ID   143E_HUMAN     STANDARD;      PRT;   255 AA.
AC   P42655; P29360; Q63631;
DT   01-NOV-1995 (REL. 32, CREATED)
DT   01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE)
DT   15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE)
DE   14-3-3 PROTEIN EPSILON (MITOCHONDRIAL IMPORT STIMULATION FACTOR L
DE   SUBUNIT) (PROTEIN KINASE C INHIBITOR PROTEIN-1) (KCIP-1) (14-3-3E).
GN   YWHAE.
OS   HOMO SAPIENS (HUMAN), RATTUS NORVEGICUS (RAT), MUS MUSCULUS (MOUSE),
OS   BOS TAURUS (BOVINE), AND OVIS ARIES (SHEEP).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   SPECIES=HUMAN;
RX   MEDLINE; 95372385.
RA   CONKLIN D.S., GALAKTIONOV K., BEACH D.;
RT   "14-3-3 proteins associate with cdc25 phosphatases.";
RL   PROC. NATL. ACAD. SCI. U.S.A. 92:7892-7896(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   SPECIES=HUMAN; TISSUE=HEART;
RA   LUK S.C.W., LEE C.Y., WAYE M.M.Y.;
RL   SUBMITTED (JUN-1995) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [3]
RP   SEQUENCE FROM N.A.
RC   SPECIES=HUMAN;
RX   MEDLINE; 96300316.
RA   JIN D.Y., LYU M.S., KOZAK C.A., JEANG K.T.;
RT   "Function of 14-3-3 proteins.";
RL   NATURE 382:308-308(1996).
RN   [4]
RP   SEQUENCE FROM N.A.
RC   SPECIES=HUMAN; TISSUE=LIVER;
RX   MEDLINE; 97011338.
RA   CHONG S.S., TANIGAMI A., ROSCHKE A.V., LEDBETTER D.H.;
RT   "14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on
RT   chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome
RT   region.";
RL   GENOME RES. 6:735-741(1996).
RN   [5]
RP   SEQUENCE FROM N.A.
RC   SPECIES=HUMAN;
RA   TANIGAMI A., CHONG S.S., LEDBETTER D.H.;
RT   "14-3-3 epsilon genomic sequence.";
RL   SUBMITTED (AUG-1998) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [6]
RP   SEQUENCE FROM N.A.
RC   SPECIES=RAT, AND SHEEP; TISSUE=PINEAL GLAND;
RX   MEDLINE; 94296566.
RA   ROSEBOOM P.H., WELLER J.L., BABILA T., AITKEN A., SELLERS L.A.,
RA   MOFFET J.R., NAMBOODIRI M.A., KLEIN D.C.;
RT   "Cloning and characterization of the epsilon and zeta isoforms of the
RT   14-3-3 proteins.";
RL   DNA CELL BIOL. 13:629-640(1994).
RN   [7]
RP   SEQUENCE FROM N.A.
RC   SPECIES=RAT; TISSUE=LIVER;
RX   MEDLINE; 95122474.
RA   ALAM R., HACHIYA N., SAKAGUCHI M., SHUN-ICHIRO K., IWANAGA S.,
RA   KITAJIMA M., MIHARA K., OMURA T.;
RT   "cDNA cloning and characterization of mitochondrial import
RT   stimulation factor (MSF) purified from rat liver cytosol.";
RL   J. BIOCHEM. 116:416-425(1994).
RN   [8]
RP   SEQUENCE FROM N.A.
RC   SPECIES=RAT; TISSUE=BRAIN;
RX   MEDLINE; 96280718.
RA   GAO L., GU X.B., YU D.S., YU R.K., ZENG G.;
RT   "Association of a 14-3-3 protein with CMP-NeuAc:GM1 alpha 2,3-
RT   sialyltransferase.";
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 224:103-107(1996).
RN   [9]
RP   SEQUENCE FROM N.A.
RC   SPECIES=MOUSE; STRAIN=SWISS; TISSUE=KIDNEY;
RX   MEDLINE; 95269876.
RA   MCCONNELL J.E., ARMSTRONG J.F., BARD J.B.;
RT   "The mouse 14-3-3 epsilon isoform, a kinase regulator whose
RT   expression pattern is modulated in mesenchyme and neuronal
RT   differentiation.";
RL   DEV. BIOL. 169:218-228(1995).
RN   [10]
RP   SEQUENCE FROM N.A.
RC   SPECIES=MOUSE; STRAIN=129/SV;
RA   TAKIHARA Y., IRIE K., NOMURA M., MOTALEB M., MATSUMOTO K.,
RA   SHIMADA K.;
RL   SUBMITTED (SEP-1996) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [11]
RP   SEQUENCE FROM N.A.
RC   SPECIES=BOVINE;
RA   JONES J.M., NIIKURA T., PINKE R.M., GUO W., MOLDAY L., LEYKAM J.,
RA   MCCONNELL D.G.;
RT   "Expression of 14-3-3 proteins in bovine retinal photoreceptors.";
RL   SUBMITTED (JAN-1998) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [12]
RP   SEQUENCE OF 1-152; 165-184 AND 216-255.
RC   SPECIES=SHEEP; TISSUE=BRAIN;
RX   MEDLINE; 92283271.
RA   TOKER A., SELLERS L.A., AMESS B., PATEL Y., HARRIS A., AITKEN A.;
RT   "Multiple isoforms of a protein kinase C inhibitor (KCIP-1/14-3-3)
RT   from sheep brain. Amino acid sequence of phosphorylated forms.";
RL   EUR. J. BIOCHEM. 206:453-461(1992).
RN   [13]
RP   SEQUENCE OF 1-23 AND 125-140.
RC   SPECIES=SHEEP; TISSUE=BRAIN;
RX   MEDLINE; 90345949.
RA   TOKER A., ELLIS C.A., SELLERS L.A., AITKEN A.;
RT   "Protein kinase C inhibitor proteins. Purification from sheep brain
RT   and sequence similarity to lipocortins and 14-3-3 protein.";
RL   EUR. J. BIOCHEM. 191:421-429(1990).
CC   -!- FUNCTION: ACTIVATES TYROSINE AND TRYPTOPHAN HYDROXYLASES IN THE
CC       PRESENCE OF CA(2+)/CALMODULIN-DEPENDENT PROTEIN KINASE II, AND
CC       STRONGLY ACTIVATES PROTEIN KINASE C. IS PROBABLY A MULTIFUNCTIONAL
CC       REGULATOR OF THE CELL SIGNALING PROCESSES MEDIATED BY BOTH
CC       KINASES.
CC   -!- SUBUNIT: HOMODIMER.
CC   -!- SUBCELLULAR LOCATION: CYTOPLASMIC.
CC   -!- TISSUE SPECIFICITY: 14-3-3 PROTEINS ARE LOCALIZED IN NEURONS, AND
CC       ARE AXONALLY TRANSPORTED TO THE NERVE TERMINALS. THEY MAY BE ALSO
CC       PRESENT, AT LOWER LEVELS, IN VARIOUS OTHER EUKARYOTIC TISSUES.
CC   -!- SIMILARITY: BELONGS TO THE 14-3-3 FAMILY.
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DR   EMBL; U28936; G984319; -.
DR   EMBL; U20972; G902787; -.
DR   EMBL; U43399; G1184725; -.
DR   EMBL; U54778; G1561719; -.
DR   EMBL; AB017103; D1033501; -.
DR   EMBL; AB017098; D1033501; JOINED.
DR   EMBL; AB017099; D1033501; JOINED.
DR   EMBL; AB017100; D1033501; JOINED.
DR   EMBL; AB017101; D1033501; JOINED.
DR   EMBL; AB017102; D1033501; JOINED.
DR   EMBL; M84416; G294504; -.
DR   EMBL; D30739; G487918; -.
DR   EMBL; Z19599; G57966; -.
DR   EMBL; U53882; G1469948; -.
DR   EMBL; L07914; G530049; -.
DR   EMBL; D87663; G1526545; -.
DR   EMBL; AF043735; G3676399; -.
DR   PIR; S10806; S10806.
DR   PIR; S10807; S10807.
DR   MGD; MGI:894689; YWHAE.
DR   PROSITE; PS00796; 1433_1; 1.
DR   PROSITE; PS00797; 1433_2; 1.
DR   PFAM; PF00244; 14-3-3; 1.
KW   BRAIN; NEURONE; ACETYLATION; MULTIGENE FAMILY.
FT   MOD_RES       1      1       ACETYLATION.
FT   CONFLICT     73     73       K -> T (IN REF. 8).
FT   CONFLICT    120    120       F -> S (IN REF. 8).
FT   CONFLICT    123    123       K -> Y (IN REF. 8).
FT   CONFLICT    129    129       H -> Y (IN REF. 13).
SQ   SEQUENCE   255 AA;  29174 MW;  40A43E62 CRC32;
     MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW
     RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF
     YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF
     YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE
     EQNKEALQDV EDENQ
//