/test.data/contact_map/agents/~session036.test
Unknown | 775 lines | 775 code | 0 blank | 0 comment | 0 complexity | b2d5c04ce2d593f15dbdbc657cd5bb2b MD5 | raw file
Possible License(s): LGPL-3.0, Apache-2.0
- <?xml version='1.0' encoding='utf-8'?>
- <!-- Automaticaly generated by Complx 3.40..4208 -->
- <ComplxSession Timestamp="25/2/2009 (21:58:11)" CommandLine="C:\DOCUME~1\LOPATK~1\LOCALS~1\Temp\tmp53467.exe ~kappa53576.tmp --output-xml ~session53575.tmp --memory-limit 1024 --reset-all --do-XML --do-low-res-contact-map --focus-on ~focus53574.tmp --key 07CFC00F0BEB0278" InputFile="~kappa53576.tmp"
- xsi:schemaLocation="http://plectix.synthesisstudios.com
- KappaSession.xsd" xmlns="http://plectix.synthesisstudios.com/schemas/kappasession"
- xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" >
- <Log>
- <Entry Type="INFO" Message="Compilation(simplx) 0.047 s."/>
- <Entry Type="INFO" Message="Second compilation(pretty printing) 0.016 s."/>
- <Entry Type="INFO" Message="Translation 0. s."/>
- <Entry Type="INFO" Message="Renaming 0.015 s."/>
- <Entry Type="INFO" Message="Boolean encoding of the initial system 0.157 s."/>
- </Log>
- <RuleSet Name="Original">
- <Rule Id="1" Name="HRG_HER3" Data="HRG(r),HER3(CR,L)->HRG(r!0),HER3(CR,L!0)" ForwardRate="1" />
- <Rule Id="2" Name="HRG_HER3_op" Data="HRG(r!0),HER3(L!0)->HRG(r),HER3(L)" ForwardRate="1" />
- <Rule Id="3" Name="EGFR_HER3" Data="EGFR(C,CR,L~ext!_,N),HER3(C,CR,L~ext!_)->EGFR(C,CR!0,L~ext!_,N),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />
- <Rule Id="4" Name="HER2_HER3" Data="HER2(C,CR,N),HER3(C,CR,L~ext!_)->HER2(C,CR!0,N),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />
- <Rule Id="5" Name="HER3_HER3" Data="HER3(C,CR,L~ext!_),HER3(C,CR,L~ext!_)->HER3(C,CR!0,L~ext!_),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />
- <Rule Id="6" Name="HER3_HER4" Data="HER3(C,CR,L~ext!_),HER4(C,CR,L~ext!_,N)->HER3(C,CR!0,L~ext!_),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
- <Rule Id="7" Name="EGFR_HER3_op" Data="EGFR(C,CR!0,N),HER3(C,CR!0)->EGFR(C,CR,N),HER3(C,CR)" ForwardRate="1" />
- <Rule Id="8" Name="HER2_HER3_op" Data="HER2(C,CR!0,N),HER3(C,CR!0)->HER2(C,CR,N),HER3(C,CR)" ForwardRate="1" />
- <Rule Id="9" Name="HER3_HER3_op" Data="HER3(C,CR!0),HER3(C,CR!0)->HER3(C,CR),HER3(C,CR)" ForwardRate="1" />
- <Rule Id="10" Name="HER3_HER4_op" Data="HER3(C,CR!0),HER4(C,CR!0,N)->HER3(C,CR),HER4(C,CR,N)" ForwardRate="1" />
- <Rule Id="11" Name="13 dimer" Data="EGFR(C,CR!0,N),HER3(C,CR!0)->EGFR(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />
- <Rule Id="12" Name="13 dimer_op" Data="EGFR(C,CR!1,N!0),HER3(C!0,CR!1)->EGFR(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />
- <Rule Id="13" Name="23 dimer" Data="HER2(C,CR!0,N),HER3(C,CR!0)->HER2(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />
- <Rule Id="14" Name="23 dimer_op" Data="HER2(C,CR!1,N!0),HER3(C!0,CR!1)->HER2(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />
- <Rule Id="15" Name="43 dimer" Data="HER4(C,CR!0,N),HER3(C,CR!0)->HER4(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />
- <Rule Id="16" Name="43 dimer_op" Data="HER4(C,CR!1,N!0),HER3(C!0,CR!1)->HER4(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />
- <Rule Id="17" Name="Rule1" Data="EGFR(N!0,bp),HER3(C!0,Y1035~u)->EGFR(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />
- <Rule Id="18" Name="Rule2" Data="HER2(N!0,bp),HER3(C!0,Y1035~u)->HER2(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />
- <Rule Id="19" Name="Rule3" Data="HER4(N!0,bp),HER3(C!0,Y1035~u)->HER4(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />
- <Rule Id="20" Name="Rule4" Data="EGFR(N!0,bp),HER3(C!0,Y1178~u)->EGFR(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />
- <Rule Id="21" Name="Rule5" Data="HER2(N!0,bp),HER3(C!0,Y1178~u)->HER2(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />
- <Rule Id="22" Name="Rule6" Data="HER4(N!0,bp),HER3(C!0,Y1178~u)->HER4(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />
- <Rule Id="23" Name="Rule7" Data="EGFR(N!0,bp),HER3(C!0,Y1203~u)->EGFR(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />
- <Rule Id="24" Name="Rule8" Data="HER2(N!0,bp),HER3(C!0,Y1203~u)->HER2(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />
- <Rule Id="25" Name="Rule9" Data="HER4(N!0,bp),HER3(C!0,Y1203~u)->HER4(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />
- <Rule Id="26" Name="Rule10" Data="EGFR(N!0,bp),HER3(C!0,Y1241~u)->EGFR(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />
- <Rule Id="27" Name="Rule11" Data="HER2(N!0,bp),HER3(C!0,Y1241~u)->HER2(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />
- <Rule Id="28" Name="Rule12" Data="HER4(N!0,bp),HER3(C!0,Y1241~u)->HER4(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />
- <Rule Id="29" Name="Rule13" Data="EGFR(N!0,bp),HER3(C!0,Y1257~u)->EGFR(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />
- <Rule Id="30" Name="Rule14" Data="HER2(N!0,bp),HER3(C!0,Y1257~u)->HER2(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />
- <Rule Id="31" Name="Rule15" Data="HER4(N!0,bp),HER3(C!0,Y1257~u)->HER4(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />
- <Rule Id="32" Name="Rule16" Data="EGFR(N!0,bp),HER3(C!0,Y1270~u)->EGFR(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />
- <Rule Id="33" Name="Rule17" Data="HER2(N!0,bp),HER3(C!0,Y1270~u)->HER2(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />
- <Rule Id="34" Name="Rule18" Data="HER4(N!0,bp),HER3(C!0,Y1270~u)->HER4(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />
- <Rule Id="35" Name="Rule19" Data="EGFR(N!0,bp),HER3(C!0,Y1309~u)->EGFR(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />
- <Rule Id="36" Name="Rule20" Data="HER2(N!0,bp),HER3(C!0,Y1309~u)->HER2(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />
- <Rule Id="37" Name="Rule21" Data="HER4(N!0,bp),HER3(C!0,Y1309~u)->HER4(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />
- <Rule Id="38" Name="Rule22" Data="HER3(Y1035~p),PTP(s)->HER3(Y1035~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="39" Name="Rule23" Data="HER3(Y1178~p),PTP(s)->HER3(Y1178~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="40" Name="Rule24" Data="HER3(Y1203~p),PTP(s)->HER3(Y1203~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="41" Name="Rule25" Data="HER3(Y1241~p),PTP(s)->HER3(Y1241~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="42" Name="Rule26" Data="HER3(Y1257~p),PTP(s)->HER3(Y1257~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="43" Name="Rule27" Data="HER3(Y1270~p),PTP(s)->HER3(Y1270~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="44" Name="Rule28" Data="HER3(Y1309~p),PTP(s)->HER3(Y1309~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="45" Name="Rule29" Data="HER3(Y1035!0),PTP(s!0)->HER3(Y1035),PTP(s)" ForwardRate="1" />
- <Rule Id="46" Name="Rule30" Data="HER3(Y1178!0),PTP(s!0)->HER3(Y1178),PTP(s)" ForwardRate="1" />
- <Rule Id="47" Name="Rule31" Data="HER3(Y1203!0),PTP(s!0)->HER3(Y1203),PTP(s)" ForwardRate="1" />
- <Rule Id="48" Name="Rule32" Data="HER3(Y1241!0),PTP(s!0)->HER3(Y1241),PTP(s)" ForwardRate="1" />
- <Rule Id="49" Name="Rule33" Data="HER3(Y1257!0),PTP(s!0)->HER3(Y1257),PTP(s)" ForwardRate="1" />
- <Rule Id="50" Name="Rule34" Data="HER3(Y1270!0),PTP(s!0)->HER3(Y1270),PTP(s)" ForwardRate="1" />
- <Rule Id="51" Name="Rule35" Data="HER3(Y1309!0),PTP(s!0)->HER3(Y1309),PTP(s)" ForwardRate="1" />
- <Rule Id="52" Name="Rule36" Data="HER3(Y1035~p!0),PTP(s!0)->HER3(Y1035~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="53" Name="Rule37" Data="HER3(Y1178~p!0),PTP(s!0)->HER3(Y1178~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="54" Name="Rule38" Data="HER3(Y1203~p!0),PTP(s!0)->HER3(Y1203~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="55" Name="Rule39" Data="HER3(Y1241~p!0),PTP(s!0)->HER3(Y1241~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="56" Name="Rule40" Data="HER3(Y1257~p!0),PTP(s!0)->HER3(Y1257~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="57" Name="Rule41" Data="HER3(Y1270~p!0),PTP(s!0)->HER3(Y1270~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="58" Name="Rule42" Data="HER3(Y1309~p!0),PTP(s!0)->HER3(Y1309~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="59" Name="HER3_PI3K#1" Data="HER3(Y1035~p),PI3K(SH2~u)=>HER3(Y1035~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="60" Name="HER3_PI3K#1_op" Data="HER3(Y1035~p!0),PI3K(SH2~rec!0)=>HER3(Y1035~p),PI3K(SH2~u)" ForwardRate="1" />
- <Rule Id="61" Name="HER3_PI3K#2" Data="HER3(Y1178~p),PI3K(SH2~u)=>HER3(Y1178~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="62" Name="HER3_PI3K#2_op" Data="HER3(Y1178~p!0),PI3K(SH2~rec!0)=>HER3(Y1178~p),PI3K(SH2~u)" ForwardRate="1" />
- <Rule Id="63" Name="HER3_PI3K#3" Data="HER3(Y1203~p),PI3K(SH2~u)=>HER3(Y1203~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="64" Name="HER3_PI3K#3_op" Data="HER3(Y1203~p!0),PI3K(SH2~rec!0)=>HER3(Y1203~p),PI3K(SH2~u)" ForwardRate="1" />
- <Rule Id="65" Name="HER3_PI3K#4" Data="HER3(Y1241~p),PI3K(SH2~u)=>HER3(Y1241~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="66" Name="HER3_PI3K#4_op" Data="HER3(Y1241~p!0),PI3K(SH2~rec!0)=>HER3(Y1241~p),PI3K(SH2~u)" ForwardRate="1" />
- <Rule Id="67" Name="HER3_PI3K#5" Data="HER3(Y1257~p),PI3K(SH2~u)=>HER3(Y1257~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="68" Name="HER3_PI3K#5_op" Data="HER3(Y1257~p!0),PI3K(SH2~rec!0)=>HER3(Y1257~p),PI3K(SH2~u)" ForwardRate="1" />
- <Rule Id="69" Name="HER3_PI3K#6" Data="HER3(Y1270~p),PI3K(SH2~u)=>HER3(Y1270~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="70" Name="HER3_PI3K#6_op" Data="HER3(Y1270~p!0),PI3K(SH2~rec!0)=>HER3(Y1270~p),PI3K(SH2~u)" ForwardRate="1" />
- <Rule Id="71" Name="HER3_Shc" Data="HER3(Y1309~p),Shc(PTB~u)=>HER3(Y1309~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
- <Rule Id="72" Name="HER3_Shc_op" Data="HER3(Y1309~p!0),Shc(PTB~rec!0)=>HER3(Y1309~p),Shc(PTB~u)" ForwardRate="1" />
- <Rule Id="73" Name="HRG_ErbB3" Data="HRG(r~ext),ErbB3(CR,L~ext)->HRG(r~ext!0),ErbB3(CR,L~ext!0)" ForwardRate="1" />
- <Rule Id="74" Name="HRG_ErbB3_op" Data="HRG(r~ext!0),ErbB3(CR,L~ext!0)->HRG(r~ext),ErbB3(CR,L~ext)" ForwardRate="1" />
- <Rule Id="75" Name="HRG_ErbB4" Data="HRG(r~ext),ErbB4(CR,L~ext)->HRG(r~ext!0),ErbB4(CR,L~ext!0)" ForwardRate="1" />
- <Rule Id="76" Name="HRG_ErbB4_op" Data="HRG(r~ext!0),ErbB4(CR,L~ext!0)->HRG(r~ext),ErbB4(CR,L~ext)" ForwardRate="1" />
- <Rule Id="77" Name="ErbB1_Shc" Data="ErbB1(Y1148~p),Shc(PTB)->ErbB1(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />
- <Rule Id="78" Name="ErbB1_Shc_op" Data="ErbB1(Y1148~p!0),Shc(PTB!0)->ErbB1(Y1148~p),Shc(PTB)" ForwardRate="1" />
- <Rule Id="79" Name="ErbB2_Shc#1" Data="ErbB2(Y1196~p),Shc(PTB)->ErbB2(Y1196~p!0),Shc(PTB!0)" ForwardRate="1" />
- <Rule Id="80" Name="ErbB2_Shc#1_op" Data="ErbB2(Y1196~p!0),Shc(PTB!0)->ErbB2(Y1196~p),Shc(PTB)" ForwardRate="1" />
- <Rule Id="81" Name="ErbB2_Shc#2" Data="ErbB2(Y1221~p),Shc(PTB)->ErbB2(Y1221~p!0),Shc(PTB!0)" ForwardRate="1" />
- <Rule Id="82" Name="ErbB2_Shc#2_op" Data="ErbB2(Y1221~p!0),Shc(PTB!0)->ErbB2(Y1221~p),Shc(PTB)" ForwardRate="1" />
- <Rule Id="83" Name="ErbB3_Shc" Data="ErbB3(Y1309~p),Shc(PTB)->ErbB3(Y1309~p!0),Shc(PTB!0)" ForwardRate="1" />
- <Rule Id="84" Name="ErbB3_Shc_op" Data="ErbB3(Y1309~p!0),Shc(PTB!0)->ErbB3(Y1309~p),Shc(PTB)" ForwardRate="1" />
- <Rule Id="85" Name="Shc#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~u)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
- <Rule Id="86" Name="Shc#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
- <Rule Id="87" Name="Shc#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
- <Rule Id="88" Name="Shc#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~u)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
- <Rule Id="89" Name="Shc_op" Data="Shc(Y318~p)=>Shc(Y318~u),Pi()" ForwardRate="1" />
- <Rule Id="90" Name="Shc_Grb2" Data="Shc(Y318~p),Grb2(SH2)->Shc(Y318~p!0),Grb2(SH2!0)" ForwardRate="1" />
- <Rule Id="91" Name="Shc_Grb2_op" Data="Shc(Y318~p!0),Grb2(SH2!0)->Shc(Y318~p),Grb2(SH2)" ForwardRate="1" />
- <Rule Id="92" Name="long arm SoS_Ras#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
- <Rule Id="93" Name="long arm SoS_Ras#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
- <Rule Id="94" Name="long arm SoS_Ras#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
- <Rule Id="95" Name="long arm SoS_Ras#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
- <Rule Id="96" Name="Gab1_PI3K@447" Data="Gab1(Y447~p),PI3K(SH2)->Gab1(Y447~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="97" Name="Gab1_PI3K@447_op" Data="Gab1(Y447~p!0),PI3K(SH2!0)->Gab1(Y447~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="98" Name="Gab1_PI3K@472" Data="Gab1(Y472~p),PI3K(SH2)->Gab1(Y472~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="99" Name="Gab1_PI3K@472_op" Data="Gab1(Y472~p!0),PI3K(SH2!0)->Gab1(Y472~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="100" Name="Gab1_PI3K@619" Data="Gab1(Y619~p),PI3K(SH2)->Gab1(Y619~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="101" Name="Gab1_PI3K@619_op" Data="Gab1(Y619~p!0),PI3K(SH2!0)->Gab1(Y619~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="102" Name="ErbB3_PI3K#1" Data="ErbB3(Y1035~p),PI3K(SH2)->ErbB3(Y1035~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="103" Name="ErbB3_PI3K#1_op" Data="ErbB3(Y1035~p!0),PI3K(SH2!0)->ErbB3(Y1035~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="104" Name="ErbB3_PI3K#2" Data="ErbB3(Y1178~p),PI3K(SH2)->ErbB3(Y1178~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="105" Name="ErbB3_PI3K#2_op" Data="ErbB3(Y1178~p!0),PI3K(SH2!0)->ErbB3(Y1178~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="106" Name="ErbB3_PI3K#3" Data="ErbB3(Y1203~p),PI3K(SH2)->ErbB3(Y1203~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="107" Name="ErbB3_PI3K#3_op" Data="ErbB3(Y1203~p!0),PI3K(SH2!0)->ErbB3(Y1203~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="108" Name="ErbB3_PI3K#4" Data="ErbB3(Y1241~p),PI3K(SH2)->ErbB3(Y1241~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="109" Name="ErbB3_PI3K#4_op" Data="ErbB3(Y1241~p!0),PI3K(SH2!0)->ErbB3(Y1241~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="110" Name="ErbB3_PI3K#5" Data="ErbB3(Y1257~p),PI3K(SH2)->ErbB3(Y1257~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="111" Name="ErbB3_PI3K#5_op" Data="ErbB3(Y1257~p!0),PI3K(SH2!0)->ErbB3(Y1257~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="112" Name="ErbB3_PI3K#6" Data="ErbB3(Y1270~p),PI3K(SH2)->ErbB3(Y1270~p!0),PI3K(SH2!0)" ForwardRate="1" />
- <Rule Id="113" Name="ErbB3_PI3K#6_op" Data="ErbB3(Y1270~p!0),PI3K(SH2!0)->ErbB3(Y1270~p),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="114" Name="short arm PI3K_PI#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
- <Rule Id="115" Name="short arm PI3K_PI#2" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
- <Rule Id="116" Name="short arm PI3K_PI#3" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
- <Rule Id="117" Name="short arm PI3K_PI#4" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
- <Rule Id="118" Name="short arm PI3K_PI#5" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
- <Rule Id="119" Name="short arm PI3K_PI#6" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
- <Rule Id="120" Name="direct PI3K_PI#1" Data="ErbB3(Y1035~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1035~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="121" Name="direct PI3K_PI#2" Data="ErbB3(Y1178~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1178~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="122" Name="direct PI3K_PI#3" Data="ErbB3(Y1203~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1203~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="123" Name="direct PI3K_PI#4" Data="ErbB3(Y1241~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1241~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="124" Name="direct PI3K_PI#5" Data="ErbB3(Y1257~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1257~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="125" Name="direct PI3K_PI#6" Data="ErbB3(Y1270~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1270~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="126" Name="PI@three" Data="PI3K(s!0),PI(three~u!0)->PI3K(s!0),PI(three~p!0)" ForwardRate="1" />
- <Rule Id="127" Name="PI3K_PI_op" Data="PI3K(s!0),PI(three!0)->PI3K(s),PI(three)" ForwardRate="1" />
- <Rule Id="128" Name="Rule43" Data="H()=>HRG(r)" ForwardRate="1" />
- <Rule Id="129" Name="EGF_EGFRe" Data="EGF(r~ext),EGFR(CR,L~ext)->EGF(r~ext!0),EGFR(CR,L~ext!0)" ForwardRate="1" />
- <Rule Id="130" Name="EGF_EGFRi" Data="EGF(r~int),EGFR(CR,L~int)->EGF(r~int!0),EGFR(CR,L~int!0)" ForwardRate="1" />
- <Rule Id="131" Name="HRG_HER4" Data="HRG(r),HER4(CR,L)->HRG(r!0),HER4(CR,L!0)" ForwardRate="1" />
- <Rule Id="132" Name="EGF_EGFR_op" Data="EGF(r!0),EGFR(L!0)->EGF(r),EGFR(L)" ForwardRate="1" />
- <Rule Id="133" Name="HRG_HER4_op" Data="HRG(r!0),HER4(L!0)->HRG(r),HER4(L)" ForwardRate="1" />
- <Rule Id="134" Name="EGFR_EGFRe" Data="EGFR(C,CR,L~ext!_,N),EGFR(C,CR,L~ext!_,N)->EGFR(C,CR!0,L~ext!_,N),EGFR(C,CR!0,L~ext!_,N)" ForwardRate="1" />
- <Rule Id="135" Name="EGFR_EGFRi" Data="EGFR(C,CR,L~int!_,N),EGFR(C,CR,L~int!_,N)->EGFR(C,CR!0,L~int!_,N),EGFR(C,CR!0,L~int!_,N)" ForwardRate="1" />
- <Rule Id="136" Name="EGFR_HER2" Data="EGFR(C,CR,L~ext!_,N),HER2(C,CR,N)->EGFR(C,CR!0,L~ext!_,N),HER2(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="137" Name="EGFR_HER4" Data="EGFR(C,CR,L~ext!_,N),HER4(C,CR,L~ext!_,N)->EGFR(C,CR!0,L~ext!_,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
- <Rule Id="138" Name="HER2_HER4" Data="HER2(C,CR,N),HER4(C,CR,L~ext!_,N)->HER2(C,CR!0,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
- <Rule Id="139" Name="HER4_HER4" Data="HER4(C,CR,L~ext!_,N),HER4(C,CR,L~ext!_,N)->HER4(C,CR!0,L~ext!_,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
- <Rule Id="140" Name="EGFR_EGFR_op" Data="EGFR(C,CR!0,N),EGFR(C,CR!0,N)->EGFR(C,CR,N),EGFR(C,CR,N)" ForwardRate="1" />
- <Rule Id="141" Name="EGFR_HER2_op" Data="EGFR(C,CR!0,N),HER2(C,CR!0,N)->EGFR(C,CR,N),HER2(C,CR,N)" ForwardRate="1" />
- <Rule Id="142" Name="EGFR_HER4_op" Data="EGFR(C,CR!0,N),HER4(C,CR!0,N)->EGFR(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />
- <Rule Id="143" Name="HER2_HER2_op" Data="HER2(C,CR!0,N),HER2(C,CR!0,N)->HER2(C,CR,N),HER2(C,CR,N)" ForwardRate="1" />
- <Rule Id="144" Name="HER2_HER4_op" Data="HER2(C,CR!0,N),HER4(C,CR!0,N)->HER2(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />
- <Rule Id="145" Name="HER4_HER4_op" Data="HER4(C,CR!0,N),HER4(C,CR!0,N)->HER4(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />
- <Rule Id="146" Name="11 dimer" Data="EGFR(C,CR!0,N),EGFR(C,CR!0,N)->EGFR(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="147" Name="11 dimer_op" Data="EGFR(C,CR!1,N!0),EGFR(C!0,CR!1,N)->EGFR(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="148" Name="21 dimer" Data="HER2(C,CR!0,N),EGFR(C,CR!0,N)->HER2(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="149" Name="21 dimer_op" Data="HER2(C,CR!1,N!0),EGFR(C!0,CR!1,N)->HER2(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="150" Name="41 dimer" Data="HER4(C,CR!0,N),EGFR(C,CR!0,N)->HER4(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="151" Name="41 dimer_op" Data="HER4(C,CR!1,N!0),EGFR(C!0,CR!1,N)->HER4(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="152" Name="12 dimer" Data="EGFR(C,CR!0,N),HER2(C,CR!0,N)->EGFR(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="153" Name="12 dimer_op" Data="EGFR(C,CR!1,N!0),HER2(C!0,CR!1,N)->EGFR(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="154" Name="22 dimer" Data="HER2(C,CR!0,N),HER2(C,CR!0,N)->HER2(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="155" Name="22 dimer_op" Data="HER2(C,CR!1,N!0),HER2(C!0,CR!1,N)->HER2(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="156" Name="42 dimer" Data="HER4(C,CR!0,N),HER2(C,CR!0,N)->HER4(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="157" Name="42 dimer_op" Data="HER4(C,CR!1,N!0),HER2(C!0,CR!1,N)->HER4(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="158" Name="14 dimer" Data="EGFR(C,CR!0,N),HER4(C,CR!0,N)->EGFR(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="159" Name="14 dimer_op" Data="EGFR(C,CR!1,N!0),HER4(C!0,CR!1,N)->EGFR(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="160" Name="24 dimer" Data="HER2(C,CR!0,N),HER4(C,CR!0,N)->HER2(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="161" Name="24 dimer_op" Data="HER2(C,CR!1,N!0),HER4(C!0,CR!1,N)->HER2(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="162" Name="44 dimer" Data="HER4(C,CR!0,N),HER4(C,CR!0,N)->HER4(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />
- <Rule Id="163" Name="44 dimer_op" Data="HER4(C,CR!1,N!0),HER4(C!0,CR!1,N)->HER4(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />
- <Rule Id="164" Name="EGFR_Inh" Data="EGFR(N!_,bp),Inh1(s)->EGFR(N!_,bp!0),Inh1(s!0)" ForwardRate="1" />
- <Rule Id="165" Name="HER2_Inh" Data="HER2(N!_,bp),Inh2(s)->HER2(N!_,bp!0),Inh2(s!0)" ForwardRate="1" />
- <Rule Id="166" Name="HER4_Inh" Data="HER4(N!_,bp),Inh4(s)->HER4(N!_,bp!0),Inh4(s!0)" ForwardRate="1" />
- <Rule Id="167" Name="EGFR_Inh_op" Data="EGFR(bp!0),Inh1(s!0)->EGFR(bp),Inh1(s)" ForwardRate="1" />
- <Rule Id="168" Name="HER2_Inh_op" Data="HER2(bp!0),Inh2(s!0)->HER2(bp),Inh2(s)" ForwardRate="1" />
- <Rule Id="169" Name="HER4_Inh_op" Data="HER4(bp!0),Inh4(s!0)->HER4(bp),Inh4(s)" ForwardRate="1" />
- <Rule Id="170" Name="EGF_mono" Data="EGF(r~ext!0),EGFR(CR,L~ext!0)=>EGF(r~int!0),EGFR(CR,L~int!0)" ForwardRate="1" />
- <Rule Id="171" Name="EGF_di" Data="EGF(r~ext!0),EGFR(CR!1,L~ext!0),EGF(r~ext!2),EGFR(CR!1,L~ext!2)=>EGF(r~int!0),EGFR(CR!1,L~int!0),EGF(r~int!2),EGFR(CR!1,L~int!2)" ForwardRate="1" />
- <Rule Id="172" Name="Rule44" Data="EGFR(N!0,bp),EGFR(C!0,Y1016~u)->EGFR(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
- <Rule Id="173" Name="Rule45" Data="HER2(N!0,bp),EGFR(C!0,Y1016~u)->HER2(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
- <Rule Id="174" Name="Rule46" Data="HER4(N!0,bp),EGFR(C!0,Y1016~u)->HER4(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
- <Rule Id="175" Name="Rule47" Data="EGFR(N!0,bp),EGFR(C!0,Y1092~u)->EGFR(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
- <Rule Id="176" Name="Rule48" Data="HER2(N!0,bp),EGFR(C!0,Y1092~u)->HER2(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
- <Rule Id="177" Name="Rule49" Data="HER4(N!0,bp),EGFR(C!0,Y1092~u)->HER4(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
- <Rule Id="178" Name="Rule50" Data="EGFR(N!0,bp),EGFR(C!0,Y1172~u)->EGFR(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
- <Rule Id="179" Name="Rule51" Data="HER2(N!0,bp),EGFR(C!0,Y1172~u)->HER2(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
- <Rule Id="180" Name="Rule52" Data="HER4(N!0,bp),EGFR(C!0,Y1172~u)->HER4(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
- <Rule Id="181" Name="Rule53" Data="EGFR(N!0,bp),HER2(C!0,Y1139~u)->EGFR(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />
- <Rule Id="182" Name="Rule54" Data="HER2(N!0,bp),HER2(C!0,Y1139~u)->HER2(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />
- <Rule Id="183" Name="Rule55" Data="HER4(N!0,bp),HER2(C!0,Y1139~u)->HER4(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />
- <Rule Id="184" Name="Rule56" Data="EGFR(N!0,bp),HER2(C!0,Y1196~u)->EGFR(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />
- <Rule Id="185" Name="Rule57" Data="HER2(N!0,bp),HER2(C!0,Y1196~u)->HER2(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />
- <Rule Id="186" Name="Rule58" Data="HER4(N!0,bp),HER2(C!0,Y1196~u)->HER4(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />
- <Rule Id="187" Name="Rule59" Data="EGFR(N!0,bp),HER2(C!0,Y1221~u)->EGFR(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />
- <Rule Id="188" Name="Rule60" Data="HER2(N!0,bp),HER2(C!0,Y1221~u)->HER2(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />
- <Rule Id="189" Name="Rule61" Data="HER4(N!0,bp),HER2(C!0,Y1221~u)->HER4(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />
- <Rule Id="190" Name="Rule62" Data="EGFR(N!0,bp),HER4(C!0,Y1~u)->EGFR(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />
- <Rule Id="191" Name="Rule63" Data="HER2(N!0,bp),HER4(C!0,Y1~u)->HER2(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />
- <Rule Id="192" Name="Rule64" Data="HER4(N!0,bp),HER4(C!0,Y1~u)->HER4(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />
- <Rule Id="193" Name="Rule65" Data="EGFR(N!0,bp),HER4(C!0,Y2~u)->EGFR(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />
- <Rule Id="194" Name="Rule66" Data="HER2(N!0,bp),HER4(C!0,Y2~u)->HER2(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />
- <Rule Id="195" Name="Rule67" Data="HER4(N!0,bp),HER4(C!0,Y2~u)->HER4(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />
- <Rule Id="196" Name="Rule68" Data="EGFR(N!0,bp),HER4(C!0,Y3~u)->EGFR(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />
- <Rule Id="197" Name="Rule69" Data="HER2(N!0,bp),HER4(C!0,Y3~u)->HER2(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />
- <Rule Id="198" Name="Rule70" Data="HER4(N!0,bp),HER4(C!0,Y3~u)->HER4(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />
- <Rule Id="199" Name="Rule71" Data="EGFR(Y1016~p),PTP(s)->EGFR(Y1016~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="200" Name="Rule72" Data="EGFR(Y1092~p),PTP(s)->EGFR(Y1092~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="201" Name="Rule73" Data="EGFR(Y1172~p),PTP(s)->EGFR(Y1172~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="202" Name="Rule74" Data="HER2(Y1139~p),PTP(s)->HER2(Y1139~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="203" Name="Rule75" Data="HER2(Y1196~p),PTP(s)->HER2(Y1196~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="204" Name="Rule76" Data="HER2(Y1221~p),PTP(s)->HER2(Y1221~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="205" Name="Rule77" Data="HER4(Y1~p),PTP(s)->HER4(Y1~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="206" Name="Rule78" Data="HER4(Y2~p),PTP(s)->HER4(Y2~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="207" Name="Rule79" Data="HER4(Y3~p),PTP(s)->HER4(Y3~p!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="208" Name="Rule80" Data="EGFR(Y1016!0),PTP(s!0)->EGFR(Y1016),PTP(s)" ForwardRate="1" />
- <Rule Id="209" Name="Rule81" Data="EGFR(Y1092!0),PTP(s!0)->EGFR(Y1092),PTP(s)" ForwardRate="1" />
- <Rule Id="210" Name="Rule82" Data="EGFR(Y1172!0),PTP(s!0)->EGFR(Y1172),PTP(s)" ForwardRate="1" />
- <Rule Id="211" Name="Rule83" Data="HER2(Y1139!0),PTP(s!0)->HER2(Y1139),PTP(s)" ForwardRate="1" />
- <Rule Id="212" Name="Rule84" Data="HER2(Y1196!0),PTP(s!0)->HER2(Y1196),PTP(s)" ForwardRate="1" />
- <Rule Id="213" Name="Rule85" Data="HER2(Y1221!0),PTP(s!0)->HER2(Y1221),PTP(s)" ForwardRate="1" />
- <Rule Id="214" Name="Rule86" Data="HER4(Y1!0),PTP(s!0)->HER4(Y1),PTP(s)" ForwardRate="1" />
- <Rule Id="215" Name="Rule87" Data="HER4(Y2!0),PTP(s!0)->HER4(Y2),PTP(s)" ForwardRate="1" />
- <Rule Id="216" Name="Rule88" Data="HER4(Y3!0),PTP(s!0)->HER4(Y3),PTP(s)" ForwardRate="1" />
- <Rule Id="217" Name="Rule89" Data="EGFR(Y1016~p!0),PTP(s!0)->EGFR(Y1016~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="218" Name="Rule90" Data="EGFR(Y1092~p!0),PTP(s!0)->EGFR(Y1092~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="219" Name="Rule91" Data="EGFR(Y1172~p!0),PTP(s!0)->EGFR(Y1172~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="220" Name="Rule92" Data="HER2(Y1139~p!0),PTP(s!0)->HER2(Y1139~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="221" Name="Rule93" Data="HER2(Y1196~p!0),PTP(s!0)->HER2(Y1196~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="222" Name="Rule94" Data="HER2(Y1221~p!0),PTP(s!0)->HER2(Y1221~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="223" Name="Rule95" Data="HER4(Y1~p!0),PTP(s!0)->HER4(Y1~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="224" Name="Rule96" Data="HER4(Y2~p!0),PTP(s!0)->HER4(Y2~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="225" Name="Rule97" Data="HER4(Y3~p!0),PTP(s!0)->HER4(Y3~u!0),PTP(s!0)" ForwardRate="1" />
- <Rule Id="226" Name="deg_EGFR" Data="EGFR(CR,L~int)->" ForwardRate="1" />
- <Rule Id="227" Name="EGFR_RasGAP" Data="EGFR(Y1016~p),RasGAP(SH2~u)=>EGFR(Y1016~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="228" Name="EGFR_RasGAP_op" Data="EGFR(Y1016~p!0),RasGAP(SH2~rec!0)=>EGFR(Y1016~p),RasGAP(SH2~u)" ForwardRate="1" />
- <Rule Id="229" Name="EGFR_Grb2" Data="EGFR(Y1092~p),Grb2(SH2~u)=>EGFR(Y1092~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="230" Name="EGFR_Grb2_op" Data="EGFR(Y1092~p!0),Grb2(SH2~rec!0)=>EGFR(Y1092~p),Grb2(SH2~u)" ForwardRate="1" />
- <Rule Id="231" Name="EGFR_Shc" Data="EGFR(Y1172~p),Shc(PTB~u)=>EGFR(Y1172~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
- <Rule Id="232" Name="EGFR_Shc_op" Data="EGFR(Y1172~p!0),Shc(PTB~rec!0)=>EGFR(Y1172~p),Shc(PTB~u)" ForwardRate="1" />
- <Rule Id="233" Name="HER2_Grb2" Data="HER2(Y1139~p),Grb2(SH2~u)=>HER2(Y1139~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="234" Name="HER2_Grb2_op" Data="HER2(Y1139~p!0),Grb2(SH2~rec!0)=>HER2(Y1139~p),Grb2(SH2~u)" ForwardRate="1" />
- <Rule Id="235" Name="HER2_Shc#1" Data="HER2(Y1196~p),Shc(PTB~u)=>HER2(Y1196~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
- <Rule Id="236" Name="HER2_Shc#1_op" Data="HER2(Y1196~p!0),Shc(PTB~rec!0)=>HER2(Y1196~p),Shc(PTB~u)" ForwardRate="1" />
- <Rule Id="237" Name="HER2_RasGAP" Data="HER2(Y1221~p),RasGAP(SH2~u)=>HER2(Y1221~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="238" Name="HER2_RasGAP_op" Data="HER2(Y1221~p!0),RasGAP(SH2~rec!0)=>HER2(Y1221~p),RasGAP(SH2~u)" ForwardRate="1" />
- <Rule Id="239" Name="HER2_Shc#2" Data="HER2(Y1221~p),Shc(PTB~u)=>HER2(Y1221~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
- <Rule Id="240" Name="HER2_Shc#2_op" Data="HER2(Y1221~p!0),Shc(PTB~rec!0)=>HER2(Y1221~p),Shc(PTB~u)" ForwardRate="1" />
- <Rule Id="241" Name="HER4_RasGAP" Data="HER4(Y1~p),RasGAP(SH2~u)=>HER4(Y1~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="242" Name="HER4_RasGAP_op" Data="HER4(Y1~p!0),RasGAP(SH2~rec!0)=>HER4(Y1~p),RasGAP(SH2~u)" ForwardRate="1" />
- <Rule Id="243" Name="HER4_Grb2" Data="HER4(Y2~p),Grb2(SH2~u)=>HER4(Y2~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
- <Rule Id="244" Name="HER4_Grb2_op" Data="HER4(Y2~p!0),Grb2(SH2~rec!0)=>HER4(Y2~p),Grb2(SH2~u)" ForwardRate="1" />
- <Rule Id="245" Name="HER4_Shc" Data="HER4(Y3~p),Shc(PTB~u)=>HER4(Y3~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
- <Rule Id="246" Name="HER4_Shc_op" Data="HER4(Y3~p!0),Shc(PTB~rec!0)=>HER4(Y3~p),Shc(PTB~u)" ForwardRate="1" />
- <Rule Id="247" Name="Shc@Y" Data="Shc(PTB~rec!_,Y~u)->Shc(PTB~rec!_,Y~p)" ForwardRate="1" />
- <Rule Id="248" Name="Gab1_PI3K@447_op" Data="Gab1(Y447!0),PI3K(SH2!0)->Gab1(Y447),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="249" Name="Gab1_PI3K@472_op" Data="Gab1(Y472!0),PI3K(SH2!0)->Gab1(Y472),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="250" Name="Gab1_PI3K@619_op" Data="Gab1(Y619!0),PI3K(SH2!0)->Gab1(Y619),PI3K(SH2)" ForwardRate="1" />
- <Rule Id="251" Name="PI3K@s Rec" Data="PI3K(SH2~rec!_,s~u)->PI3K(SH2~rec!_,s~p)" ForwardRate="1" />
- <Rule Id="252" Name="PI3K@s Gab#1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
- <Rule Id="253" Name="PI3K@s Gab#2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
- <Rule Id="254" Name="PI3K@s Gab#3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
- <Rule Id="255" Name="PI3K@s_op" Data="PI3K(s~p)->PI3K(s~u)" ForwardRate="1" />
- <Rule Id="256" Name="SoS long arm" Data="Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />
- <Rule Id="257" Name="PI3K no arm" Data="PI3K(SH2~rec!_,s~p),PI(three~u)->PI3K(SH2~rec!_,s~p!0),PI(three~u!0)" ForwardRate="1" />
- <Rule Id="258" Name="PI3K long arm #1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
- <Rule Id="259" Name="PI3K long arm #2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
- <Rule Id="260" Name="PI3K long arm #3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
- <Rule Id="261" Name="Ras_PI3K no arm" Data="Ras(s~gtp),PI3K(RBD,SH2~rec!_,s~u)->Ras(s~gtp!0),PI3K(RBD!0,SH2~rec!_,s~u)" ForwardRate="1" />
- <Rule Id="262" Name="Ras_PI3K long arm #1" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
- <Rule Id="263" Name="Ras_PI3K long arm #2" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
- <Rule Id="264" Name="Ras_PI3K long arm #3" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
- <Rule Id="265" Name="Ras_PI3K_op" Data="Ras(s!0),PI3K(RBD!0)->Ras(s),PI3K(RBD)" ForwardRate="1" />
- <Rule Id="266" Name="PI3K@s Ras" Data="PI3K(RBD!_,s~u)->PI3K(RBD!_,s~p)" ForwardRate="1" />
- <Rule Id="267" Name="PI3K Ras arm" Data="PI3K(RBD!_,s~p),PI(three~u)->PI3K(RBD!_,s~p!0),PI(three~u!0)" ForwardRate="1" />
- <Rule Id="268" Name="PI3K Gab arm #1" Data="Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="269" Name="PI3K Gab arm #2" Data="Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="270" Name="PI3K Gab arm #3" Data="Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
- <Rule Id="271" Name="EGFR_Grb2@Y1086_SH2" Data="EGFR(Y1086~p),Grb2(SH2)->EGFR(Y1086~p!0),Grb2(SH2!0)" ForwardRate="1" />
- <Rule Id="272" Name="Shc_Src@SH2_S1" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2),Src(S1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2!1),Src(S1!1)" ForwardRate="1" />
- <Rule Id="273" Name="Shc_p@Y239" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)" ForwardRate="1" />
- <Rule Id="274" Name="Shc_Src_op" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~p),Src(S1)" ForwardRate="1" />
- <Rule Id="275" Name="Shc_p@Y240" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y240~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y240~p),Src(S1!1)" ForwardRate="1" />
- <Rule Id="276" Name="SHP1_EGFR@SH2n_Y1173" Data="Shp1(SH2n),EGFR(Y1173~p)->Shp1(SH2n!0),EGFR(Y1173~p!0)" ForwardRate="1" />
- <Rule Id="277" Name="EGFR_u@Y1173" Data="Shp1(SH2n!0),EGFR(Y1173~p!0)->Shp1(SH2n!0),EGFR(Y1173~u!0)" ForwardRate="1" />
- <Rule Id="278" Name="EGFR_SHP1_op" Data="Shp1(SH2n!0),EGFR(Y1173~u!0)->Shp1(SH2n),EGFR(Y1173~u)" ForwardRate="1" />
- <Rule Id="279" Name="EGFR_Shc@Y1173_PTB" Data="Shc(PTB),EGFR(Y1173~p)->Shc(PTB!0),EGFR(Y1173~p!0)" ForwardRate="1" />
- <Rule Id="280" Name="EGFR_Shc@Y1173_SH2" Data="Shc(SH2),EGFR(Y1173~p)->Shc(SH2!0),EGFR(Y1173~p!0)" ForwardRate="1" />
- <Rule Id="281" Name="EGFR_Shc@Y992_PTB" Data="Shc(PTB),EGFR(Y992~p)->Shc(PTB!0),EGFR(Y992~p!0)" ForwardRate="1" />
- <Rule Id="282" Name="EGFR_Shc@Y992_SH2" Data="Shc(SH2),EGFR(Y992~p)->Shc(SH2!0),EGFR(Y992~p!0)" ForwardRate="1" />
- <Rule Id="283" Name="Shc_EGFR@PTB_Y1148" Data="EGFR(Y1148~p),Shc(PTB)->EGFR(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />
- <Rule Id="284" Name="Shc_EGFR@PTB_Y1148_op" Data="EGFR(Y1148~p!0),Shc(PTB!0)->EGFR(Y1148~p),Shc(PTB)" ForwardRate="1" />
- <Rule Id="285" Name="Shc_EGFR@SH2_Y1148" Data="EGFR(Y1148~p),Shc(SH2)->EGFR(Y1148~p!0),Shc(SH2!0)" ForwardRate="1" />
- <Rule Id="286" Name="Shc_EGFR@SH2_Y1148_op" Data="EGFR(Y1148~p!0),Shc(SH2!0)->EGFR(Y1148~p),Shc(SH2)" ForwardRate="1" />
- <Rule Id="287" Name="Shc_EGFR@PTB_Y1173" Data="EGFR(Y1173~p),Shc(PTB)->EGFR(Y1173~p!0),Shc(PTB!0)" ForwardRate="1" />
- <Rule Id="288" Name="Shc_EGFR@PTB_Y1173_op" Data="EGFR(Y1173~p!0),Shc(PTB!0)->EGFR(Y1173~p),Shc(PTB)" ForwardRate="1" />
- <Rule Id="289" Name="Shc_EGFR@SH2_Y1173" Data="EGFR(Y1173~p),Shc(SH2)->EGFR(Y1173~p!0),Shc(SH2!0)" ForwardRate="1" />
- <Rule Id="290" Name="Shc_EGFR@SH2_Y1173_op" Data="EGFR(Y1173~p!0),Shc(SH2!0)->EGFR(Y1173~p),Shc(SH2)" ForwardRate="1" />
- <Rule Id="291" Name="Shc_p@Y317" Data="EGFR(Y1148~p!0),Shc(PTB!0,Y317~u)->EGFR(Y1148~p!0),Shc(PTB!0,Y317~p)" ForwardRate="1" />
- <Rule Id="292" Name="EGFR_Stat3@Y1068_SH2" Data="Stat3(SH2),EGFR(Y1068~p)->Stat3(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />
- <Rule Id="293" Name="EGFR_Stat3@Y1068_SH2_op" Data="Stat3(SH2!0),EGFR(Y1068~p!0)->Stat3(SH2),EGFR(Y1068~p)" ForwardRate="1" />
- <Rule Id="294" Name="EGFR_Stat3@Y1086_SH2" Data="Stat3(SH2),EGFR(Y1086~p)->Stat3(SH2!0),EGFR(Y1086~p!0)" ForwardRate="1" />
- <Rule Id="295" Name="EGFR_Stat3@Y1086_SH2_op" Data="Stat3(SH2!0),EGFR(Y1086~p!0)->Stat3(SH2),EGFR(Y1086~p)" ForwardRate="1" />
- <Rule Id="296" Name="Stat3_p@Y705" Data="Stat3(SH2!0,Y705~u),EGFR(Y1068!0)->Stat3(SH2!0,Y705~p),EGFR(Y1068!0)" ForwardRate="1" />
- <Rule Id="297" Name="EGFR_p@Y1086" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1086~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1086~p),A(s~pp!0)" ForwardRate="1" />
- <Rule Id="298" Name="EGFR_p@Y1173" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1173~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1173~p),A(s~pp!0)" ForwardRate="1" />
- <Rule Id="299" Name="EGFR_Shc@Y1068_SH2" Data="EGFR(Y1068~p),Shc(SH2)->EGFR(Y1068~p!0),Shc(SH2!0)" ForwardRate="1" />
- <Rule Id="300" Name="EGFR_Shc@Y1068_SH2_op" Data="EGFR(Y1068~p!0),Shc(SH2!0)->EGFR(Y1068~p),Shc(SH2)" ForwardRate="1" />
- <Rule Id="301" Name="EGFR_Shc@Y1086_SH2" Data="EGFR(Y1086~p),Shc(SH2)->EGFR(Y1086~p!0),Shc(SH2!0)" ForwardRate="1" />
- <Rule Id="302" Name="EGFR_Shc@Y1086_SH2_op" Data="EGFR(Y1086~p!0),Shc(SH2!0)->EGFR(Y1086~p),Shc(SH2)" ForwardRate="1" />
- <Rule Id="303" Name="EGFR_PLCG1@Y992_SH2" Data="EGFR(Y992~p),PLCG1(SH2)->EGFR(Y992~p!0),PLCG1(SH2!0)" ForwardRate="1" />
- <Rule Id="304" Name="EGFR_PLCG1@Y992_SH2_op" Data="EGFR(Y992~p!0),PLCG1(SH2!0)->EGFR(Y992~p),PLCG1(SH2)" ForwardRate="1" />
- <Rule Id="305" Name="EGFR_PLCG1@Y1068_SH2" Data="EGFR(Y1068~p),PLCG1(SH2)->EGFR(Y1068~p!0),PLCG1(SH2!0)" ForwardRate="1" />
- <Rule Id="306" Name="EGFR_PLCG1@Y1068_SH2_op" Data="EGFR(Y1068~p!0),PLCG1(SH2!0)->EGFR(Y1068~p),PLCG1(SH2)" ForwardRate="1" />
- <Rule Id="307" Name="EGFR_PLCG1@Y1086_SH2" Data="EGFR(Y1086~p),PLCG1(SH2)->EGFR(Y1086~p!0),PLCG1(SH2!0)" ForwardRate="1" />
- <Rule Id="308" Name="EGFR_PLCG1@Y1086_SH2_op" Data="EGFR(Y1086~p!0),PLCG1(SH2!0)->EGFR(Y1086~p),PLCG1(SH2)" ForwardRate="1" />
- <Rule Id="309" Name="EGFR_PLCG1@Y1148_SH2" Data="EGFR(Y1148~p),PLCG1(SH2)->EGFR(Y1148~p!0),PLCG1(SH2!0)" ForwardRate="1" />
- <Rule Id="310" Name="EGFR_PLCG1@Y1148_SH2_op" Data="EGFR(Y1148~p!0),PLCG1(SH2!0)->EGFR(Y1148~p),PLCG1(SH2)" ForwardRate="1" />
- <Rule Id="311" Name="EGFR_PLCG1@Y1173_SH2" Data="EGFR(Y1173~p),PLCG1(SH2)->EGFR(Y1173~p!0),PLCG1(SH2!0)" ForwardRate="1" />
- <Rule Id="312" Name="EGFR_PLCG1@Y1173_SH2_op" Data="EGFR(Y1173~p!0),PLCG1(SH2!0)->EGFR(Y1173~p),PLCG1(SH2)" ForwardRate="1" />
- <Rule Id="313" Name="EGFR_Src@Y845_SH2" Data="Src(SH2),EGFR(Y845)->Src(SH2!0),EGFR(Y845!0)" ForwardRate="1" />
- <Rule Id="314" Name="EGFR_Src@Y845_SH2_op" Data="Src(SH2!0),EGFR(Y845!0)->Src(SH2),EGFR(Y845)" ForwardRate="1" />
- <Rule Id="315" Name="EGFR_p@Y845" Data="Src(SH2!0),EGFR(Y845~u!0)->Src(SH2!0),EGFR(Y845~p!0)" ForwardRate="1" />
- <Rule Id="316" Name="EGFR_Eps8@S1_S1" Data="EGFR(S1),Eps8(S1)->EGFR(S1!0),Eps8(S1!0)" ForwardRate="1" />
- <Rule Id="317" Name="EGFR_Eps8@S1_S1_op" Data="EGFR(S1!0),Eps8(S1!0)->EGFR(S1),Eps8(S1)" ForwardRate="1" />
- <Rule Id="318" Name="Eps8_p@X" Data="EGFR(S1!0),Eps8(S1!0,X~u)->EGFR(S1!0),Eps8(S1!0,X~p)" ForwardRate="1" />
- <Rule Id="319" Name="EGFR_PLCG1@Y1173_SH2n" Data="EGFR(Y1173~p),PLCG1(SH2n)->EGFR(Y1173~p!0),PLCG1(SH2n!0)" ForwardRate="1" />
- <Rule Id="320" Name="EGFR_PLCG1@Y992_SH2c" Data="EGFR(Y992~p),PLCG1(SH2c)->EGFR(Y992~p!0),PLCG1(SH2c!0)" ForwardRate="1" />
- <Rule Id="321" Name="PLCG1_p@Y472" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y472~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y472~p)" ForwardRate="1" />
- <Rule Id="322" Name="PLCG1_p@Y771" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y771~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y771~p)" ForwardRate="1" />
- <Rule Id="323" Name="PLCG1_p@Y783" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y783~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y783~p)" ForwardRate="1" />
- <Rule Id="324" Name="PLCG1_p@Y1254" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y1254~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y1254~p)" ForwardRate="1" />
- <Rule Id="325" Name="EGFR_Gab1@S1_S1" Data="Gab1(X~u),EGFR(S1)->Gab1(X~u!0),EGFR(S1!0)" ForwardRate="1" />
- <Rule Id="326" Name="Gab1_p@Y627" Data="Gab1(Y627~u!0),EGFR(S1!0)->Gab1(Y627~p!0),EGFR(S1!0)" ForwardRate="1" />
- <Rule Id="327" Name="Gab1_EGFR_op" Data="Gab1(Y627~p!0),EGFR(S1!0)->Gab1(Y627~p),EGFR(S1)" ForwardRate="1" />
- <Rule Id="328" Name="Gab1_p@Y659" Data="Gab1(Y659~u!0),EGFR(S1!0)->Gab1(Y659~p!0),EGFR(S1!0)" ForwardRate="1" />
- <Rule Id="329" Name="p85_EGFR@SH2_Y920" Data="p85(SH2),EGFR(Y920~p)->p85(SH2!0),EGFR(Y920~p!0)" ForwardRate="1" />
- <Rule Id="330" Name="Rom2_PI3K@PH_S1" Data="Rom2(PH),PI3K(S1)->Rom2(PH!0),PI3K(S1!0)" ForwardRate="1" />
- <Rule Id="331" Name="Rom2_PI3K@PH_S1_op" Data="Rom2(PH!0),PI3K(S1!0)->Rom2(PH),PI3K(S1)" ForwardRate="1" />
- <Rule Id="332" Name="EGFR_Vav2@Y992_SH2" Data="EGFR(Y992~p),Vav2(SH2)->EGFR(Y992~p!0),Vav2(SH2!0)" ForwardRate="1" />
- <Rule Id="333" Name="EGFR_Vav2@Y992_SH2_op" Data="EGFR(Y992~p!0),Vav2(SH2!0)->EGFR(Y992~p),Vav2(SH2)" ForwardRate="1" />
- <Rule Id="334" Name="EGFR_Vav@Y1148_SH2" Data="EGFR(Y1148~p),Vav2(SH2)->EGFR(Y1148~p!0),Vav2(SH2!0)" ForwardRate="1" />
- <Rule Id="335" Name="EGFR_Vav@Y1148_SH2_op" Data="EGFR(Y1148~p!0),Vav2(SH2!0)->EGFR(Y1148~p),Vav2(SH2)" ForwardRate="1" />
- <Rule Id="336" Name="Vav2_p@Y142" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y142~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y142~p)" ForwardRate="1" />
- <Rule Id="337" Name="Vav2_p@Y172" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y172~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y172~p)" ForwardRate="1" />
- <Rule Id="338" Name="Vav2_p@Y159" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y159~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y159~p)" ForwardRate="1" />
- <Rule Id="339" Name="Grb2_EGFR@SH2_Y1068" Data="Grb2(SH2),EGFR(Y1068~p)->Grb2(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />
- <Rule Id="340" Name="Pak1_Grb2@SH3_SBM" Data="Grb2(SH2!0,SH3),EGFR(Y1068~p!0),Pak1(SBM)->Grb2(SH2!1,SH3!0),EGFR(Y1068~p!1),Pak1(SBM!0)" ForwardRate="1" />
- <Rule Id="341" Name="Ang2_EGFR@r_l" Data="Ang2(r~ext),EGFR(CR,L~ext)=>Ang(r~ext!0),GFR(CR,L~ext!0)" ForwardRate="1" />
- <Rule Id="342" Name="Ang2_EGFR@r_l_op" Data="Ang(r~ext!0),GFR(CR,L~ext!0)=>Ang2(r~ext),EGFR(CR,L~ext)" ForwardRate="1" />
- <Rule Id="343" Name="EGFR_Clta(int)" Data="EGFR(C,N~ext!0),CLTA(S1!0)->EGFR(C,N~int!0),CLTA(S1!0)" ForwardRate="1" />
- </RuleSet>
- <ContactMap Name="Low resolution">
- <Agent Name="Shc">
- <Site Name="PTB" CanChangeState="true" CanBeBound="true">
- <Rule Id="71"/>
- <Rule Id="72"/>
- <Rule Id="231"/>
- <Rule Id="232"/>
- <Rule Id="235"/>
- <Rule Id="236"/>
- <Rule Id="239"/>
- <Rule Id="240"/>
- <Rule Id="245"/>
- <Rule Id="246"/>
- </Site>
- <Site Name="SH2" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="Y" CanChangeState="true" CanBeBound="true">
- <Rule Id="247"/>
- </Site>
- <Site Name="Y239" CanChangeState="true" CanBeBound="true">
- <Rule Id="273"/>
- </Site>
- <Site Name="Y240" CanChangeState="true" CanBeBound="true">
- <Rule Id="275"/>
- </Site>
- <Site Name="Y317" CanChangeState="true" CanBeBound="true">
- <Rule Id="291"/>
- </Site>
- <Site Name="Y318" CanChangeState="true" CanBeBound="true">
- <Rule Id="85"/>
- <Rule Id="86"/>
- <Rule Id="87"/>
- <Rule Id="88"/>
- <Rule Id="89"/>
- </Site>
- </Agent>
- <Agent Name="PTP">
- <Site Name="s" CanChangeState="false" CanBeBound="true">
- </Site>
- </Agent>
- <Agent Name="PI3K">
- <Site Name="RBD" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="S1" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="SH2" CanChangeState="true" CanBeBound="true">
- <Rule Id="59"/>
- <Rule Id="60"/>
- <Rule Id="61"/>
- <Rule Id="62"/>
- <Rule Id="63"/>
- <Rule Id="64"/>
- <Rule Id="65"/>
- <Rule Id="66"/>
- <Rule Id="67"/>
- <Rule Id="68"/>
- <Rule Id="69"/>
- <Rule Id="70"/>
- </Site>
- <Site Name="s" CanChangeState="true" CanBeBound="true">
- <Rule Id="251"/>
- <Rule Id="252"/>
- <Rule Id="253"/>
- <Rule Id="254"/>
- <Rule Id="255"/>
- <Rule Id="266"/>
- </Site>
- </Agent>
- <Agent Name="HRG">
- <Rule Id="128"/>
- <Site Name="r" CanChangeState="true" CanBeBound="true">
- </Site>
- </Agent>
- <Agent Name="HER4">
- <Site Name="C" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="CR" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="L" CanChangeState="true" CanBeBound="true">
- </Site>
- <Site Name="N" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="Y1" CanChangeState="true" CanBeBound="true">
- <Rule Id="190"/>
- <Rule Id="191"/>
- <Rule Id="192"/>
- <Rule Id="223"/>
- </Site>
- <Site Name="Y2" CanChangeState="true" CanBeBound="true">
- <Rule Id="193"/>
- <Rule Id="194"/>
- <Rule Id="195"/>
- <Rule Id="224"/>
- </Site>
- <Site Name="Y3" CanChangeState="true" CanBeBound="true">
- <Rule Id="196"/>
- <Rule Id="197"/>
- <Rule Id="198"/>
- <Rule Id="225"/>
- </Site>
- <Site Name="bp" CanChangeState="false" CanBeBound="true">
- </Site>
- </Agent>
- <Agent Name="HER3">
- <Site Name="C" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="CR" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="L" CanChangeState="true" CanBeBound="true">
- </Site>
- <Site Name="Y1035" CanChangeState="true" CanBeBound="true">
- <Rule Id="17"/>
- <Rule Id="18"/>
- <Rule Id="19"/>
- <Rule Id="52"/>
- </Site>
- <Site Name="Y1178" CanChangeState="true" CanBeBound="true">
- <Rule Id="20"/>
- <Rule Id="21"/>
- <Rule Id="22"/>
- <Rule Id="53"/>
- </Site>
- <Site Name="Y1203" CanChangeState="true" CanBeBound="true">
- <Rule Id="23"/>
- <Rule Id="24"/>
- <Rule Id="25"/>
- <Rule Id="54"/>
- </Site>
- <Site Name="Y1241" CanChangeState="true" CanBeBound="true">
- <Rule Id="26"/>
- <Rule Id="27"/>
- <Rule Id="28"/>
- <Rule Id="55"/>
- </Site>
- <Site Name="Y1257" CanChangeState="true" CanBeBound="true">
- <Rule Id="29"/>
- <Rule Id="30"/>
- <Rule Id="31"/>
- <Rule Id="56"/>
- </Site>
- <Site Name="Y1270" CanChangeState="true" CanBeBound="true">
- <Rule Id="32"/>
- <Rule Id="33"/>
- <Rule Id="34"/>
- <Rule Id="57"/>
- </Site>
- <Site Name="Y1309" CanChangeState="true" CanBeBound="true">
- <Rule Id="35"/>
- <Rule Id="36"/>
- <Rule Id="37"/>
- <Rule Id="58"/>
- </Site>
- </Agent>
- <Agent Name="HER2">
- <Site Name="C" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="CR" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="N" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="Y1139" CanChangeState="true" CanBeBound="true">
- <Rule Id="181"/>
- <Rule Id="182"/>
- <Rule Id="183"/>
- <Rule Id="220"/>
- </Site>
- <Site Name="Y1196" CanChangeState="true" CanBeBound="true">
- <Rule Id="184"/>
- <Rule Id="185"/>
- <Rule Id="186"/>
- <Rule Id="221"/>
- </Site>
- <Site Name="Y1221" CanChangeState="true" CanBeBound="true">
- <Rule Id="187"/>
- <Rule Id="188"/>
- <Rule Id="189"/>
- <Rule Id="222"/>
- </Site>
- <Site Name="bp" CanChangeState="false" CanBeBound="true">
- </Site>
- </Agent>
- <Agent Name="EGFR">
- <Rule Id="226"/>
- <Rule Id="341"/>
- <Rule Id="342"/>
- <Site Name="C" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="CR" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="L" CanChangeState="true" CanBeBound="true">
- <Rule Id="170"/>
- <Rule Id="171"/>
- <Rule Id="342"/>
- </Site>
- <Site Name="N" CanChangeState="true" CanBeBound="true">
- <Rule Id="343"/>
- </Site>
- <Site Name="S1" CanChangeState="false" CanBeBound="true">
- </Site>
- <Site Name="Y1016" CanChangeState="true" CanBeBound="true">
- <Rule Id="172"/>
- <Rule Id="173"/>
- <Rule Id="174"/>
- <Rule Id="217"/>
- </Site>
- <Site Name="Y1068" CanChangeState="true" CanBeBound="true">
- </Site>
- <Site Name="Y1086" CanChangeState="true" CanBeBound="true">
- <Rule Id="297"/>
- </Site>
- <Site Name="Y1092" CanChangeState="true" CanBeBound="true">
- <Rule Id="175"/>
- <Rule Id="176"/>
- <Rule Id="177"/>
- <Rule Id="218"/>
- </Site>
- <Site Name="Y1148" CanChangeState="true" CanBeBound="true">
- </Site>
- <Site Name="Y1172" CanChangeState="true" CanBeBound="true">
- <Rule Id="178"/>
- <Rule Id="179"/>
- <Rule Id="180"/>
- <Rule Id="219"/>
- </Site>
- <Site Name="Y1173" CanChangeState="true" CanBeBound="true">
- <Rule Id="277"/>
- <Rule Id="298"/>
- </Site>
- <Site Name="Y845" CanChangeState="true" CanBeBound="true">
- <Rule Id="315"/>
- </Site>
- <Site Name="Y920" CanChangeState="true" CanBeBound="true">
- </Site>
- <Site Name="Y992" CanChangeState="true" CanBeBound="true">
- </Site>
- <Site Name="bp" CanChangeState="false" CanBeBound="true">
- </Site>
- </Agent>
- <Bond FromAgent="EGFR" FromSite="CR" ToAgent="EGFR" ToSite="CR">
- <Rule Id="134"/>
- <Rule Id="135"/>
- <Rule Id="140"/>
- </Bond><Bond FromAgent="EGFR" FromSite="N" ToAgent="EGFR" ToSite="C">
- <Rule Id="146"/>
- <Rule Id="147"/>
- </Bond><Bond FromAgent="HER2" FromSite="C" ToAgent="EGFR" ToSite="N">
- <Rule Id="152"/>
- <Rule Id="153"/>
- </Bond><Bond FromAgent="HER2" FromSite="CR" ToAgent="EGFR" ToSite="CR">
- <Rule Id="136"/>
- <Rule Id="141"/>
- </Bond><Bond FromAgent="HER2" FromSite="CR" ToAgent="HER2" ToSite="CR">
- <Rule Id="143"/>
- </Bond><Bond FromAgent="HER2" FromSite="N" ToAgent="EGFR" ToSite="C">
- <Rule Id="148"/>
- <Rule Id="149"/>
- </Bond><Bond FromAgent="HER2" FromSite="N" ToAgent="HER2" ToSite="C">
- <Rule Id="154"/>
- <Rule Id="155"/>
- </Bond><Bond FromAgent="HER3" FromSite="C" ToAgent="EGFR" ToSite="N">
- <Rule Id="11"/>
- <Rule Id="12"/>
- </Bond><Bond FromAgent="HER3" FromSite="C" ToAgent="HER2" ToSite="N">
- <Rule Id="13"/>
- <Rule Id="14"/>
- </Bond><Bond FromAgent="HER3" FromSite="CR" ToAgent="EGFR" ToSite="CR">
- <Rule Id="3"/>
- <Rule Id="7"/>
- </Bond><Bond FromAgent="HER3" FromSite="CR" ToAgent="HER2" ToSite="CR">
- <Rule Id="4"/>
- <Rule Id="8"/>
- </Bond><Bond FromAgent="HER3" FromSite="CR" ToAgent="HER3" ToSite="CR">
- <Rule Id="5"/>
- <Rule Id="9"/>
- </Bond><Bond FromAgent="HER4" FromSite="C" ToAgent="EGFR" ToSite="N">
- <Rule Id="158"/>
- <Rule Id="159"/>
- </Bond><Bond FromAgent="HER4" FromSite="C" ToAgent="HER2" ToSite="N">
- <Rule Id="160"/>
- <Rule Id="161"/>
- </Bond><Bond FromAgent="HER4" FromSite="CR" ToAgent="EGFR" ToSite="CR">
- <Rule Id="137"/>
- <Rule Id="142"/>
- </Bond><Bond FromAgent="HER4" FromSite="CR" ToAgent="HER2" ToSite="CR">
- <Rule Id="138"/>
- <Rule Id="144"/>
- </Bond><Bond FromAgent="HER4" FromSite="CR" ToAgent="HER3" ToSite="CR">
- <Rule Id="6"/>
- <Rule Id="10"/>
- </Bond><Bond FromAgent="HER4" FromSite="CR" ToAgent="HER4" ToSite="CR">
- <Rule Id="139"/>
- <Rule Id="145"/>
- </Bond><Bond FromAgent="HER4" FromSite="N" ToAgent="EGFR" ToSite="C">
- <Rule Id="150"/>
- <Rule Id="151"/>
- </Bond><Bond FromAgent="HER4" FromSite="N" ToAgent="HER2" ToSite="C">
- <Rule Id="156"/>
- <Rule Id="157"/>
- </Bond><Bond FromAgent="HER4" FromSite="N" ToAgent="HER3" ToSite="C">
- <Rule Id="15"/>
- <Rule Id="16"/>
- </Bond><Bond FromAgent="HER4" FromSite="N" ToAgent="HER4" ToSite="C">
- <Rule Id="162"/>
- <Rule Id="163"/>
- </Bond><Bond FromAgent="HRG" FromSite="r" ToAgent="HER3" ToSite="L">
- <Rule Id="1"/>
- <Rule Id="2"/>
- </Bond><Bond FromAgent="HRG" FromSite="r" ToAgent="HER4" ToSite="L">
- <Rule Id="131"/>
- <Rule Id="133"/>
- </Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1035">
- <Rule Id="59"/>
- <Rule Id="60"/>
- </Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1178">
- <Rule Id="61"/>
- <Rule Id="62"/>
- </Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1203">
- <Rule Id="63"/>
- <Rule Id="64"/>
- </Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1241">
- <Rule Id="65"/>
- <Rule Id="66"/>
- </Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1257">
- <Rule Id="67"/>
- <Rule Id="68"/>
- </Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1270">
- <Rule Id="69"/>
- <Rule Id="70"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="EGFR" ToSite="Y1016">
- <Rule Id="199"/>
- <Rule Id="208"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="EGFR" ToSite="Y1092">
- <Rule Id="200"/>
- <Rule Id="209"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="EGFR" ToSite="Y1172">
- <Rule Id="201"/>
- <Rule Id="210"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER2" ToSite="Y1139">
- <Rule Id="202"/>
- <Rule Id="211"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER2" ToSite="Y1196">
- <Rule Id="203"/>
- <Rule Id="212"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER2" ToSite="Y1221">
- <Rule Id="204"/>
- <Rule Id="213"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1035">
- <Rule Id="38"/>
- <Rule Id="45"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1178">
- <Rule Id="39"/>
- <Rule Id="46"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1203">
- <Rule Id="40"/>
- <Rule Id="47"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1241">
- <Rule Id="41"/>
- <Rule Id="48"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1257">
- <Rule Id="42"/>
- <Rule Id="49"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1270">
- <Rule Id="43"/>
- <Rule Id="50"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1309">
- <Rule Id="44"/>
- <Rule Id="51"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER4" ToSite="Y1">
- <Rule Id="205"/>
- <Rule Id="214"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER4" ToSite="Y2">
- <Rule Id="206"/>
- <Rule Id="215"/>
- </Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER4" ToSite="Y3">
- <Rule Id="207"/>
- <Rule Id="216"/>
- </Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="EGFR" ToSite="Y1148">
- <Rule Id="283"/>
- <Rule Id="284"/>
- </Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="EGFR" ToSite="Y1172">
- <Rule Id="231"/>
- <Rule Id="232"/>
- </Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="EGFR" ToSite="Y1173">
- <Rule Id="279"/>
- <Rule Id="287"/>
- <Rule Id="288"/>
- </Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="EGFR" ToSite="Y992">
- <Rule Id="281"/>
- </Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="HER2" ToSite="Y1196">
- <Rule Id="235"/>
- <Rule Id="236"/>
- </Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="HER2" ToSite="Y1221">
- <Rule Id="239"/>
- <Rule Id="240"/>
- </Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="HER3" ToSite="Y1309">
- <Rule Id="71"/>
- <Rule Id="72"/>
- </Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="HER4" ToSite="Y3">
- <Rule Id="245"/>
- <Rule Id="246"/>
- </Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y1068">
- <Rule Id="299"/>
- <Rule Id="300"/>
- </Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y1086">
- <Rule Id="301"/>
- <Rule Id="302"/>
- </Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y1148">
- <Rule Id="285"/>
- <Rule Id="286"/>
- </Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y1173">
- <Rule Id="280"/>
- <Rule Id="289"/>
- <Rule Id="290"/>
- </Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y992">
- <Rule Id="282"/>
- </Bond></ContactMap>
- </ComplxSession>