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   1Mar_04
   2  MOE2005           2D
   3
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 161 69 75  2  0  0  0  0
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 163 71 73  1  0  0  0  0
 164 71 72  1  0  0  0  0
 165 71 74  1  0  0  0  0
 166 74 76  1  0  0  0  0
 167 74 84  2  0  0  0  0
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 170 78 79  1  0  0  0  0
 171 78 80  1  0  0  0  0
 172 80 81  1  0  0  0  0
 173 80 82  2  0  0  0  0
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 175 82 84  1  0  0  0  0
 176 84 85  1  0  0  0  0
 177M  END
 178>  <ID>
 179Mar_04
 180
 181>  <Cathepsin L nM>
 18239000
 183
 184>  <Cathepsin B nM>
 1851e+06
 186
 187> <FP:MACCS>
 18823 54 74 75 79 80 83 85 86 90 91 92 95 96 97 100 104 106 109 110 111 115 117 121 122 123 125 126 128 129 131 132 133 136 137 138 140 141 142 143 145 146 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165
 189
 190$$$$
 191Tri_06
 192  MOE2005           2D
 193
 194 43 43  0  0  1  0  0  0  0  0999 V2000
 195    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 196    0.6000    1.0390    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 197    0.7490   -1.2990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 198    1.9490   -1.3000    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 199   -0.0010   -2.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 200    0.5980   -3.6380    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 201   -1.5010   -2.5970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 202   -2.1020   -3.6360    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 203   -2.2510   -1.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 204   -3.7510   -1.2970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 205   -3.5430   -2.4790    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 206   -4.8780   -1.7070    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 207   -4.5000    0.0020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 208   -1.5000    0.0010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 209   -2.1000    1.0400    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 210   -6.0000    0.0030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 211   -6.7490    1.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 212   -6.1490    2.3410    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 213   -8.2490    1.3030    0.0000 C   0  0  3  0  0  0  0  0  0  0  0  0
 214   -7.6490    2.3420    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 215   -9.0000    0.0040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 216   -7.8730   -0.4060    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 217  -10.5000    0.0050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 218  -11.7000    0.0050    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 219  -11.2510   -1.2930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 220  -12.2900   -0.6930    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 221  -11.8510   -2.3320    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 222  -10.2120   -1.8940    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 223  -11.2490    1.3050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 224  -10.2100    1.9040    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 225  -11.8490    2.3440    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 226  -12.2890    0.7050    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 227   -9.2090   -1.1770    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 228   -6.7510   -1.2960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 229   -8.9990    2.6030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 230   -8.2480    3.9010    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 231   -7.0480    3.9010    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 232   -8.9970    5.2010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 233   -9.9170    4.4300    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 234   -9.9160    5.9720    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 235   -8.2470    6.4990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 236   -7.4960    7.7980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 237  -10.4990    2.6030    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 238  1 14  2  0  0  0  0
 239  1  3  1  0  0  0  0
 240  1  2  1  0  0  0  0
 241  3  4  1  0  0  0  0
 242  3  5  2  0  0  0  0
 243  5  7  1  0  0  0  0
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 250 10 11  1  0  0  0  0
 251 10 13  1  0  0  0  0
 252 13 16  1  0  0  0  0
 253 14 15  1  0  0  0  0
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 255 16 34  2  0  0  0  0
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 257 17 19  1  0  0  0  0
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 259 19 20  1  0  0  0  0
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 261 21 23  1  0  0  0  0
 262 21 22  1  0  0  0  0
 263 21 33  1  0  0  0  0
 264 23 25  1  0  0  0  0
 265 23 24  1  0  0  0  0
 266 23 29  1  0  0  0  0
 267 25 27  1  0  0  0  0
 268 25 26  1  0  0  0  0
 269 25 28  1  0  0  0  0
 270 29 31  1  0  0  0  0
 271 29 30  1  0  0  0  0
 272 29 32  1  0  0  0  0
 273 35 36  1  0  0  0  0
 274 35 43  2  0  0  0  0
 275 36 37  1  0  0  0  0
 276 36 38  1  0  0  0  0
 277 38 40  1  0  0  0  0
 278 38 39  1  0  0  0  0
 279 38 41  1  0  0  0  0
 280 41 42  3  0  0  0  0
 281M  END
 282>  <ID>
 283Tri_06
 284
 285>  <Cathepsin L nM>
 286150000
 287
 288>  <Cathepsin B nM>
 289150000
 290
 291> <FP:MACCS>
 29223 41 54 74 79 82 90 91 92 95 100 104 106 109 110 111 115 117 123 126 128 131 136 138 142 146 149 151 153 154 155 156 157 158 159 160 161 162 163 164 165
 293
 294$$$$
 295Tri_08
 296  MOE2005           2D
 297
 298 46 46  0  0  1  0  0  0  0  0999 V2000
 299    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 300   -0.5910    1.0440    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 301   -0.7610   -1.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 302   -1.9610   -1.2820    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 303   -0.0220   -2.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 304   -0.6310   -3.6320    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 305    1.4780   -2.6110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 306    2.0690   -3.6550    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 307    2.2390   -1.3180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 308    3.7390   -1.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 309    3.5200   -2.5110    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 310    4.8630   -1.7510    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 311    4.5000   -0.0390    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 312    1.5000   -0.0130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 313    2.1090    1.0210    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 314    6.0000   -0.0520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 315    6.7610    1.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 316    6.1700    2.2850    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 317    8.2610    1.2280    0.0000 C   0  0  3  0  0  0  0  0  0  0  0  0
 318    8.2480   -0.2720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 319    7.0480   -0.2620    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 320    8.2380   -1.4720    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 321    9.4480   -0.2820    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 322    9.7610    1.2150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 323    9.5630    2.3980    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 324   10.5000   -0.0900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 325   11.1000   -1.1300    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 326   12.0000   -0.1030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 327   11.9890   -1.3030    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 328   13.2000   -0.1140    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 329   12.0100    1.0960    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 330    9.7380   -1.3830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 331    8.7040   -0.7740    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 332    9.1300   -2.4170    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 333   10.7720   -1.9920    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 334   10.8920    1.6160    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 335    6.7390   -1.3570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 336    8.2740    2.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 337    6.9810    3.4890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 338    5.9370    2.8980    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 339    6.9940    4.9890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 340    8.1740    4.7700    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 341    7.4140    6.1130    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 342    5.7020    5.7500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 343    4.4090    6.5110    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 344    9.5790    3.4670    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 345  1 14  2  0  0  0  0
 346  1  3  1  0  0  0  0
 347  1  2  1  0  0  0  0
 348  3  4  1  0  0  0  0
 349  3  5  2  0  0  0  0
 350  5  7  1  0  0  0  0
 351  5  6  1  0  0  0  0
 352  7  9  2  0  0  0  0
 353  7  8  1  0  0  0  0
 354  9 14  1  0  0  0  0
 355  9 10  1  0  0  0  0
 356 10 12  1  0  0  0  0
 357 10 11  1  0  0  0  0
 358 10 13  1  0  0  0  0
 359 13 16  1  0  0  0  0
 360 14 15  1  0  0  0  0
 361 16 17  1  0  0  0  0
 362 16 37  2  0  0  0  0
 363 17 18  1  0  0  0  0
 364 17 19  1  0  0  0  0
 365 19 24  1  0  0  0  0
 366 19 20  1  0  0  0  0
 367 19 38  1  0  0  0  0
 368 20 22  1  0  0  0  0
 369 20 21  1  0  0  0  0
 370 20 23  1  0  0  0  0
 371 24 26  1  0  0  0  0
 372 24 25  1  0  0  0  0
 373 24 36  1  0  0  0  0
 374 26 28  1  0  0  0  0
 375 26 27  1  0  0  0  0
 376 26 32  1  0  0  0  0
 377 28 30  1  0  0  0  0
 378 28 29  1  0  0  0  0
 379 28 31  1  0  0  0  0
 380 32 34  1  0  0  0  0
 381 32 33  1  0  0  0  0
 382 32 35  1  0  0  0  0
 383 38 39  1  0  0  0  0
 384 38 46  2  0  0  0  0
 385 39 40  1  0  0  0  0
 386 39 41  1  0  0  0  0
 387 41 43  1  0  0  0  0
 388 41 42  1  0  0  0  0
 389 41 44  1  0  0  0  0
 390 44 45  3  0  0  0  0
 391M  END
 392>  <ID>
 393Tri_08
 394
 395>  <Cathepsin L nM>
 396150000
 397
 398>  <Cathepsin B nM>
 399150000
 400
 401> <FP:MACCS>
 40223 41 54 66 74 79 82 90 91 92 95 100 104 106 108 109 110 111 112 115 117 123 126 128 131 136 138 141 142 146 149 151 153 154 155 156 157 158 159 160 161 162 163 164 165
 403
 404$$$$
 405Tri_09
 406  MOE2005           2D
 407
 408 43 43  0  0  1  0  0  0  0  0999 V2000
 409    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 410   -0.5980   -1.0400    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 411   -0.7520    1.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 412   -1.9520    1.2960    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 413   -0.0040    2.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 414   -0.6060    3.6360    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 415    1.4960    2.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 416    2.0940    3.6410    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 417    2.2480    1.3030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 418    3.7480    1.3050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 419    3.5380    2.4860    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 420    4.8750    1.7170    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 421    4.5000    0.0070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 422    1.5000    0.0020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 423    2.1020   -1.0360    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 424    6.0000    0.0090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 425    6.7520   -1.2880    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 426    6.1540   -2.3290    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 427    8.2520   -1.2860    0.0000 C   0  0  3  0  0  0  0  0  0  0  0  0
 428    7.6520   -2.3250    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 429    9.0040   -2.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 430   10.5040   -2.5820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 431   10.5060   -3.7820    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 432   11.7040   -2.5800    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 433   10.5020   -1.3820    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 434    9.7560   -3.8820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 435    8.7180   -4.4830    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 436   10.3580   -4.9200    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 437   10.7940   -3.2800    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 438    8.2560   -3.8840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 439    7.2160   -3.2860    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 440    7.6580   -4.9240    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 441    9.2960   -4.4820    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 442    6.7480    1.3100    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 443    9.0000    0.0140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 444   10.5000    0.0160    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 445   11.1020   -1.0220    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 446   11.2480    1.3170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 447   10.1200    1.7250    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 448   11.4540    2.4990    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 449   12.7480    1.3190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 450   14.2480    1.3210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 451    8.2480    1.3120    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 452  1 14  2  0  0  0  0
 453  1  3  1  0  0  0  0
 454  1  2  1  0  0  0  0
 455  3  4  1  0  0  0  0
 456  3  5  2  0  0  0  0
 457  5  7  1  0  0  0  0
 458  5  6  1  0  0  0  0
 459  7  9  2  0  0  0  0
 460  7  8  1  0  0  0  0
 461  9 14  1  0  0  0  0
 462  9 10  1  0  0  0  0
 463 10 12  1  0  0  0  0
 464 10 11  1  0  0  0  0
 465 10 13  1  0  0  0  0
 466 13 16  1  0  0  0  0
 467 14 15  1  0  0  0  0
 468 16 17  1  0  0  0  0
 469 16 34  2  0  0  0  0
 470 17 18  1  0  0  0  0
 471 17 19  1  0  0  0  0
 472 19 21  1  0  0  0  0
 473 19 20  1  0  0  0  0
 474 19 35  1  0  0  0  0
 475 21 26  1  0  0  0  0
 476 21 22  1  0  0  0  0
 477 21 30  1  0  0  0  0
 478 22 24  1  0  0  0  0
 479 22 23  1  0  0  0  0
 480 22 25  1  0  0  0  0
 481 26 28  1  0  0  0  0
 482 26 27  1  0  0  0  0
 483 26 29  1  0  0  0  0
 484 30 32  1  0  0  0  0
 485 30 31  1  0  0  0  0
 486 30 33  1  0  0  0  0
 487 35 36  1  0  0  0  0
 488 35 43  2  0  0  0  0
 489 36 37  1  0  0  0  0
 490 36 38  1  0  0  0  0
 491 38 40  1  0  0  0  0
 492 38 39  1  0  0  0  0
 493 38 41  1  0  0  0  0
 494 41 42  3  0  0  0  0
 495M  END
 496>  <ID>
 497Tri_09
 498
 499>  <Cathepsin L nM>
 500150000
 501
 502>  <Cathepsin B nM>
 503150000
 504
 505> <FP:MACCS>
 50623 41 54 66 74 79 82 90 91 92 95 100 106 109 110 111 112 117 123 126 131 136 138 141 142 146 149 151 153 154 155 156 157 158 159 160 161 162 163 164 165
 507
 508$$$$
 509Tri_02
 510  MOE2005           2D
 511
 512 73 76  0  0  1  0  0  0  0  0999 V2000
 513    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 514    1.0350   -0.6070    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 515    0.0110    1.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 516    1.0540    2.0930    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 517   -1.2830    2.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 518   -1.2750    3.4590    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 519   -2.5870    1.5180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 520   -3.6220    2.1260    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 521   -2.5980    0.0180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 522   -3.9020   -0.7220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 523   -3.1380   -1.6470    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 524   -4.6800   -1.6360    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 525   -5.1960    0.0370    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 526   -1.3040   -0.7410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 527   -1.3130   -1.9410    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 528   -6.5000   -0.7040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 529   -7.7940    0.0550    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 530   -8.8380   -0.5380    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 531   -7.7840    1.5550    0.0000 C   0  0  3  0  0  0  0  0  0  0  0  0
 532   -8.8230    0.9550    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 533   -9.0770    2.3140    0.0000 C   0  0  3  0  0  0  0  0  0  0  0  0
 534   -8.0380    2.9140    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 535  -10.3820    1.5730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 536   -9.0670    3.8140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 537   -7.8860    3.5970    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 538   -8.6480    4.9390    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 539  -10.3600    4.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 540  -10.7790    3.4480    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 541  -11.5410    4.7900    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 542  -10.3500    6.0730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 543   -9.1700    5.8560    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 544   -9.9310    7.1980    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 545  -11.6440    6.8320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 546  -11.0360    7.8670    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 547  -12.6780    7.4400    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 548  -12.2510    5.7970    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 549   -6.5110   -2.2040    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 550   -6.4790    2.2960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 551   -6.4690    3.7960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 552   -7.5040    4.4030    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 553   -5.1640    4.5360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 554   -4.7620    3.4060    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 555   -3.9810    4.7360    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 556   -5.1540    6.0360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 557   -5.1430    7.5360    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 558   -5.1860    1.5370    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 559  -11.6750    2.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 560  -12.9800    1.5920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 561  -13.3820    2.7220    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 562  -14.1630    1.3910    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 563  -12.9900    0.0920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 564  -11.6650    3.8320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 565  -11.6960   -0.6680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 566  -10.6530   -0.0750    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 567  -11.7070   -2.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 568  -10.6720   -2.7750    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 569  -13.0110   -2.9080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 570  -13.0200   -4.1080    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 571  -14.3050   -2.1490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 572  -14.2940   -0.6490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 573  -15.6090   -2.8900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 574  -15.6200   -4.3900    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 632 44 45  3  0  0  0  0
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 647 59 60  1  0  0  0  0
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 658 68 69  1  0  0  0  0
 659 70 72  1  0  0  0  0
 660 70 71  1  0  0  0  0
 661 72 73  1  0  0  0  0
 662M  END
 663>  <ID>
 664Tri_02
 665
 666>  <Cathepsin L nM>
 66737000
 668
 669>  <Cathepsin B nM>
 670150000
 671
 672> <FP:MACCS>
 67323 41 54 57 79 82 89 90 91 92 95 97 98 100 105 106 109 110 111 113 114 115 116 117 123 125 126 128 131 132 136 137 138 140 142 143 144 145 146 147 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165
 674
 675$$$$
 676Men_12
 677  MOE2005           2D
 678
 679 67 68  0  0  1  0  0  0  0  0999 V2000
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 682    1.5000   -0.0060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 683    2.1040    1.0300    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
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 720  -12.0210   -5.1460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 726   -7.5220   -5.1650    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 727   -9.7880   -9.0530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 728   -9.0430  -10.3550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 730   -9.0540  -12.9530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 768 18 19  1  0  0  0  0
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 780 25 26  1  0  0  0  0
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 786 37 39  1  0  0  0  0
 787 37 38  1  0  0  0  0
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 801 49 56  1  0  0  0  0
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 804 51 52  1  0  0  0  0
 805 51 54  1  0  0  0  0
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 808 60 61  1  0  0  0  0
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 812 64 65  1  0  0  0  0
 813 64 66  1  0  0  0  0
 814 66 67  1  0  0  0  0
 815M  END
 816>  <ID>
 817Men_12
 818
 819>  <Cathepsin L nM>
 82022300
 821
 822>  <Cathepsin B nM>
 823150000
 824
 825> <FP:MACCS>
 82623 54 72 74 79 86 90 92 93 95 97 104 106 109 110 111 115 117 123 125 126 128 129 131 132 136 138 140 141 142 145 146 147 149 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165
 827
 828$$$$
 829Tri_07
 830  MOE2005           2D
 831
 832 73 76  0  0  1  0  0  0  0  0999 V2000
 833    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 834   -0.5970    1.0410    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 835    1.5000   -0.0050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 836    2.1030    1.0330    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 837    2.2460   -1.3060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 838    3.4460   -1.3100    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 839    1.4920   -2.6030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 840    2.0880   -3.6440    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 841   -0.0080   -2.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 842   -0.7620   -3.8950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 843    0.3640   -4.3090    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 844   -0.9740   -5.0760    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 845   -2.2620   -3.8900    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 846   -0.7540   -1.2970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 847   -1.9540   -1.2930    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 848   -3.0160   -5.1870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 853   -6.7700   -6.4740    0.0000 C   0  0  3  0  0  0  0  0  0  0  0  0
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 861   -7.5080   -2.5740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 878   -5.2790   -9.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 884   -9.7790   -9.0620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 887  -13.5160   -5.1540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 888  -14.1130   -4.1120    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 889  -14.2700   -6.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 890  -15.4700   -6.4460    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
 891  -13.5240   -7.7520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 892  -12.0240   -7.7560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 893  -14.2790   -9.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 930 21 22  1  0  0  0  0
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 932 23 47  1  0  0  0  0
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 936 27 29  1  0  0  0  0
 937 27 28  1  0  0  0  0
 938 27 33  1  0  0  0  0
 939 29 31  1  0  0  0  0
 940 29 30  1  0  0  0  0
 941 29 32  1  0  0  0  0
 942 33 35  1  0  0  0  0
 943 33 34  1  0  0  0  0
 944 33 36  1  0  0  0  0
 945 38 39  1  0  0  0  0
 946 38 46  2  0  0  0  0
 947 39 40  1  0  0  0  0
 948 39 41  1  0  0  0  0
 949 41 43  1  0  0  0  0
 950 41 42  1  0  0  0  0
 951 41 44  1  0  0  0  0
 952 44 45  3  0  0  0  0
 953 47 48  1  0  0  0  0
 954 47 52  2  0  0  0  0
 955 48 50  1  0  0  0  0
 956 48 49  1  0  0  0  0
 957 48 51  1  0  0  0  0
 958 51 53  1  0  0  0  0
 959 51 60  2  0  0  0  0
 960 53 54  1  0  0  0  0
 961 53 55  2  0  0  0  0
 962 55 56  1  0  0  0  0
 963 55 57  1  0  0  0  0
 964 57 58  1  0  0  0  0
 965 57 59  2  0  0  0  0
 966 59 61  1  0  0  0  0
 967 59 60  1  0  0  0  0
 968 60 65  1  0  0  0  0
 969 61 62  2  0  0  0  0
 970 61 63  1  0  0  0  0
 971 63 64  1  0  0  0  0
 972 63 66  2  0  0  0  0
 973 64 65  1  0  0  0  0
 974 64 72  2  0  0  0  0
 975 66 67  1  0  0  0  0
 976 66 68  1  0  0  0  0
 977 68 70  2  0  0  0  0
 978 68 69  1  0  0  0  0
 979 70 72  1  0  0  0  0
 980 70 71  1  0  0  0  0
 981 72 73  1  0  0  0  0
 982M  END
 983>  <ID>
 984Tri_07
 985
 986>  <Cathepsin L nM>
 98722000
 988
 989>  <Cathepsin B nM>
 990150000
 991
 992> <FP:MACCS>
 99323 41 42 54 57 79 82 89 90 91 92 95 97 98 100 105 106 107 109 110 111 112 113 115 117 123 125 126 128 131 132 134 136 137 138 140 142 143 144 145 146 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165
 994
 995$$$$
 996Men_13
 997  MOE2005           2D
 998
 999 70 71  0  0  1  0  0  0  0  0999 V2000
1000    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1001   -1.0400   -0.5990    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1002    0.0020    1.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1003   -1.0370    2.1010    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1004    1.3020    2.2480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1005    1.3030    3.4480    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1006    2.6000    1.4970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1007    3.6400    2.0960    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1008    2.5980   -0.0030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1009    3.8960   -0.7550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1010    5.1960   -0.0060    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
1011    3.1240   -1.6730    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1012    4.6660   -1.6750    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1013    1.2980   -0.7520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1014    1.2970   -1.9520    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1015    6.4940   -0.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1016    7.7940   -0.0090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
1017    9.0920   -0.7610    0.0000 C   0  0  3  0  0  0  0  0  0  0  0  0
1018    9.0910   -2.2610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1019   10.3890   -3.0120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1020   10.3870   -4.5120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1021    9.1870   -4.5110    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1022   10.3860   -5.7120    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1023   11.5870   -4.5140    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1024   11.6890   -2.2640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1025   12.2880   -3.3040    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1026   12.7290   -1.6650    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1027   11.0900   -1.2240    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1028   11.4280   -3.6120    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1029    7.9090   -2.0510    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1030    8.6790   -3.3880    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1031    9.0920    0.4390    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1032    7.7960    1.1910    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1033    6.4920   -2.2580    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
1034   10.3920   -0.0120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1035   10.3940    1.4880    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
1036   11.6940    2.2360    0.0000 C   0  0  3  0  0  0  0  0  0  0  0  0
1037   10.6550    2.8360    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1038   12.9920    1.4850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1039   14.2920    2.2330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1040   15.5900    1.4820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1041   13.5220    3.1530    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1042   15.0640    3.1520    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1043   12.2200    0.5660    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1044   13.7620    0.5650    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1045    9.3560    2.0890    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1046   11.6900   -0.7640    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
1047   11.6960    3.7360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1048   10.3980    4.4880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1049   10.3990    5.9880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
1050    9.9860    3.3610    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1051    9.2160    4.6980    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1052   12.9960    4.4850    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
1053   16.8900    2.2300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1054   16.8920    3.4300    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1055   18.1880    1.4790    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1056   19.2280    2.0770    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1057   18.1860   -0.0210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1058   19.2250   -0.6230    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1059   16.8870   -0.7700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1060   16.8850   -1.9700    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1061   15.5880   -0.0180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1062   14.5480   -0.6170    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1063    9.1010    6.7390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1064    9.1030    8.2390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1065   10.3030    8.2380    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1066    9.1040    9.4390    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1067    7.9030    8.2410    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1068    8.6890    5.6120    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1069    7.9200    6.9490    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1070  1 14  2  0  0  0  0
1071  1  3  1  0  0  0  0
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1073  3  4  1  0  0  0  0
1074  3  5  2  0  0  0  0
1075  5  7  1  0  0  0  0
1076  5  6  1  0  0  0  0
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1078  7  8  1  0  0  0  0
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1080  9 10  1  0  0  0  0
1081 10 12  1  0  0  0  0
1082 10 11  1  0  0  0  0
1083 10 13  1  0  0  0  0
1084 11 16  1  0  0  0  0
1085 14 15  1  0  0  0  0
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1087 16 34  2  0  0  0  0
1088 17 18  1  0  0  0  0
1089 17 33  1  0  0  0  0
1090 18 32  1  0  0  0  0
1091 18 19  1  0  0  0  0
1092 18 35  1  0  0  0  0
1093 19 30  1  0  0  0  0
1094 19 20  1  0  0  0  0
1095 19 31  1  0  0  0  0
1096 20 25  1  0  0  0  0
1097 20 21  1  0  0  0  0
1098 20 29  1  0  0  0  0
1099 21 23  1  0  0  0  0
1100 21 22  1  0  0  0  0
1101 21 24  1  0  0  0  0
1102 25 27  1  0  0  0  0
1103 25 26  1  0  0  0  0
1104 25 28  1  0  0  0  0
1105 35 36  1  0  0  0  0
1106 35 47  2  0  0  0  0
1107 36 37  1  0  0  0  0
1108 36 46  1  0  0  0  0
1109 37 39  1  0  0  0  0
1110 37 38  1  0  0  0  0
1111 37 48  1  0  0  0  0
1112 39 44  1  0  0  0  0
1113 39 40  1  0  0  0  0
1114 39 45  1  0  0  0  0
1115 40 42  1  0  0  0  0
1116 40 41  1  0  0  0  0
1117 40 43  1  0  0  0  0
1118 41 54  1  0  0  0  0
1119 41 62  2  0  0  0  0
1120 48 49  1  0  0  0  0
1121 48 53  2  0  0  0  0
1122 49 51  1  0  0  0  0
1123 49 50  1  0  0  0  0
1124 49 52  1  0  0  0  0
1125 50 64  1  0  0  0  0
1126 54 55  1  0  0  0  0
1127 54 56  2  0  0  0  0
1128 56 57  1  0  0  0  0
1129 56 58  1  0  0  0  0
1130 58 59  1  0  0  0  0
1131 58 60  2  0  0  0  0
1132 60 61  1  0  0  0  0
1133 60 62  1  0  0  0  0
1134 62 63  1  0  0  0  0
1135 64 69  1  0  0  0  0
1136 64 65  1  0  0  0  0
1137 64 70  1  0  0  0  0
1138 65 67  1  0  0  0  0
1139 65 66  1  0  0  0  0
1140 65 68  1  0  0  0  0
1141M  END
1142>  <ID>
1143Men_13
1144
1145>  <Cathepsin L nM>
114616700
1147
1148>  <Cathepsin B nM>
1149150000
1150
1151> <FP:MACCS>
115223 54 72 74 79 86 90 92 95 97 104 106 109 110 111 114 115 116 117 123 125 126 128 129 131 132 136 138 140 141 142 145 146 147 149 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165
1153
1154$$$$
1155Tri_04
1156  MOE2005           2D
1157
1158 38 38  0  0  1  0  0  0  0  0999 V2000
1159    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1160   -0.6040    1.0370    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1161    1.5000    0.0060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1162    2.0960    1.0480    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1163    2.2560   -1.2890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1164    3.4560   -1.2840    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1165    1.5110   -2.5920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1166    2.1160   -3.6280    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1167    0.0110   -2.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1168   -0.7330   -3.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
1169    0.3960   -4.3060    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1170   -0.9360   -5.0830    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
1171   -2.2330   -3.9070    0.0000…

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