/fingerprint/man/bitimp.Rd
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- \name{bit.importance}
- \alias{bit.importance}
- \title{
- Evaluate the Discriminatory Power of Individual Bits in a Binary Fingerprint
- }
- \description{
- This method evaluates the Kullback-Leibler (KL) divergence to rank the
- individual bits in a binary fingerprint in their ability to discriminate
- between database and active compounds. This method is implemented based on
- Nisius and Bajorath and includes an m-estimate correction.
- }
- \usage{
- bit.importance(actives, background)
- }
- \arguments{
- \item{actives}{A list of fingerprints for the actives}
- \item{background}{A list of fingerprints representing the background collection}
- }
- \value{
- A numeric vector of length equal to the size of the fingerprints. Each element
- of the vector is the KL divergence for the corresponding bit. If a bit position
- is never set to 1 in any of the compounds from the actives and the background, then
- the KL divergence for that position is undefined and \code{NA} is returned.
- }
- \seealso{
- \code{\link{bit.spectrum}}
- }
- \references{
- Nisius, B.; Bajorath, J.; \emph{ChemMedChem}, \bold{2010},
- \emph{5}, 859-868.
- }
- \keyword{programming}
- \author{Rajarshi Guha \email{rajarshi.guha@gmail.com}}