/test.data/contact_map/model/~kappa005.test

http://github.com/kappamodeler/jkappa · Unknown · 262 lines · 258 code · 4 blank · 0 comment · 0 complexity · 58e9e6dba24f3d75fdf3e6b4a9fc543e MD5 · raw file 

    

  1. # Rules:
    2. 

  2. #######  Simulation.ka
    3. 

  3. # Chapter 'Receptors'
    4. 

  4. '001-EGFR.EGF' EGFR(ligand),EGF(hi) -> EGFR(ligand!1),EGF(hi!1) @ 0.0
    5. 

  5. '001-EGFR.EGF Ref1' EGFR(ligand),EGF(hi) -> EGFR(ligand!1),EGF(hi!1) @ 9.88e-4
    6. 

  6. '001-EGFR.EGF Ref2' EGFR(ligand,dimer!1),EGF(hi),HER3(dimer!1) -> EGFR(ligand!1,dimer!2),EGF(hi!1),HER3(dimer!2) @ 4.94e-4
    7. 

  7. '002-EGFR...EGF' EGFR(ligand!1),EGF(hi!1) -> EGFR(ligand),EGF(hi) @ 0.0
    8. 

  8. '002-EGFR...EGF Ref1' EGF(hi!1),EGFR(ligand!1,dimer) -> EGF(hi),EGFR(ligand,dimer) @ 4.0e-3
    9. 

  9. '002-EGFR...EGF Ref2' EGFR(ligand!1,dimer!2),HER3(dimer!2),EGF(hi!1) -> EGFR(ligand,dimer!1),HER3(dimer!1),EGF(hi) @ 4.0e-3
    10. 

  10. '002-EGFR...EGF Ref3' EGF(hi!1),EGFR(dimer!2),EGFR(ligand!1,dimer!2) -> EGF(hi),EGFR(dimer!1),EGFR(ligand,dimer!1) @ 4.0e-3
    11. 

  11. '002-EGFR...EGF Ref4' EGF(hi!1),HER2(dimer!2),EGFR(ligand!1,dimer!2) -> EGF(hi),HER2(dimer!1),EGFR(ligand,dimer!1) @ 4.0e-3
    12. 

  12. '002-EGFR...EGF Ref5' NRG(hi!2),EGF(hi!1),EGFR(ligand!1,dimer!3),HER3(ligand!2,dimer!3) -> NRG(hi!1),EGF(hi),EGFR(ligand,dimer!2),HER3(ligand!1,dimer!2) @ 6.0e-3
    13. 

  13. '003-HER3.NRG' HER3(ligand),NRG(hi) -> HER3(ligand!1),NRG(hi!1) @ 0.0
    14. 

  14. '003-HER3.NRG Ref1' HER3(ligand),NRG(hi) -> HER3(ligand!1),NRG(hi!1) @ 9.88e-4
    15. 

  15. '004-HER3...NRG' NRG(hi!1),HER3(ligand!1) -> NRG(hi),HER3(ligand) @ 0.0
    16. 

  16. '004-HER3...NRG Ref1' NRG(hi!1),HER3(ligand!1,dimer) -> NRG(hi),HER3(ligand,dimer) @ 4.0e-3
    17. 

  17. '004-HER3...NRG Ref2' HER3(ligand!1,dimer!2),NRG(hi!1),HER2(dimer!2) -> HER3(ligand,dimer!1),NRG(hi),HER2(dimer!1) @ 4.0e-4
    18. 

  18. '004-HER3...NRG Ref3' HER3(ligand!1,dimer!2),NRG(hi!1),EGFR(dimer!2) -> HER3(ligand,dimer!1),NRG(hi),EGFR(dimer!1) @ 4.0e-3
    19. 

  19. '004-HER3...NRG Ref4' NRG(hi!1),HER3(dimer!2),HER3(ligand!1,dimer!2) -> NRG(hi),HER3(dimer!1),HER3(ligand,dimer!1) @ 4.0e-3
    20. 

  20. '004-HER3...NRG Ref5' HER3(ligand!2,dimer!3),HER3(ligand!1,dimer!3),NRG(hi!1),NRG(hi!2) -> HER3(ligand!2,dimer!1),HER3(ligand,dimer!1),NRG(hi),NRG(hi!2) @ 1.6e-2
    21. 

  21. '005-EGFR.EGFR' EGFR(dimer),EGFR(dimer) -> EGFR(dimer!1),EGFR(dimer!1) @ 4.15e-6
    22. 

  22. '006-HER2.HER2' HER2(dimer),HER2(dimer) -> HER2(dimer!1),HER2(dimer!1) @ 4.15e-6
    23. 

  23. '007-HER3.HER3' HER3(dimer),HER3(dimer) -> HER3(dimer!1),HER3(dimer!1) @ 4.15e-6
    24. 

  24. '008-EGFR.HER2' HER2(dimer),EGFR(dimer) -> HER2(dimer!1),EGFR(dimer!1) @ 4.15e-6
    25. 

  25. '009-EGFR.HER3' EGFR(dimer),HER3(dimer) -> EGFR(dimer!1),HER3(dimer!1) @ 4.15e-6
    26. 

  26. '010-HER2.HER3' HER3(dimer),HER2(dimer) -> HER3(dimer!1),HER2(dimer!1) @ 4.15e-6
    27. 

  27. '011-EGFR...EGFR' EGFR(dimer!1),EGFR(dimer!1) -> EGFR(dimer),EGFR(dimer) @ 0.0
    28. 

  28. '011-EGFR...EGFR Ref1' EGF(hi!2),EGFR(ligand!3,dimer!1,tail~p?),EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!3) -> EGF(hi!1),EGFR(ligand!2,dimer,tail~p?),EGFR(ligand!1,dimer,tail~p?),EGF(hi!2) @ 1.0e-2
    29. 

  29. '011-EGFR...EGFR Ref2' EGF(hi!2),EGF(hi!3),EGFR(ligand!2,dimer!1,tail~p?),EGFR(ligand!3,dimer!1,tail~u?) -> EGF(hi!2),EGF(hi!1),EGFR(ligand!2,dimer,tail~p?),EGFR(ligand!1,dimer,tail~u?) @ 2.0e-2
    30. 

  30. '011-EGFR...EGFR Ref3' EGFR(ligand!3,dimer!1,tail~u?),EGF(hi!3),EGFR(ligand!2,dimer!1,tail~u?),EGF(hi!2) -> EGFR(ligand!1,dimer,tail~u?),EGF(hi!1),EGFR(ligand!2,dimer,tail~u?),EGF(hi!2) @ 4.0e-2
    31. 

  31. '011-EGFR...EGFR Ref4' EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2),EGFR(dimer!1,ligand,tail~p?) -> EGFR(ligand!1,dimer,tail~p?),EGF(hi!1),EGFR(dimer,ligand,tail~p?) @ 5.0e-2
    32. 

  32. '011-EGFR...EGFR Ref5' EGFR(ligand!1,dimer!2,tail~p?),EGF(hi!1),EGFR(dimer!2,ligand,tail~u?) -> EGFR(ligand!1,dimer,tail~p?),EGF(hi!1),EGFR(dimer,ligand,tail~u?) @ 10.0e-2
    33. 

  33. '011-EGFR...EGFR Ref6' EGFR(dimer!2,ligand,tail~u?),EGFR(ligand!1,dimer!2,tail~u?),EGF(hi!1) -> EGFR(dimer,ligand,tail~u?),EGFR(ligand!1,dimer,tail~u?),EGF(hi!1) @ 20.0e-2
    34. 

  34. '011-EGFR...EGFR Ref7' EGFR(dimer!1,ligand,tail~p?),EGFR(dimer!1,ligand,tail~p?) -> EGFR(dimer,ligand,tail~p?),EGFR(dimer,ligand,tail~p?) @ 25.0e-2
    35. 

  35. '011-EGFR...EGFR Ref8' EGFR(dimer!1,ligand,tail~p?),EGFR(dimer!1,ligand,tail~u?) -> EGFR(dimer,ligand,tail~p?),EGFR(dimer,ligand,tail~u?) @ 50.0e-2
    36. 

  36. '011-EGFR...EGFR Ref9' EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand,tail~u?) -> EGFR(dimer,ligand,tail~u?),EGFR(dimer,ligand,tail~u?) @ 100.0e-2
    37. 

  37. '011-EGFR...EGFR Ref10' EGFR(dimer!1,ligand,tail~p?),EGFR(dimer!1,ligand!_,tail~u?) -> EGFR(dimer,ligand,tail~p?),EGFR(dimer,ligand!_,tail~u?) @ 1.0e-1
    38. 

  38. '012-HER2...HER2' HER2(dimer!1),HER2(dimer!1) -> HER2(dimer),HER2(dimer) @ 0.0
    39. 

  39. '012-HER2...HER2 Ref1' HER2(ligand,dimer!1,tail~p?),HER2(dimer!1,ligand,tail~p?) -> HER2(ligand,dimer,tail~p?),HER2(dimer,ligand,tail~p?) @ 2.5e-1
    40. 

  40. '012-HER2...HER2 Ref2' HER2(dimer!1,ligand,tail~p?),HER2(dimer!1,ligand,tail~u?) -> HER2(dimer,ligand,tail~p?),HER2(dimer,ligand,tail~u?) @ 5.0e-1
    41. 

  41. '012-HER2...HER2 Ref3' HER2(dimer!1,ligand,tail~u?),HER2(dimer!1,ligand,tail~u?) -> HER2(dimer,ligand,tail~u?),HER2(dimer,ligand,tail~u?) @ 10.0e-1
    42. 

  42. '013-EGFR...HER2' HER2(dimer!1),EGFR(dimer!1) -> HER2(dimer),EGFR(dimer) @ 0.0
    43. 

  43. '013-EGFR...HER2 Ref1' EGFR(ligand!2,dimer!1,tail~p?),HER2(dimer!1,ligand,tail~p?),EGF(hi!2) -> EGFR(ligand!1,dimer,tail~p?),HER2(dimer,ligand,tail~p?),EGF(hi!1) @ 2.0e-2
    44. 

  44. '013-EGFR...HER2 Ref2' EGFR(dimer!1,ligand!2,tail~p?),HER2(dimer!1,ligand,tail~u?),EGF(hi!2) -> EGFR(dimer,ligand!1,tail~p?),HER2(dimer,ligand,tail~u?),EGF(hi!1) @ 4.0e-2
    45. 

  45. '013-EGFR...HER2 Ref3' EGF(hi!2),EGFR(dimer!1,ligand!2,tail~u?),HER2(dimer!1,ligand,tail~p?) -> EGF(hi!1),EGFR(dimer,ligand!1,tail~u?),HER2(dimer,ligand,tail~p?) @ 4.0e-2
    46. 

  46. '013-EGFR...HER2 Ref4' EGFR(dimer!1,ligand!2,tail~u?),HER2(dimer!1,ligand,tail~u?),EGF(hi!2) -> EGFR(dimer,ligand!1,tail~u?),HER2(dimer,ligand,tail~u?),EGF(hi!1) @ 8.0e-2
    47. 

  47. '013-EGFR...HER2 Ref5' EGFR(dimer!1,ligand,tail~p?),HER2(dimer!1,ligand,tail~p?) -> EGFR(dimer,ligand,tail~p?),HER2(dimer,ligand,tail~p?) @ 10.0e-2
    48. 

  48. '013-EGFR...HER2 Ref6' HER2(dimer!1,ligand,tail~p?),EGFR(dimer!1,ligand,tail~u?) -> HER2(dimer,ligand,tail~p?),EGFR(dimer,ligand,tail~u?) @ 20.0e-2
    49. 

  49. '013-EGFR...HER2 Ref7' HER2(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand,tail~p?) -> HER2(dimer,ligand,tail~u?),EGFR(dimer,ligand,tail~p?) @ 20.0e-2
    50. 

  50. '013-EGFR...HER2 Ref8' HER2(ligand,dimer!1,tail~u?),EGFR(dimer!1,ligand,tail~u?) -> HER2(ligand,dimer,tail~u?),EGFR(dimer,ligand,tail~u?) @ 40.0e-2
    51. 

  51. '014-HER3...HER3' HER3(dimer!1),HER3(dimer!1) -> HER3(dimer),HER3(dimer) @ 0.0
    52. 

  52. '014-HER3...HER3 Ref1' NRG(hi!2),HER3(dimer!1,ligand!3,tail~p?),NRG(hi!3),HER3(ligand!2,dimer!1,tail~p?) -> NRG(hi!1),HER3(dimer,ligand!2,tail~p?),NRG(hi!2),HER3(ligand!1,dimer,tail~p?) @ 1.0e-2
    53. 

  53. '014-HER3...HER3 Ref2' HER3(dimer!1,ligand!3,tail~p?),NRG(hi!2),NRG(hi!3),HER3(ligand!2,dimer!1,tail~u?) -> HER3(dimer,ligand!2,tail~p?),NRG(hi!1),NRG(hi!2),HER3(ligand!1,dimer,tail~u?) @ 2.0e-2
    54. 

  54. '014-HER3...HER3 Ref3' NRG(hi!3),HER3(dimer!1,ligand!3,tail~u?),NRG(hi!2),HER3(ligand!2,dimer!1,tail~u?) -> NRG(hi!1),HER3(dimer,ligand!1,tail~u?),NRG(hi!2),HER3(ligand!2,dimer,tail~u?) @ 4.0e-2
    55. 

  55. '014-HER3...HER3 Ref4' HER3(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand!3,tail~p?),NRG(hi!3) -> HER3(ligand,dimer,tail~p?),HER3(dimer,ligand!2,tail~p?),NRG(hi!2) @ 5.0e-2
    56. 

  56. '014-HER3...HER3 Ref5' HER3(dimer!1,ligand!3,tail~p?),NRG(hi!3),HER3(ligand,dimer!1,tail~u?) -> HER3(dimer,ligand!1,tail~p?),NRG(hi!1),HER3(ligand,dimer,tail~u?) @ 10.0e-2
    57. 

  57. '014-HER3...HER3 Ref6' HER3(dimer!1,ligand!3,tail~u?),HER3(ligand,dimer!1,tail~p?),NRG(hi!3) -> HER3(dimer,ligand!1,tail~u?),HER3(ligand,dimer,tail~p?),NRG(hi!1) @ 10.0e-2
    58. 

  58. '014-HER3...HER3 Ref7' NRG(hi!3),HER3(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand!3,tail~u?) -> NRG(hi!1),HER3(dimer,ligand,tail~u?),HER3(dimer,ligand!1,tail~u?) @ 20.0e-2
    59. 

  59. '014-HER3...HER3 Ref8' HER3(dimer!1,ligand,tail~p?),HER3(ligand,dimer!1,tail~p?) -> HER3(dimer,ligand,tail~p?),HER3(ligand,dimer,tail~p?) @ 25.0e-2
    60. 

  60. '014-HER3...HER3 Ref9' HER3(dimer!1,ligand,tail~p?),HER3(ligand,dimer!1,tail~u?) -> HER3(dimer,ligand,tail~p?),HER3(ligand,dimer,tail~u?) @ 50.0e-2
    61. 

  61. '014-HER3...HER3 Ref10' HER3(dimer!1,ligand,tail~u?),HER3(ligand,dimer!1,tail~u?) -> HER3(dimer,ligand,tail~u?),HER3(ligand,dimer,tail~u?) @ 100.0e-2
    62. 

  62. '015-HER3...HER2' HER3(dimer!1),HER2(dimer!1) -> HER3(dimer),HER2(dimer) @ 0.0
    63. 

  63. '015-HER3...HER2 Ref1' HER3(ligand!2,dimer!1,tail~p?),HER2(ligand,dimer!1,tail~p?),NRG(hi!2) -> HER3(ligand!1,dimer,tail~p?),HER2(ligand,dimer,tail~p?),NRG(hi!1) @ 2.0e-2
    64. 

  64. '015-HER3...HER2 Ref2' HER2(ligand,dimer!1,tail~u?),NRG(hi!2),HER3(ligand!2,dimer!1,tail~p?) -> HER2(ligand,dimer,tail~u?),NRG(hi!1),HER3(ligand!1,dimer,tail~p?) @ 4.0e-2
    65. 

  65. '015-HER3...HER2 Ref3' HER3(ligand!2,dimer!1,tail~u?),NRG(hi!2),HER2(ligand,dimer!1,tail~p?) -> HER3(ligand!1,dimer,tail~u?),NRG(hi!1),HER2(ligand,dimer,tail~p?) @ 4.0e-2
    66. 

  66. '015-HER3...HER2 Ref4' HER3(ligand!2,dimer!1,tail~u?),NRG(hi!2),HER2(ligand,dimer!1,tail~u?) -> HER3(ligand!1,dimer,tail~u?),NRG(hi!1),HER2(ligand,dimer,tail~u?) @ 8.0e-2
    67. 

  67. '015-HER3...HER2 Ref5' HER2(ligand,dimer!1,tail~p?),HER3(ligand,dimer!1,tail~p?) -> HER2(ligand,dimer,tail~p?),HER3(ligand,dimer,tail~p?) @ 10.0e-2
    68. 

  68. '015-HER3...HER2 Ref6' HER2(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand,tail~u?) -> HER2(ligand,dimer,tail~p?),HER3(dimer,ligand,tail~u?) @ 20.0e-2
    69. 

  69. '015-HER3...HER2 Ref7' HER2(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand,tail~p?) -> HER2(ligand,dimer,tail~u?),HER3(dimer,ligand,tail~p?) @ 20.0e-2
    70. 

  70. '015-HER3...HER2 Ref8' HER3(dimer!1,ligand,tail~u?),HER2(ligand,dimer!1,tail~u?) -> HER3(dimer,ligand,tail~u?),HER2(ligand,dimer,tail~u?) @ 40.0e-2
    71. 

  71. '016-EGFR...HER3' HER3(dimer!1),EGFR(dimer!1) -> HER3(dimer),EGFR(dimer) @ 0.0
    72. 

  72. '016-EGFR...HER3 Ref1' EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2),HER3(dimer!1,ligand!3,tail~p?),NRG(hi!3) -> EGFR(ligand!1,dimer,tail~p?),EGF(hi!1),HER3(dimer,ligand!2,tail~p?),NRG(hi!2) @ 1.0e-2
    73. 

  73. '016-EGFR...HER3 Ref2' HER3(dimer!1,ligand!3,tail~p?),EGF(hi!2),EGFR(ligand!2,dimer!1,tail~u?),NRG(hi!3) -> HER3(dimer,ligand!2,tail~p?),EGF(hi!1),EGFR(ligand!1,dimer,tail~u?),NRG(hi!2) @ 2.0e-2
    74. 

  74. '016-EGFR...HER3 Ref3' EGF(hi!2),EGFR(ligand!2,dimer!1,tail~p?),NRG(hi!3),HER3(dimer!1,ligand!3,tail~u?) -> EGF(hi!1),EGFR(ligand!1,dimer,tail~p?),NRG(hi!2),HER3(dimer,ligand!2,tail~u?) @ 2.0e-2
    75. 

  75. '016-EGFR...HER3 Ref4' HER3(dimer!1,ligand!3,tail~u?),EGF(hi!2),NRG(hi!3),EGFR(ligand!2,dimer!1,tail~u?) -> HER3(dimer,ligand!2,tail~u?),EGF(hi!1),NRG(hi!2),EGFR(ligand!1,dimer,tail~u?) @ 4.0e-2
    76. 

  76. '016-EGFR...HER3 Ref5' HER3(dimer!1,ligand!3,tail~p?),EGFR(ligand,dimer!1,tail~p?),NRG(hi!3) -> HER3(dimer,ligand!1,tail~p?),EGFR(ligand,dimer,tail~p?),NRG(hi!1) @ 5.0e-2
    77. 

  77. '016-EGFR...HER3 Ref6' NRG(hi!3),EGFR(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand!3,tail~p?) -> NRG(hi!1),EGFR(ligand,dimer,tail~u?),HER3(dimer,ligand!1,tail~p?) @ 10.0e-2
    78. 

  78. '016-EGFR...HER3 Ref7' HER3(dimer!1,ligand!3,tail~u?),NRG(hi!3),EGFR(ligand,dimer!1,tail~p?) -> HER3(dimer,ligand!1,tail~u?),NRG(hi!1),EGFR(ligand,dimer,tail~p?) @ 10.0e-2
    79. 

  79. '016-EGFR...HER3 Ref8' EGFR(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand!3,tail~u?),NRG(hi!3) -> EGFR(ligand,dimer,tail~u?),HER3(dimer,ligand!1,tail~u?),NRG(hi!1) @ 20.0e-2
    80. 

  80. '016-EGFR...HER3 Ref9' HER3(dimer!1,ligand,tail~p?),EGF(hi!2),EGFR(ligand!2,dimer!1,tail~p?) -> HER3(dimer,ligand,tail~p?),EGF(hi!1),EGFR(ligand!1,dimer,tail~p?) @ 5.0e-2
    81. 

  81. '016-EGFR...HER3 Ref10' EGF(hi!2),EGFR(ligand!2,dimer!1,tail~u?),HER3(dimer!1,ligand,tail~p?) -> EGF(hi!1),EGFR(ligand!1,dimer,tail~u?),HER3(dimer,ligand,tail~p?) @ 10.0e-2
    82. 

  82. '016-EGFR...HER3 Ref11' HER3(dimer!1,ligand,tail~u?),EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2) -> HER3(dimer,ligand,tail~u?),EGFR(ligand!1,dimer,tail~p?),EGF(hi!1) @ 10.0e-2
    83. 

  83. '016-EGFR...HER3 Ref12' HER3(dimer!1,ligand,tail~u?),EGFR(ligand!2,dimer!1,tail~u?),EGF(hi!2) -> HER3(dimer,ligand,tail~u?),EGFR(ligand!1,dimer,tail~u?),EGF(hi!1) @ 20.0e-2
    84. 

  84. '016-EGFR...HER3 Ref13' EGFR(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand,tail~p?) -> EGFR(ligand,dimer,tail~p?),HER3(dimer,ligand,tail~p?) @ 25.0e-2
    85. 

  85. '016-EGFR...HER3 Ref14' HER3(dimer!1,ligand,tail~p?),EGFR(ligand,dimer!1,tail~u?) -> HER3(dimer,ligand,tail~p?),EGFR(ligand,dimer,tail~u?) @ 50.0e-2
    86. 

  86. '016-EGFR...HER3 Ref15' HER3(dimer!1,ligand,tail~u?),EGFR(ligand,dimer!1,tail~p?) -> HER3(dimer,ligand,tail~u?),EGFR(ligand,dimer,tail~p?) @ 50.0e-2
    87. 

  87. '016-EGFR...HER3 Ref16' HER3(dimer!1,ligand,tail~u?),EGFR(ligand,dimer!1,tail~u?) -> HER3(dimer,ligand,tail~u?),EGFR(ligand,dimer,tail~u?) @ 100.0e-2
    88. 

  88. '017-EGFR@tail_p' EGFR(dimer,ligand,tail~u?) -> EGFR(dimer,ligand,tail~p?) @ 1.0e-3
    89. 

  89. '017-EGFR@tail_p Ref1' EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand,tail~u?) -> EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand,tail~p?) @ 1.0e-2
    90. 

  90. '017-EGFR@tail_p Ref2' EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand!2,tail~u?),EGF(hi!2) -> EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand!2,tail~p?),EGF(hi!2) @ 2.0e-2
    91. 

  91. '017-EGFR@tail_p Ref3' EGFR(dimer!1,ligand!2,tail~u?),EGFR(ligand!3,dimer!1,tail~u?),EGF(hi!2),EGF(hi!3) -> EGFR(dimer!2,ligand!1,tail~p?),EGFR(ligand!3,dimer!2,tail~u?),EGF(hi!1),EGF(hi!3) @ 4.0e-2
    92. 

  92. '017-EGFR@tail_p Ref4' EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand,tail~p?) -> EGFR(dimer!1,ligand,tail~p?),EGFR(dimer!1,ligand,tail~p?) @ 3.0e-2
    93. 

  93. '017-EGFR@tail_p Ref5' EGFR(dimer!1,ligand!2,tail~u?),EGFR(dimer!1,ligand,tail~p?),EGF(hi!2) -> EGFR(dimer!1,ligand!2,tail~p?),EGFR(dimer!1,ligand,tail~p?),EGF(hi!2) @ 6.0e-2
    94. 

  94. '017-EGFR@tail_p Ref6' EGFR(dimer!1,ligand!3,tail~p?),EGFR(dimer!1,ligand!2,tail~u?),EGF(hi!2),EGF(hi!3) -> EGFR(dimer!1,ligand!3,tail~p?),EGFR(dimer!1,ligand!2,tail~p?),EGF(hi!2),EGF(hi!3) @ 12.0e-2
    95. 

  95. '017-EGFR@tail_p Ref7' EGFR(ligand!1,dimer,tail~u?),EGF(hi!1) -> EGFR(ligand!1,dimer,tail~p?),EGF(hi!1) @ 2.0e-3
    96. 

  96. '017-EGFR@tail_p Ref8' EGFR(ligand,dimer!1,tail~u?),HER2(dimer!1,ligand,tail~u?) -> EGFR(ligand,dimer!1,tail~p?),HER2(dimer!1,ligand,tail~u?) @ 16.0e-3
    97. 

  97. '017-EGFR@tail_p Ref9' EGFR(ligand!2,dimer!1,tail~u?),HER2(dimer!1,ligand,tail~u?),EGF(hi!2) -> EGFR(ligand!2,dimer!1,tail~p?),HER2(dimer!1,ligand,tail~u?),EGF(hi!2) @ 32.0e-3
    98. 

  98. '017-EGFR@tail_p Ref10' EGFR(ligand,dimer!1,tail~u?),HER2(dimer!1,ligand,tail~p?) -> EGFR(ligand,dimer!1,tail~p?),HER2(dimer!1,ligand,tail~p?) @ 48.0e-3
    99. 

  99. '017-EGFR@tail_p Ref11' HER2(dimer!1,ligand,tail~p?),EGFR(ligand!2,dimer!1,tail~u?),EGF(hi!2) -> HER2(dimer!1,ligand,tail~p?),EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2) @ 96.0e-3
    100. 

  100. '017-EGFR@tail_p Ref12' EGFR(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand,tail~u?) -> EGFR(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand,tail~u?) @ 8.0e-3
    101. 

  101. '017-EGFR@tail_p Ref13' EGFR(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand,tail~p?) -> EGFR(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand,tail~p?) @ 24.0e-3
    102. 

  102. '017-EGFR@tail_p Ref14' EGFR(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) -> EGFR(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) @ 16.0e-3
    103. 

  103. '017-EGFR@tail_p Ref15' EGFR(ligand,dimer!1,tail~u?),NRG(hi!2),HER3(dimer!1,ligand!2,tail~p?) -> EGFR(ligand,dimer!1,tail~p?),NRG(hi!2),HER3(dimer!1,ligand!2,tail~p?) @ 48.0e-3
    104. 

  104. '017-EGFR@tail_p Ref16' HER3(dimer!1,ligand,tail~u?),EGFR(ligand!2,dimer!1,tail~u?),EGF(hi!2) -> HER3(dimer!2,ligand,tail~u?),EGFR(ligand!1,dimer!2,tail~p?),EGF(hi!1) @ 16.0e-3
    105. 

  105. '017-EGFR@tail_p Ref17' HER3(ligand,dimer!1,tail~p?),EGFR(dimer!1,ligand!2,tail~u?),EGF(hi!2) -> HER3(ligand,dimer!1,tail~p?),EGFR(dimer!1,ligand!2,tail~p?),EGF(hi!2) @ 48.0e-3
    106. 

  106. '018-HER2@tail_p' HER2(dimer,ligand,tail~u?) -> HER2(dimer,ligand,tail~p?) @ 2.0e-4
    107. 

  107. '018-HER2@tail_p Ref1' HER2(dimer!1,ligand,tail~u?),HER2(dimer!1,ligand,tail~u?) -> HER2(dimer!1,ligand,tail~p?),HER2(dimer!1,ligand,tail~u?) @ 8.0e-3
    108. 

  108. '018-HER2@tail_p Ref2' HER2(dimer!1,ligand,tail~u?),HER2(dimer!1,ligand,tail~p?) -> HER2(dimer!1,ligand,tail~p?),HER2(dimer!1,ligand,tail~p?) @ 24.0e-3
    109. 

  109. '018-HER2@tail_p Ref3' HER2(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand,tail~u?) -> HER2(dimer!1,ligand,tail~p?),EGFR(dimer!1,ligand,tail~u?) @ 8.0e-3
    110. 

  110. '018-HER2@tail_p Ref4' EGFR(dimer!1,ligand!2,tail~u?),HER2(dimer!1,ligand,tail~u?),EGF(hi!2) -> EGFR(dimer!2,ligand!1,tail~u?),HER2(dimer!2,ligand,tail~p?),EGF(hi!1) @ 16.0e-3
    111. 

  111. '018-HER2@tail_p Ref5' HER2(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand,tail~p?) -> HER2(dimer!1,ligand,tail~p?),EGFR(dimer!1,ligand,tail~p?) @ 24.0e-3
    112. 

  112. '018-HER2@tail_p Ref6' EGFR(dimer!1,ligand!2,tail~p?),HER2(dimer!1,ligand,tail~u?),EGF(hi!2) -> EGFR(dimer!1,ligand!2,tail~p?),HER2(dimer!1,ligand,tail~p?),EGF(hi!2) @ 48.0e-3
    113. 

  113. '018-HER2@tail_p Ref7' HER2(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand,tail~u?) -> HER2(dimer!1,ligand,tail~p?),HER3(dimer!1,ligand,tail~u?) @ 8.0e-3
    114. 

  114. '018-HER2@tail_p Ref8' HER2(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) -> HER2(dimer!2,ligand,tail~p?),HER3(dimer!2,ligand!1,tail~u?),NRG(hi!1) @ 16.0e-3
    115. 

  115. '018-HER2@tail_p Ref9' HER3(dimer!1,ligand,tail~p?),HER2(dimer!1,ligand,tail~u?) -> HER3(dimer!1,ligand,tail~p?),HER2(dimer!1,ligand,tail~p?) @ 24.0e-3
    116. 

  116. '018-HER2@tail_p Ref10' HER3(dimer!1,ligand!2,tail~p?),HER2(dimer!1,ligand,tail~u?),NRG(hi!2) -> HER3(dimer!2,ligand!1,tail~p?),HER2(dimer!2,ligand,tail~p?),NRG(hi!1) @ 48.0e-3
    117. 

  117. '018-HER3@tail_p' HER3(ligand,dimer,tail~u?) -> HER3(ligand,dimer,tail~p?) @ 0.0
    118. 

  118. '018-HER3@tail_p Ref1' EGFR(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand,tail~u?) -> EGFR(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand,tail~p?) @ 8.0e-3
    119. 

  119. '018-HER3@tail_p Ref2' EGFR(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) -> EGFR(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand!2,tail~p?),NRG(hi!2) @ 16.0e-3
    120. 

  120. '018-HER3@tail_p Ref3' EGFR(ligand!3,dimer!1,tail~u?),EGF(hi!3),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) -> EGFR(ligand!3,dimer!2,tail~u?),EGF(hi!3),HER3(dimer!2,ligand!1,tail~p?),NRG(hi!1) @ 32.0e-3
    121. 

  121. '018-HER3@tail_p Ref4' EGFR(dimer!1,ligand,tail~p?),HER3(dimer!1,ligand,tail~u?) -> EGFR(dimer!1,ligand,tail~p?),HER3(dimer!1,ligand,tail~p?) @ 24.0e-3
    122. 

  122. '018-HER3@tail_p Ref5' EGFR(dimer!1,ligand,tail~p?),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) -> EGFR(dimer!1,ligand,tail~p?),HER3(dimer!1,ligand!2,tail~p?),NRG(hi!2) @ 48.0e-3
    123. 

  123. '018-HER3@tail_p Ref6' EGFR(dimer!1,ligand!3,tail~p?),EGF(hi!3),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) -> EGFR(dimer!1,ligand!3,tail~p?),EGF(hi!3),HER3(dimer!1,ligand!2,tail~p?),NRG(hi!2) @ 96.0e-3
    124. 

  124. '018-HER3@tail_p Ref7' HER2(dimer!1,ligand,tail~u?),HER3(ligand,dimer!1,tail~u?) -> HER2(dimer!1,ligand,tail~u?),HER3(ligand,dimer!1,tail~p?) @ 16.0e-3
    125. 

  125. '018-HER3@tail_p Ref8' HER2(dimer!1,ligand,tail~u?),HER3(ligand!2,dimer!1,tail~u?),NRG(hi!2) -> HER2(dimer!1,ligand,tail~u?),HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2) @ 32.0e-3
    126. 

  126. '018-HER3@tail_p Ref9' HER2(dimer!1,ligand,tail~p?),HER3(ligand,dimer!1,tail~u?) -> HER2(dimer!1,ligand,tail~p?),HER3(ligand,dimer!1,tail~p?) @ 48.0e-3
    127. 

  127. '018-HER3@tail_p Ref10' HER2(dimer!1,ligand,tail~p?),HER3(ligand!2,dimer!1,tail~u?),NRG(hi!2) -> HER2(dimer!1,ligand,tail~p?),HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2) @ 96.0e-3
    128. 

  128. '019-EGFR@tail_u' EGFR(dimer,ligand,tail~p?) -> EGFR(dimer,ligand,tail~u?) @ 200.0e-3
    129. 

  129. '019-EGFR@tail_u Ref1' EGFR(dimer,ligand!1,tail~p?),EGF(hi!1) -> EGFR(dimer,ligand!1,tail~u?),EGF(hi!1) @ 50.0e-3
    130. 

  130. '019-EGFR@tail_u Ref2' EGFR(ligand!1,dimer!3,tail~p?),EGFR(dimer!3,ligand!2,tail~p?),EGF(hi!1),EGF(hi!2) -> EGFR(ligand!1,dimer!3,tail~u?),EGFR(dimer!3,ligand!2,tail~p?),EGF(hi!1),EGF(hi!2) @ 5.0e-3
    131. 

  131. '019-EGFR@tail_u Ref3' EGFR(ligand!1,dimer!3,tail~p?),EGF(hi!1),EGF(hi!2),EGFR(dimer!3,ligand!2,tail~u?) -> EGFR(ligand!1,dimer!3,tail~u?),EGF(hi!1),EGF(hi!2),EGFR(dimer!3,ligand!2,tail~u?) @ 10.0e-3
    132. 

  132. '019-EGFR@tail_u Ref4' EGFR(dimer!3,ligand,tail~p?),EGFR(ligand!1,dimer!3,tail~p?),EGF(hi!1) -> EGFR(dimer!2,ligand,tail~p?),EGFR(ligand!1,dimer!2,tail~u?),EGF(hi!1) @ 20.0e-3
    133. 

  133. '019-EGFR@tail_u Ref5' EGFR(dimer!1,tail~p?,ligand),EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2) -> EGFR(dimer!1,tail~u?,ligand),EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2) @ 20.0e-3
    134. 

  134. '019-EGFR@tail_u Ref6' EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand!2,tail~p?),EGF(hi!2) -> EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand!2,tail~u?),EGF(hi!2) @ 40.0e-3
    135. 

  135. '019-EGFR@tail_u Ref7' EGFR(dimer!1,ligand,tail~p?),EGF(hi!2),EGFR(dimer!1,ligand!2,tail~u?) -> EGFR(dimer!2,ligand,tail~u?),EGF(hi!1),EGFR(dimer!2,ligand!1,tail~u?) @ 40.0e-3
    136. 

  136. '019-EGFR@tail_u Ref8' EGFR(ligand,dimer!1,tail~p?),EGFR(dimer!1,ligand,tail~p?) -> EGFR(ligand,dimer!1,tail~u?),EGFR(dimer!1,ligand,tail~p?) @ 80.0e-3
    137. 

  137. '019-EGFR@tail_u Ref9' EGFR(dimer!1,ligand,tail~p?),EGFR(dimer!1,ligand,tail~u?) -> EGFR(dimer!1,ligand,tail~u?),EGFR(dimer!1,ligand,tail~u?) @ 160.0e-3
    138. 

  138. '019-EGFR@tail_u Ref10' EGFR(ligand!2,dimer!1,tail~p?),HER2(dimer!1,ligand,tail~p?),EGF(hi!2) -> EGFR(ligand!2,dimer!1,tail~u?),HER2(dimer!1,ligand,tail~p?),EGF(hi!2) @ 5.0e-3
    139. 

  139. '019-EGFR@tail_u Ref11' EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2),HER2(dimer!1,ligand,tail~u?) -> EGFR(ligand!1,dimer!2,tail~u?),EGF(hi!1),HER2(dimer!2,ligand,tail~u?) @ 10.0e-3
    140. 

  140. '019-EGFR@tail_u Ref12' EGFR(dimer!1,tail~p?,ligand),HER2(dimer!1,ligand,tail~p?) -> EGFR(dimer!1,tail~u?,ligand),HER2(dimer!1,ligand,tail~p?) @ 20.0e-3
    141. 

  141. '019-EGFR@tail_u Ref13' HER2(dimer!1,ligand,tail~u?),EGFR(dimer!1,tail~p?,ligand) -> HER2(dimer!1,ligand,tail~u?),EGFR(dimer!1,tail~u?,ligand) @ 40.0e-3
    142. 

  142. '019-EGFR@tail_u Ref14' HER3(ligand!3,dimer!1,tail~p?),EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2),NRG(hi!3) -> HER3(ligand!3,dimer!1,tail~p?),EGFR(ligand!2,dimer!1,tail~u?),EGF(hi!2),NRG(hi!3) @ 5.0e-3
    143. 

  143. '019-EGFR@tail_u Ref15' NRG(hi!3),EGFR(ligand!2,dimer!1,tail~p?),HER3(ligand!3,dimer!1,tail~u?),EGF(hi!2) -> NRG(hi!3),EGFR(ligand!2,dimer!1,tail~u?),HER3(ligand!3,dimer!1,tail~u?),EGF(hi!2) @ 10.0e-3
    144. 

  144. '019-EGFR@tail_u Ref16' HER3(ligand,dimer!1,tail~p?),EGF(hi!2),EGFR(ligand!2,dimer!1,tail~p?) -> HER3(ligand,dimer!1,tail~p?),EGF(hi!2),EGFR(ligand!2,dimer!1,tail~u?) @ 20.0e-3
    145. 

  145. '019-EGFR@tail_u Ref17' EGF(hi!2),EGFR(ligand!2,dimer!1,tail~p?),HER3(ligand,dimer!1,tail~u?) -> EGF(hi!1),EGFR(ligand!1,dimer!2,tail~u?),HER3(ligand,dimer!2,tail~u?) @ 40.0e-3
    146. 

  146. '019-EGFR@tail_u Ref18' HER3(ligand!3,dimer!1,tail~p?),EGFR(dimer!1,ligand,tail~p?),NRG(hi!3) -> HER3(ligand!2,dimer!1,tail~p?),EGFR(dimer!1,ligand,tail~u?),NRG(hi!2) @ 20.0e-3
    147. 

  147. '019-EGFR@tail_u Ref19' HER3(ligand,dimer!1,tail~u?),EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2) -> HER3(ligand,dimer!2,tail~u?),EGFR(ligand!1,dimer!2,tail~u?),EGF(hi!1) @ 40.0e-3
    148. 

  148. '019-EGFR@tail_u Ref20' HER3(ligand,dimer!1,tail~p?),EGFR(ligand,dimer!1,tail~p?) -> HER3(ligand,dimer!1,tail~p?),EGFR(ligand,dimer!1,tail~u?) @ 80.0e-3
    149. 

  149. '019-EGFR@tail_u Ref21' EGFR(ligand,dimer!1,tail~p?),HER3(ligand,dimer!1,tail~u?) -> EGFR(ligand,dimer!1,tail~u?),HER3(ligand,dimer!1,tail~u?) @ 160.0e-3
    150. 

  150. '020-HER2@tail_u' HER2(ligand,dimer,tail~p?) -> HER2(ligand,dimer,tail~u?) @ 5.0e-2
    151. 

  151. '020-HER2@tail_u Ref1' HER2(ligand,dimer!1,tail~p?),EGFR(dimer!1,ligand!2,tail~p?),EGF(hi!2) -> HER2(ligand,dimer!1,tail~u?),EGFR(dimer!1,ligand!2,tail~p?),EGF(hi!2) @ 5.0e-3
    152. 

  152. '020-HER2@tail_u Ref2' EGFR(dimer!1,ligand!2,tail~u?),EGF(hi!2),HER2(ligand,dimer!1,tail~p?) -> EGFR(dimer!2,ligand!1,tail~u?),EGF(hi!1),HER2(ligand,dimer!2,tail~u?) @ 10.0e-3
    153. 

  153. '020-HER2@tail_u Ref3' HER2(ligand,dimer!1,tail~p?),EGFR(ligand,dimer!1,tail~p?) -> HER2(ligand,dimer!1,tail~u?),EGFR(ligand,dimer!1,tail~p?) @ 40.0e-3
    154. 

  154. '020-HER2@tail_u Ref4' EGFR(ligand,dimer!1,tail~u?),HER2(ligand,dimer!1,tail~p?) -> EGFR(ligand,dimer!1,tail~u?),HER2(ligand,dimer!1,tail~u?) @ 80.0e-3
    155. 

  155. '020-HER2@tail_u Ref5' HER2(ligand,dimer!1,tail~p?),HER2(dimer!1,ligand,tail~p?) -> HER2(ligand,dimer!1,tail~u?),HER2(dimer!1,ligand,tail~p?) @ 5.0e-3
    156. 

  156. '020-HER2@tail_u Ref6' HER2(ligand,dimer!1,tail~u?),HER2(ligand,dimer!1,tail~p?) -> HER2(ligand,dimer!1,tail~u?),HER2(ligand,dimer!1,tail~u?) @ 10.0e-3
    157. 

  157. '020-HER2@tail_u Ref7' HER2(ligand,dimer!1,tail~p?),NRG(hi!2),HER3(dimer!1,ligand!2,tail~p?) -> HER2(ligand,dimer!2,tail~u?),NRG(hi!1),HER3(dimer!2,ligand!1,tail~p?) @ 5.0e-3
    158. 

  158. '020-HER2@tail_u Ref8' HER2(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) -> HER2(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) @ 10.0e-3
    159. 

  159. '020-HER2@tail_u Ref9' HER2(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand,tail~p?) -> HER2(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand,tail~p?) @ 20.0e-3
    160. 

  160. '020-HER2@tail_u Ref10' HER2(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand,tail~u?) -> HER2(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand,tail~u?) @ 40.0e-3
    161. 

  161. '021-HER3@tail_u' HER3(dimer,ligand,tail~p?) -> HER3(dimer,ligand,tail~u?) @ 200.0e-3
    162. 

  162. '021-HER3@tail_u Ref1' HER3(dimer,ligand!1,tail~p?),NRG(hi!1) -> HER3(dimer,ligand!1,tail~u?),NRG(hi!1) @ 50.0e-3
    163. 

  163. '021-HER3@tail_u Ref2' HER3(ligand!1,dimer!3,tail~p?),HER3(dimer!3,ligand!2,tail~p?),NRG(hi!1),NRG(hi!2) -> HER3(ligand!1,dimer!3,tail~u?),HER3(dimer!3,ligand!2,tail~p?),NRG(hi!1),NRG(hi!2) @ 5.0e-3
    164. 

  164. '021-HER3@tail_u Ref3' HER3(ligand!1,dimer!3,tail~p?),HER3(dimer!3,ligand!2,tail~u?),NRG(hi!1),NRG(hi!2) -> HER3(ligand!1,dimer!3,tail~u?),HER3(dimer!3,ligand!2,tail~u?),NRG(hi!1),NRG(hi!2) @ 10.0e-3
    165. 

  165. '021-HER3@tail_u Ref4' HER3(ligand!1,dimer!3,tail~p?),HER3(dimer!3,ligand,tail~p?),NRG(hi!1) -> HER3(ligand!1,dimer!2,tail~u?),HER3(dimer!2,ligand,tail~p?),NRG(hi!1) @ 20.0e-3
    166. 

  166. '021-HER3@tail_u Ref5' HER3(dimer!1,ligand,tail~p?),HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2) -> HER3(dimer!1,ligand,tail~u?),HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2) @ 20.0e-3
    167. 

  167. '021-HER3@tail_u Ref6' HER3(dimer!1,ligand!2,tail~p?),NRG(hi!2),HER3(dimer!1,ligand,tail~u?) -> HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2),HER3(dimer!1,ligand,tail~u?) @ 40.0e-3
    168. 

  168. '021-HER3@tail_u Ref7' HER3(dimer!1,ligand,tail~p?),HER3(dimer!1,ligand!2,tail~u?),NRG(hi!2) -> HER3(dimer!2,ligand,tail~u?),HER3(dimer!2,ligand!1,tail~u?),NRG(hi!1) @ 40.0e-3
    169. 

  169. '021-HER3@tail_u Ref8' HER3(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand,tail~p?) -> HER3(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand,tail~p?) @ 80.0e-3
    170. 

  170. '021-HER3@tail_u Ref9' HER3(ligand,dimer!1,tail~p?),HER3(dimer!1,ligand,tail~u?) -> HER3(ligand,dimer!1,tail~u?),HER3(dimer!1,ligand,tail~u?) @ 160.0e-3
    171. 

  171. '021-HER3@tail_u Ref10' HER2(dimer!1,ligand,tail~p?),HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2) -> HER2(dimer!1,ligand,tail~p?),HER3(ligand!2,dimer!1,tail~u?),NRG(hi!2) @ 5.0e-3
    172. 

  172. '021-HER3@tail_u Ref11' HER2(dimer!1,ligand,tail~u?),HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2) -> HER2(dimer!2,ligand,tail~u?),HER3(ligand!1,dimer!2,tail~u?),NRG(hi!1) @ 10.0e-3
    173. 

  173. '021-HER3@tail_u Ref12' HER2(dimer!1,ligand,tail~p?),HER3(dimer!1,ligand,tail~p?) -> HER2(dimer!1,ligand,tail~p?),HER3(dimer!1,ligand,tail~u?) @ 20.0e-3
    174. 

  174. '021-HER3@tail_u Ref13' HER2(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand,tail~p?) -> HER2(dimer!1,ligand,tail~u?),HER3(dimer!1,ligand,tail~u?) @ 40.0e-3
    175. 

  175. '021-HER3@tail_u Ref14' HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2),EGF(hi!3),EGFR(ligand!3,dimer!1,tail~p?) -> HER3(ligand!2,dimer!1,tail~u?),NRG(hi!2),EGF(hi!3),EGFR(ligand!3,dimer!1,tail~p?) @ 5.0e-3
    176. 

  176. '021-HER3@tail_u Ref15' HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2),EGF(hi!3),EGFR(ligand!3,dimer!1,tail~u?) -> HER3(ligand!2,dimer!1,tail~u?),NRG(hi!2),EGF(hi!3),EGFR(ligand!3,dimer!1,tail~u?) @ 10.0e-3
    177. 

  177. '021-HER3@tail_u Ref16' HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2),EGFR(ligand,dimer!1,tail~p?) -> HER3(ligand!2,dimer!1,tail~u?),NRG(hi!2),EGFR(ligand,dimer!1,tail~p?) @ 20.0e-3
    178. 

  178. '021-HER3@tail_u Ref17' HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2),EGFR(ligand,dimer!1,tail~u?) -> HER3(ligand!1,dimer!2,tail~u?),NRG(hi!1),EGFR(ligand,dimer!2,tail~u?) @ 40.0e-3
    179. 

  179. '021-HER3@tail_u Ref18' HER3(ligand,dimer!1,tail~p?),EGFR(ligand!3,dimer!1,tail~p?),EGF(hi!3) -> HER3(ligand,dimer!1,tail~u?),EGFR(ligand!2,dimer!1,tail~p?),EGF(hi!2) @ 20.0e-3
    180. 

  180. '021-HER3@tail_u Ref19' HER3(ligand!2,dimer!1,tail~p?),NRG(hi!2),EGFR(ligand,dimer!1,tail~u?) -> HER3(ligand!1,dimer!2,tail~u?),NRG(hi!1),EGFR(ligand,dimer!2,tail~u?) @ 40.0e-3
    181. 

  181. '021-HER3@tail_u Ref20' HER3(ligand,dimer!1,tail~p?),EGFR(ligand,dimer!1,tail~p?) -> HER3(ligand,dimer!1,tail~u?),EGFR(ligand,dimer!1,tail~p?) @ 80.0e-3
    182. 

  182. '021-HER3@tail_u Ref21' HER3(ligand,dimer!1,tail~p?),EGFR(ligand,dimer!1,tail~u?) -> HER3(ligand,dimer!1,tail~u?),EGFR(ligand,dimer!1,tail~u?) @ 160.0e-3
    183. 

  183. 

  184. #######
    185. 

  185. # Chapter 'RasGAP' -- Inactive chapter
    186. 

  186. # 'Ras@tail_gdp.RasGAP' Ras(tail~gtp!1),RasGAP(GAP!1) -> Ras(tail~gdp!1),RasGAP(GAP!1) @ 1.0 # Inactive rule
    187. 

  187. # 'RasGAP...Ras' Ras(tail!1),RasGAP(GAP!1) -> Ras(tail),RasGAP(GAP) @ 1.0 # Inactive rule
    188. 

  188. # 'RasGAP.Ras' Ras(tail~gtp),RasGAP(GAP) -> Ras(tail~gtp!1),RasGAP(GAP!1) @ 1.0 # Inactive rule
    189. 

  189. 

  190. #######
    191. 

  191. # Chapter 'Et al.' -- Inactive chapter
    192. 

  192. # '519-ERK1@T183_u' ERK1(tail~p!1),MKP(s!1) -> ERK1(tail~u!1),MKP(s!1) @ 5.0e-4
    193. 

  193. # '524-ERK1@Y185.MKP' ERK1(tail~p),MKP(s) -> ERK1(tail~p!1),MKP(s!1) @ 1.0e-5
    194. 

  194. # '527-ERK1.MEK1' MEK1(erk1,tail~p),ERK1(C) -> MEK1(erk1!1,tail~p),ERK1(C!1) @ 3.0e-3
    195. 

  195. # '528-ERK1...MKP' ERK1(tail!1),MKP(s!1) -> ERK1(tail),MKP(s) @ 1.0e-2
    196. 

  196. # '529-ERK1...MEK1' ERK1(C!1),MEK1(erk1!1) -> ERK1(C),MEK1(erk1) @ 1.0
    197. 

  197. # '532-ERK1@Y185_p' ERK1(C!_,tail~u) -> ERK1(C!_,tail~p) @ 1.0e-1
    198. 

  198. # 'SoS...ERK1' ERK1(tail!1),SoS(erk1!1) -> ERK1(tail),SoS(erk1) @ 1.0e-3
    199. 

  199. # 'SoS@x_p' ERK1(tail~p!1),SoS(erk1!1,grb2!_,x~u) -> ERK1(tail~p!1),SoS(erk1!1,grb2!_,x~p) @ 1.0e-3
    200. 

  200. # 'SoS@x_u' SoS(x~p) -> SoS(x~u) @ 1.0e-3
    201. 

  201. # 'SoS.ERK1' ERK1(tail~p),SoS(grb2!_,erk1) -> ERK1(tail~p!1),SoS(grb2!_,erk1!1) @ 1.0e-5
    202. 

  202. # '530-EGFR.Shc' EGFR(tail~p),Shc(PTB) -> EGFR(tail~p!1),Shc(PTB!1) @ 1.0e-7
    203. 

  203. # '531-EGFR...Shc' EGFR(tail!1),Shc(PTB!1) -> EGFR(tail),Shc(PTB) @ 1.0
    204. 

  204. # '503-Shc@Y_px2' Shc(PTB,tail~u),EGFR(tail~p) -> Shc(PTB!1,tail~p),EGFR(tail~p!1) @ 1.0e-4
    205. 

  205. # '502-Shc@Y_u' Shc(tail~p?) -> Shc(tail~u?) @ 1.0
    206. 

  206. # '503-Shc@Y_p' HER2(tail~p),Shc(PTB,tail~u) -> HER2(tail~p!1),Shc(PTB!1,tail~p) @ 1.0e-4
    207. 

  207. # '518-HER2.Shc' HER2(tail~p),Shc(PTB) -> HER2(tail~p!1),Shc(PTB!1) @ 1.0e-7
    208. 

  208. # '520-HER2...Shc' Shc(PTB!1),HER2(tail!1) -> Shc(PTB),HER2(tail) @ 1.0
    209. 

  209. # '431-EGFR...Grb2' Grb2(SH2!1),EGFR(tail!1) -> Grb2(SH2),EGFR(tail) @ 1.0e-1
    210. 

  210. # '432-EGFR.Grb2' EGFR(tail~p),Grb2(SH2) -> EGFR(tail~p!1),Grb2(SH2!1) @ 1.0e-6
    211. 

  211. # '420-Grb2...HER3' Grb2(SH2!1),HER3(tail!1) -> Grb2(SH2),HER3(tail) @ 1.0e-1
    212. 

  212. # '421-Grb2...HER2' Grb2(SH2!1),HER2(tail!1) -> Grb2(SH2),HER2(tail) @ 1.0e-1
    213. 

  213. # '416-HER3.Grb2' Grb2(SH2),HER3(tail~p) -> Grb2(SH2!1),HER3(tail~p!1) @ 1.0e-6
    214. 

  214. # '417-HER2.Grb2' Grb2(SH2),HER2(tail~p) -> Grb2(SH2!1),HER2(tail~p!1) @ 1.0e-6
    215. 

  215. # 'Shc...Grb2' Shc(tail!1),Grb2(SH2!1) -> Shc(tail),Grb2(SH2) @ 1.0e-1
    216. 

  216. # '505-Shc.Grb2' Shc(tail~p),Grb2(SH2) -> Shc(tail~p!1),Grb2(SH2!1) @ 1.0e-6
    217. 

  217. # '500-SoS.Ras' Grb2(SH3c!1),Ras(sos),SoS(grb2!1,ras) -> Grb2(SH3c!1),Ras(sos!2),SoS(grb2!1,ras!2) @ 1.0e-5
    218. 

  218. # '507-Ras@S_gtp' Grb2(SH3c!1),SoS(grb2!1,ras!2),Ras(sos!2,tail~gdp) -> Grb2(SH3c!1),SoS(grb2!1,ras!2),Ras(sos!2,tail~gtp) @ 1.0e-3
    219. 

  219. # '521-Grb2.SoS' SoS(grb2),Grb2(SH2!_,SH3c) -> SoS(grb2!1),Grb2(SH2!_,SH3c!1) @ 1.0e-5
    220. 

  220. # '522-Grb2...SoS' Grb2(SH3c!1),SoS(grb2!1) -> Grb2(SH3c),SoS(grb2) @ 1.0
    221. 

  221. # '501-SoS...Ras' SoS(ras!2),Ras(sos!2) -> SoS(ras),Ras(sos) @ 1.0
    222. 

  222. # 'Ras@tail_gdp' Ras(tail~gtp) -> Ras(tail~gdp) @ 1.0e-4
    223. 

  223. # '511-Raf1@S_p' Raf1(RBD,tail~u) -> Raf1(RBD,tail~p) @ 5.0e-3
    224. 

  224. # '508-Ras.Raf1' Ras(tail~gtp),Raf1(RBD,tail~p) -> Ras(tail~gtp!1),Raf1(RBD!1,tail~p) @ 1.0e-5
    225. 

  225. # '510-Raf1@S_u' Raf1(RBD!_,tail~p) -> Raf1(RBD!_,tail~u) @ 1.0e-2
    226. 

  226. # '509-Ras...Raf1' Raf1(RBD!1),Ras(tail!1) -> Raf1(RBD),Ras(tail) @ 1.0
    227. 

  227. # '516-MEK1@S2_p' Raf1(tail!1),MEK1(tail~u!1) -> Raf1(tail!1),MEK1(tail~p!1) @ 1.0e-2
    228. 

  228. # 'M2KP...MEK1' M2KP(px!1),MEK1(tail!1) -> M2KP(px),MEK1(tail) @ 1.0e-2
    229. 

  229. # '514-Raf1...MEK1@S2' MEK1(tail!1),Raf1(tail!1) -> MEK1(tail),Raf1(tail) @ 1.0
    230. 

  230. # '513-Raf1.MEK1' MEK1(tail~u),Raf1(RBD,tail~u) -> MEK1(tail~u!1),Raf1(RBD,tail~u!1) @ 1.0e-6
    231. 

  231. # 'M2KP.MEK1' MEK1(tail~p),M2KP(px) -> MEK1(tail~p!1),M2KP(px!1) @ 1.0e-2
    232. 

  232. # 'MEK1@tail_u' M2KP(px!1),MEK1(tail~p!1) -> M2KP(px!1),MEK1(tail~u!1) @ 1.0e-3
    233. 

  233. 

  234. #######
    235. 

  235. # Chapter 'Akt' -- Inactive chapter
    236. 

  236. # 'PI3K@tail_u' PI3K(tail~p) -> PI3K(tail~u) @ 5.0e-2
    237. 

  237. # '410-PI3K@tail_p' PI3K(tail~u,SH2!_) -> PI3K(tail~p,SH2!_) @ 1.0e-1
    238. 

  238. # '424-Gab1.PI3K' PI3K(SH2),Gab1(Y327~p,Y627~p,PI3K) -> PI3K(SH2!1),Gab1(Y327~p,Y627~p,PI3K!1) @ 5.0e-5
    239. 

  239. # '428-Gab1...PI3K' PI3K(SH2!1),Gab1(PI3K!1) -> PI3K(SH2),Gab1(PI3K) @ 10
    240. 

  240. # '403-PTEN.PIP' PTEN(subs),PIP(three~p) -> PTEN(subs!1),PIP(three~p!1) @ 1.0
    241. 

  241. # '404-PTEN...PIP' PTEN(subs!1),PIP(three!1) -> PTEN(subs),PIP(three) @ 1.0
    242. 

  242. # '405-PIP@three_u' PTEN(subs!1),PIP(three~p!1) -> PTEN(subs!1),PIP(three~u!1) @ 1.0
    243. 

  243. # '406-PIP@three_p' PI3K(subs!1,tail~p),PIP(three~u!1) -> PI3K(subs!1,tail~p),PIP(three~p!1) @ 1.0e-2
    244. 

  244. # '407-PIP.PDK1' PIP(three~p),PDK1(PH) -> PIP(three~p!1),PDK1(PH!1) @ 1.0e-1
    245. 

  245. # '408-PIP.AKT' PIP(three~p),AKT(PH) -> PIP(three~p!1),AKT(PH!1) @ 10
    246. 

  246. # '409-PIP...PDK1' PIP(three!1),PDK1(PH!1) -> PIP(three),PDK1(PH) @ 1.0e-2
    247. 

  247. # '411-PIP...AKT' AKT(PH!1),PIP(three!1) -> AKT(PH),PIP(three) @ 1.0
    248. 

  248. # '412-PI3K.PIP' PI3K(subs,tail~p),PIP(three~u) -> PI3K(subs!1,tail~p),PIP(three~u!1) @ 1.0e-3
    249. 

  249. # '413-PI3K...PIP' PIP(three!1),PI3K(subs!1) -> PIP(three),PI3K(subs) @ 1.0e-2
    250. 

  250. # '414-PDK1.AKT' AKT(T308~u,pdk1,PH!_),PDK1(PH!1,akt),PIP(three~p!1) -> AKT(T308~u,pdk1!2,PH!_),PDK1(PH!1,akt!2),PIP(three~p!1) @ 1.0
    251. 

  251. # '434-AKT@tail_p' AKT(T308~u,pdk1!2,PH!_),PIP(three~p!1),PDK1(PH!1,akt!2) -> AKT(T308~p,pdk1,PH!_),PIP(three~p!1),PDK1(PH!1,akt) @ 10
    252. 

  252. # '433-AKT@tail_u' AKT(T308~p!1),PP2A(px!1) -> AKT(T308~u!1),PP2A(px!1) @ 1.0e-1
    253. 

  253. # '435-AKT.PP2A' AKT(T308~p),PP2A(px) -> AKT(T308~p!1),PP2A(px!1) @ 1.0
    254. 

  254. # '436-AKT...PP2A' PP2A(px!1),AKT(T308!1) -> PP2A(px),AKT(T308) @ 1.0
    255. 

  255. # '426-Gab1.EGFR' Gab1(MBD,MR),EGFR(tail~p) -> Gab1(MBD!1,MR),EGFR(tail~p!1) @ 1.0e-4
    256. 

  256. # '422-Gab1@Y627_p' Grb2(SH3c!2,SH2!_),Gab1(MR!2,Y627~u) -> Grb2(SH3c,SH2!_),Gab1(MR,Y627~p) @ 1.0
    257. 

  257. # '430-Gab1...EGFR' Gab1(MBD!1),EGFR(tail!1) -> Gab1(MBD),EGFR(tail) @ 1.0e-3
    258. 

  258. # '425-Gab1.Grb2' Gab1(MR,MBD!_),Grb2(SH3c) -> Gab1(MR!1,MBD!_),Grb2(SH3c!1) @ 1.0e-4
    259. 

  259. # '422-Gab1@Y327_p' Grb2(SH3c!2,SH2!_),Gab1(MR!2,Y327~u) -> Grb2(SH3c,SH2!_),Gab1(MR,Y327~p) @ 1.0
    260. 

  260. # 'Gab1@Y327_u' Gab1(Y327~p) -> Gab1(Y327~u) @ 2.5e-3
    261. 

  261. # 'Gab1@Y627_u' Gab1(Y627~p) -> Gab1(Y627~u) @ 5.0e-2
    262.