/test.data/contact_map/agents/~session036.test

http://github.com/kappamodeler/jkappa · Unknown · 775 lines · 775 code · 0 blank · 0 comment · 0 complexity · b2d5c04ce2d593f15dbdbc657cd5bb2b MD5 · raw file

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  1. <?xml version='1.0' encoding='utf-8'?>

    2. 

  2. <!-- Automaticaly generated by Complx 3.40..4208 -->

    3. 

  3. <ComplxSession Timestamp="25/2/2009 (21:58:11)" CommandLine="C:\DOCUME~1\LOPATK~1\LOCALS~1\Temp\tmp53467.exe ~kappa53576.tmp --output-xml ~session53575.tmp --memory-limit 1024 --reset-all --do-XML --do-low-res-contact-map --focus-on ~focus53574.tmp --key 07CFC00F0BEB0278" InputFile="~kappa53576.tmp" 

    4. 

  4. xsi:schemaLocation="http://plectix.synthesisstudios.com

    5. 

  5. KappaSession.xsd" xmlns="http://plectix.synthesisstudios.com/schemas/kappasession"

    6. 

  6. xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" >

    7. 

  7. <Log>

    8. 

  8. <Entry Type="INFO" Message="Compilation(simplx)                      0.047 s."/>

    9. 

  9. <Entry Type="INFO" Message="Second compilation(pretty printing)      0.016 s."/>

    10. 

  10. <Entry Type="INFO" Message="Translation                              0. s."/>

    11. 

  11. <Entry Type="INFO" Message="Renaming                                 0.015 s."/>

    12. 

  12. <Entry Type="INFO" Message="Boolean encoding of the initial system   0.157 s."/>

    13. 

  13. </Log>

    14. 

  14. <RuleSet Name="Original">

    15. 

  15. <Rule Id="1" Name="HRG_HER3" Data="HRG(r),HER3(CR,L)->HRG(r!0),HER3(CR,L!0)" ForwardRate="1" />

    16. 

  16. <Rule Id="2" Name="HRG_HER3_op" Data="HRG(r!0),HER3(L!0)->HRG(r),HER3(L)" ForwardRate="1" />

    17. 

  17. <Rule Id="3" Name="EGFR_HER3" Data="EGFR(C,CR,L~ext!_,N),HER3(C,CR,L~ext!_)->EGFR(C,CR!0,L~ext!_,N),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />

    18. 

  18. <Rule Id="4" Name="HER2_HER3" Data="HER2(C,CR,N),HER3(C,CR,L~ext!_)->HER2(C,CR!0,N),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />

    19. 

  19. <Rule Id="5" Name="HER3_HER3" Data="HER3(C,CR,L~ext!_),HER3(C,CR,L~ext!_)->HER3(C,CR!0,L~ext!_),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />

    20. 

  20. <Rule Id="6" Name="HER3_HER4" Data="HER3(C,CR,L~ext!_),HER4(C,CR,L~ext!_,N)->HER3(C,CR!0,L~ext!_),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    21. 

  21. <Rule Id="7" Name="EGFR_HER3_op" Data="EGFR(C,CR!0,N),HER3(C,CR!0)->EGFR(C,CR,N),HER3(C,CR)" ForwardRate="1" />

    22. 

  22. <Rule Id="8" Name="HER2_HER3_op" Data="HER2(C,CR!0,N),HER3(C,CR!0)->HER2(C,CR,N),HER3(C,CR)" ForwardRate="1" />

    23. 

  23. <Rule Id="9" Name="HER3_HER3_op" Data="HER3(C,CR!0),HER3(C,CR!0)->HER3(C,CR),HER3(C,CR)" ForwardRate="1" />

    24. 

  24. <Rule Id="10" Name="HER3_HER4_op" Data="HER3(C,CR!0),HER4(C,CR!0,N)->HER3(C,CR),HER4(C,CR,N)" ForwardRate="1" />

    25. 

  25. <Rule Id="11" Name="13 dimer" Data="EGFR(C,CR!0,N),HER3(C,CR!0)->EGFR(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />

    26. 

  26. <Rule Id="12" Name="13 dimer_op" Data="EGFR(C,CR!1,N!0),HER3(C!0,CR!1)->EGFR(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />

    27. 

  27. <Rule Id="13" Name="23 dimer" Data="HER2(C,CR!0,N),HER3(C,CR!0)->HER2(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />

    28. 

  28. <Rule Id="14" Name="23 dimer_op" Data="HER2(C,CR!1,N!0),HER3(C!0,CR!1)->HER2(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />

    29. 

  29. <Rule Id="15" Name="43 dimer" Data="HER4(C,CR!0,N),HER3(C,CR!0)->HER4(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />

    30. 

  30. <Rule Id="16" Name="43 dimer_op" Data="HER4(C,CR!1,N!0),HER3(C!0,CR!1)->HER4(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />

    31. 

  31. <Rule Id="17" Name="Rule1" Data="EGFR(N!0,bp),HER3(C!0,Y1035~u)->EGFR(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />

    32. 

  32. <Rule Id="18" Name="Rule2" Data="HER2(N!0,bp),HER3(C!0,Y1035~u)->HER2(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />

    33. 

  33. <Rule Id="19" Name="Rule3" Data="HER4(N!0,bp),HER3(C!0,Y1035~u)->HER4(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />

    34. 

  34. <Rule Id="20" Name="Rule4" Data="EGFR(N!0,bp),HER3(C!0,Y1178~u)->EGFR(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />

    35. 

  35. <Rule Id="21" Name="Rule5" Data="HER2(N!0,bp),HER3(C!0,Y1178~u)->HER2(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />

    36. 

  36. <Rule Id="22" Name="Rule6" Data="HER4(N!0,bp),HER3(C!0,Y1178~u)->HER4(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />

    37. 

  37. <Rule Id="23" Name="Rule7" Data="EGFR(N!0,bp),HER3(C!0,Y1203~u)->EGFR(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />

    38. 

  38. <Rule Id="24" Name="Rule8" Data="HER2(N!0,bp),HER3(C!0,Y1203~u)->HER2(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />

    39. 

  39. <Rule Id="25" Name="Rule9" Data="HER4(N!0,bp),HER3(C!0,Y1203~u)->HER4(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />

    40. 

  40. <Rule Id="26" Name="Rule10" Data="EGFR(N!0,bp),HER3(C!0,Y1241~u)->EGFR(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />

    41. 

  41. <Rule Id="27" Name="Rule11" Data="HER2(N!0,bp),HER3(C!0,Y1241~u)->HER2(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />

    42. 

  42. <Rule Id="28" Name="Rule12" Data="HER4(N!0,bp),HER3(C!0,Y1241~u)->HER4(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />

    43. 

  43. <Rule Id="29" Name="Rule13" Data="EGFR(N!0,bp),HER3(C!0,Y1257~u)->EGFR(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />

    44. 

  44. <Rule Id="30" Name="Rule14" Data="HER2(N!0,bp),HER3(C!0,Y1257~u)->HER2(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />

    45. 

  45. <Rule Id="31" Name="Rule15" Data="HER4(N!0,bp),HER3(C!0,Y1257~u)->HER4(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />

    46. 

  46. <Rule Id="32" Name="Rule16" Data="EGFR(N!0,bp),HER3(C!0,Y1270~u)->EGFR(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />

    47. 

  47. <Rule Id="33" Name="Rule17" Data="HER2(N!0,bp),HER3(C!0,Y1270~u)->HER2(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />

    48. 

  48. <Rule Id="34" Name="Rule18" Data="HER4(N!0,bp),HER3(C!0,Y1270~u)->HER4(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />

    49. 

  49. <Rule Id="35" Name="Rule19" Data="EGFR(N!0,bp),HER3(C!0,Y1309~u)->EGFR(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />

    50. 

  50. <Rule Id="36" Name="Rule20" Data="HER2(N!0,bp),HER3(C!0,Y1309~u)->HER2(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />

    51. 

  51. <Rule Id="37" Name="Rule21" Data="HER4(N!0,bp),HER3(C!0,Y1309~u)->HER4(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />

    52. 

  52. <Rule Id="38" Name="Rule22" Data="HER3(Y1035~p),PTP(s)->HER3(Y1035~p!0),PTP(s!0)" ForwardRate="1" />

    53. 

  53. <Rule Id="39" Name="Rule23" Data="HER3(Y1178~p),PTP(s)->HER3(Y1178~p!0),PTP(s!0)" ForwardRate="1" />

    54. 

  54. <Rule Id="40" Name="Rule24" Data="HER3(Y1203~p),PTP(s)->HER3(Y1203~p!0),PTP(s!0)" ForwardRate="1" />

    55. 

  55. <Rule Id="41" Name="Rule25" Data="HER3(Y1241~p),PTP(s)->HER3(Y1241~p!0),PTP(s!0)" ForwardRate="1" />

    56. 

  56. <Rule Id="42" Name="Rule26" Data="HER3(Y1257~p),PTP(s)->HER3(Y1257~p!0),PTP(s!0)" ForwardRate="1" />

    57. 

  57. <Rule Id="43" Name="Rule27" Data="HER3(Y1270~p),PTP(s)->HER3(Y1270~p!0),PTP(s!0)" ForwardRate="1" />

    58. 

  58. <Rule Id="44" Name="Rule28" Data="HER3(Y1309~p),PTP(s)->HER3(Y1309~p!0),PTP(s!0)" ForwardRate="1" />

    59. 

  59. <Rule Id="45" Name="Rule29" Data="HER3(Y1035!0),PTP(s!0)->HER3(Y1035),PTP(s)" ForwardRate="1" />

    60. 

  60. <Rule Id="46" Name="Rule30" Data="HER3(Y1178!0),PTP(s!0)->HER3(Y1178),PTP(s)" ForwardRate="1" />

    61. 

  61. <Rule Id="47" Name="Rule31" Data="HER3(Y1203!0),PTP(s!0)->HER3(Y1203),PTP(s)" ForwardRate="1" />

    62. 

  62. <Rule Id="48" Name="Rule32" Data="HER3(Y1241!0),PTP(s!0)->HER3(Y1241),PTP(s)" ForwardRate="1" />

    63. 

  63. <Rule Id="49" Name="Rule33" Data="HER3(Y1257!0),PTP(s!0)->HER3(Y1257),PTP(s)" ForwardRate="1" />

    64. 

  64. <Rule Id="50" Name="Rule34" Data="HER3(Y1270!0),PTP(s!0)->HER3(Y1270),PTP(s)" ForwardRate="1" />

    65. 

  65. <Rule Id="51" Name="Rule35" Data="HER3(Y1309!0),PTP(s!0)->HER3(Y1309),PTP(s)" ForwardRate="1" />

    66. 

  66. <Rule Id="52" Name="Rule36" Data="HER3(Y1035~p!0),PTP(s!0)->HER3(Y1035~u!0),PTP(s!0)" ForwardRate="1" />

    67. 

  67. <Rule Id="53" Name="Rule37" Data="HER3(Y1178~p!0),PTP(s!0)->HER3(Y1178~u!0),PTP(s!0)" ForwardRate="1" />

    68. 

  68. <Rule Id="54" Name="Rule38" Data="HER3(Y1203~p!0),PTP(s!0)->HER3(Y1203~u!0),PTP(s!0)" ForwardRate="1" />

    69. 

  69. <Rule Id="55" Name="Rule39" Data="HER3(Y1241~p!0),PTP(s!0)->HER3(Y1241~u!0),PTP(s!0)" ForwardRate="1" />

    70. 

  70. <Rule Id="56" Name="Rule40" Data="HER3(Y1257~p!0),PTP(s!0)->HER3(Y1257~u!0),PTP(s!0)" ForwardRate="1" />

    71. 

  71. <Rule Id="57" Name="Rule41" Data="HER3(Y1270~p!0),PTP(s!0)->HER3(Y1270~u!0),PTP(s!0)" ForwardRate="1" />

    72. 

  72. <Rule Id="58" Name="Rule42" Data="HER3(Y1309~p!0),PTP(s!0)->HER3(Y1309~u!0),PTP(s!0)" ForwardRate="1" />

    73. 

  73. <Rule Id="59" Name="HER3_PI3K#1" Data="HER3(Y1035~p),PI3K(SH2~u)=>HER3(Y1035~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    74. 

  74. <Rule Id="60" Name="HER3_PI3K#1_op" Data="HER3(Y1035~p!0),PI3K(SH2~rec!0)=>HER3(Y1035~p),PI3K(SH2~u)" ForwardRate="1" />

    75. 

  75. <Rule Id="61" Name="HER3_PI3K#2" Data="HER3(Y1178~p),PI3K(SH2~u)=>HER3(Y1178~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    76. 

  76. <Rule Id="62" Name="HER3_PI3K#2_op" Data="HER3(Y1178~p!0),PI3K(SH2~rec!0)=>HER3(Y1178~p),PI3K(SH2~u)" ForwardRate="1" />

    77. 

  77. <Rule Id="63" Name="HER3_PI3K#3" Data="HER3(Y1203~p),PI3K(SH2~u)=>HER3(Y1203~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    78. 

  78. <Rule Id="64" Name="HER3_PI3K#3_op" Data="HER3(Y1203~p!0),PI3K(SH2~rec!0)=>HER3(Y1203~p),PI3K(SH2~u)" ForwardRate="1" />

    79. 

  79. <Rule Id="65" Name="HER3_PI3K#4" Data="HER3(Y1241~p),PI3K(SH2~u)=>HER3(Y1241~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    80. 

  80. <Rule Id="66" Name="HER3_PI3K#4_op" Data="HER3(Y1241~p!0),PI3K(SH2~rec!0)=>HER3(Y1241~p),PI3K(SH2~u)" ForwardRate="1" />

    81. 

  81. <Rule Id="67" Name="HER3_PI3K#5" Data="HER3(Y1257~p),PI3K(SH2~u)=>HER3(Y1257~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    82. 

  82. <Rule Id="68" Name="HER3_PI3K#5_op" Data="HER3(Y1257~p!0),PI3K(SH2~rec!0)=>HER3(Y1257~p),PI3K(SH2~u)" ForwardRate="1" />

    83. 

  83. <Rule Id="69" Name="HER3_PI3K#6" Data="HER3(Y1270~p),PI3K(SH2~u)=>HER3(Y1270~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />

    84. 

  84. <Rule Id="70" Name="HER3_PI3K#6_op" Data="HER3(Y1270~p!0),PI3K(SH2~rec!0)=>HER3(Y1270~p),PI3K(SH2~u)" ForwardRate="1" />

    85. 

  85. <Rule Id="71" Name="HER3_Shc" Data="HER3(Y1309~p),Shc(PTB~u)=>HER3(Y1309~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    86. 

  86. <Rule Id="72" Name="HER3_Shc_op" Data="HER3(Y1309~p!0),Shc(PTB~rec!0)=>HER3(Y1309~p),Shc(PTB~u)" ForwardRate="1" />

    87. 

  87. <Rule Id="73" Name="HRG_ErbB3" Data="HRG(r~ext),ErbB3(CR,L~ext)->HRG(r~ext!0),ErbB3(CR,L~ext!0)" ForwardRate="1" />

    88. 

  88. <Rule Id="74" Name="HRG_ErbB3_op" Data="HRG(r~ext!0),ErbB3(CR,L~ext!0)->HRG(r~ext),ErbB3(CR,L~ext)" ForwardRate="1" />

    89. 

  89. <Rule Id="75" Name="HRG_ErbB4" Data="HRG(r~ext),ErbB4(CR,L~ext)->HRG(r~ext!0),ErbB4(CR,L~ext!0)" ForwardRate="1" />

    90. 

  90. <Rule Id="76" Name="HRG_ErbB4_op" Data="HRG(r~ext!0),ErbB4(CR,L~ext!0)->HRG(r~ext),ErbB4(CR,L~ext)" ForwardRate="1" />

    91. 

  91. <Rule Id="77" Name="ErbB1_Shc" Data="ErbB1(Y1148~p),Shc(PTB)->ErbB1(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />

    92. 

  92. <Rule Id="78" Name="ErbB1_Shc_op" Data="ErbB1(Y1148~p!0),Shc(PTB!0)->ErbB1(Y1148~p),Shc(PTB)" ForwardRate="1" />

    93. 

  93. <Rule Id="79" Name="ErbB2_Shc#1" Data="ErbB2(Y1196~p),Shc(PTB)->ErbB2(Y1196~p!0),Shc(PTB!0)" ForwardRate="1" />

    94. 

  94. <Rule Id="80" Name="ErbB2_Shc#1_op" Data="ErbB2(Y1196~p!0),Shc(PTB!0)->ErbB2(Y1196~p),Shc(PTB)" ForwardRate="1" />

    95. 

  95. <Rule Id="81" Name="ErbB2_Shc#2" Data="ErbB2(Y1221~p),Shc(PTB)->ErbB2(Y1221~p!0),Shc(PTB!0)" ForwardRate="1" />

    96. 

  96. <Rule Id="82" Name="ErbB2_Shc#2_op" Data="ErbB2(Y1221~p!0),Shc(PTB!0)->ErbB2(Y1221~p),Shc(PTB)" ForwardRate="1" />

    97. 

  97. <Rule Id="83" Name="ErbB3_Shc" Data="ErbB3(Y1309~p),Shc(PTB)->ErbB3(Y1309~p!0),Shc(PTB!0)" ForwardRate="1" />

    98. 

  98. <Rule Id="84" Name="ErbB3_Shc_op" Data="ErbB3(Y1309~p!0),Shc(PTB!0)->ErbB3(Y1309~p),Shc(PTB)" ForwardRate="1" />

    99. 

  99. <Rule Id="85" Name="Shc#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~u)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />

    100. 

  100. <Rule Id="86" Name="Shc#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />

    101. 

  101. <Rule Id="87" Name="Shc#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />

    102. 

  102. <Rule Id="88" Name="Shc#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~u)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />

    103. 

  103. <Rule Id="89" Name="Shc_op" Data="Shc(Y318~p)=>Shc(Y318~u),Pi()" ForwardRate="1" />

    104. 

  104. <Rule Id="90" Name="Shc_Grb2" Data="Shc(Y318~p),Grb2(SH2)->Shc(Y318~p!0),Grb2(SH2!0)" ForwardRate="1" />

    105. 

  105. <Rule Id="91" Name="Shc_Grb2_op" Data="Shc(Y318~p!0),Grb2(SH2!0)->Shc(Y318~p),Grb2(SH2)" ForwardRate="1" />

    106. 

  106. <Rule Id="92" Name="long arm SoS_Ras#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />

    107. 

  107. <Rule Id="93" Name="long arm SoS_Ras#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />

    108. 

  108. <Rule Id="94" Name="long arm SoS_Ras#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />

    109. 

  109. <Rule Id="95" Name="long arm SoS_Ras#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />

    110. 

  110. <Rule Id="96" Name="Gab1_PI3K@447" Data="Gab1(Y447~p),PI3K(SH2)->Gab1(Y447~p!0),PI3K(SH2!0)" ForwardRate="1" />

    111. 

  111. <Rule Id="97" Name="Gab1_PI3K@447_op" Data="Gab1(Y447~p!0),PI3K(SH2!0)->Gab1(Y447~p),PI3K(SH2)" ForwardRate="1" />

    112. 

  112. <Rule Id="98" Name="Gab1_PI3K@472" Data="Gab1(Y472~p),PI3K(SH2)->Gab1(Y472~p!0),PI3K(SH2!0)" ForwardRate="1" />

    113. 

  113. <Rule Id="99" Name="Gab1_PI3K@472_op" Data="Gab1(Y472~p!0),PI3K(SH2!0)->Gab1(Y472~p),PI3K(SH2)" ForwardRate="1" />

    114. 

  114. <Rule Id="100" Name="Gab1_PI3K@619" Data="Gab1(Y619~p),PI3K(SH2)->Gab1(Y619~p!0),PI3K(SH2!0)" ForwardRate="1" />

    115. 

  115. <Rule Id="101" Name="Gab1_PI3K@619_op" Data="Gab1(Y619~p!0),PI3K(SH2!0)->Gab1(Y619~p),PI3K(SH2)" ForwardRate="1" />

    116. 

  116. <Rule Id="102" Name="ErbB3_PI3K#1" Data="ErbB3(Y1035~p),PI3K(SH2)->ErbB3(Y1035~p!0),PI3K(SH2!0)" ForwardRate="1" />

    117. 

  117. <Rule Id="103" Name="ErbB3_PI3K#1_op" Data="ErbB3(Y1035~p!0),PI3K(SH2!0)->ErbB3(Y1035~p),PI3K(SH2)" ForwardRate="1" />

    118. 

  118. <Rule Id="104" Name="ErbB3_PI3K#2" Data="ErbB3(Y1178~p),PI3K(SH2)->ErbB3(Y1178~p!0),PI3K(SH2!0)" ForwardRate="1" />

    119. 

  119. <Rule Id="105" Name="ErbB3_PI3K#2_op" Data="ErbB3(Y1178~p!0),PI3K(SH2!0)->ErbB3(Y1178~p),PI3K(SH2)" ForwardRate="1" />

    120. 

  120. <Rule Id="106" Name="ErbB3_PI3K#3" Data="ErbB3(Y1203~p),PI3K(SH2)->ErbB3(Y1203~p!0),PI3K(SH2!0)" ForwardRate="1" />

    121. 

  121. <Rule Id="107" Name="ErbB3_PI3K#3_op" Data="ErbB3(Y1203~p!0),PI3K(SH2!0)->ErbB3(Y1203~p),PI3K(SH2)" ForwardRate="1" />

    122. 

  122. <Rule Id="108" Name="ErbB3_PI3K#4" Data="ErbB3(Y1241~p),PI3K(SH2)->ErbB3(Y1241~p!0),PI3K(SH2!0)" ForwardRate="1" />

    123. 

  123. <Rule Id="109" Name="ErbB3_PI3K#4_op" Data="ErbB3(Y1241~p!0),PI3K(SH2!0)->ErbB3(Y1241~p),PI3K(SH2)" ForwardRate="1" />

    124. 

  124. <Rule Id="110" Name="ErbB3_PI3K#5" Data="ErbB3(Y1257~p),PI3K(SH2)->ErbB3(Y1257~p!0),PI3K(SH2!0)" ForwardRate="1" />

    125. 

  125. <Rule Id="111" Name="ErbB3_PI3K#5_op" Data="ErbB3(Y1257~p!0),PI3K(SH2!0)->ErbB3(Y1257~p),PI3K(SH2)" ForwardRate="1" />

    126. 

  126. <Rule Id="112" Name="ErbB3_PI3K#6" Data="ErbB3(Y1270~p),PI3K(SH2)->ErbB3(Y1270~p!0),PI3K(SH2!0)" ForwardRate="1" />

    127. 

  127. <Rule Id="113" Name="ErbB3_PI3K#6_op" Data="ErbB3(Y1270~p!0),PI3K(SH2!0)->ErbB3(Y1270~p),PI3K(SH2)" ForwardRate="1" />

    128. 

  128. <Rule Id="114" Name="short arm PI3K_PI#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    129. 

  129. <Rule Id="115" Name="short arm PI3K_PI#2" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    130. 

  130. <Rule Id="116" Name="short arm PI3K_PI#3" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    131. 

  131. <Rule Id="117" Name="short arm PI3K_PI#4" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    132. 

  132. <Rule Id="118" Name="short arm PI3K_PI#5" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    133. 

  133. <Rule Id="119" Name="short arm PI3K_PI#6" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />

    134. 

  134. <Rule Id="120" Name="direct PI3K_PI#1" Data="ErbB3(Y1035~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1035~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    135. 

  135. <Rule Id="121" Name="direct PI3K_PI#2" Data="ErbB3(Y1178~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1178~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    136. 

  136. <Rule Id="122" Name="direct PI3K_PI#3" Data="ErbB3(Y1203~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1203~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    137. 

  137. <Rule Id="123" Name="direct PI3K_PI#4" Data="ErbB3(Y1241~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1241~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    138. 

  138. <Rule Id="124" Name="direct PI3K_PI#5" Data="ErbB3(Y1257~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1257~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    139. 

  139. <Rule Id="125" Name="direct PI3K_PI#6" Data="ErbB3(Y1270~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1270~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />

    140. 

  140. <Rule Id="126" Name="PI@three" Data="PI3K(s!0),PI(three~u!0)->PI3K(s!0),PI(three~p!0)" ForwardRate="1" />

    141. 

  141. <Rule Id="127" Name="PI3K_PI_op" Data="PI3K(s!0),PI(three!0)->PI3K(s),PI(three)" ForwardRate="1" />

    142. 

  142. <Rule Id="128" Name="Rule43" Data="H()=>HRG(r)" ForwardRate="1" />

    143. 

  143. <Rule Id="129" Name="EGF_EGFRe" Data="EGF(r~ext),EGFR(CR,L~ext)->EGF(r~ext!0),EGFR(CR,L~ext!0)" ForwardRate="1" />

    144. 

  144. <Rule Id="130" Name="EGF_EGFRi" Data="EGF(r~int),EGFR(CR,L~int)->EGF(r~int!0),EGFR(CR,L~int!0)" ForwardRate="1" />

    145. 

  145. <Rule Id="131" Name="HRG_HER4" Data="HRG(r),HER4(CR,L)->HRG(r!0),HER4(CR,L!0)" ForwardRate="1" />

    146. 

  146. <Rule Id="132" Name="EGF_EGFR_op" Data="EGF(r!0),EGFR(L!0)->EGF(r),EGFR(L)" ForwardRate="1" />

    147. 

  147. <Rule Id="133" Name="HRG_HER4_op" Data="HRG(r!0),HER4(L!0)->HRG(r),HER4(L)" ForwardRate="1" />

    148. 

  148. <Rule Id="134" Name="EGFR_EGFRe" Data="EGFR(C,CR,L~ext!_,N),EGFR(C,CR,L~ext!_,N)->EGFR(C,CR!0,L~ext!_,N),EGFR(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    149. 

  149. <Rule Id="135" Name="EGFR_EGFRi" Data="EGFR(C,CR,L~int!_,N),EGFR(C,CR,L~int!_,N)->EGFR(C,CR!0,L~int!_,N),EGFR(C,CR!0,L~int!_,N)" ForwardRate="1" />

    150. 

  150. <Rule Id="136" Name="EGFR_HER2" Data="EGFR(C,CR,L~ext!_,N),HER2(C,CR,N)->EGFR(C,CR!0,L~ext!_,N),HER2(C,CR!0,N)" ForwardRate="1" />

    151. 

  151. <Rule Id="137" Name="EGFR_HER4" Data="EGFR(C,CR,L~ext!_,N),HER4(C,CR,L~ext!_,N)->EGFR(C,CR!0,L~ext!_,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    152. 

  152. <Rule Id="138" Name="HER2_HER4" Data="HER2(C,CR,N),HER4(C,CR,L~ext!_,N)->HER2(C,CR!0,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    153. 

  153. <Rule Id="139" Name="HER4_HER4" Data="HER4(C,CR,L~ext!_,N),HER4(C,CR,L~ext!_,N)->HER4(C,CR!0,L~ext!_,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />

    154. 

  154. <Rule Id="140" Name="EGFR_EGFR_op" Data="EGFR(C,CR!0,N),EGFR(C,CR!0,N)->EGFR(C,CR,N),EGFR(C,CR,N)" ForwardRate="1" />

    155. 

  155. <Rule Id="141" Name="EGFR_HER2_op" Data="EGFR(C,CR!0,N),HER2(C,CR!0,N)->EGFR(C,CR,N),HER2(C,CR,N)" ForwardRate="1" />

    156. 

  156. <Rule Id="142" Name="EGFR_HER4_op" Data="EGFR(C,CR!0,N),HER4(C,CR!0,N)->EGFR(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />

    157. 

  157. <Rule Id="143" Name="HER2_HER2_op" Data="HER2(C,CR!0,N),HER2(C,CR!0,N)->HER2(C,CR,N),HER2(C,CR,N)" ForwardRate="1" />

    158. 

  158. <Rule Id="144" Name="HER2_HER4_op" Data="HER2(C,CR!0,N),HER4(C,CR!0,N)->HER2(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />

    159. 

  159. <Rule Id="145" Name="HER4_HER4_op" Data="HER4(C,CR!0,N),HER4(C,CR!0,N)->HER4(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />

    160. 

  160. <Rule Id="146" Name="11 dimer" Data="EGFR(C,CR!0,N),EGFR(C,CR!0,N)->EGFR(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />

    161. 

  161. <Rule Id="147" Name="11 dimer_op" Data="EGFR(C,CR!1,N!0),EGFR(C!0,CR!1,N)->EGFR(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />

    162. 

  162. <Rule Id="148" Name="21 dimer" Data="HER2(C,CR!0,N),EGFR(C,CR!0,N)->HER2(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />

    163. 

  163. <Rule Id="149" Name="21 dimer_op" Data="HER2(C,CR!1,N!0),EGFR(C!0,CR!1,N)->HER2(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />

    164. 

  164. <Rule Id="150" Name="41 dimer" Data="HER4(C,CR!0,N),EGFR(C,CR!0,N)->HER4(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />

    165. 

  165. <Rule Id="151" Name="41 dimer_op" Data="HER4(C,CR!1,N!0),EGFR(C!0,CR!1,N)->HER4(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />

    166. 

  166. <Rule Id="152" Name="12 dimer" Data="EGFR(C,CR!0,N),HER2(C,CR!0,N)->EGFR(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />

    167. 

  167. <Rule Id="153" Name="12 dimer_op" Data="EGFR(C,CR!1,N!0),HER2(C!0,CR!1,N)->EGFR(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />

    168. 

  168. <Rule Id="154" Name="22 dimer" Data="HER2(C,CR!0,N),HER2(C,CR!0,N)->HER2(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />

    169. 

  169. <Rule Id="155" Name="22 dimer_op" Data="HER2(C,CR!1,N!0),HER2(C!0,CR!1,N)->HER2(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />

    170. 

  170. <Rule Id="156" Name="42 dimer" Data="HER4(C,CR!0,N),HER2(C,CR!0,N)->HER4(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />

    171. 

  171. <Rule Id="157" Name="42 dimer_op" Data="HER4(C,CR!1,N!0),HER2(C!0,CR!1,N)->HER4(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />

    172. 

  172. <Rule Id="158" Name="14 dimer" Data="EGFR(C,CR!0,N),HER4(C,CR!0,N)->EGFR(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />

    173. 

  173. <Rule Id="159" Name="14 dimer_op" Data="EGFR(C,CR!1,N!0),HER4(C!0,CR!1,N)->EGFR(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />

    174. 

  174. <Rule Id="160" Name="24 dimer" Data="HER2(C,CR!0,N),HER4(C,CR!0,N)->HER2(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />

    175. 

  175. <Rule Id="161" Name="24 dimer_op" Data="HER2(C,CR!1,N!0),HER4(C!0,CR!1,N)->HER2(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />

    176. 

  176. <Rule Id="162" Name="44 dimer" Data="HER4(C,CR!0,N),HER4(C,CR!0,N)->HER4(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />

    177. 

  177. <Rule Id="163" Name="44 dimer_op" Data="HER4(C,CR!1,N!0),HER4(C!0,CR!1,N)->HER4(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />

    178. 

  178. <Rule Id="164" Name="EGFR_Inh" Data="EGFR(N!_,bp),Inh1(s)->EGFR(N!_,bp!0),Inh1(s!0)" ForwardRate="1" />

    179. 

  179. <Rule Id="165" Name="HER2_Inh" Data="HER2(N!_,bp),Inh2(s)->HER2(N!_,bp!0),Inh2(s!0)" ForwardRate="1" />

    180. 

  180. <Rule Id="166" Name="HER4_Inh" Data="HER4(N!_,bp),Inh4(s)->HER4(N!_,bp!0),Inh4(s!0)" ForwardRate="1" />

    181. 

  181. <Rule Id="167" Name="EGFR_Inh_op" Data="EGFR(bp!0),Inh1(s!0)->EGFR(bp),Inh1(s)" ForwardRate="1" />

    182. 

  182. <Rule Id="168" Name="HER2_Inh_op" Data="HER2(bp!0),Inh2(s!0)->HER2(bp),Inh2(s)" ForwardRate="1" />

    183. 

  183. <Rule Id="169" Name="HER4_Inh_op" Data="HER4(bp!0),Inh4(s!0)->HER4(bp),Inh4(s)" ForwardRate="1" />

    184. 

  184. <Rule Id="170" Name="EGF_mono" Data="EGF(r~ext!0),EGFR(CR,L~ext!0)=>EGF(r~int!0),EGFR(CR,L~int!0)" ForwardRate="1" />

    185. 

  185. <Rule Id="171" Name="EGF_di" Data="EGF(r~ext!0),EGFR(CR!1,L~ext!0),EGF(r~ext!2),EGFR(CR!1,L~ext!2)=>EGF(r~int!0),EGFR(CR!1,L~int!0),EGF(r~int!2),EGFR(CR!1,L~int!2)" ForwardRate="1" />

    186. 

  186. <Rule Id="172" Name="Rule44" Data="EGFR(N!0,bp),EGFR(C!0,Y1016~u)->EGFR(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />

    187. 

  187. <Rule Id="173" Name="Rule45" Data="HER2(N!0,bp),EGFR(C!0,Y1016~u)->HER2(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />

    188. 

  188. <Rule Id="174" Name="Rule46" Data="HER4(N!0,bp),EGFR(C!0,Y1016~u)->HER4(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />

    189. 

  189. <Rule Id="175" Name="Rule47" Data="EGFR(N!0,bp),EGFR(C!0,Y1092~u)->EGFR(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />

    190. 

  190. <Rule Id="176" Name="Rule48" Data="HER2(N!0,bp),EGFR(C!0,Y1092~u)->HER2(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />

    191. 

  191. <Rule Id="177" Name="Rule49" Data="HER4(N!0,bp),EGFR(C!0,Y1092~u)->HER4(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />

    192. 

  192. <Rule Id="178" Name="Rule50" Data="EGFR(N!0,bp),EGFR(C!0,Y1172~u)->EGFR(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />

    193. 

  193. <Rule Id="179" Name="Rule51" Data="HER2(N!0,bp),EGFR(C!0,Y1172~u)->HER2(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />

    194. 

  194. <Rule Id="180" Name="Rule52" Data="HER4(N!0,bp),EGFR(C!0,Y1172~u)->HER4(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />

    195. 

  195. <Rule Id="181" Name="Rule53" Data="EGFR(N!0,bp),HER2(C!0,Y1139~u)->EGFR(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />

    196. 

  196. <Rule Id="182" Name="Rule54" Data="HER2(N!0,bp),HER2(C!0,Y1139~u)->HER2(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />

    197. 

  197. <Rule Id="183" Name="Rule55" Data="HER4(N!0,bp),HER2(C!0,Y1139~u)->HER4(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />

    198. 

  198. <Rule Id="184" Name="Rule56" Data="EGFR(N!0,bp),HER2(C!0,Y1196~u)->EGFR(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />

    199. 

  199. <Rule Id="185" Name="Rule57" Data="HER2(N!0,bp),HER2(C!0,Y1196~u)->HER2(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />

    200. 

  200. <Rule Id="186" Name="Rule58" Data="HER4(N!0,bp),HER2(C!0,Y1196~u)->HER4(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />

    201. 

  201. <Rule Id="187" Name="Rule59" Data="EGFR(N!0,bp),HER2(C!0,Y1221~u)->EGFR(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />

    202. 

  202. <Rule Id="188" Name="Rule60" Data="HER2(N!0,bp),HER2(C!0,Y1221~u)->HER2(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />

    203. 

  203. <Rule Id="189" Name="Rule61" Data="HER4(N!0,bp),HER2(C!0,Y1221~u)->HER4(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />

    204. 

  204. <Rule Id="190" Name="Rule62" Data="EGFR(N!0,bp),HER4(C!0,Y1~u)->EGFR(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />

    205. 

  205. <Rule Id="191" Name="Rule63" Data="HER2(N!0,bp),HER4(C!0,Y1~u)->HER2(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />

    206. 

  206. <Rule Id="192" Name="Rule64" Data="HER4(N!0,bp),HER4(C!0,Y1~u)->HER4(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />

    207. 

  207. <Rule Id="193" Name="Rule65" Data="EGFR(N!0,bp),HER4(C!0,Y2~u)->EGFR(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />

    208. 

  208. <Rule Id="194" Name="Rule66" Data="HER2(N!0,bp),HER4(C!0,Y2~u)->HER2(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />

    209. 

  209. <Rule Id="195" Name="Rule67" Data="HER4(N!0,bp),HER4(C!0,Y2~u)->HER4(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />

    210. 

  210. <Rule Id="196" Name="Rule68" Data="EGFR(N!0,bp),HER4(C!0,Y3~u)->EGFR(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />

    211. 

  211. <Rule Id="197" Name="Rule69" Data="HER2(N!0,bp),HER4(C!0,Y3~u)->HER2(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />

    212. 

  212. <Rule Id="198" Name="Rule70" Data="HER4(N!0,bp),HER4(C!0,Y3~u)->HER4(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />

    213. 

  213. <Rule Id="199" Name="Rule71" Data="EGFR(Y1016~p),PTP(s)->EGFR(Y1016~p!0),PTP(s!0)" ForwardRate="1" />

    214. 

  214. <Rule Id="200" Name="Rule72" Data="EGFR(Y1092~p),PTP(s)->EGFR(Y1092~p!0),PTP(s!0)" ForwardRate="1" />

    215. 

  215. <Rule Id="201" Name="Rule73" Data="EGFR(Y1172~p),PTP(s)->EGFR(Y1172~p!0),PTP(s!0)" ForwardRate="1" />

    216. 

  216. <Rule Id="202" Name="Rule74" Data="HER2(Y1139~p),PTP(s)->HER2(Y1139~p!0),PTP(s!0)" ForwardRate="1" />

    217. 

  217. <Rule Id="203" Name="Rule75" Data="HER2(Y1196~p),PTP(s)->HER2(Y1196~p!0),PTP(s!0)" ForwardRate="1" />

    218. 

  218. <Rule Id="204" Name="Rule76" Data="HER2(Y1221~p),PTP(s)->HER2(Y1221~p!0),PTP(s!0)" ForwardRate="1" />

    219. 

  219. <Rule Id="205" Name="Rule77" Data="HER4(Y1~p),PTP(s)->HER4(Y1~p!0),PTP(s!0)" ForwardRate="1" />

    220. 

  220. <Rule Id="206" Name="Rule78" Data="HER4(Y2~p),PTP(s)->HER4(Y2~p!0),PTP(s!0)" ForwardRate="1" />

    221. 

  221. <Rule Id="207" Name="Rule79" Data="HER4(Y3~p),PTP(s)->HER4(Y3~p!0),PTP(s!0)" ForwardRate="1" />

    222. 

  222. <Rule Id="208" Name="Rule80" Data="EGFR(Y1016!0),PTP(s!0)->EGFR(Y1016),PTP(s)" ForwardRate="1" />

    223. 

  223. <Rule Id="209" Name="Rule81" Data="EGFR(Y1092!0),PTP(s!0)->EGFR(Y1092),PTP(s)" ForwardRate="1" />

    224. 

  224. <Rule Id="210" Name="Rule82" Data="EGFR(Y1172!0),PTP(s!0)->EGFR(Y1172),PTP(s)" ForwardRate="1" />

    225. 

  225. <Rule Id="211" Name="Rule83" Data="HER2(Y1139!0),PTP(s!0)->HER2(Y1139),PTP(s)" ForwardRate="1" />

    226. 

  226. <Rule Id="212" Name="Rule84" Data="HER2(Y1196!0),PTP(s!0)->HER2(Y1196),PTP(s)" ForwardRate="1" />

    227. 

  227. <Rule Id="213" Name="Rule85" Data="HER2(Y1221!0),PTP(s!0)->HER2(Y1221),PTP(s)" ForwardRate="1" />

    228. 

  228. <Rule Id="214" Name="Rule86" Data="HER4(Y1!0),PTP(s!0)->HER4(Y1),PTP(s)" ForwardRate="1" />

    229. 

  229. <Rule Id="215" Name="Rule87" Data="HER4(Y2!0),PTP(s!0)->HER4(Y2),PTP(s)" ForwardRate="1" />

    230. 

  230. <Rule Id="216" Name="Rule88" Data="HER4(Y3!0),PTP(s!0)->HER4(Y3),PTP(s)" ForwardRate="1" />

    231. 

  231. <Rule Id="217" Name="Rule89" Data="EGFR(Y1016~p!0),PTP(s!0)->EGFR(Y1016~u!0),PTP(s!0)" ForwardRate="1" />

    232. 

  232. <Rule Id="218" Name="Rule90" Data="EGFR(Y1092~p!0),PTP(s!0)->EGFR(Y1092~u!0),PTP(s!0)" ForwardRate="1" />

    233. 

  233. <Rule Id="219" Name="Rule91" Data="EGFR(Y1172~p!0),PTP(s!0)->EGFR(Y1172~u!0),PTP(s!0)" ForwardRate="1" />

    234. 

  234. <Rule Id="220" Name="Rule92" Data="HER2(Y1139~p!0),PTP(s!0)->HER2(Y1139~u!0),PTP(s!0)" ForwardRate="1" />

    235. 

  235. <Rule Id="221" Name="Rule93" Data="HER2(Y1196~p!0),PTP(s!0)->HER2(Y1196~u!0),PTP(s!0)" ForwardRate="1" />

    236. 

  236. <Rule Id="222" Name="Rule94" Data="HER2(Y1221~p!0),PTP(s!0)->HER2(Y1221~u!0),PTP(s!0)" ForwardRate="1" />

    237. 

  237. <Rule Id="223" Name="Rule95" Data="HER4(Y1~p!0),PTP(s!0)->HER4(Y1~u!0),PTP(s!0)" ForwardRate="1" />

    238. 

  238. <Rule Id="224" Name="Rule96" Data="HER4(Y2~p!0),PTP(s!0)->HER4(Y2~u!0),PTP(s!0)" ForwardRate="1" />

    239. 

  239. <Rule Id="225" Name="Rule97" Data="HER4(Y3~p!0),PTP(s!0)->HER4(Y3~u!0),PTP(s!0)" ForwardRate="1" />

    240. 

  240. <Rule Id="226" Name="deg_EGFR" Data="EGFR(CR,L~int)->" ForwardRate="1" />

    241. 

  241. <Rule Id="227" Name="EGFR_RasGAP" Data="EGFR(Y1016~p),RasGAP(SH2~u)=>EGFR(Y1016~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />

    242. 

  242. <Rule Id="228" Name="EGFR_RasGAP_op" Data="EGFR(Y1016~p!0),RasGAP(SH2~rec!0)=>EGFR(Y1016~p),RasGAP(SH2~u)" ForwardRate="1" />

    243. 

  243. <Rule Id="229" Name="EGFR_Grb2" Data="EGFR(Y1092~p),Grb2(SH2~u)=>EGFR(Y1092~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />

    244. 

  244. <Rule Id="230" Name="EGFR_Grb2_op" Data="EGFR(Y1092~p!0),Grb2(SH2~rec!0)=>EGFR(Y1092~p),Grb2(SH2~u)" ForwardRate="1" />

    245. 

  245. <Rule Id="231" Name="EGFR_Shc" Data="EGFR(Y1172~p),Shc(PTB~u)=>EGFR(Y1172~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    246. 

  246. <Rule Id="232" Name="EGFR_Shc_op" Data="EGFR(Y1172~p!0),Shc(PTB~rec!0)=>EGFR(Y1172~p),Shc(PTB~u)" ForwardRate="1" />

    247. 

  247. <Rule Id="233" Name="HER2_Grb2" Data="HER2(Y1139~p),Grb2(SH2~u)=>HER2(Y1139~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />

    248. 

  248. <Rule Id="234" Name="HER2_Grb2_op" Data="HER2(Y1139~p!0),Grb2(SH2~rec!0)=>HER2(Y1139~p),Grb2(SH2~u)" ForwardRate="1" />

    249. 

  249. <Rule Id="235" Name="HER2_Shc#1" Data="HER2(Y1196~p),Shc(PTB~u)=>HER2(Y1196~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    250. 

  250. <Rule Id="236" Name="HER2_Shc#1_op" Data="HER2(Y1196~p!0),Shc(PTB~rec!0)=>HER2(Y1196~p),Shc(PTB~u)" ForwardRate="1" />

    251. 

  251. <Rule Id="237" Name="HER2_RasGAP" Data="HER2(Y1221~p),RasGAP(SH2~u)=>HER2(Y1221~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />

    252. 

  252. <Rule Id="238" Name="HER2_RasGAP_op" Data="HER2(Y1221~p!0),RasGAP(SH2~rec!0)=>HER2(Y1221~p),RasGAP(SH2~u)" ForwardRate="1" />

    253. 

  253. <Rule Id="239" Name="HER2_Shc#2" Data="HER2(Y1221~p),Shc(PTB~u)=>HER2(Y1221~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    254. 

  254. <Rule Id="240" Name="HER2_Shc#2_op" Data="HER2(Y1221~p!0),Shc(PTB~rec!0)=>HER2(Y1221~p),Shc(PTB~u)" ForwardRate="1" />

    255. 

  255. <Rule Id="241" Name="HER4_RasGAP" Data="HER4(Y1~p),RasGAP(SH2~u)=>HER4(Y1~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />

    256. 

  256. <Rule Id="242" Name="HER4_RasGAP_op" Data="HER4(Y1~p!0),RasGAP(SH2~rec!0)=>HER4(Y1~p),RasGAP(SH2~u)" ForwardRate="1" />

    257. 

  257. <Rule Id="243" Name="HER4_Grb2" Data="HER4(Y2~p),Grb2(SH2~u)=>HER4(Y2~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />

    258. 

  258. <Rule Id="244" Name="HER4_Grb2_op" Data="HER4(Y2~p!0),Grb2(SH2~rec!0)=>HER4(Y2~p),Grb2(SH2~u)" ForwardRate="1" />

    259. 

  259. <Rule Id="245" Name="HER4_Shc" Data="HER4(Y3~p),Shc(PTB~u)=>HER4(Y3~p!0),Shc(PTB~rec!0)" ForwardRate="1" />

    260. 

  260. <Rule Id="246" Name="HER4_Shc_op" Data="HER4(Y3~p!0),Shc(PTB~rec!0)=>HER4(Y3~p),Shc(PTB~u)" ForwardRate="1" />

    261. 

  261. <Rule Id="247" Name="Shc@Y" Data="Shc(PTB~rec!_,Y~u)->Shc(PTB~rec!_,Y~p)" ForwardRate="1" />

    262. 

  262. <Rule Id="248" Name="Gab1_PI3K@447_op" Data="Gab1(Y447!0),PI3K(SH2!0)->Gab1(Y447),PI3K(SH2)" ForwardRate="1" />

    263. 

  263. <Rule Id="249" Name="Gab1_PI3K@472_op" Data="Gab1(Y472!0),PI3K(SH2!0)->Gab1(Y472),PI3K(SH2)" ForwardRate="1" />

    264. 

  264. <Rule Id="250" Name="Gab1_PI3K@619_op" Data="Gab1(Y619!0),PI3K(SH2!0)->Gab1(Y619),PI3K(SH2)" ForwardRate="1" />

    265. 

  265. <Rule Id="251" Name="PI3K@s Rec" Data="PI3K(SH2~rec!_,s~u)->PI3K(SH2~rec!_,s~p)" ForwardRate="1" />

    266. 

  266. <Rule Id="252" Name="PI3K@s Gab#1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p)" ForwardRate="1" />

    267. 

  267. <Rule Id="253" Name="PI3K@s Gab#2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p)" ForwardRate="1" />

    268. 

  268. <Rule Id="254" Name="PI3K@s Gab#3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p)" ForwardRate="1" />

    269. 

  269. <Rule Id="255" Name="PI3K@s_op" Data="PI3K(s~p)->PI3K(s~u)" ForwardRate="1" />

    270. 

  270. <Rule Id="256" Name="SoS long arm" Data="Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />

    271. 

  271. <Rule Id="257" Name="PI3K no arm" Data="PI3K(SH2~rec!_,s~p),PI(three~u)->PI3K(SH2~rec!_,s~p!0),PI(three~u!0)" ForwardRate="1" />

    272. 

  272. <Rule Id="258" Name="PI3K long arm #1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />

    273. 

  273. <Rule Id="259" Name="PI3K long arm #2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />

    274. 

  274. <Rule Id="260" Name="PI3K long arm #3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />

    275. 

  275. <Rule Id="261" Name="Ras_PI3K no arm" Data="Ras(s~gtp),PI3K(RBD,SH2~rec!_,s~u)->Ras(s~gtp!0),PI3K(RBD!0,SH2~rec!_,s~u)" ForwardRate="1" />

    276. 

  276. <Rule Id="262" Name="Ras_PI3K long arm #1" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />

    277. 

  277. <Rule Id="263" Name="Ras_PI3K long arm #2" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />

    278. 

  278. <Rule Id="264" Name="Ras_PI3K long arm #3" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />

    279. 

  279. <Rule Id="265" Name="Ras_PI3K_op" Data="Ras(s!0),PI3K(RBD!0)->Ras(s),PI3K(RBD)" ForwardRate="1" />

    280. 

  280. <Rule Id="266" Name="PI3K@s Ras" Data="PI3K(RBD!_,s~u)->PI3K(RBD!_,s~p)" ForwardRate="1" />

    281. 

  281. <Rule Id="267" Name="PI3K Ras arm" Data="PI3K(RBD!_,s~p),PI(three~u)->PI3K(RBD!_,s~p!0),PI(three~u!0)" ForwardRate="1" />

    282. 

  282. <Rule Id="268" Name="PI3K Gab arm #1" Data="Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />

    283. 

  283. <Rule Id="269" Name="PI3K Gab arm #2" Data="Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />

    284. 

  284. <Rule Id="270" Name="PI3K Gab arm #3" Data="Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />

    285. 

  285. <Rule Id="271" Name="EGFR_Grb2@Y1086_SH2" Data="EGFR(Y1086~p),Grb2(SH2)->EGFR(Y1086~p!0),Grb2(SH2!0)" ForwardRate="1" />

    286. 

  286. <Rule Id="272" Name="Shc_Src@SH2_S1" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2),Src(S1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2!1),Src(S1!1)" ForwardRate="1" />

    287. 

  287. <Rule Id="273" Name="Shc_p@Y239" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)" ForwardRate="1" />

    288. 

  288. <Rule Id="274" Name="Shc_Src_op" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~p),Src(S1)" ForwardRate="1" />

    289. 

  289. <Rule Id="275" Name="Shc_p@Y240" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y240~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y240~p),Src(S1!1)" ForwardRate="1" />

    290. 

  290. <Rule Id="276" Name="SHP1_EGFR@SH2n_Y1173" Data="Shp1(SH2n),EGFR(Y1173~p)->Shp1(SH2n!0),EGFR(Y1173~p!0)" ForwardRate="1" />

    291. 

  291. <Rule Id="277" Name="EGFR_u@Y1173" Data="Shp1(SH2n!0),EGFR(Y1173~p!0)->Shp1(SH2n!0),EGFR(Y1173~u!0)" ForwardRate="1" />

    292. 

  292. <Rule Id="278" Name="EGFR_SHP1_op" Data="Shp1(SH2n!0),EGFR(Y1173~u!0)->Shp1(SH2n),EGFR(Y1173~u)" ForwardRate="1" />

    293. 

  293. <Rule Id="279" Name="EGFR_Shc@Y1173_PTB" Data="Shc(PTB),EGFR(Y1173~p)->Shc(PTB!0),EGFR(Y1173~p!0)" ForwardRate="1" />

    294. 

  294. <Rule Id="280" Name="EGFR_Shc@Y1173_SH2" Data="Shc(SH2),EGFR(Y1173~p)->Shc(SH2!0),EGFR(Y1173~p!0)" ForwardRate="1" />

    295. 

  295. <Rule Id="281" Name="EGFR_Shc@Y992_PTB" Data="Shc(PTB),EGFR(Y992~p)->Shc(PTB!0),EGFR(Y992~p!0)" ForwardRate="1" />

    296. 

  296. <Rule Id="282" Name="EGFR_Shc@Y992_SH2" Data="Shc(SH2),EGFR(Y992~p)->Shc(SH2!0),EGFR(Y992~p!0)" ForwardRate="1" />

    297. 

  297. <Rule Id="283" Name="Shc_EGFR@PTB_Y1148" Data="EGFR(Y1148~p),Shc(PTB)->EGFR(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />

    298. 

  298. <Rule Id="284" Name="Shc_EGFR@PTB_Y1148_op" Data="EGFR(Y1148~p!0),Shc(PTB!0)->EGFR(Y1148~p),Shc(PTB)" ForwardRate="1" />

    299. 

  299. <Rule Id="285" Name="Shc_EGFR@SH2_Y1148" Data="EGFR(Y1148~p),Shc(SH2)->EGFR(Y1148~p!0),Shc(SH2!0)" ForwardRate="1" />

    300. 

  300. <Rule Id="286" Name="Shc_EGFR@SH2_Y1148_op" Data="EGFR(Y1148~p!0),Shc(SH2!0)->EGFR(Y1148~p),Shc(SH2)" ForwardRate="1" />

    301. 

  301. <Rule Id="287" Name="Shc_EGFR@PTB_Y1173" Data="EGFR(Y1173~p),Shc(PTB)->EGFR(Y1173~p!0),Shc(PTB!0)" ForwardRate="1" />

    302. 

  302. <Rule Id="288" Name="Shc_EGFR@PTB_Y1173_op" Data="EGFR(Y1173~p!0),Shc(PTB!0)->EGFR(Y1173~p),Shc(PTB)" ForwardRate="1" />

    303. 

  303. <Rule Id="289" Name="Shc_EGFR@SH2_Y1173" Data="EGFR(Y1173~p),Shc(SH2)->EGFR(Y1173~p!0),Shc(SH2!0)" ForwardRate="1" />

    304. 

  304. <Rule Id="290" Name="Shc_EGFR@SH2_Y1173_op" Data="EGFR(Y1173~p!0),Shc(SH2!0)->EGFR(Y1173~p),Shc(SH2)" ForwardRate="1" />

    305. 

  305. <Rule Id="291" Name="Shc_p@Y317" Data="EGFR(Y1148~p!0),Shc(PTB!0,Y317~u)->EGFR(Y1148~p!0),Shc(PTB!0,Y317~p)" ForwardRate="1" />

    306. 

  306. <Rule Id="292" Name="EGFR_Stat3@Y1068_SH2" Data="Stat3(SH2),EGFR(Y1068~p)->Stat3(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />

    307. 

  307. <Rule Id="293" Name="EGFR_Stat3@Y1068_SH2_op" Data="Stat3(SH2!0),EGFR(Y1068~p!0)->Stat3(SH2),EGFR(Y1068~p)" ForwardRate="1" />

    308. 

  308. <Rule Id="294" Name="EGFR_Stat3@Y1086_SH2" Data="Stat3(SH2),EGFR(Y1086~p)->Stat3(SH2!0),EGFR(Y1086~p!0)" ForwardRate="1" />

    309. 

  309. <Rule Id="295" Name="EGFR_Stat3@Y1086_SH2_op" Data="Stat3(SH2!0),EGFR(Y1086~p!0)->Stat3(SH2),EGFR(Y1086~p)" ForwardRate="1" />

    310. 

  310. <Rule Id="296" Name="Stat3_p@Y705" Data="Stat3(SH2!0,Y705~u),EGFR(Y1068!0)->Stat3(SH2!0,Y705~p),EGFR(Y1068!0)" ForwardRate="1" />

    311. 

  311. <Rule Id="297" Name="EGFR_p@Y1086" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1086~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1086~p),A(s~pp!0)" ForwardRate="1" />

    312. 

  312. <Rule Id="298" Name="EGFR_p@Y1173" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1173~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1173~p),A(s~pp!0)" ForwardRate="1" />

    313. 

  313. <Rule Id="299" Name="EGFR_Shc@Y1068_SH2" Data="EGFR(Y1068~p),Shc(SH2)->EGFR(Y1068~p!0),Shc(SH2!0)" ForwardRate="1" />

    314. 

  314. <Rule Id="300" Name="EGFR_Shc@Y1068_SH2_op" Data="EGFR(Y1068~p!0),Shc(SH2!0)->EGFR(Y1068~p),Shc(SH2)" ForwardRate="1" />

    315. 

  315. <Rule Id="301" Name="EGFR_Shc@Y1086_SH2" Data="EGFR(Y1086~p),Shc(SH2)->EGFR(Y1086~p!0),Shc(SH2!0)" ForwardRate="1" />

    316. 

  316. <Rule Id="302" Name="EGFR_Shc@Y1086_SH2_op" Data="EGFR(Y1086~p!0),Shc(SH2!0)->EGFR(Y1086~p),Shc(SH2)" ForwardRate="1" />

    317. 

  317. <Rule Id="303" Name="EGFR_PLCG1@Y992_SH2" Data="EGFR(Y992~p),PLCG1(SH2)->EGFR(Y992~p!0),PLCG1(SH2!0)" ForwardRate="1" />

    318. 

  318. <Rule Id="304" Name="EGFR_PLCG1@Y992_SH2_op" Data="EGFR(Y992~p!0),PLCG1(SH2!0)->EGFR(Y992~p),PLCG1(SH2)" ForwardRate="1" />

    319. 

  319. <Rule Id="305" Name="EGFR_PLCG1@Y1068_SH2" Data="EGFR(Y1068~p),PLCG1(SH2)->EGFR(Y1068~p!0),PLCG1(SH2!0)" ForwardRate="1" />

    320. 

  320. <Rule Id="306" Name="EGFR_PLCG1@Y1068_SH2_op" Data="EGFR(Y1068~p!0),PLCG1(SH2!0)->EGFR(Y1068~p),PLCG1(SH2)" ForwardRate="1" />

    321. 

  321. <Rule Id="307" Name="EGFR_PLCG1@Y1086_SH2" Data="EGFR(Y1086~p),PLCG1(SH2)->EGFR(Y1086~p!0),PLCG1(SH2!0)" ForwardRate="1" />

    322. 

  322. <Rule Id="308" Name="EGFR_PLCG1@Y1086_SH2_op" Data="EGFR(Y1086~p!0),PLCG1(SH2!0)->EGFR(Y1086~p),PLCG1(SH2)" ForwardRate="1" />

    323. 

  323. <Rule Id="309" Name="EGFR_PLCG1@Y1148_SH2" Data="EGFR(Y1148~p),PLCG1(SH2)->EGFR(Y1148~p!0),PLCG1(SH2!0)" ForwardRate="1" />

    324. 

  324. <Rule Id="310" Name="EGFR_PLCG1@Y1148_SH2_op" Data="EGFR(Y1148~p!0),PLCG1(SH2!0)->EGFR(Y1148~p),PLCG1(SH2)" ForwardRate="1" />

    325. 

  325. <Rule Id="311" Name="EGFR_PLCG1@Y1173_SH2" Data="EGFR(Y1173~p),PLCG1(SH2)->EGFR(Y1173~p!0),PLCG1(SH2!0)" ForwardRate="1" />

    326. 

  326. <Rule Id="312" Name="EGFR_PLCG1@Y1173_SH2_op" Data="EGFR(Y1173~p!0),PLCG1(SH2!0)->EGFR(Y1173~p),PLCG1(SH2)" ForwardRate="1" />

    327. 

  327. <Rule Id="313" Name="EGFR_Src@Y845_SH2" Data="Src(SH2),EGFR(Y845)->Src(SH2!0),EGFR(Y845!0)" ForwardRate="1" />

    328. 

  328. <Rule Id="314" Name="EGFR_Src@Y845_SH2_op" Data="Src(SH2!0),EGFR(Y845!0)->Src(SH2),EGFR(Y845)" ForwardRate="1" />

    329. 

  329. <Rule Id="315" Name="EGFR_p@Y845" Data="Src(SH2!0),EGFR(Y845~u!0)->Src(SH2!0),EGFR(Y845~p!0)" ForwardRate="1" />

    330. 

  330. <Rule Id="316" Name="EGFR_Eps8@S1_S1" Data="EGFR(S1),Eps8(S1)->EGFR(S1!0),Eps8(S1!0)" ForwardRate="1" />

    331. 

  331. <Rule Id="317" Name="EGFR_Eps8@S1_S1_op" Data="EGFR(S1!0),Eps8(S1!0)->EGFR(S1),Eps8(S1)" ForwardRate="1" />

    332. 

  332. <Rule Id="318" Name="Eps8_p@X" Data="EGFR(S1!0),Eps8(S1!0,X~u)->EGFR(S1!0),Eps8(S1!0,X~p)" ForwardRate="1" />

    333. 

  333. <Rule Id="319" Name="EGFR_PLCG1@Y1173_SH2n" Data="EGFR(Y1173~p),PLCG1(SH2n)->EGFR(Y1173~p!0),PLCG1(SH2n!0)" ForwardRate="1" />

    334. 

  334. <Rule Id="320" Name="EGFR_PLCG1@Y992_SH2c" Data="EGFR(Y992~p),PLCG1(SH2c)->EGFR(Y992~p!0),PLCG1(SH2c!0)" ForwardRate="1" />

    335. 

  335. <Rule Id="321" Name="PLCG1_p@Y472" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y472~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y472~p)" ForwardRate="1" />

    336. 

  336. <Rule Id="322" Name="PLCG1_p@Y771" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y771~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y771~p)" ForwardRate="1" />

    337. 

  337. <Rule Id="323" Name="PLCG1_p@Y783" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y783~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y783~p)" ForwardRate="1" />

    338. 

  338. <Rule Id="324" Name="PLCG1_p@Y1254" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y1254~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y1254~p)" ForwardRate="1" />

    339. 

  339. <Rule Id="325" Name="EGFR_Gab1@S1_S1" Data="Gab1(X~u),EGFR(S1)->Gab1(X~u!0),EGFR(S1!0)" ForwardRate="1" />

    340. 

  340. <Rule Id="326" Name="Gab1_p@Y627" Data="Gab1(Y627~u!0),EGFR(S1!0)->Gab1(Y627~p!0),EGFR(S1!0)" ForwardRate="1" />

    341. 

  341. <Rule Id="327" Name="Gab1_EGFR_op" Data="Gab1(Y627~p!0),EGFR(S1!0)->Gab1(Y627~p),EGFR(S1)" ForwardRate="1" />

    342. 

  342. <Rule Id="328" Name="Gab1_p@Y659" Data="Gab1(Y659~u!0),EGFR(S1!0)->Gab1(Y659~p!0),EGFR(S1!0)" ForwardRate="1" />

    343. 

  343. <Rule Id="329" Name="p85_EGFR@SH2_Y920" Data="p85(SH2),EGFR(Y920~p)->p85(SH2!0),EGFR(Y920~p!0)" ForwardRate="1" />

    344. 

  344. <Rule Id="330" Name="Rom2_PI3K@PH_S1" Data="Rom2(PH),PI3K(S1)->Rom2(PH!0),PI3K(S1!0)" ForwardRate="1" />

    345. 

  345. <Rule Id="331" Name="Rom2_PI3K@PH_S1_op" Data="Rom2(PH!0),PI3K(S1!0)->Rom2(PH),PI3K(S1)" ForwardRate="1" />

    346. 

  346. <Rule Id="332" Name="EGFR_Vav2@Y992_SH2" Data="EGFR(Y992~p),Vav2(SH2)->EGFR(Y992~p!0),Vav2(SH2!0)" ForwardRate="1" />

    347. 

  347. <Rule Id="333" Name="EGFR_Vav2@Y992_SH2_op" Data="EGFR(Y992~p!0),Vav2(SH2!0)->EGFR(Y992~p),Vav2(SH2)" ForwardRate="1" />

    348. 

  348. <Rule Id="334" Name="EGFR_Vav@Y1148_SH2" Data="EGFR(Y1148~p),Vav2(SH2)->EGFR(Y1148~p!0),Vav2(SH2!0)" ForwardRate="1" />

    349. 

  349. <Rule Id="335" Name="EGFR_Vav@Y1148_SH2_op" Data="EGFR(Y1148~p!0),Vav2(SH2!0)->EGFR(Y1148~p),Vav2(SH2)" ForwardRate="1" />

    350. 

  350. <Rule Id="336" Name="Vav2_p@Y142" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y142~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y142~p)" ForwardRate="1" />

    351. 

  351. <Rule Id="337" Name="Vav2_p@Y172" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y172~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y172~p)" ForwardRate="1" />

    352. 

  352. <Rule Id="338" Name="Vav2_p@Y159" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y159~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y159~p)" ForwardRate="1" />

    353. 

  353. <Rule Id="339" Name="Grb2_EGFR@SH2_Y1068" Data="Grb2(SH2),EGFR(Y1068~p)->Grb2(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />

    354. 

  354. <Rule Id="340" Name="Pak1_Grb2@SH3_SBM" Data="Grb2(SH2!0,SH3),EGFR(Y1068~p!0),Pak1(SBM)->Grb2(SH2!1,SH3!0),EGFR(Y1068~p!1),Pak1(SBM!0)" ForwardRate="1" />

    355. 

  355. <Rule Id="341" Name="Ang2_EGFR@r_l" Data="Ang2(r~ext),EGFR(CR,L~ext)=>Ang(r~ext!0),GFR(CR,L~ext!0)" ForwardRate="1" />

    356. 

  356. <Rule Id="342" Name="Ang2_EGFR@r_l_op" Data="Ang(r~ext!0),GFR(CR,L~ext!0)=>Ang2(r~ext),EGFR(CR,L~ext)" ForwardRate="1" />

    357. 

  357. <Rule Id="343" Name="EGFR_Clta(int)" Data="EGFR(C,N~ext!0),CLTA(S1!0)->EGFR(C,N~int!0),CLTA(S1!0)" ForwardRate="1" />

    358. 

  358. </RuleSet>

    359. 

  359. <ContactMap Name="Low resolution">

    360. 

  360. <Agent Name="Shc">

    361. 

  361. <Site Name="PTB" CanChangeState="true" CanBeBound="true">

    362. 

  362. <Rule Id="71"/>

    363. 

  363. <Rule Id="72"/>

    364. 

  364. <Rule Id="231"/>

    365. 

  365. <Rule Id="232"/>

    366. 

  366. <Rule Id="235"/>

    367. 

  367. <Rule Id="236"/>

    368. 

  368. <Rule Id="239"/>

    369. 

  369. <Rule Id="240"/>

    370. 

  370. <Rule Id="245"/>

    371. 

  371. <Rule Id="246"/>

    372. 

  372. </Site>

    373. 

  373. <Site Name="SH2" CanChangeState="false" CanBeBound="true">

    374. 

  374. </Site>

    375. 

  375. <Site Name="Y" CanChangeState="true" CanBeBound="true">

    376. 

  376. <Rule Id="247"/>

    377. 

  377. </Site>

    378. 

  378. <Site Name="Y239" CanChangeState="true" CanBeBound="true">

    379. 

  379. <Rule Id="273"/>

    380. 

  380. </Site>

    381. 

  381. <Site Name="Y240" CanChangeState="true" CanBeBound="true">

    382. 

  382. <Rule Id="275"/>

    383. 

  383. </Site>

    384. 

  384. <Site Name="Y317" CanChangeState="true" CanBeBound="true">

    385. 

  385. <Rule Id="291"/>

    386. 

  386. </Site>

    387. 

  387. <Site Name="Y318" CanChangeState="true" CanBeBound="true">

    388. 

  388. <Rule Id="85"/>

    389. 

  389. <Rule Id="86"/>

    390. 

  390. <Rule Id="87"/>

    391. 

  391. <Rule Id="88"/>

    392. 

  392. <Rule Id="89"/>

    393. 

  393. </Site>

    394. 

  394. </Agent>

    395. 

  395. <Agent Name="PTP">

    396. 

  396. <Site Name="s" CanChangeState="false" CanBeBound="true">

    397. 

  397. </Site>

    398. 

  398. </Agent>

    399. 

  399. <Agent Name="PI3K">

    400. 

  400. <Site Name="RBD" CanChangeState="false" CanBeBound="true">

    401. 

  401. </Site>

    402. 

  402. <Site Name="S1" CanChangeState="false" CanBeBound="true">

    403. 

  403. </Site>

    404. 

  404. <Site Name="SH2" CanChangeState="true" CanBeBound="true">

    405. 

  405. <Rule Id="59"/>

    406. 

  406. <Rule Id="60"/>

    407. 

  407. <Rule Id="61"/>

    408. 

  408. <Rule Id="62"/>

    409. 

  409. <Rule Id="63"/>

    410. 

  410. <Rule Id="64"/>

    411. 

  411. <Rule Id="65"/>

    412. 

  412. <Rule Id="66"/>

    413. 

  413. <Rule Id="67"/>

    414. 

  414. <Rule Id="68"/>

    415. 

  415. <Rule Id="69"/>

    416. 

  416. <Rule Id="70"/>

    417. 

  417. </Site>

    418. 

  418. <Site Name="s" CanChangeState="true" CanBeBound="true">

    419. 

  419. <Rule Id="251"/>

    420. 

  420. <Rule Id="252"/>

    421. 

  421. <Rule Id="253"/>

    422. 

  422. <Rule Id="254"/>

    423. 

  423. <Rule Id="255"/>

    424. 

  424. <Rule Id="266"/>

    425. 

  425. </Site>

    426. 

  426. </Agent>

    427. 

  427. <Agent Name="HRG">

    428. 

  428. <Rule Id="128"/>

    429. 

  429. <Site Name="r" CanChangeState="true" CanBeBound="true">

    430. 

  430. </Site>

    431. 

  431. </Agent>

    432. 

  432. <Agent Name="HER4">

    433. 

  433. <Site Name="C" CanChangeState="false" CanBeBound="true">

    434. 

  434. </Site>

    435. 

  435. <Site Name="CR" CanChangeState="false" CanBeBound="true">

    436. 

  436. </Site>

    437. 

  437. <Site Name="L" CanChangeState="true" CanBeBound="true">

    438. 

  438. </Site>

    439. 

  439. <Site Name="N" CanChangeState="false" CanBeBound="true">

    440. 

  440. </Site>

    441. 

  441. <Site Name="Y1" CanChangeState="true" CanBeBound="true">

    442. 

  442. <Rule Id="190"/>

    443. 

  443. <Rule Id="191"/>

    444. 

  444. <Rule Id="192"/>

    445. 

  445. <Rule Id="223"/>

    446. 

  446. </Site>

    447. 

  447. <Site Name="Y2" CanChangeState="true" CanBeBound="true">

    448. 

  448. <Rule Id="193"/>

    449. 

  449. <Rule Id="194"/>

    450. 

  450. <Rule Id="195"/>

    451. 

  451. <Rule Id="224"/>

    452. 

  452. </Site>

    453. 

  453. <Site Name="Y3" CanChangeState="true" CanBeBound="true">

    454. 

  454. <Rule Id="196"/>

    455. 

  455. <Rule Id="197"/>

    456. 

  456. <Rule Id="198"/>

    457. 

  457. <Rule Id="225"/>

    458. 

  458. </Site>

    459. 

  459. <Site Name="bp" CanChangeState="false" CanBeBound="true">

    460. 

  460. </Site>

    461. 

  461. </Agent>

    462. 

  462. <Agent Name="HER3">

    463. 

  463. <Site Name="C" CanChangeState="false" CanBeBound="true">

    464. 

  464. </Site>

    465. 

  465. <Site Name="CR" CanChangeState="false" CanBeBound="true">

    466. 

  466. </Site>

    467. 

  467. <Site Name="L" CanChangeState="true" CanBeBound="true">

    468. 

  468. </Site>

    469. 

  469. <Site Name="Y1035" CanChangeState="true" CanBeBound="true">

    470. 

  470. <Rule Id="17"/>

    471. 

  471. <Rule Id="18"/>

    472. 

  472. <Rule Id="19"/>

    473. 

  473. <Rule Id="52"/>

    474. 

  474. </Site>

    475. 

  475. <Site Name="Y1178" CanChangeState="true" CanBeBound="true">

    476. 

  476. <Rule Id="20"/>

    477. 

  477. <Rule Id="21"/>

    478. 

  478. <Rule Id="22"/>

    479. 

  479. <Rule Id="53"/>

    480. 

  480. </Site>

    481. 

  481. <Site Name="Y1203" CanChangeState="true" CanBeBound="true">

    482. 

  482. <Rule Id="23"/>

    483. 

  483. <Rule Id="24"/>

    484. 

  484. <Rule Id="25"/>

    485. 

  485. <Rule Id="54"/>

    486. 

  486. </Site>

    487. 

  487. <Site Name="Y1241" CanChangeState="true" CanBeBound="true">

    488. 

  488. <Rule Id="26"/>

    489. 

  489. <Rule Id="27"/>

    490. 

  490. <Rule Id="28"/>

    491. 

  491. <Rule Id="55"/>

    492. 

  492. </Site>

    493. 

  493. <Site Name="Y1257" CanChangeState="true" CanBeBound="true">

    494. 

  494. <Rule Id="29"/>

    495. 

  495. <Rule Id="30"/>

    496. 

  496. <Rule Id="31"/>

    497. 

  497. <Rule Id="56"/>

    498. 

  498. </Site>

    499. 

  499. <Site Name="Y1270" CanChangeState="true" CanBeBound="true">

    500. 

  500. <Rule Id="32"/>

    501. 

  501. <Rule Id="33"/>

    502. 

  502. <Rule Id="34"/>

    503. 

  503. <Rule Id="57"/>

    504. 

  504. </Site>

    505. 

  505. <Site Name="Y1309" CanChangeState="true" CanBeBound="true">

    506. 

  506. <Rule Id="35"/>

    507. 

  507. <Rule Id="36"/>

    508. 

  508. <Rule Id="37"/>

    509. 

  509. <Rule Id="58"/>

    510. 

  510. </Site>

    511. 

  511. </Agent>

    512. 

  512. <Agent Name="HER2">

    513. 

  513. <Site Name="C" CanChangeState="false" CanBeBound="true">

    514. 

  514. </Site>

    515. 

  515. <Site Name="CR" CanChangeState="false" CanBeBound="true">

    516. 

  516. </Site>

    517. 

  517. <Site Name="N" CanChangeState="false" CanBeBound="true">

    518. 

  518. </Site>

    519. 

  519. <Site Name="Y1139" CanChangeState="true" CanBeBound="true">

    520. 

  520. <Rule Id="181"/>

    521. 

  521. <Rule Id="182"/>

    522. 

  522. <Rule Id="183"/>

    523. 

  523. <Rule Id="220"/>

    524. 

  524. </Site>

    525. 

  525. <Site Name="Y1196" CanChangeState="true" CanBeBound="true">

    526. 

  526. <Rule Id="184"/>

    527. 

  527. <Rule Id="185"/>

    528. 

  528. <Rule Id="186"/>

    529. 

  529. <Rule Id="221"/>

    530. 

  530. </Site>

    531. 

  531. <Site Name="Y1221" CanChangeState="true" CanBeBound="true">

    532. 

  532. <Rule Id="187"/>

    533. 

  533. <Rule Id="188"/>

    534. 

  534. <Rule Id="189"/>

    535. 

  535. <Rule Id="222"/>

    536. 

  536. </Site>

    537. 

  537. <Site Name="bp" CanChangeState="false" CanBeBound="true">

    538. 

  538. </Site>

    539. 

  539. </Agent>

    540. 

  540. <Agent Name="EGFR">

    541. 

  541. <Rule Id="226"/>

    542. 

  542. <Rule Id="341"/>

    543. 

  543. <Rule Id="342"/>

    544. 

  544. <Site Name="C" CanChangeState="false" CanBeBound="true">

    545. 

  545. </Site>

    546. 

  546. <Site Name="CR" CanChangeState="false" CanBeBound="true">

    547. 

  547. </Site>

    548. 

  548. <Site Name="L" CanChangeState="true" CanBeBound="true">

    549. 

  549. <Rule Id="170"/>

    550. 

  550. <Rule Id="171"/>

    551. 

  551. <Rule Id="342"/>

    552. 

  552. </Site>

    553. 

  553. <Site Name="N" CanChangeState="true" CanBeBound="true">

    554. 

  554. <Rule Id="343"/>

    555. 

  555. </Site>

    556. 

  556. <Site Name="S1" CanChangeState="false" CanBeBound="true">

    557. 

  557. </Site>

    558. 

  558. <Site Name="Y1016" CanChangeState="true" CanBeBound="true">

    559. 

  559. <Rule Id="172"/>

    560. 

  560. <Rule Id="173"/>

    561. 

  561. <Rule Id="174"/>

    562. 

  562. <Rule Id="217"/>

    563. 

  563. </Site>

    564. 

  564. <Site Name="Y1068" CanChangeState="true" CanBeBound="true">

    565. 

  565. </Site>

    566. 

  566. <Site Name="Y1086" CanChangeState="true" CanBeBound="true">

    567. 

  567. <Rule Id="297"/>

    568. 

  568. </Site>

    569. 

  569. <Site Name="Y1092" CanChangeState="true" CanBeBound="true">

    570. 

  570. <Rule Id="175"/>

    571. 

  571. <Rule Id="176"/>

    572. 

  572. <Rule Id="177"/>

    573. 

  573. <Rule Id="218"/>

    574. 

  574. </Site>

    575. 

  575. <Site Name="Y1148" CanChangeState="true" CanBeBound="true">

    576. 

  576. </Site>

    577. 

  577. <Site Name="Y1172" CanChangeState="true" CanBeBound="true">

    578. 

  578. <Rule Id="178"/>

    579. 

  579. <Rule Id="179"/>

    580. 

  580. <Rule Id="180"/>

    581. 

  581. <Rule Id="219"/>

    582. 

  582. </Site>

    583. 

  583. <Site Name="Y1173" CanChangeState="true" CanBeBound="true">

    584. 

  584. <Rule Id="277"/>

    585. 

  585. <Rule Id="298"/>

    586. 

  586. </Site>

    587. 

  587. <Site Name="Y845" CanChangeState="true" CanBeBound="true">

    588. 

  588. <Rule Id="315"/>

    589. 

  589. </Site>

    590. 

  590. <Site Name="Y920" CanChangeState="true" CanBeBound="true">

    591. 

  591. </Site>

    592. 

  592. <Site Name="Y992" CanChangeState="true" CanBeBound="true">

    593. 

  593. </Site>

    594. 

  594. <Site Name="bp" CanChangeState="false" CanBeBound="true">

    595. 

  595. </Site>

    596. 

  596. </Agent>

    597. 

  597. <Bond FromAgent="EGFR" FromSite="CR" ToAgent="EGFR" ToSite="CR">

    598. 

  598. <Rule Id="134"/>

    599. 

  599. <Rule Id="135"/>

    600. 

  600. <Rule Id="140"/>

    601. 

  601. </Bond><Bond FromAgent="EGFR" FromSite="N" ToAgent="EGFR" ToSite="C">

    602. 

  602. <Rule Id="146"/>

    603. 

  603. <Rule Id="147"/>

    604. 

  604. </Bond><Bond FromAgent="HER2" FromSite="C" ToAgent="EGFR" ToSite="N">

    605. 

  605. <Rule Id="152"/>

    606. 

  606. <Rule Id="153"/>

    607. 

  607. </Bond><Bond FromAgent="HER2" FromSite="CR" ToAgent="EGFR" ToSite="CR">

    608. 

  608. <Rule Id="136"/>

    609. 

  609. <Rule Id="141"/>

    610. 

  610. </Bond><Bond FromAgent="HER2" FromSite="CR"…
    611.