI" Data="PTEN(s),PI(three~p)->PTEN(s!0),PI(three~p!0)" ForwardRate="1" />

    198. 

  198. <Rule Id="184" Name="PI@three_op" Data="PTEN(s!0),PI(three~p!0)->PTEN(s!0),PI(three~u!0)" ForwardRate="1" />

    199. 

  199. <Rule Id="185" Name="PTEN_PI_op" Data="PTEN(s!0),PI(three!0)->PTEN(s),PI(three)" ForwardRate="1" />

    200. 

  200. <Rule Id="186" Name="PIP3_PDK1" Data="PI(five~p,four~p,three~p),PDK1(PH)->PI(five~p,four~p,three~p!0),PDK1(PH!0)" ForwardRate="1" />

    201. 

  201. <Rule Id="187" Name="PIP3_PDK1_op" Data="PI(three!0),PDK1(PH!0)->PI(three),PDK1(PH)" ForwardRate="1" />

    202. 

  202. <Rule Id="188" Name="PIP3_Akt" Data="PI(five~p,four~p,three~p),Akt(PH)->PI(five~p,four~p,three~p!0),Akt(PH!0)" ForwardRate="1" />

    203. 

  203. <Rule Id="189" Name="PIP3_Akt_op" Data="PI(three!0),Akt(PH!0)->PI(three),Akt(PH)" ForwardRate="1" />

    204. 

  204. <Rule Id="190" Name="Ras_Raf" Data="Ras(S1S2~gtp),Raf(x~u)->Ras(S1S2~gtp!0),Raf(x~u!0)" ForwardRate="1" />

    205. 

  205. <Rule Id="191" Name="Raf" Data="Ras(S1S2~gtp!0),Raf(x~u!0)->Ras(S1S2~gtp!0),Raf(x~p!0)" ForwardRate="1" />

    206. 

  206. <Rule Id="192" Name="Ras_Raf_op" Data="Ras(S1S2~gtp!0),Raf(x!0)->Ras(S1S2~gtp),Raf(x)" ForwardRate="1" />

    207. 

  207. <Rule Id="193" Name="SoS_ERK" Data="SoS(SS),ERK(T185~p,Y187~p,s)->SoS(SS!0),ERK(T185~p,Y187~p,s!0)" ForwardRate="1" />

    208. 

  208. <Rule Id="194" Name="SoS_ERK_op" Data="SoS(SS!0),ERK(T185~p,Y187~p,s!0)->SoS(SS),ERK(T185~p,Y187~p,s)" ForwardRate="1" />

    209. 

  209. <Rule Id="195" Name="SoS@SS" Data="SoS(SS~u!0),ERK(T185~p,Y187~p,s!0)->SoS(SS~p!0),ERK(T185~p,Y187~p,s!0)" ForwardRate="1" />

    210. 

  210. <Rule Id="196" Name="SoS@SS_op" Data="SoS(SS~p)=>SoS(SS~u),Pi()" ForwardRate="1" />

    211. 

  211. <Rule Id="197" Name="EGFR_RasGAP" Data="EGFR(Y1016~p),RasGAP(SH2~u)=>EGFR(Y1016~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />

    212. 

  212. <Rule Id="198" Name="EGFR_RasGAP_op" Data="EGFR(Y1016~p!0),RasGAP(SH2~rec!0)=>EGFR(Y1016~p),RasGAP(SH2~u)" ForwardRate="1" />

    213. 

  213. <Rule Id="199" Name="EGFR_Grb2" Data="EGFR(Y1092~p),Grb2(SH2~u)=>EGFR(Y1092~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />

    214. 

  214. <Rule Id="200" Name="EGFR_Grb2_op" Data="EGFR(Y1092~p!0),Grb2(SH2~rec!0)=>EGFR(Y1092~p),Grb2(SH2~u)" ForwardRate="1" />

    215. 

  215. <Rule Id="201" Name="EGFR_Shc" Data="EGFR(Y1172~p),Shc(PTB~u)=>EGFR(Y1172~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    216. 

  216. <Rule Id="202" Name="EGFR_Shc_op" Data="EGFR(Y1172~p!0),Shc(PTB~rec!0)=>EGFR(Y1172~p),Shc(PTB~u)" ForwardRate="1" />

    217. 

  217. <Rule Id="203" Name="HER2_Grb2" Data="HER2(Y1139~p),Grb2(SH2~u)=>HER2(Y1139~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />

    218. 

  218. <Rule Id="204" Name="HER2_Grb2_op" Data="HER2(Y1139~p!0),Grb2(SH2~rec!0)=>HER2(Y1139~p),Grb2(SH2~u)" ForwardRate="1" />

    219. 

  219. <Rule Id="205" Name="HER2_Shc#1" Data="HER2(Y1196~p),Shc(PTB~u)=>HER2(Y1196~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    220. 

  220. <Rule Id="206" Name="HER2_Shc#1_op" Data="HER2(Y1196~p!0),Shc(PTB~rec!0)=>HER2(Y1196~p),Shc(PTB~u)" ForwardRate="1" />

    221. 

  221. <Rule Id="207" Name="HER2_RasGAP" Data="HER2(Y1221~p),RasGAP(SH2~u)=>HER2(Y1221~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />

    222. 

  222. <Rule Id="208" Name="HER2_RasGAP_op" Data="HER2(Y1221~p!0),RasGAP(SH2~rec!0)=>HER2(Y1221~p),RasGAP(SH2~u)" ForwardRate="1" />

    223. 

  223. <Rule Id="209" Name="HER2_Shc#2" Data="HER2(Y1221~p),Shc(PTB~u)=>HER2(Y1221~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    224. 

  224. <Rule Id="210" Name="HER2_Shc#2_op" Data="HER2(Y1221~p!0),Shc(PTB~rec!0)=>HER2(Y1221~p),Shc(PTB~u)" ForwardRate="1" />

    225. 

  225. <Rule Id="211" Name="HER3_PI3K#1" Data="HER3(Y1035~p),PI3K(SH2~u)=>HER3(Y1035~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    226. 

  226. <Rule Id="212" Name="HER3_PI3K#1_op" Data="HER3(Y1035~p!0),PI3K(SH2~rec!0)=>HER3(Y1035~p),PI3K(SH2~u)" ForwardRate="1" />

    227. 

  227. <Rule Id="213" Name="HER3_PI3K#2" Data="HER3(Y1178~p),PI3K(SH2~u)=>HER3(Y1178~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    228. 

  228. <Rule Id="214" Name="HER3_PI3K#2_op" Data="HER3(Y1178~p!0),PI3K(SH2~rec!0)=>HER3(Y1178~p),PI3K(SH2~u)" ForwardRate="1" />

    229. 

  229. <Rule Id="215" Name="HER3_PI3K#3" Data="HER3(Y1203~p),PI3K(SH2~u)=>HER3(Y1203~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    230. 

  230. <Rule Id="216" Name="HER3_PI3K#3_op" Data="HER3(Y1203~p!0),PI3K(SH2~rec!0)=>HER3(Y1203~p),PI3K(SH2~u)" ForwardRate="1" />

    231. 

  231. <Rule Id="217" Name="HER3_PI3K#4" Data="HER3(Y1241~p),PI3K(SH2~u)=>HER3(Y1241~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    232. 

  232. <Rule Id="218" Name="HER3_PI3K#4_op" Data="HER3(Y1241~p!0),PI3K(SH2~rec!0)=>HER3(Y1241~p),PI3K(SH2~u)" ForwardRate="1" />

    233. 

  233. <Rule Id="219" Name="HER3_PI3K#5" Data="HER3(Y1257~p),PI3K(SH2~u)=>HER3(Y1257~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    234. 

  234. <Rule Id="220" Name="HER3_PI3K#5_op" Data="HER3(Y1257~p!0),PI3K(SH2~rec!0)=>HER3(Y1257~p),PI3K(SH2~u)" ForwardRate="1" />

    235. 

  235. <Rule Id="221" Name="HER3_PI3K#6" Data="HER3(Y1270~p),PI3K(SH2~u)=>HER3(Y1270~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    236. 

  236. <Rule Id="222" Name="HER3_PI3K#6_op" Data="HER3(Y1270~p!0),PI3K(SH2~rec!0)=>HER3(Y1270~p),PI3K(SH2~u)" ForwardRate="1" />

    237. 

  237. <Rule Id="223" Name="HER3_Shc" Data="HER3(Y1309~p),Shc(PTB~u)=>HER3(Y1309~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    238. 

  238. <Rule Id="224" Name="HER3_Shc_op" Data="HER3(Y1309~p!0),Shc(PTB~rec!0)=>HER3(Y1309~p),Shc(PTB~u)" ForwardRate="1" />

    239. 

  239. <Rule Id="225" Name="HER4_RasGAP" Data="HER4(Y1~p),RasGAP(SH2~u)=>HER4(Y1~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />

    240. 

  240. <Rule Id="226" Name="HER4_RasGAP_op" Data="HER4(Y1~p!0),RasGAP(SH2~rec!0)=>HER4(Y1~p),RasGAP(SH2~u)" ForwardRate="1" />

    241. 

  241. <Rule Id="227" Name="HER4_Grb2" Data="HER4(Y2~p),Grb2(SH2~u)=>HER4(Y2~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />

    242. 

  242. <Rule Id="228" Name="HER4_Grb2_op" Data="HER4(Y2~p!0),Grb2(SH2~rec!0)=>HER4(Y2~p),Grb2(SH2~u)" ForwardRate="1" />

    243. 

  243. <Rule Id="229" Name="HER4_Shc" Data="HER4(Y3~p),Shc(PTB~u)=>HER4(Y3~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    244. 

  244. <Rule Id="230" Name="HER4_Shc_op" Data="HER4(Y3~p!0),Shc(PTB~rec!0)=>HER4(Y3~p),Shc(PTB~u)" ForwardRate="1" />

    245. 

  245. <Rule Id="231" Name="Shc@Y" Data="Shc(PTB~rec!_,Y~u)->Shc(PTB~rec!_,Y~p)" ForwardRate="1" />

    246. 

  246. <Rule Id="232" Name="Gab1@48" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48~p)" ForwardRate="1" />

    247. 

  247. <Rule Id="233" Name="Gab1@317" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317~p)" ForwardRate="1" />

    248. 

  248. <Rule Id="234" Name="Gab1@447" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447~p)" ForwardRate="1" />

    249. 

  249. <Rule Id="235" Name="Gab1@472" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472~p)" ForwardRate="1" />

    250. 

  250. <Rule Id="236" Name="Gab1@619" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619~p)" ForwardRate="1" />

    251. 

  251. <Rule Id="237" Name="Gab1@657" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y657~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y657~p)" ForwardRate="1" />

    252. 

  252. <Rule Id="238" Name="Gab1@689" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y689~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y689~p)" ForwardRate="1" />

    253. 

  253. <Rule Id="239" Name="Gab1@48_op" Data="Gab1(Y48~p)->Gab1(Y48~u)" ForwardRate="1" />

    254. 

  254. <Rule Id="240" Name="Gab1@317_op" Data="Gab1(Y317~p)->Gab1(Y317~u)" ForwardRate="1" />

    255. 

  255. <Rule Id="241" Name="Gab1@657_op" Data="Gab1(Y657~p)->Gab1(Y657~u)" ForwardRate="1" />

    256. 

  256. <Rule Id="242" Name="Gab1@689_op" Data="Gab1(Y689~p)->Gab1(Y689~u)" ForwardRate="1" />

    257. 

  257. <Rule Id="243" Name="Gab1_Grb2" Data="Gab1(Y48~p),Grb2(SH2)->Gab1(Y48~p!0),Grb2(SH2!0)" ForwardRate="1" />

    258. 

  258. <Rule Id="244" Name="Gab1_Grb2_op" Data="Gab1(Y48~p!0),Grb2(SH2!0)->Gab1(Y48~p),Grb2(SH2)" ForwardRate="1" />

    259. 

  259. <Rule Id="245" Name="Gab1_RasGAP" Data="Gab1(Y317~p),RasGAP(SH2)->Gab1(Y317~p!0),RasGAP(SH2!0)" ForwardRate="1" />

    260. 

  260. <Rule Id="246" Name="Gab1_RasGAP_op" Data="Gab1(Y317~p!0),RasGAP(SH2!0)->Gab1(Y317~p),RasGAP(SH2)" ForwardRate="1" />

    261. 

  261. <Rule Id="247" Name="Gab1_PI3K@447_op" Data="Gab1(Y447!0),PI3K(SH2!0)->Gab1(Y447),PI3K(SH2)" ForwardRate="1" />

    262. 

  262. <Rule Id="248" Name="Gab1_PI3K@472_op" Data="Gab1(Y472!0),PI3K(SH2!0)->Gab1(Y472),PI3K(SH2)" ForwardRate="1" />

    263. 

  263. <Rule Id="249" Name="Gab1_PI3K@619_op" Data="Gab1(Y619!0),PI3K(SH2!0)->Gab1(Y619),PI3K(SH2)" ForwardRate="1" />

    264. 

  264. <Rule Id="250" Name="Gab1_Shp2#1" Data="Gab1(Y689~p),Shp2(SH2c)->Gab1(Y689~p!0),Shp2(SH2c!0)" ForwardRate="1" />

    265. 

  265. <Rule Id="251" Name="Gab1_Shp2#2" Data="Gab1(Y657~p,Y689!0),Shp2(SH2c!0,SH2n)->Gab1(Y657~p!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />

    266. 

  266. <Rule Id="252" Name="Gab1_Shp2_op#1" Data="Gab1(Y657!0),Shp2(SH2n!0)->Gab1(Y657),Shp2(SH2n)" ForwardRate="1" />

    267. 

  267. <Rule Id="253" Name="Gab1_Shp2_op#2" Data="Gab1(Y689!0),Shp2(SH2c!0)->Gab1(Y689),Shp2(SH2c)" ForwardRate="1" />

    268. 

  268. <Rule Id="254" Name="Rule62" Data="Gab1(Y317~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y317~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />

    269. 

  269. <Rule Id="255" Name="Rule63" Data="Gab1(Y447~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y447~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />

    270. 

  270. <Rule Id="256" Name="Rule64" Data="Gab1(Y472~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y472~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />

    271. 

  271. <Rule Id="257" Name="Rule65" Data="Gab1(Y619~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y619~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />

    272. 

  272. <Rule Id="258" Name="PI3K@s Rec" Data="PI3K(SH2~rec!_,s~u)->PI3K(SH2~rec!_,s~p)" ForwardRate="1" />

    273. 

  273. <Rule Id="259" Name="PI3K@s Gab#1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p)" ForwardRate="1" />

    274. 

  274. <Rule Id="260" Name="PI3K@s Gab#2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p)" ForwardRate="1" />

    275. 

  275. <Rule Id="261" Name="PI3K@s Gab#3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p)" ForwardRate="1" />

    276. 

  276. <Rule Id="262" Name="PI3K@s_op" Data="PI3K(s~p)->PI3K(s~u)" ForwardRate="1" />

    277. 

  277. <Rule Id="263" Name="SoS short arm" Data="Grb2(SH2~rec!_,SH3n!0),SoS(GEF,PR!0),Ras(s~gdp)->Grb2(SH2~rec!_,SH3n!0),SoS(GEF!1,PR!0),Ras(s~gdp!1)" ForwardRate="1" />

    278. 

  278. <Rule Id="264" Name="SoS long arm" Data="Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />

    279. 

  279. <Rule Id="265" Name="SoS vlong arm" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48!1),Grb2(SH2!1,SH3n!2),SoS(GEF,PR!2),Ras(s~gdp)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48!1),Grb2(SH2!1,SH3n!2),SoS(GEF!3,PR!2),Ras(s~gdp!3)" ForwardRate="1" />

    280. 

  280. <Rule Id="266" Name="RasGAP no arm" Data="RasGAP(GAP,SH2~rec!_),Ras(s~gtp)->RasGAP(GAP!0,SH2~rec!_),Ras(s~gtp!0)" ForwardRate="1" />

    281. 

  281. <Rule Id="267" Name="RasGAP long arm" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317!1),RasGAP(GAP,SH2!1),Ras(s~gtp)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317!1),RasGAP(GAP!2,SH2!1),Ras(s~gtp!2)" ForwardRate="1" />

    282. 

  282. <Rule Id="268" Name="PI3K no arm" Data="PI3K(SH2~rec!_,s~p),PI(three~u)->PI3K(SH2~rec!_,s~p!0),PI(three~u!0)" ForwardRate="1" />

    283. 

  283. <Rule Id="269" Name="PI3K long arm #1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />

    284. 

  284. <Rule Id="270" Name="PI3K long arm #2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />

    285. 

  285. <Rule Id="271" Name="PI3K long arm #3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />

    286. 

  286. <Rule Id="272" Name="intrinsic GDP" Data="Ras(s~gtp)->Ras(s~gdp)" ForwardRate="1" />

    287. 

  287. <Rule Id="273" Name="PI@five" Data="PI(five~u)->PI(five~p)" ForwardRate="1" />

    288. 

  288. <Rule Id="274" Name="PI@five_op" Data="SHIP(s!0),PI(five~p!0)->SHIP(s!0),PI(five~u!0)" ForwardRate="1" />

    289. 

  289. <Rule Id="275" Name="Ras_PI3K no arm" Data="Ras(s~gtp),PI3K(RBD,SH2~rec!_,s~u)->Ras(s~gtp!0),PI3K(RBD!0,SH2~rec!_,s~u)" ForwardRate="1" />

    290. 

  290. <Rule Id="276" Name="Ras_PI3K long arm #1" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />

    291. 

  291. <Rule Id="277" Name="Ras_PI3K long arm #2" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />

    292. 

  292. <Rule Id="278" Name="Ras_PI3K long arm #3" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />

    293. 

  293. <Rule Id="279" Name="Ras_PI3K_op" Data="Ras(s!0),PI3K(RBD!0)->Ras(s),PI3K(RBD)" ForwardRate="1" />

    294. 

  294. <Rule Id="280" Name="PIP3_Gab1" Data="PI(five~p,four~p,three~p),Grb2(SH2~rec!_,SH3c!0),Gab1(PH,PR!0)->PI(five~p,four~p,three~p!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PH!0,PR!1)" ForwardRate="1" />

    295. 

  295. <Rule Id="281" Name="PIP3_Gab1_op" Data="PI(three!0),Gab1(PH!0)->PI(three),Gab1(PH)" ForwardRate="1" />

    296. 

  296. <Rule Id="282" Name="PI3K@s Ras" Data="PI3K(RBD!_,s~u)->PI3K(RBD!_,s~p)" ForwardRate="1" />

    297. 

  297. <Rule Id="283" Name="RasGAP Gab arm" Data="Gab1(PH!_,Y317~p!0),RasGAP(GAP,SH2!0),Ras(s~gtp)->Gab1(PH!_,Y317~p!0),RasGAP(GAP!1,SH2!0),Ras(s~gtp!1)" ForwardRate="1" />

    298. 

  298. <Rule Id="284" Name="SoS Gab arm #1" Data="Gab1(PH!_,Y48~p!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Gab1(PH!_,Y48~p!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />

    299. 

  299. <Rule Id="285" Name="SoS Gab arm #2" Data="Gab1(PH!_,PR!0),Grb2(SH3c!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Gab1(PH!_,PR!0),Grb2(SH3c!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />

    300. 

  300. <Rule Id="286" Name="PI3K Ras arm" Data="PI3K(RBD!_,s~p),PI(three~u)->PI3K(RBD!_,s~p!0),PI(three~u!0)" ForwardRate="1" />

    301. 

  301. <Rule Id="287" Name="PI3K Gab arm #1" Data="Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />

    302. 

  302. <Rule Id="288" Name="PI3K Gab arm #2" Data="Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />

    303. 

  303. <Rule Id="289" Name="PI3K Gab arm #3" Data="Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />

    304. 

  304. <Rule Id="290" Name="ERK_SoS" Data="ERK(T~p,Y~p,s),SoS(S~u)->ERK(T~p,Y~p,s!0),SoS(S~u!0)" ForwardRate="1" />

    305. 

  305. <Rule Id="291" Name="ERK_SoS_op" Data="ERK(s!0),SoS(S!0)->ERK(s),SoS(S)" ForwardRate="1" />

    306. 

  306. <Rule Id="292" Name="ERK_Gab1#1" Data="ERK(T~p,Y~p,s),Gab1(S454~u)->ERK(T~p,Y~p,s!0),Gab1(S454~u!0)" ForwardRate="1" />

    307. 

  307. <Rule Id="293" Name="ERK_Gab1#2" Data="ERK(T~p,Y~p,s),Gab1(T476~u)->ERK(T~p,Y~p,s!0),Gab1(T476~u!0)" ForwardRate="1" />

    308. 

  308. <Rule Id="294" Name="ERK_Gab1#3" Data="ERK(T~p,Y~p,s),Gab1(S597~u)->ERK(T~p,Y~p,s!0),Gab1(S597~u!0)" ForwardRate="1" />

    309. 

  309. <Rule Id="295" Name="ERK_Gab1#1_op" Data="ERK(s!0),Gab1(S454!0)->ERK(s),Gab1(S454)" ForwardRate="1" />

    310. 

  310. <Rule Id="296" Name="ERK_Gab1#2_op" Data="ERK(s!0),Gab1(T476!0)->ERK(s),Gab1(T476)" ForwardRate="1" />

    311. 

  311. <Rule Id="297" Name="ERK_Gab1#3_op" Data="ERK(s!0),Gab1(S597!0)->ERK(s),Gab1(S597)" ForwardRate="1" />

    312. 

  312. <Rule Id="298" Name="SoS@S" Data="ERK(s!0),SoS(S~u!0)->ERK(s!0),SoS(S~p!0)" ForwardRate="1" />

    313. 

  313. <Rule Id="299" Name="SoS@S_op" Data="SoS(S~p)->SoS(S~u)" ForwardRate="1" />

    314. 

  314. <Rule Id="300" Name="Gab1@454" Data="ERK(s!0),Gab1(S454~u!0)->ERK(s!0),Gab1(S454~p!0)" ForwardRate="1" />

    315. 

  315. <Rule Id="301" Name="Gab1@476" Data="ERK(s!0),Gab1(T476~u!0)->ERK(s!0),Gab1(T476~p!0)" ForwardRate="1" />

    316. 

  316. <Rule Id="302" Name="Gab1@597" Data="ERK(s!0),Gab1(S597~u!0)->ERK(s!0),Gab1(S597~p!0)" ForwardRate="1" />

    317. 

  317. <Rule Id="303" Name="Gab1@454_op" Data="Gab1(S454~p)->Gab1(S454~u)" ForwardRate="1" />

    318. 

  318. <Rule Id="304" Name="Gab1@476_op" Data="Gab1(T476~p)->Gab1(T476~u)" ForwardRate="1" />

    319. 

  319. <Rule Id="305" Name="Gab1@597_op" Data="Gab1(S597~p)->Gab1(S597~u)" ForwardRate="1" />

    320. 

  320. <Rule Id="306" Name="EGFR_Grb2@Y1086_SH2" Data="EGFR(Y1086~p),Grb2(SH2)->EGFR(Y1086~p!0),Grb2(SH2!0)" ForwardRate="1" />

    321. 

  321. <Rule Id="307" Name="Shc_Src@SH2_S1" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2),Src(S1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2!1),Src(S1!1)" ForwardRate="1" />

    322. 

  322. <Rule Id="308" Name="Shc_p@Y239" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)" ForwardRate="1" />

    323. 

  323. <Rule Id="309" Name="Shc_Src_op" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~p),Src(S1)" ForwardRate="1" />

    324. 

  324. <Rule Id="310" Name="Shc_p@Y240" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y240~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y240~p),Src(S1!1)" ForwardRate="1" />

    325. 

  325. <Rule Id="311" Name="EGFR_Shc@Y1173_PTB" Data="Shc(PTB),EGFR(Y1173~p)->Shc(PTB!0),EGFR(Y1173~p!0)" ForwardRate="1" />

    326. 

  326. <Rule Id="312" Name="EGFR_Shc@Y1173_SH2" Data="Shc(SH2),EGFR(Y1173~p)->Shc(SH2!0),EGFR(Y1173~p!0)" ForwardRate="1" />

    327. 

  327. <Rule Id="313" Name="EGFR_Shc@Y992_PTB" Data="Shc(PTB),EGFR(Y992~p)->Shc(PTB!0),EGFR(Y992~p!0)" ForwardRate="1" />

    328. 

  328. <Rule Id="314" Name="EGFR_Shc@Y992_SH2" Data="Shc(SH2),EGFR(Y992~p)->Shc(SH2!0),EGFR(Y992~p!0)" ForwardRate="1" />

    329. 

  329. <Rule Id="315" Name="Shc_EGFR@PTB_Y1148" Data="EGFR(Y1148~p),Shc(PTB)->EGFR(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />

    330. 

  330. <Rule Id="316" Name="Shc_EGFR@PTB_Y1148_op" Data="EGFR(Y1148~p!0),Shc(PTB!0)->EGFR(Y1148~p),Shc(PTB)" ForwardRate="1" />

    331. 

  331. <Rule Id="317" Name="Shc_EGFR@SH2_Y1148" Data="EGFR(Y1148~p),Shc(SH2)->EGFR(Y1148~p!0),Shc(SH2!0)" ForwardRate="1" />

    332. 

  332. <Rule Id="318" Name="Shc_EGFR@SH2_Y1148_op" Data="EGFR(Y1148~p!0),Shc(SH2!0)->EGFR(Y1148~p),Shc(SH2)" ForwardRate="1" />

    333. 

  333. <Rule Id="319" Name="Shc_EGFR@PTB_Y1173" Data="EGFR(Y1173~p),Shc(PTB)->EGFR(Y1173~p!0),Shc(PTB!0)" ForwardRate="1" />

    334. 

  334. <Rule Id="320" Name="Shc_EGFR@PTB_Y1173_op" Data="EGFR(Y1173~p!0),Shc(PTB!0)->EGFR(Y1173~p),Shc(PTB)" ForwardRate="1" />

    335. 

  335. <Rule Id="321" Name="Shc_EGFR@SH2_Y1173" Data="EGFR(Y1173~p),Shc(SH2)->EGFR(Y1173~p!0),Shc(SH2!0)" ForwardRate="1" />

    336. 

  336. <Rule Id="322" Name="Shc_EGFR@SH2_Y1173_op" Data="EGFR(Y1173~p!0),Shc(SH2!0)->EGFR(Y1173~p),Shc(SH2)" ForwardRate="1" />

    337. 

  337. <Rule Id="323" Name="Shc_p@Y317" Data="EGFR(Y1148~p!0),Shc(PTB!0,Y317~u)->EGFR(Y1148~p!0),Shc(PTB!0,Y317~p)" ForwardRate="1" />

    338. 

  338. <Rule Id="324" Name="EGFR_p@Y1086" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1086~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1086~p),A(s~pp!0)" ForwardRate="1" />

    339. 

  339. <Rule Id="325" Name="EGFR_p@Y1173" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1173~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1173~p),A(s~pp!0)" ForwardRate="1" />

    340. 

  340. <Rule Id="326" Name="EGFR_Shc@Y1068_SH2" Data="EGFR(Y1068~p),Shc(SH2)->EGFR(Y1068~p!0),Shc(SH2!0)" ForwardRate="1" />

    341. 

  341. <Rule Id="327" Name="EGFR_Shc@Y1068_SH2_op" Data="EGFR(Y1068~p!0),Shc(SH2!0)->EGFR(Y1068~p),Shc(SH2)" ForwardRate="1" />

    342. 

  342. <Rule Id="328" Name="EGFR_Shc@Y1086_SH2" Data="EGFR(Y1086~p),Shc(SH2)->EGFR(Y1086~p!0),Shc(SH2!0)" ForwardRate="1" />

    343. 

  343. <Rule Id="329" Name="EGFR_Shc@Y1086_SH2_op" Data="EGFR(Y1086~p!0),Shc(SH2!0)->EGFR(Y1086~p),Shc(SH2)" ForwardRate="1" />

    344. 

  344. <Rule Id="330" Name="EGFR_Gab1@S1_S1" Data="Gab1(X~u),EGFR(S1)->Gab1(X~u!0),EGFR(S1!0)" ForwardRate="1" />

    345. 

  345. <Rule Id="331" Name="Gab1_p@Y627" Data="Gab1(Y627~u!0),EGFR(S1!0)->Gab1(Y627~p!0),EGFR(S1!0)" ForwardRate="1" />

    346. 

  346. <Rule Id="332" Name="Gab1_EGFR_op" Data="Gab1(Y627~p!0),EGFR(S1!0)->Gab1(Y627~p),EGFR(S1)" ForwardRate="1" />

    347. 

  347. <Rule Id="333" Name="Gab1_p@Y659" Data="Gab1(Y659~u!0),EGFR(S1!0)->Gab1(Y659~p!0),EGFR(S1!0)" ForwardRate="1" />

    348. 

  348. <Rule Id="334" Name="Gab1_PIP3@PH" Data="Gab1(PH),PI(five~p,four~p,three~p)->Gab1(PH!0),PI(five~p!0,four~p,three~p)" ForwardRate="1" />

    349. 

  349. <Rule Id="335" Name="Gab1_SHP2@Y627_SH2n" Data="Gab1(Y627~p),SHP2(SH2n)->Gab1(Y627~p!0),SHP2(SH2n!0)" ForwardRate="1" />

    350. 

  350. <Rule Id="336" Name="Gab1_SHP2@Y659_SH2c" Data="Gab1(Y659~p),SHP2(SH2c)->Gab1(Y659~p!0),SHP2(SH2c!0)" ForwardRate="1" />

    351. 

  351. <Rule Id="337" Name="Gab1_u@Y659" Data="Gab1(Y659~p!0),SHP2(SH2c!0)->Gab1(Y659~u!0),SHP2(SH2c!0)" ForwardRate="1" />

    352. 

  352. <Rule Id="338" Name="Gab1_u@Y627" Data="Gab1(Y627~p!0),SHP2(SH2c!0)->Gab1(Y627~u!0),SHP2(SH2c!0)" ForwardRate="1" />

    353. 

  353. <Rule Id="339" Name="Gab1_PLCG1@Y307_SH2" Data="Gab1(Y307~p),PLCG1(SH2)->Gab1(Y307~p!0),PLCG1(SH2!0)" ForwardRate="1" />

    354. 

  354. <Rule Id="340" Name="Gab1_PLCG1@Y373_SH2" Data="Gab1(Y373~p),PLCG1(SH2)->Gab1(Y373~p!0),PLCG1(SH2!0)" ForwardRate="1" />

    355. 

  355. <Rule Id="341" Name="Gab1_PLCG1@Y407_SH2" Data="Gab1(Y407~p),PLCG1(SH2)->Gab1(Y407~p!0),PLCG1(SH2!0)" ForwardRate="1" />

    356. 

  356. <Rule Id="342" Name="Akt_PIP2@PH" Data="Akt(PH),PI(four~p,three~p)->Akt(PH!0),PI(four~p!0,three~p)" ForwardRate="1" />

    357. 

  357. <Rule Id="343" Name="Vav_PIP3@PH" Data="PI(five~p,four~p,three~p),Vav(PH)->PI(five~p!0,four~p,three~p),Vav(PH!0)" ForwardRate="1" />

    358. 

  358. <Rule Id="344" Name="Vav_PIP3@PH_op" Data="PI(five~p!0,four~p,three~p),Vav(PH!0)->PI(five~p,four~p,three~p),Vav(PH)" ForwardRate="1" />

    359. 

  359. <Rule Id="345" Name="Vav_Rac@DH_X~u" Data="PI(five~p!0,four~p,three~p),Vav(DH,PH!0,X~p),Rac(X~u)->PI(five~p!0,four~p,three~p),Vav(DH!1,PH!0,X~p),Rac(X~u!1)" ForwardRate="1" />

    360. 

  360. <Rule Id="346" Name="Vav_Rac@DH_X~u_op" Data="PI(five~p!0,four~p,three~p),Vav(DH!1,PH!0,X~p),Rac(X~u!1)->PI(five~p!0,four~p,three~p),Vav(DH,PH!0,X~p),Rac(X~u)" ForwardRate="1" />

    361. 

  361. <Rule Id="347" Name="Rac_p@X" Data="Rac(X~gdp!0),Vav(DH!0,PH!1,X~p),PI(five~p!1,four~p,three~p)->Rac(X~gtp!0),Vav(DH!0,PH!1,X~p),PI(five~p!1,four~p,three~p)" ForwardRate="1" />

    362. 

  362. <Rule Id="348" Name="PIP3_Sos@PH" Data="PI(five~p,four~p,three~p),Sos(PH)->PI(five~p!0,four~p,three~p),Sos(PH!0)" ForwardRate="1" />

    363. 

  363. <Rule Id="349" Name="Sos_Rac@DH_X~u" Data="PI(five~p!0,four~p,three~p),Sos(DH,PH!0,X~p),Rac(X~u)->PI(five~p!0,four~p,three~p),Sos(DH!1,PH!0,X~p),Rac(X~u!1)" ForwardRate="1" />

    364. 

  364. <Rule Id="350" Name="Sos_Rac@DH_X~u_op" Data="PI(five~p!0,four~p,three~p),Sos(DH!1,PH!0,X~p),Rac(X~u!1)->PI(five~p!0,four~p,three~p),Sos(DH,PH!0,X~p),Rac(X~u)" ForwardRate="1" />

    365. 

  365. <Rule Id="351" Name="PIP2_PLD@PH" Data="PI(five~p,four~p),PLD(PH)->PI(five~p!0,four~p),PLD(PH!0)" ForwardRate="1" />

    366. 

  366. <Rule Id="352" Name="PIP2_PLD@PH_op" Data="PI(five~p!0,four~p),PLD(PH!0)->PI(five~p,four~p),PLD(PH)" ForwardRate="1" />

    367. 

  367. <Rule Id="353" Name="Rom2_PI3K@PH_S1" Data="Rom2(PH),PI3K(S1)->Rom2(PH!0),PI3K(S1!0)" ForwardRate="1" />

    368. 

  368. <Rule Id="354" Name="Rom2_PI3K@PH_S1_op" Data="Rom2(PH!0),PI3K(S1!0)->Rom2(PH),PI3K(S1)" ForwardRate="1" />

    369. 

  369. <Rule Id="355" Name="Grb2_EGFR@SH2_Y1068" Data="Grb2(SH2),EGFR(Y1068~p)->Grb2(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />

    370. 

  370. <Rule Id="356" Name="Pak1_Grb2@SH3_SBM" Data="Grb2(SH2!0,SH3),EGFR(Y1068~p!0),Pak1(SBM)->Grb2(SH2!1,SH3!0),EGFR(Y1068~p!1),Pak1(SBM!0)" ForwardRate="1" />

    371. 

  371. <Rule Id="357" Name="Raf1_Ras@CR1_rafts" Data="Raf1(CR1,Y341~p),Ras(rafts)->Raf1(CR1!0,Y341~p),Ras(rafts!0)" ForwardRate="1" />

    372. 

  372. <Rule Id="358" Name="Raf1_p@S338" Data="Raf1(CR1!0,S338~u,Y341~p),Ras(rafts!0)->Raf1(CR1!0,S338~p,Y341~p),Ras(rafts!0)" ForwardRate="1" />

    373. 

  373. <Rule Id="359" Name="New Rule" Data="A(x~u)->A(x~p)" ForwardRate="1" />

    374. 

  374. <Rule Id="360" Name="New Rule_op" Data="A(x~p)->A(x~u)" ForwardRate="1" />

    375. 

  375. <Rule Id="361" Name="Rule66" Data="A(x~p),B(x1)->A(x~p!0),B(x1!0)" ForwardRate="1" />

    376. 

  376. <Rule Id="362" Name="Rule67" Data="A(x!0),B(x1!0)->A(x),B(x1)" ForwardRate="1" />

    377. 

  377. <Rule Id="363" Name="Rule68" Data="A(x!0),B(x1!0,y1~u)->A(x!0),B(x1!0,y1~p)" ForwardRate="1" />

    378. 

  378. <Rule Id="364" Name="Rule69" Data="A(x~p),B(x2)->A(x~p!0),B(x2!0)" ForwardRate="1" />

    379. 

  379. <Rule Id="365" Name="Rule70" Data="A(x!0),B(x2!0)->A(x),B(x2)" ForwardRate="1" />

    380. 

  380. <Rule Id="366" Name="Rule71" Data="A(x!0),B(x2!0,y2~u)->A(x!0),B(x2!0,y2~p)" ForwardRate="1" />

    381. 

  381. </RuleSet>

    382. 

  382. <ContactMap Name="Low resolution">

    383. 

  383. <Agent Name="Shc">

    384. 

  384. <Site Name="PTB" CanChangeState="true" CanBeBound="true">

    385. 

  385. <Rule Id="201"/>

    386. 

  386. <Rule Id="202"/>

    387. 

  387. <Rule Id="205"/>

    388. 

  388. <Rule Id="206"/>

    389. 

  389. <Rule Id="209"/>

    390. 

  390. <Rule Id="210"/>

    391. 

  391. <Rule Id="223"/>

    392. 

  392. <Rule Id="224"/>

    393. 

  393. <Rule Id="229"/>

    394. 

  394. <Rule Id="230"/>

    395. 

  395. </Site>

    396. 

  396. <Site Name="SH2" CanChangeState="false" CanBeBound="true">

    397. 

  397. </Site>

    398. 

  398. <Site Name="Y" CanChangeState="true" CanBeBound="true">

    399. 

  399. <Rule Id="231"/>

    400. 

  400. </Site>

    401. 

  401. <Site Name="Y239" CanChangeState="true" CanBeBound="true">

    402. 

  402. <Rule Id="308"/>

    403. 

  403. </Site>

    404. 

  404. <Site Name="Y240" CanChangeState="true" CanBeBound="true">

    405. 

  405. <Rule Id="310"/>

    406. 

  406. </Site>

    407. 

  407. <Site Name="Y317" CanChangeState="true" CanBeBound="true">

    408. 

  408. <Rule Id="323"/>

    409. 

  409. </Site>

    410. 

  410. <Site Name="Y318" CanChangeState="true" CanBeBound="true">

    411. 

  411. <Rule Id="51"/>

    412. 

  412. <Rule Id="52"/>

    413. 

  413. <Rule Id="125"/>

    414. 

  414. <Rule Id="126"/>

    415. 

  415. <Rule Id="127"/>

    416. 

  416. </Site>

    417. 

  417. </Agent>

    418. 

  418. <Agent Name="RasGAP">

    419. 

  419. <Site Name="GAP" CanChangeState="false" CanBeBound="true">

    420. 

  420. </Site>

    421. 

  421. <Site Name="SH2" CanChangeState="true" CanBeBound="true">

    422. 

  422. <Rule Id="197"/>

    423. 

  423. <Rule Id="198"/>

    424. 

  424. <Rule Id="207"/>

    425. 

  425. <Rule Id="208"/>

    426. 

  426. <Rule Id="225"/>

    427. 

  427. <Rule Id="226"/>

    428. 

  428. </Site>

    429. 

  429. <Site Name="s" CanChangeState="false" CanBeBound="true">

    430. 

  430. </Site>

    431. 

  431. </Agent>

    432. 

  432. <Agent Name="Grb2">

    433. 

  433. <Site Name="SH2" CanChangeState="true" CanBeBound="true">

    434. 

  434. <Rule Id="199"/>

    435. 

  435. <Rule Id="200"/>

    436. 

  436. <Rule Id="203"/>

    437. 

  437. <Rule Id="204"/>

    438. 

  438. <Rule Id="227"/>

    439. 

  439. <Rule Id="228"/>

    440. 

  440. </Site…
    441.