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/test.data/contact_map/rules/~kappa019.test

http://github.com/kappamodeler/jkappa
Unknown | 384 lines | 384 code | 0 blank | 0 comment | 0 complexity | 4731fd8a972cbb9117569d2fc26b83ba MD5 | raw file
Possible License(s): LGPL-3.0, Apache-2.0
  1'ATP recycling'A(s~pp),Pi() -> A(s~ppp)
  2'EGF_ErbB1'EGF(r~ext),ErbB1(L~ext,CR) <-> EGF(r~ext!1),ErbB1(L~ext!1,CR)
  3'ErbB1_ErbB1'ErbB1(L~ext!_,CR,N,C),ErbB1(L~ext!_,CR,N,C) <-> ErbB1(L~ext!_,CR!1,N,C),ErbB1(L~ext!_,CR!1,N,C)
  4'ErbB1_ErbB2'ErbB1(L~ext!_,CR,N,C),ErbB2(L~ext,CR,N,C) <-> ErbB1(L~ext!_,CR!1,N,C),ErbB2(L~ext,CR!1,N,C)
  5'ErbB2_ErbB3'ErbB2(L~ext,CR,N,C),ErbB3(L~ext!_,CR,N,C) <-> ErbB2(L~ext,CR!1,N,C),ErbB3(L~ext!_,CR!1,N,C)
  6'ErbB2_ErbB4'ErbB2(L~ext,CR,N,C),ErbB4(L~ext!_,CR,N,C) <-> ErbB2(L~ext,CR!1,N,C),ErbB4(L~ext!_,CR!1,N,C)
  7'ErbB1_ErbB3'ErbB1(L~ext,CR,N,C),ErbB3(L~ext!_,CR,N,C) <-> ErbB1(L~ext,CR!1,N,C),ErbB3(L~ext!_,CR!1,N,C)
  8'ErbB1_ErbB4'ErbB1(L~ext,CR,N,C),ErbB4(L~ext!_,CR,N,C) <-> ErbB1(L~ext,CR!1,N,C),ErbB4(L~ext!_,CR!1,N,C)
  9'ErbB1_ATP'ErbB1(bp),A(s~ppp) -> ErbB1(bp!1),A(s~ppp!1)
 10'ErbB1_A_op'ErbB1(bp!1),A(s!1) -> ErbB1(bp),A(s)
 11'ErbB2_ATP'ErbB2(bp),A(s~ppp) -> ErbB2(bp!1),A(s~ppp!1)
 12'ErbB2_A_op'ErbB2(bp!1),A(s!1) -> ErbB2(bp),A(s)
 13'ErbB4_ATP'ErbB4(bp),A(s~ppp) -> ErbB4(bp!1),A(s~ppp!1)
 14'ErbB4_A_op'ErbB4(bp!1),A(s!1) -> ErbB4(bp),A(s)
 15'Rule1'ErbB1(CR!1,N,C),ErbB1(CR!1,N,C) <-> ErbB1(CR!1,N!2,C),ErbB1(CR!1,N,C!2)
 16'Rule2'ErbB2(CR!1,N,C),ErbB1(CR!1,N,C) <-> ErbB2(CR!1,N!2,C),ErbB1(CR!1,N,C!2)
 17'Rule3'ErbB4(CR!1,N,C),ErbB1(CR!1,N,C) <-> ErbB4(CR!1,N!2,C),ErbB1(CR!1,N,C!2)
 18'Rule4'ErbB1(N!1,bp!2),ErbB1(C!1,Y992~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB1(C!1,Y992~p),A(s~pp!2)
 19'Rule5'ErbB1(N!1,bp!2),ErbB1(C!1,Y1068~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB1(C!1,Y1068~p),A(s~pp!2)
 20'Rule6'ErbB1(N!1,bp!2),ErbB1(C!1,Y1148~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB1(C!1,Y1148~p),A(s~pp!2)
 21'Rule7'ErbB2(N!1,bp!2),ErbB1(C!1,Y992~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB1(C!1,Y992~p),A(s~pp!2)
 22'Rule8'ErbB2(N!1,bp!2),ErbB1(C!1,Y1068~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB1(C!1,Y1068~p),A(s~pp!2)
 23'Rule9'ErbB2(N!1,bp!2),ErbB1(C!1,Y1148~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB1(C!1,Y1148~p),A(s~pp!2)
 24'Rule10'ErbB4(N!1,bp!2),ErbB1(C!1,Y992~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB1(C!1,Y992~p),A(s~pp!2)
 25'Rule11'ErbB4(N!1,bp!2),ErbB1(C!1,Y1068~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB1(C!1,Y1068~p),A(s~pp!2)
 26'Rule12'ErbB4(N!1,bp!2),ErbB1(C!1,Y1148~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB1(C!1,Y1148~p),A(s~pp!2)
 27'Rule13'ErbB1(CR!1,N,C),ErbB2(CR!1,N,C) <-> ErbB1(CR!1,N!2,C),ErbB2(CR!1,N,C!2)
 28'Rule14'ErbB2(CR!1,N,C),ErbB2(CR!1,N,C) <-> ErbB2(CR!1,N!2,C),ErbB2(CR!1,N,C!2)
 29'Rule15'ErbB4(CR!1,N,C),ErbB2(CR!1,N,C) <-> ErbB4(CR!1,N!2,C),ErbB2(CR!1,N,C!2)
 30'Rule16'ErbB1(N!1,bp!2),ErbB2(C!1,Y1139~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB2(C!1,Y1139~p),A(s~pp!2)
 31'Rule17'ErbB1(N!1,bp!2),ErbB2(C!1,Y1196~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB2(C!1,Y1196~p),A(s~pp!2)
 32'Rule18'ErbB4(N!1,bp!2),ErbB2(C!1,Y1139~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB2(C!1,Y1139~p),A(s~pp!2)
 33'Rule19'ErbB4(N!1,bp!2),ErbB2(C!1,Y1196~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB2(C!1,Y1196~p),A(s~pp!2)
 34'Rule20'ErbB4(N!1,bp!2),ErbB2(C!1,Y1221~u),A(s~ppp!2) -> ErbB4(N!1,bp!2),ErbB2(C!1,Y1221~p),A(s~pp!2)
 35'Rule21'ErbB1(CR!1,N,C),ErbB3(CR!1,C,N) <-> ErbB1(CR!1,N!2,C),ErbB3(CR!1,C!2,N)
 36'Rule22'ErbB2(CR!1,N,C),ErbB3(CR!1,C,N) <-> ErbB2(CR!1,N!2,C),ErbB3(CR!1,C!2,N)
 37'Rule23'ErbB1(N!1,bp!2),ErbB3(C!1,Y1035~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1035~p),A(s~pp!2)
 38'Rule24'ErbB1(N!1,bp!2),ErbB3(C!1,Y1178~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1178~p),A(s~pp!2)
 39'Rule25'ErbB1(N!1,bp!2),ErbB3(C!1,Y1203~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1203~p),A(s~pp!2)
 40'Rule26'ErbB1(N!1,bp!2),ErbB3(C!1,Y1241~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1241~p),A(s~pp!2)
 41'Rule27'ErbB1(N!1,bp!2),ErbB3(C!1,Y1257~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1257~p),A(s~pp!2)
 42'Rule28'ErbB1(N!1,bp!2),ErbB3(C!1,Y1270~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1270~p),A(s~pp!2)
 43'Rule29'ErbB1(N!1,bp!2),ErbB3(C!1,Y1309~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB3(C!1,Y1309~p),A(s~pp!2)
 44'Rule30'ErbB2(N!1,bp!2),ErbB3(C!1,Y1035~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1035~p),A(s~pp!2)
 45'Rule31'ErbB2(N!1,bp!2),ErbB3(C!1,Y1178~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1178~p),A(s~pp!2)
 46'Rule32'ErbB2(N!1,bp!2),ErbB3(C!1,Y1203~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1203~p),A(s~pp!2)
 47'Rule33'ErbB2(N!1,bp!2),ErbB3(C!1,Y1241~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1241~p),A(s~pp!2)
 48'Rule34'ErbB2(N!1,bp!2),ErbB3(C!1,Y1257~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1257~p),A(s~pp!2)
 49'Rule35'ErbB2(N!1,bp!2),ErbB3(C!1,Y1270~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1270~p),A(s~pp!2)
 50'Rule36'ErbB2(N!1,bp!2),ErbB3(C!1,Y1309~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB3(C!1,Y1309~p),A(s~pp!2)
 51'Rule37'ErbB1(CR!1,N,C),ErbB4(CR!1,N,C) <-> ErbB1(CR!1,N!2,C),ErbB4(CR!1,N,C!2)
 52'Rule38'ErbB2(CR!1,N,C),ErbB4(CR!1,N,C) <-> ErbB2(CR!1,N!2,C),ErbB4(CR!1,N,C!2)
 53'Rule39'ErbB1(N!1,bp!2),ErbB4(C!1,Y1056~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB4(C!1,Y1056~p),A(s~pp!2)
 54'Rule40'ErbB1(N!1,bp!2),ErbB4(C!1,Y1188~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB4(C!1,Y1188~p),A(s~pp!2)
 55'Rule41'ErbB1(N!1,bp!2),ErbB4(C!1,Y1242~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB4(C!1,Y1242~p),A(s~pp!2)
 56'Rule42'ErbB2(N!1,bp!2),ErbB4(C!1,Y1056~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB4(C!1,Y1056~p),A(s~pp!2)
 57'Rule43'ErbB2(N!1,bp!2),ErbB4(C!1,Y1188~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB4(C!1,Y1188~p),A(s~pp!2)
 58'Rule44'ErbB2(N!1,bp!2),ErbB4(C!1,Y1242~u),A(s~ppp!2) -> ErbB2(N!1,bp!2),ErbB4(C!1,Y1242~p),A(s~pp!2)
 59'Rule45'ErbB1(Y992~p) -> ErbB1(Y992~u),Pi()
 60'Rule46'ErbB1(Y1068~p) -> ErbB1(Y1068~u),Pi()
 61'Rule47'ErbB1(Y1148~p) -> ErbB1(Y1148~u),Pi()
 62'Rule48'ErbB2(Y1139~p) -> ErbB2(Y1139~u),Pi()
 63'Rule49'ErbB2(Y1196~p) -> ErbB2(Y1196~u),Pi()
 64'Rule50'ErbB2(Y1221~p) -> ErbB2(Y1221~u),Pi()
 65'ErbB1_RasGAP'ErbB1(Y992~p),RasGAP(SH2) <-> ErbB1(Y992~p!1),RasGAP(SH2!1)
 66'ErbB2_RasGAP'ErbB2(Y1221~p),RasGAP(SH2) <-> ErbB2(Y1221~p!1),RasGAP(SH2!1)
 67'ErbB1_Grb2'ErbB1(Y1068~p),Grb2(SH2) <-> ErbB1(Y1068~p!1),Grb2(SH2!1)
 68'ErbB2_Grb2'ErbB2(Y1139~p),Grb2(SH2) <-> ErbB2(Y1139~p!1),Grb2(SH2!1)
 69'ErbB1_Shc'ErbB1(Y1148~p),Shc(PTB) <-> ErbB1(Y1148~p!1),Shc(PTB!1)
 70'ErbB2_Shc#1'ErbB2(Y1196~p),Shc(PTB) <-> ErbB2(Y1196~p!1),Shc(PTB!1)
 71'ErbB2_Shc#2'ErbB2(Y1221~p),Shc(PTB) <-> ErbB2(Y1221~p!1),Shc(PTB!1)
 72'Shc#1'ErbB1(Y1148~p!1),Shc(PTB!1,Y318~u) -> ErbB1(Y1148~p!1),Shc(PTB!1,Y318~p)
 73'Shc#2'ErbB2(Y1196~p!1),Shc(PTB!1,Y318~u) -> ErbB2(Y1196~p!1),Shc(PTB!1,Y318~p)
 74'Shc#3'ErbB2(Y1221~p!1),Shc(PTB!1,Y318~u) -> ErbB2(Y1221~p!1),Shc(PTB!1,Y318~p)
 75'long arm SoS_Ras#1'ErbB1(Y1148~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b),Ras(S1S2~gdp) -> ErbB1(Y1148~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b!4),Ras(S1S2~gdp!4)
 76'long arm SoS_Ras#2'ErbB2(Y1196~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b),Ras(S1S2~gdp) -> ErbB2(Y1196~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b!4),Ras(S1S2~gdp!4)
 77'long arm SoS_Ras#3'ErbB2(Y1221~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b),Ras(S1S2~gdp) -> ErbB2(Y1221~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b!4),Ras(S1S2~gdp!4)
 78'short arm SoS_Ras#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)
 79'short arm SoS_Ras#2'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)
 80'direct RasGAP_Ras#1'ErbB1(Y992~p!1),RasGAP(SH2!1,s),Ras(S1S2~gtp) -> ErbB1(Y992~p!1),RasGAP(SH2!1,s!2),Ras(S1S2~gtp!2)
 81'direct RasGAP_Ras#2'ErbB2(Y1221~p!1),RasGAP(SH2!1,s),Ras(S1S2~gtp) -> ErbB2(Y1221~p!1),RasGAP(SH2!1,s!2),Ras(S1S2~gtp!2)
 82'Gab1@447#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p)
 83'Gab1@472#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p)
 84'Gab1@619#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p)
 85'Gab1@447#2'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p)
 86'Gab1@472#2'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p)
 87'Gab1@619#2'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p)
 88'short arm PI3K_PI#1'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
 89'short arm PI3K_PI#2'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
 90'short arm PI3K_PI#3'ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB1(Y1068~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
 91'short arm PI3K_PI#4'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y447~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
 92'short arm PI3K_PI#5'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y472~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
 93'short arm PI3K_PI#6'ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p!3),PI3K(SH2!3,s),PI(three~u) -> ErbB2(Y1139~p!1),Grb2(SH2!1,SH3c!2),Gab1(PR!2,Y619~p!3),PI3K(SH2!3,s!4),PI(three~u!4)
 94'EGFR_p@Y1086'EGFR(N!1,bp!2),EGFR(C!1,Y1086~u),A(s~ppp!2) -> EGFR(N!1,bp!2),EGFR(C!1,Y1086~p),A(s~pp!2)
 95'EGFR_p@Y1173'EGFR(N!1,bp!2),EGFR(C!1,Y1173~u),A(s~ppp!2) -> EGFR(N!1,bp!2),EGFR(C!1,Y1173~p),A(s~pp!2)
 96'New Rule'A(x~u) <-> A(x~p)
 97'Rule51'A(x~p),B(x1) -> A(x~p!1),B(x1!1)
 98'Rule52'A(x!1),B(x1!1) -> A(x),B(x1)
 99'Rule53'A(x!1),B(x1!1,y1~u) -> A(x!1),B(x1!1,y1~p)
100'Rule54'A(x~p),B(x2) -> A(x~p!1),B(x2!1)
101'Rule55'A(x!1),B(x2!1) -> A(x),B(x2)
102'Rule56'A(x!1),B(x2!1,y2~u) -> A(x!1),B(x2!1,y2~p)
103'HRG_ErbB3'HRG(r~ext),ErbB3(L~ext,CR) <-> HRG(r~ext!1),ErbB3(L~ext!1,CR)
104'HRG_ErbB4'HRG(r~ext),ErbB4(L~ext,CR) <-> HRG(r~ext!1),ErbB4(L~ext!1,CR)
105'Rule57'ErbB3(Y1035~p) -> ErbB3(Y1035~u),Pi()
106'Rule58'ErbB3(Y1178~p) -> ErbB3(Y1178~u),Pi()
107'Rule59'ErbB3(Y1203~p) -> ErbB3(Y1203~u),Pi()
108'Rule60'ErbB3(Y1241~p) -> ErbB3(Y1241~u),Pi()
109'Rule61'ErbB3(Y1257~p) -> ErbB3(Y1257~u),Pi()
110'Rule62'ErbB3(Y1270~p) -> ErbB3(Y1270~u),Pi()
111'Rule63'ErbB3(Y1309~p) -> ErbB3(Y1309~u),Pi()
112'Rule64'ErbB4(Y1056~p) -> ErbB4(Y1056~u),Pi()
113'Rule65'ErbB4(Y1188~p) -> ErbB4(Y1188~u),Pi()
114'Rule66'ErbB4(Y1242~p) -> ErbB4(Y1242~u),Pi()
115'ErbB3_Shc'ErbB3(Y1309~p),Shc(PTB) <-> ErbB3(Y1309~p!1),Shc(PTB!1)
116'Shc#4'ErbB3(Y1309~p!1),Shc(PTB!1,Y318~u) -> ErbB3(Y1309~p!1),Shc(PTB!1,Y318~p)
117'Shc_op'Shc(Y318~p) -> Shc(Y318~u),Pi()
118'Shc_Grb2'Shc(Y318~p),Grb2(SH2) <-> Shc(Y318~p!1),Grb2(SH2!1)
119'Grb2_SoS'Grb2(SH3),SoS(a,SS~u) -> Grb2(SH3!1),SoS(a!1,SS~u)
120'Grb2_SoS_op'Grb2(SH3!1),SoS(a!1) -> Grb2(SH3),SoS(a)
121'long arm SoS_Ras#4'ErbB3(Y1309~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b),Ras(S1S2~gdp) -> ErbB3(Y1309~p!1),Shc(PTB!1,Y318~p!2),Grb2(SH2!2,SH3n!3),SoS(a!3,b!4),Ras(S1S2~gdp!4)
122'Ras GTP'SoS(b!1),Ras(S1S2~gdp!1) -> SoS(b!1),Ras(S1S2~gtp!1)
123'SoS_Ras_op'SoS(b!1),Ras(S1S2!1) -> SoS(b),Ras(S1S2)
124'Ras GDP'RasGAP(s!1),Ras(S1S2~gtp!1) -> RasGAP(s!1),Ras(S1S2~gdp!1)
125'RasGAP_Ras_op'RasGAP(s!1),Ras(S1S2!1) -> RasGAP(s),Ras(S1S2)
126'Grb2_Gab1'Grb2(SH3c),Gab1(PR) <-> Grb2(SH3c!1),Gab1(PR!1)
127'Gab1_PI3K@447'Gab1(Y447~p),PI3K(SH2) <-> Gab1(Y447~p!1),PI3K(SH2!1)
128'Gab1_PI3K@472'Gab1(Y472~p),PI3K(SH2) <-> Gab1(Y472~p!1),PI3K(SH2!1)
129'Gab1_PI3K@619'Gab1(Y619~p),PI3K(SH2) <-> Gab1(Y619~p!1),PI3K(SH2!1)
130'Gab1_Shp2@447'Gab1(Y447~p),Shp2(s) -> Gab1(Y447~p!1),Shp2(s!1)
131'Gab1_Shp2@472'Gab1(Y472~p),Shp2(s) -> Gab1(Y472~p!1),Shp2(s!1)
132'Gab1_Shp2@619'Gab1(Y619~p),Shp2(s) -> Gab1(Y619~p!1),Shp2(s!1)
133'Gab1@447_op'Gab1(Y447~p!1),Shp2(s!1) -> Gab1(Y447~u!1),Shp2(s!1),Pi()
134'Gab1@472_op'Gab1(Y472~p!1),Shp2(s!1) -> Gab1(Y472~u!1),Shp2(s!1),Pi()
135'Gab1@619_op'Gab1(Y619~p!1),Shp2(s!1) -> Gab1(Y619~u!1),Shp2(s!1),Pi()
136'Gab1_Shp2@447_op'Gab1(Y447!1),Shp2(s!1) -> Gab1(Y447),Shp2(s)
137'Gab1_Shp2@472_op'Gab1(Y472!1),Shp2(s!1) -> Gab1(Y472),Shp2(s)
138'Gab1_Shp2@619_op'Gab1(Y619!1),Shp2(s!1) -> Gab1(Y619),Shp2(s)
139'ErbB3_PI3K#1'ErbB3(Y1035~p),PI3K(SH2) <-> ErbB3(Y1035~p!1),PI3K(SH2!1)
140'ErbB3_PI3K#2'ErbB3(Y1178~p),PI3K(SH2) <-> ErbB3(Y1178~p!1),PI3K(SH2!1)
141'ErbB3_PI3K#3'ErbB3(Y1203~p),PI3K(SH2) <-> ErbB3(Y1203~p!1),PI3K(SH2!1)
142'ErbB3_PI3K#4'ErbB3(Y1241~p),PI3K(SH2) <-> ErbB3(Y1241~p!1),PI3K(SH2!1)
143'ErbB3_PI3K#5'ErbB3(Y1257~p),PI3K(SH2) <-> ErbB3(Y1257~p!1),PI3K(SH2!1)
144'ErbB3_PI3K#6'ErbB3(Y1270~p),PI3K(SH2) <-> ErbB3(Y1270~p!1),PI3K(SH2!1)
145'direct PI3K_PI#1'ErbB3(Y1035~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1035~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
146'direct PI3K_PI#2'ErbB3(Y1178~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1178~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
147'direct PI3K_PI#3'ErbB3(Y1203~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1203~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
148'direct PI3K_PI#4'ErbB3(Y1241~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1241~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
149'direct PI3K_PI#5'ErbB3(Y1257~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1257~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
150'direct PI3K_PI#6'ErbB3(Y1270~p!1),PI3K(SH2!1,s),PI(three~u) -> ErbB3(Y1270~p!1),PI3K(SH2!1,s!2),PI(three~u!2)
151'PI@three'PI3K(s!1),PI(three~u!1) -> PI3K(s!1),PI(three~p!1)
152'PI3K_PI_op'PI3K(s!1),PI(three!1) -> PI3K(s),PI(three)
153'PTEN_PI'PTEN(s),PI(three~p) -> PTEN(s!1),PI(three~p!1)
154'PI@three_op'PTEN(s!1),PI(three~p!1) -> PTEN(s!1),PI(three~u!1)
155'PTEN_PI_op'PTEN(s!1),PI(three!1) -> PTEN(s),PI(three)
156'PIP3_PDK1'PI(three~p,four~p,five~p),PDK1(PH) -> PI(three~p!1,four~p,five~p),PDK1(PH!1)
157'PIP3_PDK1_op'PI(three!1),PDK1(PH!1) -> PI(three),PDK1(PH)
158'PIP3_Akt'PI(three~p,four~p,five~p),Akt(PH) -> PI(three~p!1,four~p,five~p),Akt(PH!1)
159'PIP3_Akt_op'PI(three!1),Akt(PH!1) -> PI(three),Akt(PH)
160'Ras_Raf'Ras(S1S2~gtp),Raf(x~u) -> Ras(S1S2~gtp!1),Raf(x~u!1)
161'Raf'Ras(S1S2~gtp!1),Raf(x~u!1) -> Ras(S1S2~gtp!1),Raf(x~p!1)
162'Ras_Raf_op'Ras(S1S2~gtp!1),Raf(x!1) -> Ras(S1S2~gtp),Raf(x)
163'SoS_ERK'SoS(SS),ERK(s,T185~p,Y187~p) <-> SoS(SS!1),ERK(s!1,T185~p,Y187~p)
164'SoS@SS'SoS(SS~u!1),ERK(s!1,T185~p,Y187~p) -> SoS(SS~p!1),ERK(s!1,T185~p,Y187~p)
165'SoS@SS_op'SoS(SS~p) -> SoS(SS~u),Pi()
166'Rule67'E() -> EGF(r~ext)
167'EGF_EGFRe'EGF(r~ext),EGFR(L~ext,CR) -> EGF(r~ext!1),EGFR(L~ext!1,CR)
168'EGF_EGFRi'EGF(r~int),EGFR(L~int,CR) -> EGF(r~int!1),EGFR(L~int!1,CR)
169'EGF_EGFR_op'EGF(r!1),EGFR(L!1) -> EGF(r),EGFR(L)
170'EGFR_EGFRe'EGFR(L~ext!_,CR,N,C),EGFR(L~ext!_,CR,N,C) -> EGFR(L~ext!_,CR!1,N,C),EGFR(L~ext!_,CR!1,N,C)
171'EGFR_EGFRi'EGFR(L~int!_,CR,N,C),EGFR(L~int!_,CR,N,C) -> EGFR(L~int!_,CR!1,N,C),EGFR(L~int!_,CR!1,N,C)
172'EGFR_HER2'EGFR(L~ext!_,CR,N,C),HER2(CR,N,C) -> EGFR(L~ext!_,CR!1,N,C),HER2(CR!1,N,C)
173'EGFR_HER3'EGFR(L~ext!_,CR,N,C),HER3(L~ext!_,CR,C) -> EGFR(L~ext!_,CR!1,N,C),HER3(L~ext!_,CR!1,C)
174'EGFR_HER4'EGFR(L~ext!_,CR,N,C),HER4(L~ext!_,CR,N,C) -> EGFR(L~ext!_,CR!1,N,C),HER4(L~ext!_,CR!1,N,C)
175'EGFR_EGFR_op'EGFR(CR!1,N,C),EGFR(CR!1,N,C) -> EGFR(CR,N,C),EGFR(CR,N,C)
176'EGFR_HER2_op'EGFR(CR!1,N,C),HER2(CR!1,N,C) -> EGFR(CR,N,C),HER2(CR,N,C)
177'EGFR_HER3_op'EGFR(CR!1,N,C),HER3(CR!1,C) -> EGFR(CR,N,C),HER3(CR,C)
178'EGFR_HER4_op'EGFR(CR!1,N,C),HER4(CR!1,N,C) -> EGFR(CR,N,C),HER4(CR,N,C)
179'11 dimer'EGFR(CR!1,N,C),EGFR(CR!1,N,C) <-> EGFR(CR!1,N!2,C),EGFR(CR!1,N,C!2)
180'21 dimer'HER2(CR!1,N,C),EGFR(CR!1,N,C) <-> HER2(CR!1,N!2,C),EGFR(CR!1,N,C!2)
181'41 dimer'HER4(CR!1,N,C),EGFR(CR!1,N,C) <-> HER4(CR!1,N!2,C),EGFR(CR!1,N,C!2)
182'12 dimer'EGFR(CR!1,N,C),HER2(CR!1,N,C) <-> EGFR(CR!1,N!2,C),HER2(CR!1,N,C!2)
183'13 dimer'EGFR(CR!1,N,C),HER3(CR!1,C) <-> EGFR(CR!1,N!2,C),HER3(CR!1,C!2)
184'14 dimer'EGFR(CR!1,N,C),HER4(CR!1,N,C) <-> EGFR(CR!1,N!2,C),HER4(CR!1,N,C!2)
185'EGFR_Inh'EGFR(N!_,bp),Inh1(s) -> EGFR(N!_,bp!1),Inh1(s!1)
186'EGFR_Inh_op'EGFR(bp!1),Inh1(s!1) -> EGFR(bp),Inh1(s)
187'EGF_mono'EGF(r~ext!1),EGFR(L~ext!1,CR) -> EGF(r~int!1),EGFR(L~int!1,CR)
188'EGF_di'EGF(r~ext!1),EGFR(L~ext!1,CR!2),EGF(r~ext!3),EGFR(L~ext!3,CR!2) -> EGF(r~int!1),EGFR(L~int!1,CR!2),EGF(r~int!3),EGFR(L~int!3,CR!2)
189'Rule68'EGFR(N!1,bp),EGFR(C!1,Y1016~u) -> EGFR(N!1,bp),EGFR(C!1,Y1016~p)
190'Rule69'HER2(N!1,bp),EGFR(C!1,Y1016~u) -> HER2(N!1,bp),EGFR(C!1,Y1016~p)
191'Rule70'HER4(N!1,bp),EGFR(C!1,Y1016~u) -> HER4(N!1,bp),EGFR(C!1,Y1016~p)
192'Rule71'EGFR(N!1,bp),EGFR(C!1,Y1092~u) -> EGFR(N!1,bp),EGFR(C!1,Y1092~p)
193'Rule72'HER2(N!1,bp),EGFR(C!1,Y1092~u) -> HER2(N!1,bp),EGFR(C!1,Y1092~p)
194'Rule73'HER4(N!1,bp),EGFR(C!1,Y1092~u) -> HER4(N!1,bp),EGFR(C!1,Y1092~p)
195'Rule74'EGFR(N!1,bp),EGFR(C!1,Y1172~u) -> EGFR(N!1,bp),EGFR(C!1,Y1172~p)
196'Rule75'HER2(N!1,bp),EGFR(C!1,Y1172~u) -> HER2(N!1,bp),EGFR(C!1,Y1172~p)
197'Rule76'HER4(N!1,bp),EGFR(C!1,Y1172~u) -> HER4(N!1,bp),EGFR(C!1,Y1172~p)
198'Rule77'EGFR(N!1,bp),HER2(C!1,Y1139~u) -> EGFR(N!1,bp),HER2(C!1,Y1139~p)
199'Rule78'EGFR(N!1,bp),HER2(C!1,Y1196~u) -> EGFR(N!1,bp),HER2(C!1,Y1196~p)
200'Rule79'EGFR(N!1,bp),HER2(C!1,Y1221~u) -> EGFR(N!1,bp),HER2(C!1,Y1221~p)
201'Rule80'EGFR(N!1,bp),HER3(C!1,Y1035~u) -> EGFR(N!1,bp),HER3(C!1,Y1035~p)
202'Rule81'EGFR(N!1,bp),HER3(C!1,Y1178~u) -> EGFR(N!1,bp),HER3(C!1,Y1178~p)
203'Rule82'EGFR(N!1,bp),HER3(C!1,Y1203~u) -> EGFR(N!1,bp),HER3(C!1,Y1203~p)
204'Rule83'EGFR(N!1,bp),HER3(C!1,Y1241~u) -> EGFR(N!1,bp),HER3(C!1,Y1241~p)
205'Rule84'EGFR(N!1,bp),HER3(C!1,Y1257~u) -> EGFR(N!1,bp),HER3(C!1,Y1257~p)
206'Rule85'EGFR(N!1,bp),HER3(C!1,Y1270~u) -> EGFR(N!1,bp),HER3(C!1,Y1270~p)
207'Rule86'EGFR(N!1,bp),HER3(C!1,Y1309~u) -> EGFR(N!1,bp),HER3(C!1,Y1309~p)
208'Rule87'EGFR(N!1,bp),HER4(C!1,Y1~u) -> EGFR(N!1,bp),HER4(C!1,Y1~p)
209'Rule88'EGFR(N!1,bp),HER4(C!1,Y2~u) -> EGFR(N!1,bp),HER4(C!1,Y2~p)
210'Rule89'EGFR(N!1,bp),HER4(C!1,Y3~u) -> EGFR(N!1,bp),HER4(C!1,Y3~p)
211'Rule90'EGFR(Y1016~p),PTP(s) -> EGFR(Y1016~p!1),PTP(s!1)
212'Rule91'EGFR(Y1092~p),PTP(s) -> EGFR(Y1092~p!1),PTP(s!1)
213'Rule92'EGFR(Y1172~p),PTP(s) -> EGFR(Y1172~p!1),PTP(s!1)
214'Rule93'EGFR(Y1016!1),PTP(s!1) -> EGFR(Y1016),PTP(s)
215'Rule94'EGFR(Y1092!1),PTP(s!1) -> EGFR(Y1092),PTP(s)
216'Rule95'EGFR(Y1172!1),PTP(s!1) -> EGFR(Y1172),PTP(s)
217'Rule96'EGFR(Y1016~p!1),PTP(s!1) -> EGFR(Y1016~u!1),PTP(s!1)
218'Rule97'EGFR(Y1092~p!1),PTP(s!1) -> EGFR(Y1092~u!1),PTP(s!1)
219'Rule98'EGFR(Y1172~p!1),PTP(s!1) -> EGFR(Y1172~u!1),PTP(s!1)
220'deg_EGF'EGF(r~int) ->
221'deg_EGFR'EGFR(L~int,CR) ->
222'EGFR_RasGAP'EGFR(Y1016~p),RasGAP(SH2~u) <-> EGFR(Y1016~p!1),RasGAP(SH2~rec!1)
223'EGFR_Grb2'EGFR(Y1092~p),Grb2(SH2~u) <-> EGFR(Y1092~p!1),Grb2(SH2~rec!1)
224'EGFR_Shc'EGFR(Y1172~p),Shc(PTB~u) <-> EGFR(Y1172~p!1),Shc(PTB~rec!1)
225'HER2_Grb2'HER2(Y1139~p),Grb2(SH2~u) <-> HER2(Y1139~p!1),Grb2(SH2~rec!1)
226'HER2_Shc#1'HER2(Y1196~p),Shc(PTB~u) <-> HER2(Y1196~p!1),Shc(PTB~rec!1)
227'HER2_RasGAP'HER2(Y1221~p),RasGAP(SH2~u) <-> HER2(Y1221~p!1),RasGAP(SH2~rec!1)
228'HER2_Shc#2'HER2(Y1221~p),Shc(PTB~u) <-> HER2(Y1221~p!1),Shc(PTB~rec!1)
229'HER3_PI3K#1'HER3(Y1035~p),PI3K(SH2~u) <-> HER3(Y1035~p!1),PI3K(SH2~rec!1)
230'HER3_PI3K#2'HER3(Y1178~p),PI3K(SH2~u) <-> HER3(Y1178~p!1),PI3K(SH2~rec!1)
231'HER3_PI3K#3'HER3(Y1203~p),PI3K(SH2~u) <-> HER3(Y1203~p!1),PI3K(SH2~rec!1)
232'HER3_PI3K#4'HER3(Y1241~p),PI3K(SH2~u) <-> HER3(Y1241~p!1),PI3K(SH2~rec!1)
233'HER3_PI3K#5'HER3(Y1257~p),PI3K(SH2~u) <-> HER3(Y1257~p!1),PI3K(SH2~rec!1)
234'HER3_PI3K#6'HER3(Y1270~p),PI3K(SH2~u) <-> HER3(Y1270~p!1),PI3K(SH2~rec!1)
235'HER3_Shc'HER3(Y1309~p),Shc(PTB~u) <-> HER3(Y1309~p!1),Shc(PTB~rec!1)
236'HER4_RasGAP'HER4(Y1~p),RasGAP(SH2~u) <-> HER4(Y1~p!1),RasGAP(SH2~rec!1)
237'HER4_Grb2'HER4(Y2~p),Grb2(SH2~u) <-> HER4(Y2~p!1),Grb2(SH2~rec!1)
238'HER4_Shc'HER4(Y3~p),Shc(PTB~u) <-> HER4(Y3~p!1),Shc(PTB~rec!1)
239'Shc@Y'Shc(PTB~rec!_,Y~u) -> Shc(PTB~rec!_,Y~p)
240'Gab1@48'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y48~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y48~p)
241'Gab1@317'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y317~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y317~p)
242'Gab1@447'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447~p)
243'Gab1@472'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472~p)
244'Gab1@619'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619~p)
245'Gab1@657'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y657~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y657~p)
246'Gab1@689'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y689~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y689~p)
247'Gab1@48_op'Gab1(Y48~p) -> Gab1(Y48~u)
248'Gab1@317_op'Gab1(Y317~p) -> Gab1(Y317~u)
249'Gab1@657_op'Gab1(Y657~p) -> Gab1(Y657~u)
250'Gab1@689_op'Gab1(Y689~p) -> Gab1(Y689~u)
251'Gab1_Grb2'Gab1(Y48~p),Grb2(SH2) <-> Gab1(Y48~p!1),Grb2(SH2!1)
252'Gab1_RasGAP'Gab1(Y317~p),RasGAP(SH2) <-> Gab1(Y317~p!1),RasGAP(SH2!1)
253'Gab1_PI3K@447_op'Gab1(Y447!1),PI3K(SH2!1) -> Gab1(Y447),PI3K(SH2)
254'Gab1_PI3K@472_op'Gab1(Y472!1),PI3K(SH2!1) -> Gab1(Y472),PI3K(SH2)
255'Gab1_PI3K@619_op'Gab1(Y619!1),PI3K(SH2!1) -> Gab1(Y619),PI3K(SH2)
256'Gab1_Shp2#1'Gab1(Y689~p),Shp2(SH2c) -> Gab1(Y689~p!1),Shp2(SH2c!1)
257'Gab1_Shp2#2'Gab1(Y657~p,Y689!1),Shp2(SH2n,SH2c!1) -> Gab1(Y657~p!2,Y689!1),Shp2(SH2n!2,SH2c!1)
258'Gab1_Shp2_op#1'Gab1(Y657!1),Shp2(SH2n!1) -> Gab1(Y657),Shp2(SH2n)
259'Gab1_Shp2_op#2'Gab1(Y689!1),Shp2(SH2c!1) -> Gab1(Y689),Shp2(SH2c)
260'Rule99'Gab1(Y317~p,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2) -> Gab1(Y317~u,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2)
261'Rule100'Gab1(Y447~p,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2) -> Gab1(Y447~u,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2)
262'Rule101'Gab1(Y472~p,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2) -> Gab1(Y472~u,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2)
263'Rule102'Gab1(Y619~p,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2) -> Gab1(Y619~u,Y657!1,Y689!2),Shp2(SH2n!1,SH2c!2)
264'PI3K@s Rec'PI3K(SH2~rec!_,s~u) -> PI3K(SH2~rec!_,s~p)
265'PI3K@s Gab#1'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,s~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,s~p)
266'PI3K@s Gab#2'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,s~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,s~p)
267'PI3K@s Gab#3'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,s~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,s~p)
268'PI3K@s_op'PI3K(s~p) -> PI3K(s~u)
269'SoS short arm'Grb2(SH2~rec!_,SH3n!1),SoS(PR!1,GEF),Ras(s~gdp) -> Grb2(SH2~rec!_,SH3n!1),SoS(PR!1,GEF!2),Ras(s~gdp!2)
270'SoS long arm'Shc(PTB~rec!_,Y!1),Grb2(SH2!1,SH3n!2),SoS(PR!2,GEF),Ras(s~gdp) -> Shc(PTB~rec!_,Y!1),Grb2(SH2!1,SH3n!2),SoS(PR!2,GEF!3),Ras(s~gdp!3)
271'SoS vlong arm'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y48!2),Grb2(SH2!2,SH3n!3),SoS(PR!3,GEF),Ras(s~gdp) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y48!2),Grb2(SH2!2,SH3n!3),SoS(PR!3,GEF!4),Ras(s~gdp!4)
272'RasGAP no arm'RasGAP(SH2~rec!_,GAP),Ras(s~gtp) -> RasGAP(SH2~rec!_,GAP!1),Ras(s~gtp!1)
273'RasGAP long arm'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y317!2),RasGAP(SH2!2,GAP),Ras(s~gtp) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y317!2),RasGAP(SH2!2,GAP!3),Ras(s~gtp!3)
274'PI3K no arm'PI3K(SH2~rec!_,s~p),PI(three~u) -> PI3K(SH2~rec!_,s~p!1),PI(three~u!1)
275'PI3K long arm #1'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,s~p),PI(three~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,s~p!3),PI(three~u!3)
276'PI3K long arm #2'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,s~p),PI(three~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,s~p!3),PI(three~u!3)
277'PI3K long arm #3'Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,s~p),PI(three~u) -> Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,s~p!3),PI(three~u!3)
278'intrinsic GDP'Ras(s~gtp) -> Ras(s~gdp)
279'PI@five'PI(five~u) -> PI(five~p)
280'PI@five_op'SHIP(s!1),PI(five~p!1) -> SHIP(s!1),PI(five~u!1)
281'Ras_PI3K no arm'Ras(s~gtp),PI3K(SH2~rec!_,RBD,s~u) -> Ras(s~gtp!1),PI3K(SH2~rec!_,RBD!1,s~u)
282'Ras_PI3K long arm #1'Ras(s~gtp),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,RBD,s~u) -> Ras(s~gtp!3),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(SH2!2,RBD!3,s~u)
283'Ras_PI3K long arm #2'Ras(s~gtp),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,RBD,s~u) -> Ras(s~gtp!3),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(SH2!2,RBD!3,s~u)
284'Ras_PI3K long arm #3'Ras(s~gtp),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,RBD,s~u) -> Ras(s~gtp!3),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(SH2!2,RBD!3,s~u)
285'Ras_PI3K_op'Ras(s!1),PI3K(RBD!1) -> Ras(s),PI3K(RBD)
286'PIP3_Gab1'PI(three~p,four~p,five~p),Grb2(SH2~rec!_,SH3c!1),Gab1(PH,PR!1) -> PI(three~p!2,four~p,five~p),Grb2(SH2~rec!_,SH3c!1),Gab1(PH!2,PR!1)
287'PIP3_Gab1_op'PI(three!1),Gab1(PH!1) -> PI(three),Gab1(PH)
288'PI3K@s Ras'PI3K(RBD!_,s~u) -> PI3K(RBD!_,s~p)
289'RasGAP Gab arm'Gab1(PH!_,Y317~p!1),RasGAP(SH2!1,GAP),Ras(s~gtp) -> Gab1(PH!_,Y317~p!1),RasGAP(SH2!1,GAP!2),Ras(s~gtp!2)
290'SoS Gab arm #1'Gab1(PH!_,Y48~p!1),Grb2(SH2!1,SH3n!2),SoS(PR!2,GEF),Ras(s~gdp) -> Gab1(PH!_,Y48~p!1),Grb2(SH2!1,SH3n!2),SoS(PR!2,GEF!3),Ras(s~gdp!3)
291'SoS Gab arm #2'Gab1(PH!_,PR!1),Grb2(SH3c!1,SH3n!2),SoS(PR!2,GEF),Ras(s~gdp) -> Gab1(PH!_,PR!1),Grb2(SH3c!1,SH3n!2),SoS(PR!2,GEF!3),Ras(s~gdp!3)
292'PI3K Ras arm'PI3K(RBD!_,s~p),PI(three~u) -> PI3K(RBD!_,s~p!1),PI(three~u!1)
293'PI3K Gab arm #1'Gab1(PH!_,Y447!1),PI3K(SH2!1,s~p),PI(three~u) -> Gab1(PH!_,Y447!1),PI3K(SH2!1,s~p!2),PI(three~u!2)
294'PI3K Gab arm #2'Gab1(PH!_,Y472!1),PI3K(SH2!1,s~p),PI(three~u) -> Gab1(PH!_,Y472!1),PI3K(SH2!1,s~p!2),PI(three~u!2)
295'PI3K Gab arm #3'Gab1(PH!_,Y619!1),PI3K(SH2!1,s~p),PI(three~u) -> Gab1(PH!_,Y619!1),PI3K(SH2!1,s~p!2),PI(three~u!2)
296'ERK_SoS'ERK(s,T~p,Y~p),SoS(S~u) -> ERK(s!1,T~p,Y~p),SoS(S~u!1)
297'ERK_SoS_op'ERK(s!1),SoS(S!1) -> ERK(s),SoS(S)
298'ERK_Gab1#1'ERK(s,T~p,Y~p),Gab1(S454~u) -> ERK(s!1,T~p,Y~p),Gab1(S454~u!1)
299'ERK_Gab1#2'ERK(s,T~p,Y~p),Gab1(T476~u) -> ERK(s!1,T~p,Y~p),Gab1(T476~u!1)
300'ERK_Gab1#3'ERK(s,T~p,Y~p),Gab1(S597~u) -> ERK(s!1,T~p,Y~p),Gab1(S597~u!1)
301'ERK_Gab1#1_op'ERK(s!1),Gab1(S454!1) -> ERK(s),Gab1(S454)
302'ERK_Gab1#2_op'ERK(s!1),Gab1(T476!1) -> ERK(s),Gab1(T476)
303'ERK_Gab1#3_op'ERK(s!1),Gab1(S597!1) -> ERK(s),Gab1(S597)
304'SoS@S'ERK(s!1),SoS(S~u!1) -> ERK(s!1),SoS(S~p!1)
305'SoS@S_op'SoS(S~p) -> SoS(S~u)
306'Gab1@454'ERK(s!1),Gab1(S454~u!1) -> ERK(s!1),Gab1(S454~p!1)
307'Gab1@476'ERK(s!1),Gab1(T476~u!1) -> ERK(s!1),Gab1(T476~p!1)
308'Gab1@597'ERK(s!1),Gab1(S597~u!1) -> ERK(s!1),Gab1(S597~p!1)
309'Gab1@454_op'Gab1(S454~p) -> Gab1(S454~u)
310'Gab1@476_op'Gab1(T476~p) -> Gab1(T476~u)
311'Gab1@597_op'Gab1(S597~p) -> Gab1(S597~u)
312'EGFR_Grb2@Y1086_SH2'EGFR(Y1086~p),Grb2(SH2) -> EGFR(Y1086~p!1),Grb2(SH2!1)
313'Shc_Src@SH2_S1'PI(four~p,Five~p!1),Shc(PTB!1,SH2),Src(S1) -> PI(four~p,Five~p!1),Shc(PTB!1,SH2!2),Src(S1!2)
314'Shc_p@Y239'PI(four~p,Five~p!1),Shc(PTB!1,SH2,Y239~u),Src(S1) -> PI(four~p,Five~p!1),Shc(PTB!1,SH2!2,Y239~p),Src(S1!2)
315'Shc_Src_op'PI(four~p,Five~p!1),Shc(PTB!1,SH2!2,Y239~p),Src(S1!2) -> PI(four~p,Five~p!1),Shc(PTB!1,SH2,Y239~p),Src(S1)
316'Shc_p@Y240'PI(four~p,Five~p!1),Shc(PTB!1,SH2,Y240~u),Src(S1) -> PI(four~p,Five~p!1),Shc(PTB!1,SH2!2,Y240~p),Src(S1!2)
317'SHP1_EGFR@SH2n_Y1173'Shp1(SH2n),EGFR(Y1173~p) -> Shp1(SH2n!1),EGFR(Y1173~p!1)
318'EGFR_u@Y1173'Shp1(SH2n!1),EGFR(Y1173~p!1) -> Shp1(SH2n!1),EGFR(Y1173~u!1)
319'EGFR_SHP1_op'Shp1(SH2n!1),EGFR(Y1173~u!1) -> Shp1(SH2n),EGFR(Y1173~u)
320'EGFR_Shc@Y1173_PTB'Shc(PTB),EGFR(Y1173~p) -> Shc(PTB!1),EGFR(Y1173~p!1)
321'EGFR_Shc@Y1173_SH2'Shc(SH2),EGFR(Y1173~p) -> Shc(SH2!1),EGFR(Y1173~p!1)
322'EGFR_Shc@Y992_PTB'Shc(PTB),EGFR(Y992~p) -> Shc(PTB!1),EGFR(Y992~p!1)
323'EGFR_Shc@Y992_SH2'Shc(SH2),EGFR(Y992~p) -> Shc(SH2!1),EGFR(Y992~p!1)
324'Shc_EGFR@PTB_Y1148'EGFR(Y1148~p),Shc(PTB) <-> EGFR(Y1148~p!1),Shc(PTB!1)
325'Shc_EGFR@SH2_Y1148'EGFR(Y1148~p),Shc(SH2) <-> EGFR(Y1148~p!1),Shc(SH2!1)
326'Shc_EGFR@PTB_Y1173'EGFR(Y1173~p),Shc(PTB) <-> EGFR(Y1173~p!1),Shc(PTB!1)
327'Shc_EGFR@SH2_Y1173'EGFR(Y1173~p),Shc(SH2) <-> EGFR(Y1173~p!1),Shc(SH2!1)
328'Shc_p@Y317'EGFR(Y1148~p!1),Shc(PTB!1,Y317~u) -> EGFR(Y1148~p!1),Shc(PTB!1,Y317~p)
329'EGFR_Stat3@Y1068_SH2'Stat3(SH2),EGFR(Y1068~p) <-> Stat3(SH2!1),EGFR(Y1068~p!1)
330'EGFR_Stat3@Y1086_SH2'Stat3(SH2),EGFR(Y1086~p) <-> Stat3(SH2!1),EGFR(Y1086~p!1)
331'Stat3_p@Y705'Stat3(SH2!1,Y705~u),EGFR(Y1068!1) -> Stat3(SH2!1,Y705~p),EGFR(Y1068!1)
332'EGFR_Shc@Y1068_SH2'EGFR(Y1068~p),Shc(SH2) <-> EGFR(Y1068~p!1),Shc(SH2!1)
333'EGFR_Shc@Y1086_SH2'EGFR(Y1086~p),Shc(SH2) <-> EGFR(Y1086~p!1),Shc(SH2!1)
334'EGFR_PLCG1@Y992_SH2'EGFR(Y992~p),PLCG1(SH2) <-> EGFR(Y992~p!1),PLCG1(SH2!1)
335'EGFR_PLCG1@Y1068_SH2'EGFR(Y1068~p),PLCG1(SH2) <-> EGFR(Y1068~p!1),PLCG1(SH2!1)
336'EGFR_PLCG1@Y1086_SH2'EGFR(Y1086~p),PLCG1(SH2) <-> EGFR(Y1086~p!1),PLCG1(SH2!1)
337'EGFR_PLCG1@Y1148_SH2'EGFR(Y1148~p),PLCG1(SH2) <-> EGFR(Y1148~p!1),PLCG1(SH2!1)
338'EGFR_PLCG1@Y1173_SH2'EGFR(Y1173~p),PLCG1(SH2) <-> EGFR(Y1173~p!1),PLCG1(SH2!1)
339'EGFR_Src@Y845_SH2'Src(SH2),EGFR(Y845) <-> Src(SH2!1),EGFR(Y845!1)
340'EGFR_p@Y845'Src(SH2!1),EGFR(Y845~u!1) -> Src(SH2!1),EGFR(Y845~p!1)
341'EGFR_Eps8@S1_S1'EGFR(S1),Eps8(S1) <-> EGFR(S1!1),Eps8(S1!1)
342'Eps8_p@X'EGFR(S1!1),Eps8(S1!1,X~u) -> EGFR(S1!1),Eps8(S1!1,X~p)
343'EGFR_PLCG1@Y1173_SH2n'EGFR(Y1173~p),PLCG1(SH2n) -> EGFR(Y1173~p!1),PLCG1(SH2n!1)
344'EGFR_PLCG1@Y992_SH2c'EGFR(Y992~p),PLCG1(SH2c) -> EGFR(Y992~p!2),PLCG1(SH2c!2)
345'PLCG1_p@Y472'EGFR(Y1173~p!1),PLCG1(SH2n!1,Y472~u) -> EGFR(Y1173~p!1),PLCG1(SH2n!1,Y472~p)
346'PLCG1_p@Y771'EGFR(Y1173~p!1),PLCG1(SH2n!1,Y771~u) -> EGFR(Y1173~p!1),PLCG1(SH2n!1,Y771~p)
347'PLCG1_p@Y783'EGFR(Y1173~p!1),PLCG1(SH2n!1,Y783~u) -> EGFR(Y1173~p!1),PLCG1(SH2n!1,Y783~p)
348'PLCG1_p@Y1254'EGFR(Y1173~p!1),PLCG1(SH2n!1,Y1254~u) -> EGFR(Y1173~p!1),PLCG1(SH2n!1,Y1254~p)
349'EGFR_Gab1@S1_S1'Gab1(X~u),EGFR(S1) -> Gab1(X~u!1),EGFR(S1!1)
350'Gab1_p@Y627'Gab1(Y627~u!1),EGFR(S1!1) -> Gab1(Y627~p!1),EGFR(S1!1)
351'Gab1_EGFR_op'Gab1(Y627~p!1),EGFR(S1!1) -> Gab1(Y627~p),EGFR(S1)
352'Gab1_p@Y659'Gab1(Y659~u!1),EGFR(S1!1) -> Gab1(Y659~p!1),EGFR(S1!1)
353'Gab1_PIP3@PH'Gab1(PH),PI(three~p,four~p,five~p) -> Gab1(PH!1),PI(three~p,four~p,five~p!1)
354'Gab1_SHP2@Y627_SH2n'Gab1(Y627~p),SHP2(SH2n) -> Gab1(Y627~p!1),SHP2(SH2n!1)
355'Gab1_SHP2@Y659_SH2c'Gab1(Y659~p),SHP2(SH2c) -> Gab1(Y659~p!1),SHP2(SH2c!1)
356'Gab1_u@Y659'Gab1(Y659~p!1),SHP2(SH2c!1) -> Gab1(Y659~u!1),SHP2(SH2c!1)
357'Gab1_u@Y627'Gab1(Y627~p!1),SHP2(SH2c!1) -> Gab1(Y627~u!1),SHP2(SH2c!1)
358'Gab1_PLCG1@Y307_SH2'Gab1(Y307~p),PLCG1(SH2) -> Gab1(Y307~p!1),PLCG1(SH2!1)
359'Gab1_PLCG1@Y373_SH2'Gab1(Y373~p),PLCG1(SH2) -> Gab1(Y373~p!1),PLCG1(SH2!1)
360'Gab1_PLCG1@Y407_SH2'Gab1(Y407~p),PLCG1(SH2) -> Gab1(Y407~p!1),PLCG1(SH2!1)
361'Akt_PIP2@PH'Akt(PH),PI(three~p,four~p) -> Akt(PH!1),PI(three~p,four~p!1)
362'Vav_PIP3@PH'PI(three~p,four~p,five~p),Vav(PH) <-> PI(three~p,four~p,five~p!1),Vav(PH!1)
363'Vav_Rac@DH_X~u'PI(three~p,four~p,five~p!1),Vav(PH!1,DH,X~p),Rac(X~u) <-> PI(three~p,four~p,five~p!1),Vav(PH!1,DH!2,X~p),Rac(X~u!2)
364'Rac_p@X'Rac(X~gdp!1),Vav(DH!1,PH!2,X~p),PI(three~p,four~p,five~p!2) -> Rac(X~gtp!1),Vav(DH!1,PH!2,X~p),PI(three~p,four~p,five~p!2)
365'PIP3_Sos@PH'PI(three~p,four~p,five~p),Sos(PH) -> PI(three~p,four~p,five~p!1),Sos(PH!1)
366'Sos_Rac@DH_X~u'PI(three~p,four~p,five~p!1),Sos(PH!1,DH,X~p),Rac(X~u) <-> PI(three~p,four~p,five~p!1),Sos(PH!1,DH!2,X~p),Rac(X~u!2)
367'PIP2_PLD@PH'PI(four~p,five~p),PLD(PH) <-> PI(four~p,five~p!1),PLD(PH!1)
368'p85_EGFR@SH2_Y920'p85(SH2),EGFR(Y920~p) -> p85(SH2!1),EGFR(Y920~p!1)
369'Rom2_PI3K@PH_S1'Rom2(PH),PI3K(S1) <-> Rom2(PH!1),PI3K(S1!1)
370'EGFR_Vav2@Y992_SH2'EGFR(Y992~p),Vav2(SH2) <-> EGFR(Y992~p!1),Vav2(SH2!1)
371'EGFR_Vav@Y1148_SH2'EGFR(Y1148~p),Vav2(SH2) <-> EGFR(Y1148~p!1),Vav2(SH2!1)
372'Vav2_p@Y142'EGFR(Y1148~p!1),Vav2(SH2!1,Y142~u) -> EGFR(Y1148~p!1),Vav2(SH2!1,Y142~p)
373'Vav2_p@Y172'EGFR(Y1148~p!1),Vav2(SH2!1,Y172~u) -> EGFR(Y1148~p!1),Vav2(SH2!1,Y172~p)
374'Vav2_p@Y159'EGFR(Y1148~p!1),Vav2(SH2!1,Y159~u) -> EGFR(Y1148~p!1),Vav2(SH2!1,Y159~p)
375'Grb2_EGFR@SH2_Y1068'Grb2(SH2),EGFR(Y1068~p) -> Grb2(SH2!1),EGFR(Y1068~p!1)
376'Pak1_Grb2@SH3_SBM'Grb2(SH2!1,SH3),EGFR(Y1068~p!1),Pak1(SBM) -> Grb2(SH2!1,SH3!2),EGFR(Y1068~p!1),Pak1(SBM!2)
377'Raf1_Ras@CR1_rafts'Raf1(Y341~p,CR1),Ras(rafts) -> Raf1(Y341~p,CR1!1),Ras(rafts!1)
378'Raf1_p@S338'Raf1(Y341~p,CR1!1,S338~u),Ras(rafts!1) -> Raf1(Y341~p,CR1!1,S338~p),Ras(rafts!1)
379'Ang2_EGFR@r_l'Ang2(r~ext),EGFR(L~ext,CR) <-> Ang(r~ext!1),GFR(L~ext!1,CR)
380'EGFR_Clta(int)'EGFR(N~ext!1,C),CLTA(S1!1) -> EGFR(N~int!1,C),CLTA(S1!1)
381'Rule103'B(y1~p) -> B(y1~u)
382'Rule104'B(y2~p) -> B(y2~u)
383'goal'B(y1~p,y2~p,z~u) -> B(y1~p,y2~p,z~p)
384'Rule105'ErbB1(N!1,bp!2),ErbB2(C!1,Y1221~u),A(s~ppp!2) -> ErbB1(N!1,bp!2),ErbB2(C!1,Y1221~p),A(s~pp!2)