/test.data/contact_map/agents/~session036.test
Unknown | 775 lines | 775 code | 0 blank | 0 comment | 0 complexity | b2d5c04ce2d593f15dbdbc657cd5bb2b MD5 | raw file
Possible License(s): LGPL-3.0, Apache-2.0
1<?xml version='1.0' encoding='utf-8'?>
2<!-- Automaticaly generated by Complx 3.40..4208 -->
3<ComplxSession Timestamp="25/2/2009 (21:58:11)" CommandLine="C:\DOCUME~1\LOPATK~1\LOCALS~1\Temp\tmp53467.exe ~kappa53576.tmp --output-xml ~session53575.tmp --memory-limit 1024 --reset-all --do-XML --do-low-res-contact-map --focus-on ~focus53574.tmp --key 07CFC00F0BEB0278" InputFile="~kappa53576.tmp"
4xsi:schemaLocation="http://plectix.synthesisstudios.com
5KappaSession.xsd" xmlns="http://plectix.synthesisstudios.com/schemas/kappasession"
6xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" >
7<Log>
8<Entry Type="INFO" Message="Compilation(simplx) 0.047 s."/>
9<Entry Type="INFO" Message="Second compilation(pretty printing) 0.016 s."/>
10<Entry Type="INFO" Message="Translation 0. s."/>
11<Entry Type="INFO" Message="Renaming 0.015 s."/>
12<Entry Type="INFO" Message="Boolean encoding of the initial system 0.157 s."/>
13</Log>
14<RuleSet Name="Original">
15<Rule Id="1" Name="HRG_HER3" Data="HRG(r),HER3(CR,L)->HRG(r!0),HER3(CR,L!0)" ForwardRate="1" />
16<Rule Id="2" Name="HRG_HER3_op" Data="HRG(r!0),HER3(L!0)->HRG(r),HER3(L)" ForwardRate="1" />
17<Rule Id="3" Name="EGFR_HER3" Data="EGFR(C,CR,L~ext!_,N),HER3(C,CR,L~ext!_)->EGFR(C,CR!0,L~ext!_,N),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />
18<Rule Id="4" Name="HER2_HER3" Data="HER2(C,CR,N),HER3(C,CR,L~ext!_)->HER2(C,CR!0,N),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />
19<Rule Id="5" Name="HER3_HER3" Data="HER3(C,CR,L~ext!_),HER3(C,CR,L~ext!_)->HER3(C,CR!0,L~ext!_),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />
20<Rule Id="6" Name="HER3_HER4" Data="HER3(C,CR,L~ext!_),HER4(C,CR,L~ext!_,N)->HER3(C,CR!0,L~ext!_),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
21<Rule Id="7" Name="EGFR_HER3_op" Data="EGFR(C,CR!0,N),HER3(C,CR!0)->EGFR(C,CR,N),HER3(C,CR)" ForwardRate="1" />
22<Rule Id="8" Name="HER2_HER3_op" Data="HER2(C,CR!0,N),HER3(C,CR!0)->HER2(C,CR,N),HER3(C,CR)" ForwardRate="1" />
23<Rule Id="9" Name="HER3_HER3_op" Data="HER3(C,CR!0),HER3(C,CR!0)->HER3(C,CR),HER3(C,CR)" ForwardRate="1" />
24<Rule Id="10" Name="HER3_HER4_op" Data="HER3(C,CR!0),HER4(C,CR!0,N)->HER3(C,CR),HER4(C,CR,N)" ForwardRate="1" />
25<Rule Id="11" Name="13 dimer" Data="EGFR(C,CR!0,N),HER3(C,CR!0)->EGFR(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />
26<Rule Id="12" Name="13 dimer_op" Data="EGFR(C,CR!1,N!0),HER3(C!0,CR!1)->EGFR(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />
27<Rule Id="13" Name="23 dimer" Data="HER2(C,CR!0,N),HER3(C,CR!0)->HER2(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />
28<Rule Id="14" Name="23 dimer_op" Data="HER2(C,CR!1,N!0),HER3(C!0,CR!1)->HER2(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />
29<Rule Id="15" Name="43 dimer" Data="HER4(C,CR!0,N),HER3(C,CR!0)->HER4(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />
30<Rule Id="16" Name="43 dimer_op" Data="HER4(C,CR!1,N!0),HER3(C!0,CR!1)->HER4(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />
31<Rule Id="17" Name="Rule1" Data="EGFR(N!0,bp),HER3(C!0,Y1035~u)->EGFR(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />
32<Rule Id="18" Name="Rule2" Data="HER2(N!0,bp),HER3(C!0,Y1035~u)->HER2(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />
33<Rule Id="19" Name="Rule3" Data="HER4(N!0,bp),HER3(C!0,Y1035~u)->HER4(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />
34<Rule Id="20" Name="Rule4" Data="EGFR(N!0,bp),HER3(C!0,Y1178~u)->EGFR(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />
35<Rule Id="21" Name="Rule5" Data="HER2(N!0,bp),HER3(C!0,Y1178~u)->HER2(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />
36<Rule Id="22" Name="Rule6" Data="HER4(N!0,bp),HER3(C!0,Y1178~u)->HER4(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />
37<Rule Id="23" Name="Rule7" Data="EGFR(N!0,bp),HER3(C!0,Y1203~u)->EGFR(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />
38<Rule Id="24" Name="Rule8" Data="HER2(N!0,bp),HER3(C!0,Y1203~u)->HER2(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />
39<Rule Id="25" Name="Rule9" Data="HER4(N!0,bp),HER3(C!0,Y1203~u)->HER4(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />
40<Rule Id="26" Name="Rule10" Data="EGFR(N!0,bp),HER3(C!0,Y1241~u)->EGFR(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />
41<Rule Id="27" Name="Rule11" Data="HER2(N!0,bp),HER3(C!0,Y1241~u)->HER2(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />
42<Rule Id="28" Name="Rule12" Data="HER4(N!0,bp),HER3(C!0,Y1241~u)->HER4(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />
43<Rule Id="29" Name="Rule13" Data="EGFR(N!0,bp),HER3(C!0,Y1257~u)->EGFR(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />
44<Rule Id="30" Name="Rule14" Data="HER2(N!0,bp),HER3(C!0,Y1257~u)->HER2(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />
45<Rule Id="31" Name="Rule15" Data="HER4(N!0,bp),HER3(C!0,Y1257~u)->HER4(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />
46<Rule Id="32" Name="Rule16" Data="EGFR(N!0,bp),HER3(C!0,Y1270~u)->EGFR(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />
47<Rule Id="33" Name="Rule17" Data="HER2(N!0,bp),HER3(C!0,Y1270~u)->HER2(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />
48<Rule Id="34" Name="Rule18" Data="HER4(N!0,bp),HER3(C!0,Y1270~u)->HER4(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />
49<Rule Id="35" Name="Rule19" Data="EGFR(N!0,bp),HER3(C!0,Y1309~u)->EGFR(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />
50<Rule Id="36" Name="Rule20" Data="HER2(N!0,bp),HER3(C!0,Y1309~u)->HER2(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />
51<Rule Id="37" Name="Rule21" Data="HER4(N!0,bp),HER3(C!0,Y1309~u)->HER4(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />
52<Rule Id="38" Name="Rule22" Data="HER3(Y1035~p),PTP(s)->HER3(Y1035~p!0),PTP(s!0)" ForwardRate="1" />
53<Rule Id="39" Name="Rule23" Data="HER3(Y1178~p),PTP(s)->HER3(Y1178~p!0),PTP(s!0)" ForwardRate="1" />
54<Rule Id="40" Name="Rule24" Data="HER3(Y1203~p),PTP(s)->HER3(Y1203~p!0),PTP(s!0)" ForwardRate="1" />
55<Rule Id="41" Name="Rule25" Data="HER3(Y1241~p),PTP(s)->HER3(Y1241~p!0),PTP(s!0)" ForwardRate="1" />
56<Rule Id="42" Name="Rule26" Data="HER3(Y1257~p),PTP(s)->HER3(Y1257~p!0),PTP(s!0)" ForwardRate="1" />
57<Rule Id="43" Name="Rule27" Data="HER3(Y1270~p),PTP(s)->HER3(Y1270~p!0),PTP(s!0)" ForwardRate="1" />
58<Rule Id="44" Name="Rule28" Data="HER3(Y1309~p),PTP(s)->HER3(Y1309~p!0),PTP(s!0)" ForwardRate="1" />
59<Rule Id="45" Name="Rule29" Data="HER3(Y1035!0),PTP(s!0)->HER3(Y1035),PTP(s)" ForwardRate="1" />
60<Rule Id="46" Name="Rule30" Data="HER3(Y1178!0),PTP(s!0)->HER3(Y1178),PTP(s)" ForwardRate="1" />
61<Rule Id="47" Name="Rule31" Data="HER3(Y1203!0),PTP(s!0)->HER3(Y1203),PTP(s)" ForwardRate="1" />
62<Rule Id="48" Name="Rule32" Data="HER3(Y1241!0),PTP(s!0)->HER3(Y1241),PTP(s)" ForwardRate="1" />
63<Rule Id="49" Name="Rule33" Data="HER3(Y1257!0),PTP(s!0)->HER3(Y1257),PTP(s)" ForwardRate="1" />
64<Rule Id="50" Name="Rule34" Data="HER3(Y1270!0),PTP(s!0)->HER3(Y1270),PTP(s)" ForwardRate="1" />
65<Rule Id="51" Name="Rule35" Data="HER3(Y1309!0),PTP(s!0)->HER3(Y1309),PTP(s)" ForwardRate="1" />
66<Rule Id="52" Name="Rule36" Data="HER3(Y1035~p!0),PTP(s!0)->HER3(Y1035~u!0),PTP(s!0)" ForwardRate="1" />
67<Rule Id="53" Name="Rule37" Data="HER3(Y1178~p!0),PTP(s!0)->HER3(Y1178~u!0),PTP(s!0)" ForwardRate="1" />
68<Rule Id="54" Name="Rule38" Data="HER3(Y1203~p!0),PTP(s!0)->HER3(Y1203~u!0),PTP(s!0)" ForwardRate="1" />
69<Rule Id="55" Name="Rule39" Data="HER3(Y1241~p!0),PTP(s!0)->HER3(Y1241~u!0),PTP(s!0)" ForwardRate="1" />
70<Rule Id="56" Name="Rule40" Data="HER3(Y1257~p!0),PTP(s!0)->HER3(Y1257~u!0),PTP(s!0)" ForwardRate="1" />
71<Rule Id="57" Name="Rule41" Data="HER3(Y1270~p!0),PTP(s!0)->HER3(Y1270~u!0),PTP(s!0)" ForwardRate="1" />
72<Rule Id="58" Name="Rule42" Data="HER3(Y1309~p!0),PTP(s!0)->HER3(Y1309~u!0),PTP(s!0)" ForwardRate="1" />
73<Rule Id="59" Name="HER3_PI3K#1" Data="HER3(Y1035~p),PI3K(SH2~u)=>HER3(Y1035~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
74<Rule Id="60" Name="HER3_PI3K#1_op" Data="HER3(Y1035~p!0),PI3K(SH2~rec!0)=>HER3(Y1035~p),PI3K(SH2~u)" ForwardRate="1" />
75<Rule Id="61" Name="HER3_PI3K#2" Data="HER3(Y1178~p),PI3K(SH2~u)=>HER3(Y1178~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
76<Rule Id="62" Name="HER3_PI3K#2_op" Data="HER3(Y1178~p!0),PI3K(SH2~rec!0)=>HER3(Y1178~p),PI3K(SH2~u)" ForwardRate="1" />
77<Rule Id="63" Name="HER3_PI3K#3" Data="HER3(Y1203~p),PI3K(SH2~u)=>HER3(Y1203~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
78<Rule Id="64" Name="HER3_PI3K#3_op" Data="HER3(Y1203~p!0),PI3K(SH2~rec!0)=>HER3(Y1203~p),PI3K(SH2~u)" ForwardRate="1" />
79<Rule Id="65" Name="HER3_PI3K#4" Data="HER3(Y1241~p),PI3K(SH2~u)=>HER3(Y1241~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
80<Rule Id="66" Name="HER3_PI3K#4_op" Data="HER3(Y1241~p!0),PI3K(SH2~rec!0)=>HER3(Y1241~p),PI3K(SH2~u)" ForwardRate="1" />
81<Rule Id="67" Name="HER3_PI3K#5" Data="HER3(Y1257~p),PI3K(SH2~u)=>HER3(Y1257~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
82<Rule Id="68" Name="HER3_PI3K#5_op" Data="HER3(Y1257~p!0),PI3K(SH2~rec!0)=>HER3(Y1257~p),PI3K(SH2~u)" ForwardRate="1" />
83<Rule Id="69" Name="HER3_PI3K#6" Data="HER3(Y1270~p),PI3K(SH2~u)=>HER3(Y1270~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
84<Rule Id="70" Name="HER3_PI3K#6_op" Data="HER3(Y1270~p!0),PI3K(SH2~rec!0)=>HER3(Y1270~p),PI3K(SH2~u)" ForwardRate="1" />
85<Rule Id="71" Name="HER3_Shc" Data="HER3(Y1309~p),Shc(PTB~u)=>HER3(Y1309~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
86<Rule Id="72" Name="HER3_Shc_op" Data="HER3(Y1309~p!0),Shc(PTB~rec!0)=>HER3(Y1309~p),Shc(PTB~u)" ForwardRate="1" />
87<Rule Id="73" Name="HRG_ErbB3" Data="HRG(r~ext),ErbB3(CR,L~ext)->HRG(r~ext!0),ErbB3(CR,L~ext!0)" ForwardRate="1" />
88<Rule Id="74" Name="HRG_ErbB3_op" Data="HRG(r~ext!0),ErbB3(CR,L~ext!0)->HRG(r~ext),ErbB3(CR,L~ext)" ForwardRate="1" />
89<Rule Id="75" Name="HRG_ErbB4" Data="HRG(r~ext),ErbB4(CR,L~ext)->HRG(r~ext!0),ErbB4(CR,L~ext!0)" ForwardRate="1" />
90<Rule Id="76" Name="HRG_ErbB4_op" Data="HRG(r~ext!0),ErbB4(CR,L~ext!0)->HRG(r~ext),ErbB4(CR,L~ext)" ForwardRate="1" />
91<Rule Id="77" Name="ErbB1_Shc" Data="ErbB1(Y1148~p),Shc(PTB)->ErbB1(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />
92<Rule Id="78" Name="ErbB1_Shc_op" Data="ErbB1(Y1148~p!0),Shc(PTB!0)->ErbB1(Y1148~p),Shc(PTB)" ForwardRate="1" />
93<Rule Id="79" Name="ErbB2_Shc#1" Data="ErbB2(Y1196~p),Shc(PTB)->ErbB2(Y1196~p!0),Shc(PTB!0)" ForwardRate="1" />
94<Rule Id="80" Name="ErbB2_Shc#1_op" Data="ErbB2(Y1196~p!0),Shc(PTB!0)->ErbB2(Y1196~p),Shc(PTB)" ForwardRate="1" />
95<Rule Id="81" Name="ErbB2_Shc#2" Data="ErbB2(Y1221~p),Shc(PTB)->ErbB2(Y1221~p!0),Shc(PTB!0)" ForwardRate="1" />
96<Rule Id="82" Name="ErbB2_Shc#2_op" Data="ErbB2(Y1221~p!0),Shc(PTB!0)->ErbB2(Y1221~p),Shc(PTB)" ForwardRate="1" />
97<Rule Id="83" Name="ErbB3_Shc" Data="ErbB3(Y1309~p),Shc(PTB)->ErbB3(Y1309~p!0),Shc(PTB!0)" ForwardRate="1" />
98<Rule Id="84" Name="ErbB3_Shc_op" Data="ErbB3(Y1309~p!0),Shc(PTB!0)->ErbB3(Y1309~p),Shc(PTB)" ForwardRate="1" />
99<Rule Id="85" Name="Shc#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~u)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
100<Rule Id="86" Name="Shc#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
101<Rule Id="87" Name="Shc#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
102<Rule Id="88" Name="Shc#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~u)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
103<Rule Id="89" Name="Shc_op" Data="Shc(Y318~p)=>Shc(Y318~u),Pi()" ForwardRate="1" />
104<Rule Id="90" Name="Shc_Grb2" Data="Shc(Y318~p),Grb2(SH2)->Shc(Y318~p!0),Grb2(SH2!0)" ForwardRate="1" />
105<Rule Id="91" Name="Shc_Grb2_op" Data="Shc(Y318~p!0),Grb2(SH2!0)->Shc(Y318~p),Grb2(SH2)" ForwardRate="1" />
106<Rule Id="92" Name="long arm SoS_Ras#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
107<Rule Id="93" Name="long arm SoS_Ras#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
108<Rule Id="94" Name="long arm SoS_Ras#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
109<Rule Id="95" Name="long arm SoS_Ras#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
110<Rule Id="96" Name="Gab1_PI3K@447" Data="Gab1(Y447~p),PI3K(SH2)->Gab1(Y447~p!0),PI3K(SH2!0)" ForwardRate="1" />
111<Rule Id="97" Name="Gab1_PI3K@447_op" Data="Gab1(Y447~p!0),PI3K(SH2!0)->Gab1(Y447~p),PI3K(SH2)" ForwardRate="1" />
112<Rule Id="98" Name="Gab1_PI3K@472" Data="Gab1(Y472~p),PI3K(SH2)->Gab1(Y472~p!0),PI3K(SH2!0)" ForwardRate="1" />
113<Rule Id="99" Name="Gab1_PI3K@472_op" Data="Gab1(Y472~p!0),PI3K(SH2!0)->Gab1(Y472~p),PI3K(SH2)" ForwardRate="1" />
114<Rule Id="100" Name="Gab1_PI3K@619" Data="Gab1(Y619~p),PI3K(SH2)->Gab1(Y619~p!0),PI3K(SH2!0)" ForwardRate="1" />
115<Rule Id="101" Name="Gab1_PI3K@619_op" Data="Gab1(Y619~p!0),PI3K(SH2!0)->Gab1(Y619~p),PI3K(SH2)" ForwardRate="1" />
116<Rule Id="102" Name="ErbB3_PI3K#1" Data="ErbB3(Y1035~p),PI3K(SH2)->ErbB3(Y1035~p!0),PI3K(SH2!0)" ForwardRate="1" />
117<Rule Id="103" Name="ErbB3_PI3K#1_op" Data="ErbB3(Y1035~p!0),PI3K(SH2!0)->ErbB3(Y1035~p),PI3K(SH2)" ForwardRate="1" />
118<Rule Id="104" Name="ErbB3_PI3K#2" Data="ErbB3(Y1178~p),PI3K(SH2)->ErbB3(Y1178~p!0),PI3K(SH2!0)" ForwardRate="1" />
119<Rule Id="105" Name="ErbB3_PI3K#2_op" Data="ErbB3(Y1178~p!0),PI3K(SH2!0)->ErbB3(Y1178~p),PI3K(SH2)" ForwardRate="1" />
120<Rule Id="106" Name="ErbB3_PI3K#3" Data="ErbB3(Y1203~p),PI3K(SH2)->ErbB3(Y1203~p!0),PI3K(SH2!0)" ForwardRate="1" />
121<Rule Id="107" Name="ErbB3_PI3K#3_op" Data="ErbB3(Y1203~p!0),PI3K(SH2!0)->ErbB3(Y1203~p),PI3K(SH2)" ForwardRate="1" />
122<Rule Id="108" Name="ErbB3_PI3K#4" Data="ErbB3(Y1241~p),PI3K(SH2)->ErbB3(Y1241~p!0),PI3K(SH2!0)" ForwardRate="1" />
123<Rule Id="109" Name="ErbB3_PI3K#4_op" Data="ErbB3(Y1241~p!0),PI3K(SH2!0)->ErbB3(Y1241~p),PI3K(SH2)" ForwardRate="1" />
124<Rule Id="110" Name="ErbB3_PI3K#5" Data="ErbB3(Y1257~p),PI3K(SH2)->ErbB3(Y1257~p!0),PI3K(SH2!0)" ForwardRate="1" />
125<Rule Id="111" Name="ErbB3_PI3K#5_op" Data="ErbB3(Y1257~p!0),PI3K(SH2!0)->ErbB3(Y1257~p),PI3K(SH2)" ForwardRate="1" />
126<Rule Id="112" Name="ErbB3_PI3K#6" Data="ErbB3(Y1270~p),PI3K(SH2)->ErbB3(Y1270~p!0),PI3K(SH2!0)" ForwardRate="1" />
127<Rule Id="113" Name="ErbB3_PI3K#6_op" Data="ErbB3(Y1270~p!0),PI3K(SH2!0)->ErbB3(Y1270~p),PI3K(SH2)" ForwardRate="1" />
128<Rule Id="114" Name="short arm PI3K_PI#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
129<Rule Id="115" Name="short arm PI3K_PI#2" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
130<Rule Id="116" Name="short arm PI3K_PI#3" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
131<Rule Id="117" Name="short arm PI3K_PI#4" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
132<Rule Id="118" Name="short arm PI3K_PI#5" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
133<Rule Id="119" Name="short arm PI3K_PI#6" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
134<Rule Id="120" Name="direct PI3K_PI#1" Data="ErbB3(Y1035~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1035~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
135<Rule Id="121" Name="direct PI3K_PI#2" Data="ErbB3(Y1178~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1178~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
136<Rule Id="122" Name="direct PI3K_PI#3" Data="ErbB3(Y1203~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1203~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
137<Rule Id="123" Name="direct PI3K_PI#4" Data="ErbB3(Y1241~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1241~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
138<Rule Id="124" Name="direct PI3K_PI#5" Data="ErbB3(Y1257~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1257~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
139<Rule Id="125" Name="direct PI3K_PI#6" Data="ErbB3(Y1270~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1270~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
140<Rule Id="126" Name="PI@three" Data="PI3K(s!0),PI(three~u!0)->PI3K(s!0),PI(three~p!0)" ForwardRate="1" />
141<Rule Id="127" Name="PI3K_PI_op" Data="PI3K(s!0),PI(three!0)->PI3K(s),PI(three)" ForwardRate="1" />
142<Rule Id="128" Name="Rule43" Data="H()=>HRG(r)" ForwardRate="1" />
143<Rule Id="129" Name="EGF_EGFRe" Data="EGF(r~ext),EGFR(CR,L~ext)->EGF(r~ext!0),EGFR(CR,L~ext!0)" ForwardRate="1" />
144<Rule Id="130" Name="EGF_EGFRi" Data="EGF(r~int),EGFR(CR,L~int)->EGF(r~int!0),EGFR(CR,L~int!0)" ForwardRate="1" />
145<Rule Id="131" Name="HRG_HER4" Data="HRG(r),HER4(CR,L)->HRG(r!0),HER4(CR,L!0)" ForwardRate="1" />
146<Rule Id="132" Name="EGF_EGFR_op" Data="EGF(r!0),EGFR(L!0)->EGF(r),EGFR(L)" ForwardRate="1" />
147<Rule Id="133" Name="HRG_HER4_op" Data="HRG(r!0),HER4(L!0)->HRG(r),HER4(L)" ForwardRate="1" />
148<Rule Id="134" Name="EGFR_EGFRe" Data="EGFR(C,CR,L~ext!_,N),EGFR(C,CR,L~ext!_,N)->EGFR(C,CR!0,L~ext!_,N),EGFR(C,CR!0,L~ext!_,N)" ForwardRate="1" />
149<Rule Id="135" Name="EGFR_EGFRi" Data="EGFR(C,CR,L~int!_,N),EGFR(C,CR,L~int!_,N)->EGFR(C,CR!0,L~int!_,N),EGFR(C,CR!0,L~int!_,N)" ForwardRate="1" />
150<Rule Id="136" Name="EGFR_HER2" Data="EGFR(C,CR,L~ext!_,N),HER2(C,CR,N)->EGFR(C,CR!0,L~ext!_,N),HER2(C,CR!0,N)" ForwardRate="1" />
151<Rule Id="137" Name="EGFR_HER4" Data="EGFR(C,CR,L~ext!_,N),HER4(C,CR,L~ext!_,N)->EGFR(C,CR!0,L~ext!_,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
152<Rule Id="138" Name="HER2_HER4" Data="HER2(C,CR,N),HER4(C,CR,L~ext!_,N)->HER2(C,CR!0,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
153<Rule Id="139" Name="HER4_HER4" Data="HER4(C,CR,L~ext!_,N),HER4(C,CR,L~ext!_,N)->HER4(C,CR!0,L~ext!_,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
154<Rule Id="140" Name="EGFR_EGFR_op" Data="EGFR(C,CR!0,N),EGFR(C,CR!0,N)->EGFR(C,CR,N),EGFR(C,CR,N)" ForwardRate="1" />
155<Rule Id="141" Name="EGFR_HER2_op" Data="EGFR(C,CR!0,N),HER2(C,CR!0,N)->EGFR(C,CR,N),HER2(C,CR,N)" ForwardRate="1" />
156<Rule Id="142" Name="EGFR_HER4_op" Data="EGFR(C,CR!0,N),HER4(C,CR!0,N)->EGFR(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />
157<Rule Id="143" Name="HER2_HER2_op" Data="HER2(C,CR!0,N),HER2(C,CR!0,N)->HER2(C,CR,N),HER2(C,CR,N)" ForwardRate="1" />
158<Rule Id="144" Name="HER2_HER4_op" Data="HER2(C,CR!0,N),HER4(C,CR!0,N)->HER2(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />
159<Rule Id="145" Name="HER4_HER4_op" Data="HER4(C,CR!0,N),HER4(C,CR!0,N)->HER4(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />
160<Rule Id="146" Name="11 dimer" Data="EGFR(C,CR!0,N),EGFR(C,CR!0,N)->EGFR(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
161<Rule Id="147" Name="11 dimer_op" Data="EGFR(C,CR!1,N!0),EGFR(C!0,CR!1,N)->EGFR(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
162<Rule Id="148" Name="21 dimer" Data="HER2(C,CR!0,N),EGFR(C,CR!0,N)->HER2(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
163<Rule Id="149" Name="21 dimer_op" Data="HER2(C,CR!1,N!0),EGFR(C!0,CR!1,N)->HER2(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
164<Rule Id="150" Name="41 dimer" Data="HER4(C,CR!0,N),EGFR(C,CR!0,N)->HER4(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
165<Rule Id="151" Name="41 dimer_op" Data="HER4(C,CR!1,N!0),EGFR(C!0,CR!1,N)->HER4(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
166<Rule Id="152" Name="12 dimer" Data="EGFR(C,CR!0,N),HER2(C,CR!0,N)->EGFR(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />
167<Rule Id="153" Name="12 dimer_op" Data="EGFR(C,CR!1,N!0),HER2(C!0,CR!1,N)->EGFR(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />
168<Rule Id="154" Name="22 dimer" Data="HER2(C,CR!0,N),HER2(C,CR!0,N)->HER2(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />
169<Rule Id="155" Name="22 dimer_op" Data="HER2(C,CR!1,N!0),HER2(C!0,CR!1,N)->HER2(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />
170<Rule Id="156" Name="42 dimer" Data="HER4(C,CR!0,N),HER2(C,CR!0,N)->HER4(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />
171<Rule Id="157" Name="42 dimer_op" Data="HER4(C,CR!1,N!0),HER2(C!0,CR!1,N)->HER4(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />
172<Rule Id="158" Name="14 dimer" Data="EGFR(C,CR!0,N),HER4(C,CR!0,N)->EGFR(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />
173<Rule Id="159" Name="14 dimer_op" Data="EGFR(C,CR!1,N!0),HER4(C!0,CR!1,N)->EGFR(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />
174<Rule Id="160" Name="24 dimer" Data="HER2(C,CR!0,N),HER4(C,CR!0,N)->HER2(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />
175<Rule Id="161" Name="24 dimer_op" Data="HER2(C,CR!1,N!0),HER4(C!0,CR!1,N)->HER2(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />
176<Rule Id="162" Name="44 dimer" Data="HER4(C,CR!0,N),HER4(C,CR!0,N)->HER4(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />
177<Rule Id="163" Name="44 dimer_op" Data="HER4(C,CR!1,N!0),HER4(C!0,CR!1,N)->HER4(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />
178<Rule Id="164" Name="EGFR_Inh" Data="EGFR(N!_,bp),Inh1(s)->EGFR(N!_,bp!0),Inh1(s!0)" ForwardRate="1" />
179<Rule Id="165" Name="HER2_Inh" Data="HER2(N!_,bp),Inh2(s)->HER2(N!_,bp!0),Inh2(s!0)" ForwardRate="1" />
180<Rule Id="166" Name="HER4_Inh" Data="HER4(N!_,bp),Inh4(s)->HER4(N!_,bp!0),Inh4(s!0)" ForwardRate="1" />
181<Rule Id="167" Name="EGFR_Inh_op" Data="EGFR(bp!0),Inh1(s!0)->EGFR(bp),Inh1(s)" ForwardRate="1" />
182<Rule Id="168" Name="HER2_Inh_op" Data="HER2(bp!0),Inh2(s!0)->HER2(bp),Inh2(s)" ForwardRate="1" />
183<Rule Id="169" Name="HER4_Inh_op" Data="HER4(bp!0),Inh4(s!0)->HER4(bp),Inh4(s)" ForwardRate="1" />
184<Rule Id="170" Name="EGF_mono" Data="EGF(r~ext!0),EGFR(CR,L~ext!0)=>EGF(r~int!0),EGFR(CR,L~int!0)" ForwardRate="1" />
185<Rule Id="171" Name="EGF_di" Data="EGF(r~ext!0),EGFR(CR!1,L~ext!0),EGF(r~ext!2),EGFR(CR!1,L~ext!2)=>EGF(r~int!0),EGFR(CR!1,L~int!0),EGF(r~int!2),EGFR(CR!1,L~int!2)" ForwardRate="1" />
186<Rule Id="172" Name="Rule44" Data="EGFR(N!0,bp),EGFR(C!0,Y1016~u)->EGFR(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
187<Rule Id="173" Name="Rule45" Data="HER2(N!0,bp),EGFR(C!0,Y1016~u)->HER2(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
188<Rule Id="174" Name="Rule46" Data="HER4(N!0,bp),EGFR(C!0,Y1016~u)->HER4(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
189<Rule Id="175" Name="Rule47" Data="EGFR(N!0,bp),EGFR(C!0,Y1092~u)->EGFR(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
190<Rule Id="176" Name="Rule48" Data="HER2(N!0,bp),EGFR(C!0,Y1092~u)->HER2(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
191<Rule Id="177" Name="Rule49" Data="HER4(N!0,bp),EGFR(C!0,Y1092~u)->HER4(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
192<Rule Id="178" Name="Rule50" Data="EGFR(N!0,bp),EGFR(C!0,Y1172~u)->EGFR(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
193<Rule Id="179" Name="Rule51" Data="HER2(N!0,bp),EGFR(C!0,Y1172~u)->HER2(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
194<Rule Id="180" Name="Rule52" Data="HER4(N!0,bp),EGFR(C!0,Y1172~u)->HER4(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
195<Rule Id="181" Name="Rule53" Data="EGFR(N!0,bp),HER2(C!0,Y1139~u)->EGFR(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />
196<Rule Id="182" Name="Rule54" Data="HER2(N!0,bp),HER2(C!0,Y1139~u)->HER2(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />
197<Rule Id="183" Name="Rule55" Data="HER4(N!0,bp),HER2(C!0,Y1139~u)->HER4(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />
198<Rule Id="184" Name="Rule56" Data="EGFR(N!0,bp),HER2(C!0,Y1196~u)->EGFR(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />
199<Rule Id="185" Name="Rule57" Data="HER2(N!0,bp),HER2(C!0,Y1196~u)->HER2(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />
200<Rule Id="186" Name="Rule58" Data="HER4(N!0,bp),HER2(C!0,Y1196~u)->HER4(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />
201<Rule Id="187" Name="Rule59" Data="EGFR(N!0,bp),HER2(C!0,Y1221~u)->EGFR(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />
202<Rule Id="188" Name="Rule60" Data="HER2(N!0,bp),HER2(C!0,Y1221~u)->HER2(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />
203<Rule Id="189" Name="Rule61" Data="HER4(N!0,bp),HER2(C!0,Y1221~u)->HER4(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />
204<Rule Id="190" Name="Rule62" Data="EGFR(N!0,bp),HER4(C!0,Y1~u)->EGFR(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />
205<Rule Id="191" Name="Rule63" Data="HER2(N!0,bp),HER4(C!0,Y1~u)->HER2(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />
206<Rule Id="192" Name="Rule64" Data="HER4(N!0,bp),HER4(C!0,Y1~u)->HER4(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />
207<Rule Id="193" Name="Rule65" Data="EGFR(N!0,bp),HER4(C!0,Y2~u)->EGFR(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />
208<Rule Id="194" Name="Rule66" Data="HER2(N!0,bp),HER4(C!0,Y2~u)->HER2(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />
209<Rule Id="195" Name="Rule67" Data="HER4(N!0,bp),HER4(C!0,Y2~u)->HER4(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />
210<Rule Id="196" Name="Rule68" Data="EGFR(N!0,bp),HER4(C!0,Y3~u)->EGFR(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />
211<Rule Id="197" Name="Rule69" Data="HER2(N!0,bp),HER4(C!0,Y3~u)->HER2(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />
212<Rule Id="198" Name="Rule70" Data="HER4(N!0,bp),HER4(C!0,Y3~u)->HER4(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />
213<Rule Id="199" Name="Rule71" Data="EGFR(Y1016~p),PTP(s)->EGFR(Y1016~p!0),PTP(s!0)" ForwardRate="1" />
214<Rule Id="200" Name="Rule72" Data="EGFR(Y1092~p),PTP(s)->EGFR(Y1092~p!0),PTP(s!0)" ForwardRate="1" />
215<Rule Id="201" Name="Rule73" Data="EGFR(Y1172~p),PTP(s)->EGFR(Y1172~p!0),PTP(s!0)" ForwardRate="1" />
216<Rule Id="202" Name="Rule74" Data="HER2(Y1139~p),PTP(s)->HER2(Y1139~p!0),PTP(s!0)" ForwardRate="1" />
217<Rule Id="203" Name="Rule75" Data="HER2(Y1196~p),PTP(s)->HER2(Y1196~p!0),PTP(s!0)" ForwardRate="1" />
218<Rule Id="204" Name="Rule76" Data="HER2(Y1221~p),PTP(s)->HER2(Y1221~p!0),PTP(s!0)" ForwardRate="1" />
219<Rule Id="205" Name="Rule77" Data="HER4(Y1~p),PTP(s)->HER4(Y1~p!0),PTP(s!0)" ForwardRate="1" />
220<Rule Id="206" Name="Rule78" Data="HER4(Y2~p),PTP(s)->HER4(Y2~p!0),PTP(s!0)" ForwardRate="1" />
221<Rule Id="207" Name="Rule79" Data="HER4(Y3~p),PTP(s)->HER4(Y3~p!0),PTP(s!0)" ForwardRate="1" />
222<Rule Id="208" Name="Rule80" Data="EGFR(Y1016!0),PTP(s!0)->EGFR(Y1016),PTP(s)" ForwardRate="1" />
223<Rule Id="209" Name="Rule81" Data="EGFR(Y1092!0),PTP(s!0)->EGFR(Y1092),PTP(s)" ForwardRate="1" />
224<Rule Id="210" Name="Rule82" Data="EGFR(Y1172!0),PTP(s!0)->EGFR(Y1172),PTP(s)" ForwardRate="1" />
225<Rule Id="211" Name="Rule83" Data="HER2(Y1139!0),PTP(s!0)->HER2(Y1139),PTP(s)" ForwardRate="1" />
226<Rule Id="212" Name="Rule84" Data="HER2(Y1196!0),PTP(s!0)->HER2(Y1196),PTP(s)" ForwardRate="1" />
227<Rule Id="213" Name="Rule85" Data="HER2(Y1221!0),PTP(s!0)->HER2(Y1221),PTP(s)" ForwardRate="1" />
228<Rule Id="214" Name="Rule86" Data="HER4(Y1!0),PTP(s!0)->HER4(Y1),PTP(s)" ForwardRate="1" />
229<Rule Id="215" Name="Rule87" Data="HER4(Y2!0),PTP(s!0)->HER4(Y2),PTP(s)" ForwardRate="1" />
230<Rule Id="216" Name="Rule88" Data="HER4(Y3!0),PTP(s!0)->HER4(Y3),PTP(s)" ForwardRate="1" />
231<Rule Id="217" Name="Rule89" Data="EGFR(Y1016~p!0),PTP(s!0)->EGFR(Y1016~u!0),PTP(s!0)" ForwardRate="1" />
232<Rule Id="218" Name="Rule90" Data="EGFR(Y1092~p!0),PTP(s!0)->EGFR(Y1092~u!0),PTP(s!0)" ForwardRate="1" />
233<Rule Id="219" Name="Rule91" Data="EGFR(Y1172~p!0),PTP(s!0)->EGFR(Y1172~u!0),PTP(s!0)" ForwardRate="1" />
234<Rule Id="220" Name="Rule92" Data="HER2(Y1139~p!0),PTP(s!0)->HER2(Y1139~u!0),PTP(s!0)" ForwardRate="1" />
235<Rule Id="221" Name="Rule93" Data="HER2(Y1196~p!0),PTP(s!0)->HER2(Y1196~u!0),PTP(s!0)" ForwardRate="1" />
236<Rule Id="222" Name="Rule94" Data="HER2(Y1221~p!0),PTP(s!0)->HER2(Y1221~u!0),PTP(s!0)" ForwardRate="1" />
237<Rule Id="223" Name="Rule95" Data="HER4(Y1~p!0),PTP(s!0)->HER4(Y1~u!0),PTP(s!0)" ForwardRate="1" />
238<Rule Id="224" Name="Rule96" Data="HER4(Y2~p!0),PTP(s!0)->HER4(Y2~u!0),PTP(s!0)" ForwardRate="1" />
239<Rule Id="225" Name="Rule97" Data="HER4(Y3~p!0),PTP(s!0)->HER4(Y3~u!0),PTP(s!0)" ForwardRate="1" />
240<Rule Id="226" Name="deg_EGFR" Data="EGFR(CR,L~int)->" ForwardRate="1" />
241<Rule Id="227" Name="EGFR_RasGAP" Data="EGFR(Y1016~p),RasGAP(SH2~u)=>EGFR(Y1016~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
242<Rule Id="228" Name="EGFR_RasGAP_op" Data="EGFR(Y1016~p!0),RasGAP(SH2~rec!0)=>EGFR(Y1016~p),RasGAP(SH2~u)" ForwardRate="1" />
243<Rule Id="229" Name="EGFR_Grb2" Data="EGFR(Y1092~p),Grb2(SH2~u)=>EGFR(Y1092~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
244<Rule Id="230" Name="EGFR_Grb2_op" Data="EGFR(Y1092~p!0),Grb2(SH2~rec!0)=>EGFR(Y1092~p),Grb2(SH2~u)" ForwardRate="1" />
245<Rule Id="231" Name="EGFR_Shc" Data="EGFR(Y1172~p),Shc(PTB~u)=>EGFR(Y1172~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
246<Rule Id="232" Name="EGFR_Shc_op" Data="EGFR(Y1172~p!0),Shc(PTB~rec!0)=>EGFR(Y1172~p),Shc(PTB~u)" ForwardRate="1" />
247<Rule Id="233" Name="HER2_Grb2" Data="HER2(Y1139~p),Grb2(SH2~u)=>HER2(Y1139~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
248<Rule Id="234" Name="HER2_Grb2_op" Data="HER2(Y1139~p!0),Grb2(SH2~rec!0)=>HER2(Y1139~p),Grb2(SH2~u)" ForwardRate="1" />
249<Rule Id="235" Name="HER2_Shc#1" Data="HER2(Y1196~p),Shc(PTB~u)=>HER2(Y1196~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
250<Rule Id="236" Name="HER2_Shc#1_op" Data="HER2(Y1196~p!0),Shc(PTB~rec!0)=>HER2(Y1196~p),Shc(PTB~u)" ForwardRate="1" />
251<Rule Id="237" Name="HER2_RasGAP" Data="HER2(Y1221~p),RasGAP(SH2~u)=>HER2(Y1221~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
252<Rule Id="238" Name="HER2_RasGAP_op" Data="HER2(Y1221~p!0),RasGAP(SH2~rec!0)=>HER2(Y1221~p),RasGAP(SH2~u)" ForwardRate="1" />
253<Rule Id="239" Name="HER2_Shc#2" Data="HER2(Y1221~p),Shc(PTB~u)=>HER2(Y1221~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
254<Rule Id="240" Name="HER2_Shc#2_op" Data="HER2(Y1221~p!0),Shc(PTB~rec!0)=>HER2(Y1221~p),Shc(PTB~u)" ForwardRate="1" />
255<Rule Id="241" Name="HER4_RasGAP" Data="HER4(Y1~p),RasGAP(SH2~u)=>HER4(Y1~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
256<Rule Id="242" Name="HER4_RasGAP_op" Data="HER4(Y1~p!0),RasGAP(SH2~rec!0)=>HER4(Y1~p),RasGAP(SH2~u)" ForwardRate="1" />
257<Rule Id="243" Name="HER4_Grb2" Data="HER4(Y2~p),Grb2(SH2~u)=>HER4(Y2~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
258<Rule Id="244" Name="HER4_Grb2_op" Data="HER4(Y2~p!0),Grb2(SH2~rec!0)=>HER4(Y2~p),Grb2(SH2~u)" ForwardRate="1" />
259<Rule Id="245" Name="HER4_Shc" Data="HER4(Y3~p),Shc(PTB~u)=>HER4(Y3~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
260<Rule Id="246" Name="HER4_Shc_op" Data="HER4(Y3~p!0),Shc(PTB~rec!0)=>HER4(Y3~p),Shc(PTB~u)" ForwardRate="1" />
261<Rule Id="247" Name="Shc@Y" Data="Shc(PTB~rec!_,Y~u)->Shc(PTB~rec!_,Y~p)" ForwardRate="1" />
262<Rule Id="248" Name="Gab1_PI3K@447_op" Data="Gab1(Y447!0),PI3K(SH2!0)->Gab1(Y447),PI3K(SH2)" ForwardRate="1" />
263<Rule Id="249" Name="Gab1_PI3K@472_op" Data="Gab1(Y472!0),PI3K(SH2!0)->Gab1(Y472),PI3K(SH2)" ForwardRate="1" />
264<Rule Id="250" Name="Gab1_PI3K@619_op" Data="Gab1(Y619!0),PI3K(SH2!0)->Gab1(Y619),PI3K(SH2)" ForwardRate="1" />
265<Rule Id="251" Name="PI3K@s Rec" Data="PI3K(SH2~rec!_,s~u)->PI3K(SH2~rec!_,s~p)" ForwardRate="1" />
266<Rule Id="252" Name="PI3K@s Gab#1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
267<Rule Id="253" Name="PI3K@s Gab#2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
268<Rule Id="254" Name="PI3K@s Gab#3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
269<Rule Id="255" Name="PI3K@s_op" Data="PI3K(s~p)->PI3K(s~u)" ForwardRate="1" />
270<Rule Id="256" Name="SoS long arm" Data="Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />
271<Rule Id="257" Name="PI3K no arm" Data="PI3K(SH2~rec!_,s~p),PI(three~u)->PI3K(SH2~rec!_,s~p!0),PI(three~u!0)" ForwardRate="1" />
272<Rule Id="258" Name="PI3K long arm #1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
273<Rule Id="259" Name="PI3K long arm #2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
274<Rule Id="260" Name="PI3K long arm #3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
275<Rule Id="261" Name="Ras_PI3K no arm" Data="Ras(s~gtp),PI3K(RBD,SH2~rec!_,s~u)->Ras(s~gtp!0),PI3K(RBD!0,SH2~rec!_,s~u)" ForwardRate="1" />
276<Rule Id="262" Name="Ras_PI3K long arm #1" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
277<Rule Id="263" Name="Ras_PI3K long arm #2" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
278<Rule Id="264" Name="Ras_PI3K long arm #3" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
279<Rule Id="265" Name="Ras_PI3K_op" Data="Ras(s!0),PI3K(RBD!0)->Ras(s),PI3K(RBD)" ForwardRate="1" />
280<Rule Id="266" Name="PI3K@s Ras" Data="PI3K(RBD!_,s~u)->PI3K(RBD!_,s~p)" ForwardRate="1" />
281<Rule Id="267" Name="PI3K Ras arm" Data="PI3K(RBD!_,s~p),PI(three~u)->PI3K(RBD!_,s~p!0),PI(three~u!0)" ForwardRate="1" />
282<Rule Id="268" Name="PI3K Gab arm #1" Data="Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
283<Rule Id="269" Name="PI3K Gab arm #2" Data="Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
284<Rule Id="270" Name="PI3K Gab arm #3" Data="Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
285<Rule Id="271" Name="EGFR_Grb2@Y1086_SH2" Data="EGFR(Y1086~p),Grb2(SH2)->EGFR(Y1086~p!0),Grb2(SH2!0)" ForwardRate="1" />
286<Rule Id="272" Name="Shc_Src@SH2_S1" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2),Src(S1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2!1),Src(S1!1)" ForwardRate="1" />
287<Rule Id="273" Name="Shc_p@Y239" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)" ForwardRate="1" />
288<Rule Id="274" Name="Shc_Src_op" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~p),Src(S1)" ForwardRate="1" />
289<Rule Id="275" Name="Shc_p@Y240" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y240~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y240~p),Src(S1!1)" ForwardRate="1" />
290<Rule Id="276" Name="SHP1_EGFR@SH2n_Y1173" Data="Shp1(SH2n),EGFR(Y1173~p)->Shp1(SH2n!0),EGFR(Y1173~p!0)" ForwardRate="1" />
291<Rule Id="277" Name="EGFR_u@Y1173" Data="Shp1(SH2n!0),EGFR(Y1173~p!0)->Shp1(SH2n!0),EGFR(Y1173~u!0)" ForwardRate="1" />
292<Rule Id="278" Name="EGFR_SHP1_op" Data="Shp1(SH2n!0),EGFR(Y1173~u!0)->Shp1(SH2n),EGFR(Y1173~u)" ForwardRate="1" />
293<Rule Id="279" Name="EGFR_Shc@Y1173_PTB" Data="Shc(PTB),EGFR(Y1173~p)->Shc(PTB!0),EGFR(Y1173~p!0)" ForwardRate="1" />
294<Rule Id="280" Name="EGFR_Shc@Y1173_SH2" Data="Shc(SH2),EGFR(Y1173~p)->Shc(SH2!0),EGFR(Y1173~p!0)" ForwardRate="1" />
295<Rule Id="281" Name="EGFR_Shc@Y992_PTB" Data="Shc(PTB),EGFR(Y992~p)->Shc(PTB!0),EGFR(Y992~p!0)" ForwardRate="1" />
296<Rule Id="282" Name="EGFR_Shc@Y992_SH2" Data="Shc(SH2),EGFR(Y992~p)->Shc(SH2!0),EGFR(Y992~p!0)" ForwardRate="1" />
297<Rule Id="283" Name="Shc_EGFR@PTB_Y1148" Data="EGFR(Y1148~p),Shc(PTB)->EGFR(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />
298<Rule Id="284" Name="Shc_EGFR@PTB_Y1148_op" Data="EGFR(Y1148~p!0),Shc(PTB!0)->EGFR(Y1148~p),Shc(PTB)" ForwardRate="1" />
299<Rule Id="285" Name="Shc_EGFR@SH2_Y1148" Data="EGFR(Y1148~p),Shc(SH2)->EGFR(Y1148~p!0),Shc(SH2!0)" ForwardRate="1" />
300<Rule Id="286" Name="Shc_EGFR@SH2_Y1148_op" Data="EGFR(Y1148~p!0),Shc(SH2!0)->EGFR(Y1148~p),Shc(SH2)" ForwardRate="1" />
301<Rule Id="287" Name="Shc_EGFR@PTB_Y1173" Data="EGFR(Y1173~p),Shc(PTB)->EGFR(Y1173~p!0),Shc(PTB!0)" ForwardRate="1" />
302<Rule Id="288" Name="Shc_EGFR@PTB_Y1173_op" Data="EGFR(Y1173~p!0),Shc(PTB!0)->EGFR(Y1173~p),Shc(PTB)" ForwardRate="1" />
303<Rule Id="289" Name="Shc_EGFR@SH2_Y1173" Data="EGFR(Y1173~p),Shc(SH2)->EGFR(Y1173~p!0),Shc(SH2!0)" ForwardRate="1" />
304<Rule Id="290" Name="Shc_EGFR@SH2_Y1173_op" Data="EGFR(Y1173~p!0),Shc(SH2!0)->EGFR(Y1173~p),Shc(SH2)" ForwardRate="1" />
305<Rule Id="291" Name="Shc_p@Y317" Data="EGFR(Y1148~p!0),Shc(PTB!0,Y317~u)->EGFR(Y1148~p!0),Shc(PTB!0,Y317~p)" ForwardRate="1" />
306<Rule Id="292" Name="EGFR_Stat3@Y1068_SH2" Data="Stat3(SH2),EGFR(Y1068~p)->Stat3(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />
307<Rule Id="293" Name="EGFR_Stat3@Y1068_SH2_op" Data="Stat3(SH2!0),EGFR(Y1068~p!0)->Stat3(SH2),EGFR(Y1068~p)" ForwardRate="1" />
308<Rule Id="294" Name="EGFR_Stat3@Y1086_SH2" Data="Stat3(SH2),EGFR(Y1086~p)->Stat3(SH2!0),EGFR(Y1086~p!0)" ForwardRate="1" />
309<Rule Id="295" Name="EGFR_Stat3@Y1086_SH2_op" Data="Stat3(SH2!0),EGFR(Y1086~p!0)->Stat3(SH2),EGFR(Y1086~p)" ForwardRate="1" />
310<Rule Id="296" Name="Stat3_p@Y705" Data="Stat3(SH2!0,Y705~u),EGFR(Y1068!0)->Stat3(SH2!0,Y705~p),EGFR(Y1068!0)" ForwardRate="1" />
311<Rule Id="297" Name="EGFR_p@Y1086" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1086~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1086~p),A(s~pp!0)" ForwardRate="1" />
312<Rule Id="298" Name="EGFR_p@Y1173" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1173~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1173~p),A(s~pp!0)" ForwardRate="1" />
313<Rule Id="299" Name="EGFR_Shc@Y1068_SH2" Data="EGFR(Y1068~p),Shc(SH2)->EGFR(Y1068~p!0),Shc(SH2!0)" ForwardRate="1" />
314<Rule Id="300" Name="EGFR_Shc@Y1068_SH2_op" Data="EGFR(Y1068~p!0),Shc(SH2!0)->EGFR(Y1068~p),Shc(SH2)" ForwardRate="1" />
315<Rule Id="301" Name="EGFR_Shc@Y1086_SH2" Data="EGFR(Y1086~p),Shc(SH2)->EGFR(Y1086~p!0),Shc(SH2!0)" ForwardRate="1" />
316<Rule Id="302" Name="EGFR_Shc@Y1086_SH2_op" Data="EGFR(Y1086~p!0),Shc(SH2!0)->EGFR(Y1086~p),Shc(SH2)" ForwardRate="1" />
317<Rule Id="303" Name="EGFR_PLCG1@Y992_SH2" Data="EGFR(Y992~p),PLCG1(SH2)->EGFR(Y992~p!0),PLCG1(SH2!0)" ForwardRate="1" />
318<Rule Id="304" Name="EGFR_PLCG1@Y992_SH2_op" Data="EGFR(Y992~p!0),PLCG1(SH2!0)->EGFR(Y992~p),PLCG1(SH2)" ForwardRate="1" />
319<Rule Id="305" Name="EGFR_PLCG1@Y1068_SH2" Data="EGFR(Y1068~p),PLCG1(SH2)->EGFR(Y1068~p!0),PLCG1(SH2!0)" ForwardRate="1" />
320<Rule Id="306" Name="EGFR_PLCG1@Y1068_SH2_op" Data="EGFR(Y1068~p!0),PLCG1(SH2!0)->EGFR(Y1068~p),PLCG1(SH2)" ForwardRate="1" />
321<Rule Id="307" Name="EGFR_PLCG1@Y1086_SH2" Data="EGFR(Y1086~p),PLCG1(SH2)->EGFR(Y1086~p!0),PLCG1(SH2!0)" ForwardRate="1" />
322<Rule Id="308" Name="EGFR_PLCG1@Y1086_SH2_op" Data="EGFR(Y1086~p!0),PLCG1(SH2!0)->EGFR(Y1086~p),PLCG1(SH2)" ForwardRate="1" />
323<Rule Id="309" Name="EGFR_PLCG1@Y1148_SH2" Data="EGFR(Y1148~p),PLCG1(SH2)->EGFR(Y1148~p!0),PLCG1(SH2!0)" ForwardRate="1" />
324<Rule Id="310" Name="EGFR_PLCG1@Y1148_SH2_op" Data="EGFR(Y1148~p!0),PLCG1(SH2!0)->EGFR(Y1148~p),PLCG1(SH2)" ForwardRate="1" />
325<Rule Id="311" Name="EGFR_PLCG1@Y1173_SH2" Data="EGFR(Y1173~p),PLCG1(SH2)->EGFR(Y1173~p!0),PLCG1(SH2!0)" ForwardRate="1" />
326<Rule Id="312" Name="EGFR_PLCG1@Y1173_SH2_op" Data="EGFR(Y1173~p!0),PLCG1(SH2!0)->EGFR(Y1173~p),PLCG1(SH2)" ForwardRate="1" />
327<Rule Id="313" Name="EGFR_Src@Y845_SH2" Data="Src(SH2),EGFR(Y845)->Src(SH2!0),EGFR(Y845!0)" ForwardRate="1" />
328<Rule Id="314" Name="EGFR_Src@Y845_SH2_op" Data="Src(SH2!0),EGFR(Y845!0)->Src(SH2),EGFR(Y845)" ForwardRate="1" />
329<Rule Id="315" Name="EGFR_p@Y845" Data="Src(SH2!0),EGFR(Y845~u!0)->Src(SH2!0),EGFR(Y845~p!0)" ForwardRate="1" />
330<Rule Id="316" Name="EGFR_Eps8@S1_S1" Data="EGFR(S1),Eps8(S1)->EGFR(S1!0),Eps8(S1!0)" ForwardRate="1" />
331<Rule Id="317" Name="EGFR_Eps8@S1_S1_op" Data="EGFR(S1!0),Eps8(S1!0)->EGFR(S1),Eps8(S1)" ForwardRate="1" />
332<Rule Id="318" Name="Eps8_p@X" Data="EGFR(S1!0),Eps8(S1!0,X~u)->EGFR(S1!0),Eps8(S1!0,X~p)" ForwardRate="1" />
333<Rule Id="319" Name="EGFR_PLCG1@Y1173_SH2n" Data="EGFR(Y1173~p),PLCG1(SH2n)->EGFR(Y1173~p!0),PLCG1(SH2n!0)" ForwardRate="1" />
334<Rule Id="320" Name="EGFR_PLCG1@Y992_SH2c" Data="EGFR(Y992~p),PLCG1(SH2c)->EGFR(Y992~p!0),PLCG1(SH2c!0)" ForwardRate="1" />
335<Rule Id="321" Name="PLCG1_p@Y472" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y472~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y472~p)" ForwardRate="1" />
336<Rule Id="322" Name="PLCG1_p@Y771" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y771~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y771~p)" ForwardRate="1" />
337<Rule Id="323" Name="PLCG1_p@Y783" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y783~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y783~p)" ForwardRate="1" />
338<Rule Id="324" Name="PLCG1_p@Y1254" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y1254~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y1254~p)" ForwardRate="1" />
339<Rule Id="325" Name="EGFR_Gab1@S1_S1" Data="Gab1(X~u),EGFR(S1)->Gab1(X~u!0),EGFR(S1!0)" ForwardRate="1" />
340<Rule Id="326" Name="Gab1_p@Y627" Data="Gab1(Y627~u!0),EGFR(S1!0)->Gab1(Y627~p!0),EGFR(S1!0)" ForwardRate="1" />
341<Rule Id="327" Name="Gab1_EGFR_op" Data="Gab1(Y627~p!0),EGFR(S1!0)->Gab1(Y627~p),EGFR(S1)" ForwardRate="1" />
342<Rule Id="328" Name="Gab1_p@Y659" Data="Gab1(Y659~u!0),EGFR(S1!0)->Gab1(Y659~p!0),EGFR(S1!0)" ForwardRate="1" />
343<Rule Id="329" Name="p85_EGFR@SH2_Y920" Data="p85(SH2),EGFR(Y920~p)->p85(SH2!0),EGFR(Y920~p!0)" ForwardRate="1" />
344<Rule Id="330" Name="Rom2_PI3K@PH_S1" Data="Rom2(PH),PI3K(S1)->Rom2(PH!0),PI3K(S1!0)" ForwardRate="1" />
345<Rule Id="331" Name="Rom2_PI3K@PH_S1_op" Data="Rom2(PH!0),PI3K(S1!0)->Rom2(PH),PI3K(S1)" ForwardRate="1" />
346<Rule Id="332" Name="EGFR_Vav2@Y992_SH2" Data="EGFR(Y992~p),Vav2(SH2)->EGFR(Y992~p!0),Vav2(SH2!0)" ForwardRate="1" />
347<Rule Id="333" Name="EGFR_Vav2@Y992_SH2_op" Data="EGFR(Y992~p!0),Vav2(SH2!0)->EGFR(Y992~p),Vav2(SH2)" ForwardRate="1" />
348<Rule Id="334" Name="EGFR_Vav@Y1148_SH2" Data="EGFR(Y1148~p),Vav2(SH2)->EGFR(Y1148~p!0),Vav2(SH2!0)" ForwardRate="1" />
349<Rule Id="335" Name="EGFR_Vav@Y1148_SH2_op" Data="EGFR(Y1148~p!0),Vav2(SH2!0)->EGFR(Y1148~p),Vav2(SH2)" ForwardRate="1" />
350<Rule Id="336" Name="Vav2_p@Y142" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y142~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y142~p)" ForwardRate="1" />
351<Rule Id="337" Name="Vav2_p@Y172" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y172~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y172~p)" ForwardRate="1" />
352<Rule Id="338" Name="Vav2_p@Y159" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y159~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y159~p)" ForwardRate="1" />
353<Rule Id="339" Name="Grb2_EGFR@SH2_Y1068" Data="Grb2(SH2),EGFR(Y1068~p)->Grb2(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />
354<Rule Id="340" Name="Pak1_Grb2@SH3_SBM" Data="Grb2(SH2!0,SH3),EGFR(Y1068~p!0),Pak1(SBM)->Grb2(SH2!1,SH3!0),EGFR(Y1068~p!1),Pak1(SBM!0)" ForwardRate="1" />
355<Rule Id="341" Name="Ang2_EGFR@r_l" Data="Ang2(r~ext),EGFR(CR,L~ext)=>Ang(r~ext!0),GFR(CR,L~ext!0)" ForwardRate="1" />
356<Rule Id="342" Name="Ang2_EGFR@r_l_op" Data="Ang(r~ext!0),GFR(CR,L~ext!0)=>Ang2(r~ext),EGFR(CR,L~ext)" ForwardRate="1" />
357<Rule Id="343" Name="EGFR_Clta(int)" Data="EGFR(C,N~ext!0),CLTA(S1!0)->EGFR(C,N~int!0),CLTA(S1!0)" ForwardRate="1" />
358</RuleSet>
359<ContactMap Name="Low resolution">
360<Agent Name="Shc">
361<Site Name="PTB" CanChangeState="true" CanBeBound="true">
362<Rule Id="71"/>
363<Rule Id="72"/>
364<Rule Id="231"/>
365<Rule Id="232"/>
366<Rule Id="235"/>
367<Rule Id="236"/>
368<Rule Id="239"/>
369<Rule Id="240"/>
370<Rule Id="245"/>
371<Rule Id="246"/>
372</Site>
373<Site Name="SH2" CanChangeState="false" CanBeBound="true">
374</Site>
375<Site Name="Y" CanChangeState="true" CanBeBound="true">
376<Rule Id="247"/>
377</Site>
378<Site Name="Y239" CanChangeState="true" CanBeBound="true">
379<Rule Id="273"/>
380</Site>
381<Site Name="Y240" CanChangeState="true" CanBeBound="true">
382<Rule Id="275"/>
383</Site>
384<Site Name="Y317" CanChangeState="true" CanBeBound="true">
385<Rule Id="291"/>
386</Site>
387<Site Name="Y318" CanChangeState="true" CanBeBound="true">
388<Rule Id="85"/>
389<Rule Id="86"/>
390<Rule Id="87"/>
391<Rule Id="88"/>
392<Rule Id="89"/>
393</Site>
394</Agent>
395<Agent Name="PTP">
396<Site Name="s" CanChangeState="false" CanBeBound="true">
397</Site>
398</Agent>
399<Agent Name="PI3K">
400<Site Name="RBD" CanChangeState="false" CanBeBound="true">
401</Site>
402<Site Name="S1" CanChangeState="false" CanBeBound="true">
403</Site>
404<Site Name="SH2" CanChangeState="true" CanBeBound="true">
405<Rule Id="59"/>
406<Rule Id="60"/>
407<Rule Id="61"/>
408<Rule Id="62"/>
409<Rule Id="63"/>
410<Rule Id="64"/>
411<Rule Id="65"/>
412<Rule Id="66"/>
413<Rule Id="67"/>
414<Rule Id="68"/>
415<Rule Id="69"/>
416<Rule Id="70"/>
417</Site>
418<Site Name="s" CanChangeState="true" CanBeBound="true">
419<Rule Id="251"/>
420<Rule Id="252"/>
421<Rule Id="253"/>
422<Rule Id="254"/>
423<Rule Id="255"/>
424<Rule Id="266"/>
425</Site>
426</Agent>
427<Agent Name="HRG">
428<Rule Id="128"/>
429<Site Name="r" CanChangeState="true" CanBeBound="true">
430</Site>
431</Agent>
432<Agent Name="HER4">
433<Site Name="C" CanChangeState="false" CanBeBound="true">
434</Site>
435<Site Name="CR" CanChangeState="false" CanBeBound="true">
436</Site>
437<Site Name="L" CanChangeState="true" CanBeBound="true">
438</Site>
439<Site Name="N" CanChangeState="false" CanBeBound="true">
440</Site>
441<Site Name="Y1" CanChangeState="true" CanBeBound="true">
442<Rule Id="190"/>
443<Rule Id="191"/>
444<Rule Id="192"/>
445<Rule Id="223"/>
446</Site>
447<Site Name="Y2" CanChangeState="true" CanBeBound="true">
448<Rule Id="193"/>
449<Rule Id="194"/>
450<Rule Id="195"/>
451<Rule Id="224"/>
452</Site>
453<Site Name="Y3" CanChangeState="true" CanBeBound="true">
454<Rule Id="196"/>
455<Rule Id="197"/>
456<Rule Id="198"/>
457<Rule Id="225"/>
458</Site>
459<Site Name="bp" CanChangeState="false" CanBeBound="true">
460</Site>
461</Agent>
462<Agent Name="HER3">
463<Site Name="C" CanChangeState="false" CanBeBound="true">
464</Site>
465<Site Name="CR" CanChangeState="false" CanBeBound="true">
466</Site>
467<Site Name="L" CanChangeState="true" CanBeBound="true">
468</Site>
469<Site Name="Y1035" CanChangeState="true" CanBeBound="true">
470<Rule Id="17"/>
471<Rule Id="18"/>
472<Rule Id="19"/>
473<Rule Id="52"/>
474</Site>
475<Site Name="Y1178" CanChangeState="true" CanBeBound="true">
476<Rule Id="20"/>
477<Rule Id="21"/>
478<Rule Id="22"/>
479<Rule Id="53"/>
480</Site>
481<Site Name="Y1203" CanChangeState="true" CanBeBound="true">
482<Rule Id="23"/>
483<Rule Id="24"/>
484<Rule Id="25"/>
485<Rule Id="54"/>
486</Site>
487<Site Name="Y1241" CanChangeState="true" CanBeBound="true">
488<Rule Id="26"/>
489<Rule Id="27"/>
490<Rule Id="28"/>
491<Rule Id="55"/>
492</Site>
493<Site Name="Y1257" CanChangeState="true" CanBeBound="true">
494<Rule Id="29"/>
495<Rule Id="30"/>
496<Rule Id="31"/>
497<Rule Id="56"/>
498</Site>
499<Site Name="Y1270" CanChangeState="true" CanBeBound="true">
500<Rule Id="32"/>
501<Rule Id="33"/>
502<Rule Id="34"/>
503<Rule Id="57"/>
504</Site>
505<Site Name="Y1309" CanChangeState="true" CanBeBound="true">
506<Rule Id="35"/>
507<Rule Id="36"/>
508<Rule Id="37"/>
509<Rule Id="58"/>
510</Site>
511</Agent>
512<Agent Name="HER2">
513<Site Name="C" CanChangeState="false" CanBeBound="true">
514</Site>
515<Site Name="CR" CanChangeState="false" CanBeBound="true">
516</Site>
517<Site Name="N" CanChangeState="false" CanBeBound="true">
518</Site>
519<Site Name="Y1139" CanChangeState="true" CanBeBound="true">
520<Rule Id="181"/>
521<Rule Id="182"/>
522<Rule Id="183"/>
523<Rule Id="220"/>
524</Site>
525<Site Name="Y1196" CanChangeState="true" CanBeBound="true">
526<Rule Id="184"/>
527<Rule Id="185"/>
528<Rule Id="186"/>
529<Rule Id="221"/>
530</Site>
531<Site Name="Y1221" CanChangeState="true" CanBeBound="true">
532<Rule Id="187"/>
533<Rule Id="188"/>
534<Rule Id="189"/>
535<Rule Id="222"/>
536</Site>
537<Site Name="bp" CanChangeState="false" CanBeBound="true">
538</Site>
539</Agent>
540<Agent Name="EGFR">
541<Rule Id="226"/>
542<Rule Id="341"/>
543<Rule Id="342"/>
544<Site Name="C" CanChangeState="false" CanBeBound="true">
545</Site>
546<Site Name="CR" CanChangeState="false" CanBeBound="true">
547</Site>
548<Site Name="L" CanChangeState="true" CanBeBound="true">
549<Rule Id="170"/>
550<Rule Id="171"/>
551<Rule Id="342"/>
552</Site>
553<Site Name="N" CanChangeState="true" CanBeBound="true">
554<Rule Id="343"/>
555</Site>
556<Site Name="S1" CanChangeState="false" CanBeBound="true">
557</Site>
558<Site Name="Y1016" CanChangeState="true" CanBeBound="true">
559<Rule Id="172"/>
560<Rule Id="173"/>
561<Rule Id="174"/>
562<Rule Id="217"/>
563</Site>
564<Site Name="Y1068" CanChangeState="true" CanBeBound="true">
565</Site>
566<Site Name="Y1086" CanChangeState="true" CanBeBound="true">
567<Rule Id="297"/>
568</Site>
569<Site Name="Y1092" CanChangeState="true" CanBeBound="true">
570<Rule Id="175"/>
571<Rule Id="176"/>
572<Rule Id="177"/>
573<Rule Id="218"/>
574</Site>
575<Site Name="Y1148" CanChangeState="true" CanBeBound="true">
576</Site>
577<Site Name="Y1172" CanChangeState="true" CanBeBound="true">
578<Rule Id="178"/>
579<Rule Id="179"/>
580<Rule Id="180"/>
581<Rule Id="219"/>
582</Site>
583<Site Name="Y1173" CanChangeState="true" CanBeBound="true">
584<Rule Id="277"/>
585<Rule Id="298"/>
586</Site>
587<Site Name="Y845" CanChangeState="true" CanBeBound="true">
588<Rule Id="315"/>
589</Site>
590<Site Name="Y920" CanChangeState="true" CanBeBound="true">
591</Site>
592<Site Name="Y992" CanChangeState="true" CanBeBound="true">
593</Site>
594<Site Name="bp" CanChangeState="false" CanBeBound="true">
595</Site>
596</Agent>
597<Bond FromAgent="EGFR" FromSite="CR" ToAgent="EGFR" ToSite="CR">
598<Rule Id="134"/>
599<Rule Id="135"/>
600<Rule Id="140"/>
601</Bond><Bond FromAgent="EGFR" FromSite="N" ToAgent="EGFR" ToSite="C">
602<Rule Id="146"/>
603<Rule Id="147"/>
604</Bond><Bond FromAgent="HER2" FromSite="C" ToAgent="EGFR" ToSite="N">
605<Rule Id="152"/>
606<Rule Id="153"/>
607</Bond><Bond FromAgent="HER2" FromSite="CR" ToAgent="EGFR" ToSite="CR">
608<Rule Id="136"/>
609<Rule Id="141"/>
610</Bond><Bond FromAgent="HER2" FromSite="CR" ToAgent="HER2" ToSite="CR">
611<Rule Id="143"/>
612</Bond><Bond FromAgent="HER2" FromSite="N" ToAgent="EGFR" ToSite="C">
613<Rule Id="148"/>
614<Rule Id="149"/>
615</Bond><Bond FromAgent="HER2" FromSite="N" ToAgent="HER2" ToSite="C">
616<Rule Id="154"/>
617<Rule Id="155"/>
618</Bond><Bond FromAgent="HER3" FromSite="C" ToAgent="EGFR" ToSite="N">
619<Rule Id="11"/>
620<Rule Id="12"/>
621</Bond><Bond FromAgent="HER3" FromSite="C" ToAgent="HER2" ToSite="N">
622<Rule Id="13"/>
623<Rule Id="14"/>
624</Bond><Bond FromAgent="HER3" FromSite="CR" ToAgent="EGFR" ToSite="CR">
625<Rule Id="3"/>
626<Rule Id="7"/>
627</Bond><Bond FromAgent="HER3" FromSite="CR" ToAgent="HER2" ToSite="CR">
628<Rule Id="4"/>
629<Rule Id="8"/>
630</Bond><Bond FromAgent="HER3" FromSite="CR" ToAgent="HER3" ToSite="CR">
631<Rule Id="5"/>
632<Rule Id="9"/>
633</Bond><Bond FromAgent="HER4" FromSite="C" ToAgent="EGFR" ToSite="N">
634<Rule Id="158"/>
635<Rule Id="159"/>
636</Bond><Bond FromAgent="HER4" FromSite="C" ToAgent="HER2" ToSite="N">
637<Rule Id="160"/>
638<Rule Id="161"/>
639</Bond><Bond FromAgent="HER4" FromSite="CR" ToAgent="EGFR" ToSite="CR">
640<Rule Id="137"/>
641<Rule Id="142"/>
642</Bond><Bond FromAgent="HER4" FromSite="CR" ToAgent="HER2" ToSite="CR">
643<Rule Id="138"/>
644<Rule Id="144"/>
645</Bond><Bond FromAgent="HER4" FromSite="CR" ToAgent="HER3" ToSite="CR">
646<Rule Id="6"/>
647<Rule Id="10"/>
648</Bond><Bond FromAgent="HER4" FromSite="CR" ToAgent="HER4" ToSite="CR">
649<Rule Id="139"/>
650<Rule Id="145"/>
651</Bond><Bond FromAgent="HER4" FromSite="N" ToAgent="EGFR" ToSite="C">
652<Rule Id="150"/>
653<Rule Id="151"/>
654</Bond><Bond FromAgent="HER4" FromSite="N" ToAgent="HER2" ToSite="C">
655<Rule Id="156"/>
656<Rule Id="157"/>
657</Bond><Bond FromAgent="HER4" FromSite="N" ToAgent="HER3" ToSite="C">
658<Rule Id="15"/>
659<Rule Id="16"/>
660</Bond><Bond FromAgent="HER4" FromSite="N" ToAgent="HER4" ToSite="C">
661<Rule Id="162"/>
662<Rule Id="163"/>
663</Bond><Bond FromAgent="HRG" FromSite="r" ToAgent="HER3" ToSite="L">
664<Rule Id="1"/>
665<Rule Id="2"/>
666</Bond><Bond FromAgent="HRG" FromSite="r" ToAgent="HER4" ToSite="L">
667<Rule Id="131"/>
668<Rule Id="133"/>
669</Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1035">
670<Rule Id="59"/>
671<Rule Id="60"/>
672</Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1178">
673<Rule Id="61"/>
674<Rule Id="62"/>
675</Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1203">
676<Rule Id="63"/>
677<Rule Id="64"/>
678</Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1241">
679<Rule Id="65"/>
680<Rule Id="66"/>
681</Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1257">
682<Rule Id="67"/>
683<Rule Id="68"/>
684</Bond><Bond FromAgent="PI3K" FromSite="SH2" ToAgent="HER3" ToSite="Y1270">
685<Rule Id="69"/>
686<Rule Id="70"/>
687</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="EGFR" ToSite="Y1016">
688<Rule Id="199"/>
689<Rule Id="208"/>
690</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="EGFR" ToSite="Y1092">
691<Rule Id="200"/>
692<Rule Id="209"/>
693</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="EGFR" ToSite="Y1172">
694<Rule Id="201"/>
695<Rule Id="210"/>
696</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER2" ToSite="Y1139">
697<Rule Id="202"/>
698<Rule Id="211"/>
699</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER2" ToSite="Y1196">
700<Rule Id="203"/>
701<Rule Id="212"/>
702</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER2" ToSite="Y1221">
703<Rule Id="204"/>
704<Rule Id="213"/>
705</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1035">
706<Rule Id="38"/>
707<Rule Id="45"/>
708</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1178">
709<Rule Id="39"/>
710<Rule Id="46"/>
711</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1203">
712<Rule Id="40"/>
713<Rule Id="47"/>
714</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1241">
715<Rule Id="41"/>
716<Rule Id="48"/>
717</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1257">
718<Rule Id="42"/>
719<Rule Id="49"/>
720</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1270">
721<Rule Id="43"/>
722<Rule Id="50"/>
723</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER3" ToSite="Y1309">
724<Rule Id="44"/>
725<Rule Id="51"/>
726</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER4" ToSite="Y1">
727<Rule Id="205"/>
728<Rule Id="214"/>
729</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER4" ToSite="Y2">
730<Rule Id="206"/>
731<Rule Id="215"/>
732</Bond><Bond FromAgent="PTP" FromSite="s" ToAgent="HER4" ToSite="Y3">
733<Rule Id="207"/>
734<Rule Id="216"/>
735</Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="EGFR" ToSite="Y1148">
736<Rule Id="283"/>
737<Rule Id="284"/>
738</Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="EGFR" ToSite="Y1172">
739<Rule Id="231"/>
740<Rule Id="232"/>
741</Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="EGFR" ToSite="Y1173">
742<Rule Id="279"/>
743<Rule Id="287"/>
744<Rule Id="288"/>
745</Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="EGFR" ToSite="Y992">
746<Rule Id="281"/>
747</Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="HER2" ToSite="Y1196">
748<Rule Id="235"/>
749<Rule Id="236"/>
750</Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="HER2" ToSite="Y1221">
751<Rule Id="239"/>
752<Rule Id="240"/>
753</Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="HER3" ToSite="Y1309">
754<Rule Id="71"/>
755<Rule Id="72"/>
756</Bond><Bond FromAgent="Shc" FromSite="PTB" ToAgent="HER4" ToSite="Y3">
757<Rule Id="245"/>
758<Rule Id="246"/>
759</Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y1068">
760<Rule Id="299"/>
761<Rule Id="300"/>
762</Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y1086">
763<Rule Id="301"/>
764<Rule Id="302"/>
765</Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y1148">
766<Rule Id="285"/>
767<Rule Id="286"/>
768</Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y1173">
769<Rule Id="280"/>
770<Rule Id="289"/>
771<Rule Id="290"/>
772</Bond><Bond FromAgent="Shc" FromSite="SH2" ToAgent="EGFR" ToSite="Y992">
773<Rule Id="282"/>
774</Bond></ContactMap>
775</ComplxSession>