'EGF_ErbB1'EGF(r~ext),ErbB1(L~ext,CR) <-> EGF(r~ext!1),ErbB1(L~ext!1,CR)
'ErbB1_ErbB1'ErbB1(L~ext!_,CR,N,C),ErbB1(L~ext!_,CR,N,C) <-> ErbB1(L~ext!_,CR!1,N,C),ErbB1(L~ext!_,CR!1,N,C)
'ErbB1_ErbB2'ErbB1(L~ext!_,CR,N,C),ErbB2(L~ext,CR,N,C) <-> ErbB1(L~ext!_,CR!1,N,C),ErbB2(L~ext,CR!1,N,C)
'ErbB2_ErbB3'ErbB2(L~ext,CR,N,C),ErbB3(L~ext!_,CR,N,C) <-> ErbB2(L~ext,CR!1,N,C),ErbB3(L~ext!_,CR!1,N,C)
'ErbB2_ErbB4'ErbB2(L~ext,CR,N,C),ErbB4(L~ext!_,CR,N,C) <-> ErbB2(L~ext,CR!1,N,C),ErbB4(L~ext!_,CR!1,N,C)
'ErbB1_ErbB3'ErbB1(L~ext,CR,N,C),ErbB3(L~ext!_,CR,N,C) <-> ErbB1(L~ext,CR!1,N,C),ErbB3(L~ext!_,CR!1,N,C)
'ErbB1_ErbB4'ErbB1(L~ext,CR,N,C),ErbB4(L~ext!_,CR,N,C) <-> ErbB1(L~ext,CR!1,N,C),ErbB4(L~ext!_,CR!1,N,C)
'ErbB1_ATP'ErbB1(bp),A(s~ppp) -> ErbB1(bp!1),A(s~ppp!1)
'ErbB1_A_op'ErbB1(bp!1),A(s!1) -> ErbB1(bp),A(s)
'ErbB2_ATP'ErbB2(bp),A(s~ppp) -> ErbB2(bp!1),A(s~ppp!1)
'ErbB2_A_op'ErbB2(bp!1),A(s!1) -> ErbB2(bp),A(s)
'Rule1'ErbB1(CR!1,N,C),ErbB1(CR!1,N,C) <-> ErbB1(CR!1,N!2,C),ErbB1(CR!1,N,C!2)
'Rule2'ErbB4(CR!1,N,C),ErbB1(CR!1,N,C) <-> ErbB4(CR!1,N!2,C),ErbB1(CR!1,N,C!2)
'Rule3'ErbB1(N!1,bp!2),ErbB1(C!1,Y992~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB1(C!1,Y992~p),A(s~pp!2)
'Rule4'ErbB1(N!1,bp!2),ErbB1(C!1,Y1068~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB1(C!1,Y1068~p),A(s~pp!2)
'Rule5'ErbB1(N!1,bp!2),ErbB1(C!1,Y1148~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB1(C!1,Y1148~p),A(s~pp!2)
'Rule6'ErbB2(N!1,bp!2),ErbB1(C!1,Y992~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB1(C!1,Y992~p),A(s~pp!2)
'Rule7'ErbB2(N!1,bp!2),ErbB1(C!1,Y1068~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB1(C!1,Y1068~p),A(s~pp!2)
'Rule8'ErbB2(N!1,bp!2),ErbB1(C!1,Y1148~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB1(C!1,Y1148~p),A(s~pp!2)
'Rule9'ErbB4(N!1,bp!2),ErbB1(C!1,Y992~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB1(C!1,Y992~p),A(s~pp!2)
'Rule10'ErbB4(N!1,bp!2),ErbB1(C!1,Y1068~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB1(C!1,Y1068~p),A(s~pp!2)
'Rule11'ErbB4(N!1,bp!2),ErbB1(C!1,Y1148~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB1(C!1,Y1148~p),A(s~pp!2)
'Rule12'ErbB1(CR!1,N,C),ErbB2(CR!1,N,C) <-> ErbB1(CR!1,N!2,C),ErbB2(CR!1,N,C!2)
'Rule13'ErbB2(CR!1,N,C),ErbB2(CR!1,N,C) <-> ErbB2(CR!1,N!2,C),ErbB2(CR!1,N,C!2)
'Rule14'ErbB4(CR!1,N,C),ErbB2(CR!1,N,C) <-> ErbB4(CR!1,N!2,C),ErbB2(CR!1,N,C!2)
'Rule15'ErbB1(N!1,bp!2),ErbB2(C!1,Y1139~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB2(C!1,Y1139~p),A(s~pp!2)
'Rule16'ErbB1(N!1,bp!2),ErbB2(C!1,Y1196~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB2(C!1,Y1196~p),A(s~pp!2)
'Rule17'ErbB1(N!1,bp!2),ErbB2(C!1,Y1221~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB2(C!1,Y1221~p),A(s~pp!2)
'Rule18'ErbB4(N!1,bp!2),ErbB2(C!1,Y1139~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB2(C!1,Y1139~p),A(s~pp!2)
'Rule19'ErbB4(N!1,bp!2),ErbB2(C!1,Y1196~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB2(C!1,Y1196~p),A(s~pp!2)
'Rule20'ErbB4(N!1,bp!2),ErbB2(C!1,Y1221~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB2(C!1,Y1221~p),A(s~pp!2)
'Rule21'ErbB1(CR!1,N,C),ErbB3(CR!1,C,N) <-> ErbB1(CR!1,N!2,C),ErbB3(CR!1,C!2,N)
'Rule22'ErbB2(CR!1,N,C),ErbB3(CR!1,C,N) <-> ErbB2(CR!1,N!2,C),ErbB3(CR!1,C!2,N)
'Rule23'ErbB1(N!1,bp!2),ErbB3(C!1,Y1035~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1035~p),A(s~pp!2)
'Rule24'ErbB1(N!1,bp!2),ErbB3(C!1,Y1178~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1178~p),A(s~pp!2)
'Rule25'ErbB1(N!1,bp!2),ErbB3(C!1,Y1203~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1203~p),A(s~pp!2)
'Rule26'ErbB1(N!1,bp!2),ErbB3(C!1,Y1241~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1241~p),A(s~pp!2)
'Rule27'ErbB1(N!1,bp!2),ErbB3(C!1,Y1257~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1257~p),A(s~pp!2)
'Rule28'ErbB1(N!1,bp!2),ErbB3(C!1,Y1270~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1270~p),A(s~pp!2)
'Rule29'ErbB1(N!1,bp!2),ErbB3(C!1,Y1309~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1309~p),A(s~pp!2)
'Rule30'ErbB2(N!1,bp!2),ErbB3(C!1,Y1035~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1035~p),A(s~pp!2)
'Rule31'ErbB2(N!1,bp!2),ErbB3(C!1,Y1178~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1178~p),A(s~pp!2)
'Rule32'ErbB2(N!1,bp!2),ErbB3(C!1,Y1203~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1203~p),A(s~pp!2)
'Rule33'ErbB2(N!1,bp!2),ErbB3(C!1,Y1241~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1241~p),A(s~pp!2)
'Rule34'ErbB2(N!1,bp!2),ErbB3(C!1,Y1257~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1257~p),A(s~pp!2)
'Rule35'ErbB2(N!1,bp!2),ErbB3(C!1,Y1270~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1270~p),A(s~pp!2)
'Rule36'ErbB2(N!1,bp!2),ErbB3(C!1,Y1309~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1309~p),A(s~pp!2)
'Rule37'ErbB1(CR!1,N,C),ErbB4(CR!1,N,C) <-> ErbB1(CR!1,N!2,C),ErbB4(CR!1,N,C!2)
'Rule38'ErbB2(CR!1,N,C),ErbB4(CR!1,N,C) <-> ErbB2(CR!1,N!2,C),ErbB4(CR!1,N,C!2)
'Rule39'ErbB1(N!1,bp!2),ErbB4(C!1,Y1056~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB4(C!1,Y1056~p),A(s~pp!2)
'Rule40'ErbB1(N!1,bp!2),ErbB4(C!1,Y1188~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB4(C!1,Y1188~p),A(s~pp!2)
'Rule41'ErbB1(N!1,bp!2),ErbB4(C!1,Y1242~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB4(C!1,Y1242~p),A(s~pp!2)
'Rule42'ErbB2(N!1,bp!2),ErbB4(C!1,Y1056~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB4(C!1,Y1056~p),A(s~pp!2)
'Rule43'ErbB2(N!1,bp!2),ErbB4(C!1,Y1188~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB4(C!1,Y1188~p),A(s~pp!2)
'Rule44'ErbB2(N!1,bp!2),ErbB4(C!1,Y1242~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB4(C!1,Y1242~p),A(s~pp!2)
'Rule45'ErbB1(Y992~p) -> ErbB1(Y992~u),Pi()
'Rule46'ErbB1(Y1068~p) -> ErbB1(Y1068~u),Pi()
'Rule47'ErbB1(Y1148~p) -> ErbB1(Y1148~u),Pi()
'Rule48'ErbB2(Y1139~p) -> ErbB2(Y1139~u),Pi()
'Rule49'ErbB2(Y1196~p) -> ErbB2(Y1196~u),Pi()
'Rule50'ErbB2(Y1221~p) -> ErbB2(Y1221~u),Pi()
'ErbB1_RasGAP'ErbB1(Y992~p),RasGAP(SH2) <-> ErbB1(Y992~p!1),RasGAP(SH2!1)
'ErbB2_RasGAP'ErbB2(Y1221~p),RasGAP(SH2) <-> ErbB2(Y1221~p!1),RasGAP(SH2!1)
'ErbB1_Grb2'ErbB1(Y1068~p),Grb2(SH2) <-> ErbB1(Y1068~p!1),Grb2(SH2!1)
'ErbB2_Grb2'ErbB2(Y1139~p),Grb2(SH2) <-> ErbB2(Y1139~p!1),Grb2(SH2!1)
'ErbB1_Shc'ErbB1(Y1148~p),Shc(PTB) <-> ErbB1(Y1148~p!1),Shc(PTB!1)
'ErbB2_Shc#1'ErbB2(Y1196~p),Shc(PTB) <-> ErbB2(Y1196~p!1),Shc(PTB!1)
'ErbB2_Shc#2'ErbB2(Y1221~p),Shc(PTB) <-> ErbB2(Y1221~p!1),Shc(PTB!1)
'Shc#1'ErbB1(Y1148~p!1),Shc(PTB!1,Y318~u) -> ErbB1(Y1148~p!1),Shc(PTB!1,Y318~p)
'Shc#2'ErbB2(Y1196~p!1),Shc(PTB!1,Y318~u) -> ErbB2(Y1196~p!1),Shc(PTB!1,Y318~p)
'Shc#3'ErbB2(Y1221~p!1),Shc(PTB!1,Y318~u) -> ErbB2(Y1221~p!1),Shc(PTB!1,Y318~p)
'long arm SoS_Ras#1'ErbB1(Y1148~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b),Ras(S1S2~gdp) -> ErbB1(Y1148~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b!4),Ras(S1S2~gdp!4)
'long arm SoS_Ras#2'ErbB2(Y1196~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b),Ras(S1S2~gdp) -> ErbB2(Y1196~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b!4),Ras(S1S2~gdp!4)
'long arm SoS_Ras#3'ErbB2(Y1221~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b),Ras(S1S2~gdp) -> ErbB2(Y1221~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b!4),Ras(S1S2~gdp!4)
'short arm SoS_Ras#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)
'short arm SoS_Ras#2'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)
'direct RasGAP_Ras#1'ErbB1(Y992~p!1),RasGAP(SH2!1,s),Ras(S1S2~gtp) -> ErbB1(Y992~p!1),RasGAP(SH2!1,s!2),Ras(S1S2~gtp!2)
'direct RasGAP_Ras#2'ErbB2(Y1221~p!1),RasGAP(SH2!1,s),Ras(S1S2~gtp) -> ErbB2(Y1221~p!1),RasGAP(SH2!1,s!2),Ras(S1S2~gtp!2)
'Gab1@447#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p)
'Gab1@472#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p)
'Gab1@619#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p)
'Gab1@447#2'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p)
'Gab1@472#2'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p)
'Gab1@619#2'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p)
'short arm PI3K_PI#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
'short arm PI3K_PI#2'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
'short arm PI3K_PI#3'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
'short arm PI3K_PI#4'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
'short arm PI3K_PI#5'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
'short arm PI3K_PI#6'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
'ATP recycling'A(s~pp),Pi() -> A(s~ppp)
'HRG_ErbB3'HRG(r~ext),ErbB3(L~ext,CR) <-> HRG(r~ext!1),ErbB3(L~ext!1,CR)
'HRG_ErbB4'HRG(r~ext),ErbB4(L~ext,CR) <-> HRG(r~ext!1),ErbB4(L~ext!1,CR)
'ErbB4_ATP'ErbB4(bp),A(s~ppp) -> ErbB4(bp!1),A(s~ppp!1)
'ErbB4_A_op'ErbB4(bp!1),A(s!1) -> ErbB4(bp),A(s)
'Rule51'ErbB3(Y1035~p) -> ErbB3(Y1035~u),Pi()
'Rule52'ErbB3(Y1178~p) -> ErbB3(Y1178~u),Pi()
'Rule53'ErbB3(Y1203~p) -> ErbB3(Y1203~u),Pi()
'Rule54'ErbB3(Y1241~p) -> ErbB3(Y1241~u),Pi()
'Rule55'ErbB3(Y1257~p) -> ErbB3(Y1257~u),Pi()
'Rule56'ErbB3(Y1270~p) -> ErbB3(Y1270~u),Pi()
'Rule57'ErbB3(Y1309~p) -> ErbB3(Y1309~u),Pi()
'Rule58'ErbB4(Y1056~p) -> ErbB4(Y1056~u),Pi()
'Rule59'ErbB4(Y1188~p) -> ErbB4(Y1188~u),Pi()
'Rule60'ErbB4(Y1242~p) -> ErbB4(Y1242~u),Pi()
'ErbB3_Shc'ErbB3(Y1309~p),Shc(PTB) <-> ErbB3(Y1309~p!1),Shc(PTB!1)
'Shc#4'ErbB3(Y1309~p!1),Shc(PTB!1,Y318~u) -> ErbB3(Y1309~p!1),Shc(PTB!1,Y318~p)
'Shc_op'Shc(Y318~p) -> Shc(Y318~u),Pi()
'Shc_Grb2'Shc(Y318~p),Grb2(SH2) <-> Shc(Y318~p!1),Grb2(SH2!1)
'Grb2_SoS'Grb2(SH3),SoS(a,SS~u) -> Grb2(SH3!1),SoS(a!1,SS~u)
'Grb2_SoS_op'Grb2(SH3!1),SoS(a!1) -> Grb2(SH3),SoS(a)
'long arm SoS_Ras#4'ErbB3(Y1309~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b),Ras(S1S2~gdp) -> ErbB3(Y1309~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b!4),Ras(S1S2~gdp!4)
'Ras GTP'SoS(b!1),Ras(S1S2~gdp!1) -> SoS(b!1),Ras(S1S2~gtp!1)
'SoS_Ras_op'SoS(b!1),Ras(S1S2!1) -> SoS(b),Ras(S1S2)
'Ras GDP'RasGAP(s!1),Ras(S1S2~gtp!1) -> RasGAP(s!1),Ras(S1S2~gdp!1)
'RasGAP_Ras_op'RasGAP(s!1),Ras(S1S2!1) -> RasGAP(s),Ras(S1S2)
'Grb2_Gab1'Grb2(SH3c),Gab1(PR) <-> Grb2(SH3c!1),Gab1(PR!1)
'Gab1_PI3K@447'Gab1(Y447~p),PI3K(SH2) <-> Gab1(Y447~p!1),PI3K(SH2!1)
'Gab1_PI3K@472'Gab1(Y472~p),PI3K(SH2) <-> Gab1(Y472~p!1),PI3K(SH2!1)
'Gab1_PI3K@619'Gab1(Y619~p),PI3K(SH2) <-> Gab1(Y619~p!1),PI3K(SH2!1)
'Gab1_Shp2@447'Gab1(Y447~p),Shp2(s) -> Gab1(Y447~p!1),Shp2(s!1)
'Gab1_Shp2@472'Gab1(Y472~p),Shp2(s) -> Gab1(Y472~p!1),Shp2(s!1)
'Gab1_Shp2@619'Gab1(Y619~p),Shp2(s) -> Gab1(Y619~p!1),Shp2(s!1)
'Gab1@447_op'Gab1(Y447~p!1),Shp2(s!1) -> Gab1(Y447~u!1),Shp2(s!1),Pi()
'Gab1@472_op'Gab1(Y472~p!1),Shp2(s!1) -> Gab1(Y472~u!1),Shp2(s!1),Pi()
'Gab1@619_op'Gab1(Y619~p!1),Shp2(s!1) -> Gab1(Y619~u!1),Shp2(s!1),Pi()
'Gab1_Shp2@447_op'Gab1(Y447!1),Shp2(s!1) -> Gab1(Y447),Shp2(s)
'Gab1_Shp2@472_op'Gab1(Y472!1),Shp2(s!1) -> Gab1(Y472),Shp2(s)
'Gab1_Shp2@619_op'Gab1(Y619!1),Shp2(s!1) -> Gab1(Y619),Shp2(s)
'ErbB3_PI3K#1'ErbB3(Y1035~p),PI3K(SH2) <-> ErbB3(Y1035~p!1),PI3K(SH2!1)
'ErbB3_PI3K#2'ErbB3(Y1178~p),PI3K(SH2) <-> ErbB3(Y1178~p!1),PI3K(SH2!1)
'ErbB3_PI3K#3'ErbB3(Y1203~p),PI3K(SH2) <-> ErbB3(Y1203~p!1),PI3K(SH2!1)
'ErbB3_PI3K#4'ErbB3(Y1241~p),PI3K(SH2) <-> ErbB3(Y1241~p!1),PI3K(SH2!1)
'ErbB3_PI3K#5'ErbB3(Y1257~p),PI3K(SH2) <-> ErbB3(Y1257~p!1),PI3K(SH2!1)
'ErbB3_PI3K#6'ErbB3(Y1270~p),PI3K(SH2) <-> ErbB3(Y1270~p!1),PI3K(SH2!1)
'direct PI3K_PI#1'ErbB3(Y1035~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1035~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
'direct PI3K_PI#2'ErbB3(Y1178~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1178~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
'direct PI3K_PI#3'ErbB3(Y1203~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1203~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
'direct PI3K_PI#4'ErbB3(Y1241~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1241~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
'direct PI3K_PI#5'ErbB3(Y1257~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1257~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
'direct PI3K_PI#6'ErbB3(Y1270~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1270~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
'PI@three'PI3K(s!1),PI(three~u!1) -> PI3K(s!1),PI(three~p!1)
'PI3K_PI_op'PI3K(s!1),PI(three!1) -> PI3K(s),PI(three)
'PTEN_PI'PTEN(s),PI(three~p) -> PTEN(s!1),PI(three~p!1)
'PI@three_op'PTEN(s!1),PI(three~p!1) -> PTEN(s!1),PI(three~u!1)
'PTEN_PI_op'PTEN(s!1),PI(three!1) -> PTEN(s),PI(three)
'PIP3_PDK1'PI(three~p,four~p,five~p),PDK1(PH) -> PI(three~p!1,four~p,five~p),PDK1(PH!1)
'PIP3_PDK1_op'PI(three!1),PDK1(PH!1) -> PI(three),PDK1(PH)
'PIP3_Akt'PI(three~p,four~p,five~p),Akt(PH) -> PI(three~p!1,four~p,five~p),Akt(PH!1)
'PIP3_Akt_op'PI(three!1),Akt(PH!1) -> PI(three),Akt(PH)
'Ras_Raf'Ras(S1S2~gtp),Raf(x~u) -> Ras(S1S2~gtp!1),Raf(x~u!1)
'Raf'Ras(S1S2~gtp!1),Raf(x~u!1) -> Ras(S1S2~gtp!1),Raf(x~p!1)
'Ras_Raf_op'Ras(S1S2~gtp!1),Raf(x!1) -> Ras(S1S2~gtp),Raf(x)
'SoS_ERK'SoS(SS),ERK(s,T185~p,Y187~p) <-> SoS(SS!1),ERK(s!1,T185~p,Y187~p)
'SoS@SS'SoS(SS~u!1),ERK(s!1,T185~p,Y187~p) -> SoS(SS~p!1),ERK(s!1,T185~p,Y187~p)
'SoS@SS_op'SoS(SS~p) -> SoS(SS~u),Pi()
'Rule61'E() -> EGF(r~ext)
'EGF_EGFRe'EGF(r~ext),EGFR(L~ext,CR) -> EGF(r~ext!1),EGFR(L~ext!1,CR)
'EGF_EGFRi'EGF(r~int),EGFR(L~int,CR) -> EGF(r~int!1),EGFR(L~int!1,CR)
'EGF_EGFR_op'EGF(r!1),EGFR(L!1) -> EGF(r),EGFR(L)
'EGF_mono'EGF(r~ext!1),EGFR(L~ext!1,CR) -> EGF(r~int!1),EGFR(L~int!1,CR)
'EGF_di'EGF(r~ext!1),EGFR(L~ext!1,CR!2),EGF(r~ext!3),EGFR(L~ext!3,CR!2) -> EGF(r~int!1),EGFR(L~int!1,CR!2),EGF(r~int!3),EGFR(L~int!3,CR!2)
'deg_EGF'EGF(r~int) ->
'EGFR_RasGAP'EGFR(Y1016~p),RasGAP(SH2~u) <-> EGFR(Y1016~p!1),RasGAP(SH2~rec!1)
'EGFR_Grb2'EGFR(Y1092~p),Grb2(SH2~u) <-> EGFR(Y1092~p!1),Grb2(SH2~rec!1)
'EGFR_Shc'EGFR(Y1172~p),Shc(PTB~u) <-> EGFR(Y1172~p!1),Shc(PTB~rec!1)
'HER2_Grb2'HER2(Y1139~p),Grb2(SH2~u) <-> HER2(Y1139~p!1),Grb2(SH2~rec!1)
'HER2_Shc#1'HER2(Y1196~p),Shc(PTB~u) <-> HER2(Y1196~p!1),Shc(PTB~rec!1)
'HER2_RasGAP'HER2(Y1221~p),RasGAP(SH2~u) <-> HER2(Y1221~p!1),RasGAP(SH2~rec!1)
'HER2_Shc#2'HER2(Y1221~p),Shc(PTB~u) <-> HER2(Y1221~p!1),Shc(PTB~rec!1)
'HER3_PI3K#1'HER3(Y1035~p),PI3K(SH2~u) <-> HER3(Y1035~p!1),PI3K(SH2~rec!1)
'HER3_PI3K#2'HER3(Y1178~p),PI3K(SH2~u) <-> HER3(Y1178~p!1),PI3K(SH2~rec!1)
'HER3_PI3K#3'HER3(Y1203~p),PI3K(SH2~u) <-> HER3(Y1203~p!1),PI3K(SH2~rec!1)
'HER3_PI3K#4'HER3(Y1241~p),PI3K(SH2~u) <-> HER3(Y1241~p!1),PI3K(SH2~rec!1)
'HER3_PI3K#5'HER3(Y1257~p),PI3K(SH2~u) <-> HER3(Y1257~p!1),PI3K(SH2~rec!1)
'HER3_PI3K#6'HER3(Y1270~p),PI3K(SH2~u) <-> HER3(Y1270~p!1),PI3K(SH2~rec!1)
'HER3_Shc'HER3(Y1309~p),Shc(PTB~u) <-> HER3(Y1309~p!1),Shc(PTB~rec!1)
'HER4_RasGAP'HER4(Y1~p),RasGAP(SH2~u) <-> HER4(Y1~p!1),RasGAP(SH2~rec!1)
'HER4_Grb2'HER4(Y2~p),Grb2(SH2~u) <-> HER4(Y2~p!1),Grb2(SH2~rec!1)
'HER4_Shc'HER4(Y3~p),Shc(PTB~u) <-> HER4(Y3~p!1),Shc(PTB~rec!1)
'Shc@Y'Shc(PTB~rec!_,Y~u) -> Shc(PTB~rec!_,Y~p)
'Gab1@48'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y48~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y48~p)
'Gab1@317'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y317~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y317~p)
'Gab1@447'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447~p)
'Gab1@472'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472~p)
'Gab1@619'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619~p)
'Gab1@657'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y657~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y657~p)
'Gab1@689'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y689~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y689~p)
'Gab1@48_op'Gab1(Y48~p) -> Gab1(Y48~u)
'Gab1@317_op'Gab1(Y317~p) -> Gab1(Y317~u)
'Gab1@657_op'Gab1(Y657~p) -> Gab1(Y657~u)
'Gab1@689_op'Gab1(Y689~p) -> Gab1(Y689~u)
'Gab1_Grb2'Gab1(Y48~p),Grb2(SH2) <-> Gab1(Y48~p!1),Grb2(SH2!1)
'Gab1_RasGAP'Gab1(Y317~p),RasGAP(SH2) <-> Gab1(Y317~p!1),RasGAP(SH2!1)
'Gab1_PI3K@447_op'Gab1(Y447!1),PI3K(SH2!1) -> Gab1(Y447),PI3K(SH2)
'Gab1_PI3K@472_op'Gab1(Y472!1),PI3K(SH2!1) -> Gab1(Y472),PI3K(SH2)
'Gab1_PI3K@619_op'Gab1(Y619!1),PI3K(SH2!1) -> Gab1(Y619),PI3K(SH2)
'Gab1_Shp2#1'Gab1(Y689~p),Shp2(SH2c) -> Gab1(Y689~p!1),Shp2(SH2c!1)
'Gab1_Shp2#2'Gab1(Y657~p,Y689!1),Shp2(SH2n,SH2c!1) -> Gab1(Y657~p!2,Y689!1),Shp2(SH2n!2,SH2c!1)
'Gab1_Shp2_op#1'Gab1(Y657!1),Shp2(SH2n!1) -> Gab1(Y657),Shp2(SH2n)
'Gab1_Shp2_op#2'Gab1(Y689!1),Shp2(SH2c!1) -> Gab1(Y689),Shp2(SH2c)
'Rule62'Gab1(Y317~p,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2) -> Gab1(Y317~u,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2)
'Rule63'Gab1(Y447~p,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2) -> Gab1(Y447~u,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2)
'Rule64'Gab1(Y472~p,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2) -> Gab1(Y472~u,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2)
'Rule65'Gab1(Y619~p,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2) -> Gab1(Y619~u,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2)
'PI3K@s Rec'PI3K(SH2~rec!_,s~u) -> PI3K(SH2~rec!_,s~p)
'PI3K@s Gab#1'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,s~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,s~p)
'PI3K@s Gab#2'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,s~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,s~p)
'PI3K@s Gab#3'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,s~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,s~p)
'PI3K@s_op'PI3K(s~p) -> PI3K(s~u)
'SoS short arm'Grb2(SH2~rec!_,SH3n!1),SoS(PR!1,GEF),Ras(s~gdp) -> Grb2(SH2~rec!_,SH3n!1),SoS(PR!1,GEF!2),Ras(s~gdp!2)
'SoS long arm'Shc(PTB~rec!_,Y!1),Grb2(SH2!1,SH3n!2),SoS(PR!2,GEF),Ras(s~gdp) -> Shc(PTB~rec!_,Y!1),Grb2(SH2!1,SH3n!2),SoS(PR!2,GEF!3),Ras(s~gdp!3)
'SoS vlong arm'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y48!2),Grb2(SH2!2,SH3n!3),SoS(PR!3,GEF),Ras(s~gdp) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y48!2),Grb2(SH2!2,SH3n!3),SoS(PR!3,GEF!4),Ras(s~gdp!4)
'RasGAP no arm'RasGAP(SH2~rec!_,GAP),Ras(s~gtp) -> RasGAP(SH2~rec!_,GAP!1),Ras(s~gtp!1)
'RasGAP long arm'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y317!2),RasGAP(SH2!2,GAP),Ras(s~gtp) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y317!2),RasGAP(SH2!2,GAP!3),Ras(s~gtp!3)
'PI3K no arm'PI3K(SH2~rec!_,s~p),PI(three~u) -> PI3K(SH2~rec!_,s~p!1),PI(three~u!1)
'PI3K long arm #1'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,s~p),PI(three~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,s~p!3),PI(three~u!3)
'PI3K long arm #2'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,s~p),PI(three~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,s~p!3),PI(three~u!3)
'PI3K long arm #3'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,s~p),PI(three~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,s~p!3),PI(three~u!3)
'intrinsic GDP'Ras(s~gtp) -> Ras(s~gdp)
'PI@five'PI(five~u) -> PI(five~p)
'PI@five_op'SHIP(s!1),PI(five~p!1) -> SHIP(s!1),PI(five~u!1)
'Ras_PI3K no arm'Ras(s~gtp),PI3K(SH2~rec!_,RBD,s~u) -> Ras(s~gtp!1),PI3K(SH2~rec!_,RBD!1,s~u)
'Ras_PI3K long arm #1'Ras(s~gtp),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,RBD,s~u) -> Ras(s~gtp!3),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,RBD!3,s~u)
'Ras_PI3K long arm #2'Ras(s~gtp),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,RBD,s~u) -> Ras(s~gtp!3),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,RBD!3,s~u)
'Ras_PI3K long arm #3'Ras(s~gtp),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,RBD,s~u) -> Ras(s~gtp!3),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,RBD!3,s~u)
'Ras_PI3K_op'Ras(s!1),PI3K(RBD!1) -> Ras(s),PI3K(RBD)
'PIP3_Gab1'PI(three~p,four~p,five~p),Grb2(SH2~rec!_,SH3c!1),Gab1(PH,PR!1) -> PI(three~p!2,four~p,five~p),Grb2(SH2~rec!_,SH3c!1),Gab1(PH!2,PR!1)
'PIP3_Gab1_op'PI(three!1),Gab1(PH!1) -> PI(three),Gab1(PH)
'PI3K@s Ras'PI3K(RBD!_,s~u) -> PI3K(RBD!_,s~p)
'RasGAP Gab arm'Gab1(PH!_,Y317~p!1),RasGAP(SH2!1,GAP),Ras(s~gtp) -> Gab1(PH!_,Y317~p!1),RasGAP(SH2!1,GAP!2),Ras(s~gtp!2)
'SoS Gab arm #1'Gab1(PH!_,Y48~p!1),Grb2(SH2!1,SH3n!2),SoS(PR!2,GEF),Ras(s~gdp) -> Gab1(PH!_,Y48~p!1),Grb2(SH2!1,SH3n!2),SoS(PR!2,GEF!3),Ras(s~gdp!3)
'SoS Gab arm #2'Gab1(PH!_,PR!1),Grb2(SH3c!1,SH3n!2),SoS(PR!2,GEF),Ras(s~gdp) -> Gab1(PH!_,PR!1),Grb2(SH3c!1,SH3n!2),SoS(PR!2,GEF!3),Ras(s~gdp!3)
'PI3K Ras arm'PI3K(RBD!_,s~p),PI(three~u) -> PI3K(RBD!_,s~p!1),PI(three~u!1)
'PI3K Gab arm #1'Gab1(PH!_,Y447!1),PI3K(SH2!1,s~p),PI(three~u) -> Gab1(PH!_,Y447!1),PI3K(SH2!1,s~p!2),PI(three~u!2)
'PI3K Gab arm #2'Gab1(PH!_,Y472!1),PI3K(SH2!1,s~p),PI(three~u) -> Gab1(PH!_,Y472!1),PI3K(SH2!1,s~p!2),PI(three~u!2)
'PI3K Gab arm #3'Gab1(PH!_,Y619!1),PI3K(SH2!1,s~p),PI(three~u) -> Gab1(PH!_,Y619!1),PI3K(SH2!1,s~p!2),PI(three~u!2)
'ERK_SoS'ERK(s,T~p,Y~p),SoS(S~u) -> ERK(s!1,T~p,Y~p),SoS(S~u!1)
'ERK_SoS_op'ERK(s!1),SoS(S!1) -> ERK(s),SoS(S)
'ERK_Gab1#1'ERK(s,T~p,Y~p),Gab1(S454~u) -> ERK(s!1,T~p,Y~p),Gab1(S454~u!1)
'ERK_Gab1#2'ERK(s,T~p,Y~p),Gab1(T476~u) -> ERK(s!1,T~p,Y~p),Gab1(T476~u!1)
'ERK_Gab1#3'ERK(s,T~p,Y~p),Gab1(S597~u) -> ERK(s!1,T~p,Y~p),Gab1(S597~u!1)
'ERK_Gab1#1_op'ERK(s!1),Gab1(S454!1) -> ERK(s),Gab1(S454)
'ERK_Gab1#2_op'ERK(s!1),Gab1(T476!1) -> ERK(s),Gab1(T476)
'ERK_Gab1#3_op'ERK(s!1),Gab1(S597!1) -> ERK(s),Gab1(S597)
'SoS@S'ERK(s!1),SoS(S~u!1) -> ERK(s!1),SoS(S~p!1)
'SoS@S_op'SoS(S~p) -> SoS(S~u)
'Gab1@454'ERK(s!1),Gab1(S454~u!1) -> ERK(s!1),Gab1(S454~p!1)
'Gab1@476'ERK(s!1),Gab1(T476~u!1) -> ERK(s!1),Gab1(T476~p!1)
'Gab1@597'ERK(s!1),Gab1(S597~u!1) -> ERK(s!1),Gab1(S597~p!1)
'Gab1@454_op'Gab1(S454~p) -> Gab1(S454~u)
'Gab1@476_op'Gab1(T476~p) -> Gab1(T476~u)
'Gab1@597_op'Gab1(S597~p) -> Gab1(S597~u)
'EGFR_Grb2@Y1086_SH2'EGFR(Y1086~p),Grb2(SH2) -> EGFR(Y1086~p!1),Grb2(SH2!1)
'Shc_Src@SH2_S1'PI(four~p,Five~p!1),Shc(PTB!1,SH2),Src(S1) -> PI(four~p,Five~p!1),Shc(PTB!1,SH2!2),Src(S1!2)
'Shc_p@Y239'PI(four~p,Five~p!1),Shc(PTB!1,SH2,Y239~u),Src(S1) -> PI(four~p,Five~p!1),Shc(PTB!1,SH2!2,Y239~p),Src(S1!2)
'Shc_Src_op'PI(four~p,Five~p!1),Shc(PTB!1,SH2!2,Y239~p),Src(S1!2) -> PI(four~p,Five~p!1),Shc(PTB!1,SH2,Y239~p),Src(S1)
'Shc_p@Y240'PI(four~p,Five~p!1),Shc(PTB!1,SH2,Y240~u),Src(S1) -> PI(four~p,Five~p!1),Shc(PTB!1,SH2!2,Y240~p),Src(S1!2)
'EGFR_Shc@Y1173_PTB'Shc(PTB),EGFR(Y1173~p) -> Shc(PTB!1),EGFR(Y1173~p!1)
'EGFR_Shc@Y1173_SH2'Shc(SH2),EGFR(Y1173~p) -> Shc(SH2!1),EGFR(Y1173~p!1)
'EGFR_Shc@Y992_PTB'Shc(PTB),EGFR(Y992~p) -> Shc(PTB!1),EGFR(Y992~p!1)
'EGFR_Shc@Y992_SH2'Shc(SH2),EGFR(Y992~p) -> Shc(SH2!1),EGFR(Y992~p!1)
'Shc_EGFR@PTB_Y1148'EGFR(Y1148~p),Shc(PTB) <-> EGFR(Y1148~p!1),Shc(PTB!1)
'Shc_EGFR@SH2_Y1148'EGFR(Y1148~p),Shc(SH2) <-> EGFR(Y1148~p!1),Shc(SH2!1)
'Shc_EGFR@PTB_Y1173'EGFR(Y1173~p),Shc(PTB) <-> EGFR(Y1173~p!1),Shc(PTB!1)
'Shc_EGFR@SH2_Y1173'EGFR(Y1173~p),Shc(SH2) <-> EGFR(Y1173~p!1),Shc(SH2!1)
'Shc_p@Y317'EGFR(Y1148~p!1),Shc(PTB!1,Y317~u) -> EGFR(Y1148~p!1),Shc(PTB!1,Y317~p)
'EGFR_p@Y1086'EGFR(N!1,bp!2),EGFR(C!1,Y1086~u),A(s~ppp!2) -> EGFR(N!1,bp!2),EGFR(C!1,Y1086~p),A(s~pp!2)
'EGFR_p@Y1173'EGFR(N!1,bp!2),EGFR(C!1,Y1173~u),A(s~ppp!2) -> EGFR(N!1,bp!2),EGFR(C!1,Y1173~p),A(s~pp!2)
'EGFR_Shc@Y1068_SH2'EGFR(Y1068~p),Shc(SH2) <-> EGFR(Y1068~p!1),Shc(SH2!1)
'EGFR_Shc@Y1086_SH2'EGFR(Y1086~p),Shc(SH2) <-> EGFR(Y1086~p!1),Shc(SH2!1)
'EGFR_Gab1@S1_S1'Gab1(X~u),EGFR(S1) -> Gab1(X~u!1),EGFR(S1!1)
'Gab1_p@Y627'Gab1(Y627~u!1),EGFR(S1!1) -> Gab1(Y627~p!1),EGFR(S1!1)
'Gab1_EGFR_op'Gab1(Y627~p!1),EGFR(S1!1) -> Gab1(Y627~p),EGFR(S1)
'Gab1_p@Y659'Gab1(Y659~u!1),EGFR(S1!1) -> Gab1(Y659~p!1),EGFR(S1!1)
'Gab1_PIP3@PH'Gab1(PH),PI(three~p,four~p,five~p) -> Gab1(PH!1),PI(three~p,four~p,five~p!1)
'Gab1_SHP2@Y627_SH2n'Gab1(Y627~p),SHP2(SH2n) -> Gab1(Y627~p!1),SHP2(SH2n!1)
'Gab1_SHP2@Y659_SH2c'Gab1(Y659~p),SHP2(SH2c) -> Gab1(Y659~p!1),SHP2(SH2c!1)
'Gab1_u@Y659'Gab1(Y659~p!1),SHP2(SH2c!1) -> Gab1(Y659~u!1),SHP2(SH2c!1)
'Gab1_u@Y627'Gab1(Y627~p!1),SHP2(SH2c!1) -> Gab1(Y627~u!1),SHP2(SH2c!1)
'Gab1_PLCG1@Y307_SH2'Gab1(Y307~p),PLCG1(SH2) -> Gab1(Y307~p!1),PLCG1(SH2!1)
'Gab1_PLCG1@Y373_SH2'Gab1(Y373~p),PLCG1(SH2) -> Gab1(Y373~p!1),PLCG1(SH2!1)
'Gab1_PLCG1@Y407_SH2'Gab1(Y407~p),PLCG1(SH2) -> Gab1(Y407~p!1),PLCG1(SH2!1)
'Akt_PIP2@PH'Akt(PH),PI(three~p,four~p) -> Akt(PH!1),PI(three~p,four~p!1)
'Vav_PIP3@PH'PI(three~p,four~p,five~p),Vav(PH) <-> PI(three~p,four~p,five~p!1),Vav(PH!1)
'Vav_Rac@DH_X~u'PI(three~p,four~p,five~p!1),Vav(PH!1,DH,X~p),Rac(X~u) <-> PI(three~p,four~p,five~p!1),Vav(PH!1,DH!2,X~p),Rac(X~u!2)
'Rac_p@X'Rac(X~gdp!1),Vav(DH!1,PH!2,X~p),PI(three~p,four~p,five~p!2) -> Rac(X~gtp!1),Vav(DH!1,PH!2,X~p),PI(three~p,four~p,five~p!2)
'PIP3_Sos@PH'PI(three~p,four~p,five~p),Sos(PH) -> PI(three~p,four~p,five~p!1),Sos(PH!1)
'Sos_Rac@DH_X~u'PI(three~p,four~p,five~p!1),Sos(PH!1,DH,X~p),Rac(X~u) <-> PI(three~p,four~p,five~p!1),Sos(PH!1,DH!2,X~p),Rac(X~u!2)
'PIP2_PLD@PH'PI(four~p,five~p),PLD(PH) <-> PI(four~p,five~p!1),PLD(PH!1)
'Rom2_PI3K@PH_S1'Rom2(PH),PI3K(S1) <-> Rom2(PH!1),PI3K(S1!1)
'Grb2_EGFR@SH2_Y1068'Grb2(SH2),EGFR(Y1068~p) -> Grb2(SH2!1),EGFR(Y1068~p!1)
'Pak1_Grb2@SH3_SBM'Grb2(SH2!1,SH3),EGFR(Y1068~p!1),Pak1(SBM) -> Grb2(SH2!1,SH3!2),EGFR(Y1068~p!1),Pak1(SBM!2)
'Raf1_Ras@CR1_rafts'Raf1(Y341~p,CR1),Ras(rafts) -> Raf1(Y341~p,CR1!1),Ras(rafts!1)
'Raf1_p@S338'Raf1(Y341~p,CR1!1,S338~u),Ras(rafts!1) -> Raf1(Y341~p,CR1!1,S338~p),Ras(rafts!1)
'New Rule'A(x~u) <-> A(x~p)
'Rule66'A(x~p),B(x1) -> A(x~p!1),B(x1!1)
'Rule67'A(x!1),B(x1!1) -> A(x),B(x1)
'Rule68'A(x!1),B(x1!1,y1~u) -> A(x!1),B(x1!1,y1~p)
'Rule69'A(x~p),B(x2) -> A(x~p!1),B(x2!1)
'Rule70'A(x!1),B(x2!1) -> A(x),B(x2)
'Rule71'A(x!1),B(x2!1,y2~u) -> A(x!1),B(x2!1,y2~p)
'Rule72'ErbB2(CR!1,N,C),ErbB1(CR!1,N,C) <-> ErbB2(CR!1,N!2,C),ErbB1(CR!1,N,C!2)