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/test.data/contact_map/rules/~session017.test

http://github.com/kappamodeler/jkappa
Unknown | 656 lines | 656 code | 0 blank | 0 comment | 0 complexity | b7f8e5c0a6f6b1de9944d09ca05974ea MD5 | raw file
Possible License(s): LGPL-3.0, Apache-2.0
  1. <?xml version='1.0' encoding='utf-8'?>
  2. <!-- Automaticaly generated by Complx 3.40..4208 -->
  3. <ComplxSession Timestamp="18/2/2009 (19:56:49)" CommandLine="C:\DOCUME~1\LOPATK~1\LOCALS~1\Temp\tmp30947.exe ~kappa31024.tmp --output-xml ~session31023.tmp --memory-limit 1024 --reset-all --do-XML --do-low-res-contact-map --focus-on ~focus31022.tmp --key 07CFC00F00ED0042" InputFile="~kappa31024.tmp"
  4. xsi:schemaLocation="http://plectix.synthesisstudios.com
  5. KappaSession.xsd" xmlns="http://plectix.synthesisstudios.com/schemas/kappasession"
  6. xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" >
  7. <Log>
  8. <Entry Type="INFO" Message="Compilation(simplx) 0.078 s."/>
  9. <Entry Type="INFO" Message="Second compilation(pretty printing) 0.015 s."/>
  10. <Entry Type="INFO" Message="Translation 0.016 s."/>
  11. <Entry Type="INFO" Message="Renaming 0.016 s."/>
  12. <Entry Type="INFO" Message="Boolean encoding of the initial system 0.218 s."/>
  13. </Log>
  14. <RuleSet Name="Original">
  15. <Rule Id="1" Name="ATP recycling" Data="A(s~pp),Pi()=>A(s~ppp)" ForwardRate="1" />
  16. <Rule Id="2" Name="EGF_ErbB1" Data="EGF(r~ext),ErbB1(CR,L~ext)->EGF(r~ext!0),ErbB1(CR,L~ext!0)" ForwardRate="1" />
  17. <Rule Id="3" Name="EGF_ErbB1_op" Data="EGF(r~ext!0),ErbB1(CR,L~ext!0)->EGF(r~ext),ErbB1(CR,L~ext)" ForwardRate="1" />
  18. <Rule Id="4" Name="ErbB1_ErbB1" Data="ErbB1(C,CR,L~ext!_,N),ErbB1(C,CR,L~ext!_,N)->ErbB1(C,CR!0,L~ext!_,N),ErbB1(C,CR!0,L~ext!_,N)" ForwardRate="1" />
  19. <Rule Id="5" Name="ErbB1_ErbB1_op" Data="ErbB1(C,CR!0,L~ext!_,N),ErbB1(C,CR!0,L~ext!_,N)->ErbB1(C,CR,L~ext!_,N),ErbB1(C,CR,L~ext!_,N)" ForwardRate="1" />
  20. <Rule Id="6" Name="ErbB1_ErbB2" Data="ErbB1(C,CR,L~ext!_,N),ErbB2(C,CR,L~ext,N)->ErbB1(C,CR!0,L~ext!_,N),ErbB2(C,CR!0,L~ext,N)" ForwardRate="1" />
  21. <Rule Id="7" Name="ErbB1_ErbB2_op" Data="ErbB1(C,CR!0,L~ext!_,N),ErbB2(C,CR!0,L~ext,N)->ErbB1(C,CR,L~ext!_,N),ErbB2(C,CR,L~ext,N)" ForwardRate="1" />
  22. <Rule Id="8" Name="ErbB2_ErbB3" Data="ErbB2(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)->ErbB2(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)" ForwardRate="1" />
  23. <Rule Id="9" Name="ErbB2_ErbB3_op" Data="ErbB2(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)->ErbB2(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)" ForwardRate="1" />
  24. <Rule Id="10" Name="ErbB2_ErbB4" Data="ErbB2(C,CR,L~ext,N),ErbB4(C,CR,L~ext!_,N)->ErbB2(C,CR!0,L~ext,N),ErbB4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
  25. <Rule Id="11" Name="ErbB2_ErbB4_op" Data="ErbB2(C,CR!0,L~ext,N),ErbB4(C,CR!0,L~ext!_,N)->ErbB2(C,CR,L~ext,N),ErbB4(C,CR,L~ext!_,N)" ForwardRate="1" />
  26. <Rule Id="12" Name="ErbB1_ErbB3" Data="ErbB1(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)->ErbB1(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)" ForwardRate="1" />
  27. <Rule Id="13" Name="ErbB1_ErbB3_op" Data="ErbB1(C,CR!0,L~ext,N),ErbB3(C,CR!0,L~ext!_,N)->ErbB1(C,CR,L~ext,N),ErbB3(C,CR,L~ext!_,N)" ForwardRate="1" />
  28. <Rule Id="14" Name="ErbB1_ErbB4" Data="ErbB1(C,CR,L~ext,N),ErbB4(C,CR,L~ext!_,N)->ErbB1(C,CR!0,L~ext,N),ErbB4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
  29. <Rule Id="15" Name="ErbB1_ErbB4_op" Data="ErbB1(C,CR!0,L~ext,N),ErbB4(C,CR!0,L~ext!_,N)->ErbB1(C,CR,L~ext,N),ErbB4(C,CR,L~ext!_,N)" ForwardRate="1" />
  30. <Rule Id="16" Name="ErbB1_ATP" Data="ErbB1(bp),A(s~ppp)->ErbB1(bp!0),A(s~ppp!0)" ForwardRate="1" />
  31. <Rule Id="17" Name="ErbB1_A_op" Data="ErbB1(bp!0),A(s!0)->ErbB1(bp),A(s)" ForwardRate="1" />
  32. <Rule Id="18" Name="ErbB2_ATP" Data="ErbB2(bp),A(s~ppp)->ErbB2(bp!0),A(s~ppp!0)" ForwardRate="1" />
  33. <Rule Id="19" Name="ErbB2_A_op" Data="ErbB2(bp!0),A(s!0)->ErbB2(bp),A(s)" ForwardRate="1" />
  34. <Rule Id="20" Name="ErbB4_ATP" Data="ErbB4(bp),A(s~ppp)->ErbB4(bp!0),A(s~ppp!0)" ForwardRate="1" />
  35. <Rule Id="21" Name="ErbB4_A_op" Data="ErbB4(bp!0),A(s!0)->ErbB4(bp),A(s)" ForwardRate="1" />
  36. <Rule Id="22" Name="Rule1" Data="ErbB1(C,CR!0,N),ErbB1(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB1(C!0,CR!1,N)" ForwardRate="1" />
  37. <Rule Id="23" Name="Rule1_op" Data="ErbB1(C,CR!1,N!0),ErbB1(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB1(C,CR!0,N)" ForwardRate="1" />
  38. <Rule Id="24" Name="Rule2" Data="ErbB2(C,CR!0,N),ErbB1(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB1(C!0,CR!1,N)" ForwardRate="1" />
  39. <Rule Id="25" Name="Rule2_op" Data="ErbB2(C,CR!1,N!0),ErbB1(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB1(C,CR!0,N)" ForwardRate="1" />
  40. <Rule Id="26" Name="Rule3" Data="ErbB4(C,CR!0,N),ErbB1(C,CR!0,N)->ErbB4(C,CR!1,N!0),ErbB1(C!0,CR!1,N)" ForwardRate="1" />
  41. <Rule Id="27" Name="Rule3_op" Data="ErbB4(C,CR!1,N!0),ErbB1(C!0,CR!1,N)->ErbB4(C,CR!0,N),ErbB1(C,CR!0,N)" ForwardRate="1" />
  42. <Rule Id="28" Name="Rule4" Data="ErbB1(N!1,bp!0),ErbB1(C!1,Y992~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB1(C!1,Y992~p),A(s~pp!0)" ForwardRate="1" />
  43. <Rule Id="29" Name="Rule5" Data="ErbB1(N!1,bp!0),ErbB1(C!1,Y1068~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB1(C!1,Y1068~p),A(s~pp!0)" ForwardRate="1" />
  44. <Rule Id="30" Name="Rule6" Data="ErbB1(N!1,bp!0),ErbB1(C!1,Y1148~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB1(C!1,Y1148~p),A(s~pp!0)" ForwardRate="1" />
  45. <Rule Id="31" Name="Rule7" Data="ErbB2(N!1,bp!0),ErbB1(C!1,Y992~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB1(C!1,Y992~p),A(s~pp!0)" ForwardRate="1" />
  46. <Rule Id="32" Name="Rule8" Data="ErbB2(N!1,bp!0),ErbB1(C!1,Y1068~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB1(C!1,Y1068~p),A(s~pp!0)" ForwardRate="1" />
  47. <Rule Id="33" Name="Rule9" Data="ErbB2(N!1,bp!0),ErbB1(C!1,Y1148~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB1(C!1,Y1148~p),A(s~pp!0)" ForwardRate="1" />
  48. <Rule Id="34" Name="Rule10" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y992~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y992~p),A(s~pp!0)" ForwardRate="1" />
  49. <Rule Id="35" Name="Rule11" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y1068~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y1068~p),A(s~pp!0)" ForwardRate="1" />
  50. <Rule Id="36" Name="Rule12" Data="ErbB4(N!1,bp!0),ErbB1(C!1,Y1148~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB1(C!1,Y1148~p),A(s~pp!0)" ForwardRate="1" />
  51. <Rule Id="37" Name="Rule13" Data="ErbB1(C,CR!0,N),ErbB2(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB2(C!0,CR!1,N)" ForwardRate="1" />
  52. <Rule Id="38" Name="Rule13_op" Data="ErbB1(C,CR!1,N!0),ErbB2(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB2(C,CR!0,N)" ForwardRate="1" />
  53. <Rule Id="39" Name="Rule14" Data="ErbB2(C,CR!0,N),ErbB2(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB2(C!0,CR!1,N)" ForwardRate="1" />
  54. <Rule Id="40" Name="Rule14_op" Data="ErbB2(C,CR!1,N!0),ErbB2(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB2(C,CR!0,N)" ForwardRate="1" />
  55. <Rule Id="41" Name="Rule15" Data="ErbB4(C,CR!0,N),ErbB2(C,CR!0,N)->ErbB4(C,CR!1,N!0),ErbB2(C!0,CR!1,N)" ForwardRate="1" />
  56. <Rule Id="42" Name="Rule15_op" Data="ErbB4(C,CR!1,N!0),ErbB2(C!0,CR!1,N)->ErbB4(C,CR!0,N),ErbB2(C,CR!0,N)" ForwardRate="1" />
  57. <Rule Id="43" Name="Rule16" Data="ErbB1(N!1,bp!0),ErbB2(C!1,Y1196~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB2(C!1,Y1196~p),A(s~pp!0)" ForwardRate="1" />
  58. <Rule Id="44" Name="Rule17" Data="ErbB1(N!1,bp!0),ErbB2(C!1,Y1221~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB2(C!1,Y1221~p),A(s~pp!0)" ForwardRate="1" />
  59. <Rule Id="45" Name="Rule18" Data="ErbB4(N!1,bp!0),ErbB2(C!1,Y1139~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB2(C!1,Y1139~p),A(s~pp!0)" ForwardRate="1" />
  60. <Rule Id="46" Name="Rule19" Data="ErbB4(N!1,bp!0),ErbB2(C!1,Y1196~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB2(C!1,Y1196~p),A(s~pp!0)" ForwardRate="1" />
  61. <Rule Id="47" Name="Rule20" Data="ErbB4(N!1,bp!0),ErbB2(C!1,Y1221~u),A(s~ppp!0)=>ErbB4(N!1,bp!0),ErbB2(C!1,Y1221~p),A(s~pp!0)" ForwardRate="1" />
  62. <Rule Id="48" Name="Rule21" Data="ErbB1(C,CR!0,N),ErbB3(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB3(C!0,CR!1,N)" ForwardRate="1" />
  63. <Rule Id="49" Name="Rule21_op" Data="ErbB1(C,CR!1,N!0),ErbB3(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB3(C,CR!0,N)" ForwardRate="1" />
  64. <Rule Id="50" Name="Rule22" Data="ErbB2(C,CR!0,N),ErbB3(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB3(C!0,CR!1,N)" ForwardRate="1" />
  65. <Rule Id="51" Name="Rule22_op" Data="ErbB2(C,CR!1,N!0),ErbB3(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB3(C,CR!0,N)" ForwardRate="1" />
  66. <Rule Id="52" Name="Rule23" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1035~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1035~p),A(s~pp!0)" ForwardRate="1" />
  67. <Rule Id="53" Name="Rule24" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1178~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1178~p),A(s~pp!0)" ForwardRate="1" />
  68. <Rule Id="54" Name="Rule25" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1203~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1203~p),A(s~pp!0)" ForwardRate="1" />
  69. <Rule Id="55" Name="Rule26" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1241~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1241~p),A(s~pp!0)" ForwardRate="1" />
  70. <Rule Id="56" Name="Rule27" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1257~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1257~p),A(s~pp!0)" ForwardRate="1" />
  71. <Rule Id="57" Name="Rule28" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1270~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1270~p),A(s~pp!0)" ForwardRate="1" />
  72. <Rule Id="58" Name="Rule29" Data="ErbB1(N!1,bp!0),ErbB3(C!1,Y1309~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB3(C!1,Y1309~p),A(s~pp!0)" ForwardRate="1" />
  73. <Rule Id="59" Name="Rule30" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1035~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1035~p),A(s~pp!0)" ForwardRate="1" />
  74. <Rule Id="60" Name="Rule31" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1178~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1178~p),A(s~pp!0)" ForwardRate="1" />
  75. <Rule Id="61" Name="Rule32" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1203~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1203~p),A(s~pp!0)" ForwardRate="1" />
  76. <Rule Id="62" Name="Rule33" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1241~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1241~p),A(s~pp!0)" ForwardRate="1" />
  77. <Rule Id="63" Name="Rule34" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1257~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1257~p),A(s~pp!0)" ForwardRate="1" />
  78. <Rule Id="64" Name="Rule35" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1270~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1270~p),A(s~pp!0)" ForwardRate="1" />
  79. <Rule Id="65" Name="Rule36" Data="ErbB2(N!1,bp!0),ErbB3(C!1,Y1309~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB3(C!1,Y1309~p),A(s~pp!0)" ForwardRate="1" />
  80. <Rule Id="66" Name="Rule37" Data="ErbB1(C,CR!0,N),ErbB4(C,CR!0,N)->ErbB1(C,CR!1,N!0),ErbB4(C!0,CR!1,N)" ForwardRate="1" />
  81. <Rule Id="67" Name="Rule37_op" Data="ErbB1(C,CR!1,N!0),ErbB4(C!0,CR!1,N)->ErbB1(C,CR!0,N),ErbB4(C,CR!0,N)" ForwardRate="1" />
  82. <Rule Id="68" Name="Rule38" Data="ErbB2(C,CR!0,N),ErbB4(C,CR!0,N)->ErbB2(C,CR!1,N!0),ErbB4(C!0,CR!1,N)" ForwardRate="1" />
  83. <Rule Id="69" Name="Rule38_op" Data="ErbB2(C,CR!1,N!0),ErbB4(C!0,CR!1,N)->ErbB2(C,CR!0,N),ErbB4(C,CR!0,N)" ForwardRate="1" />
  84. <Rule Id="70" Name="Rule39" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1056~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1056~p),A(s~pp!0)" ForwardRate="1" />
  85. <Rule Id="71" Name="Rule40" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1188~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1188~p),A(s~pp!0)" ForwardRate="1" />
  86. <Rule Id="72" Name="Rule41" Data="ErbB1(N!1,bp!0),ErbB4(C!1,Y1242~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB4(C!1,Y1242~p),A(s~pp!0)" ForwardRate="1" />
  87. <Rule Id="73" Name="Rule42" Data="ErbB2(N!1,bp!0),ErbB4(C!1,Y1056~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB4(C!1,Y1056~p),A(s~pp!0)" ForwardRate="1" />
  88. <Rule Id="74" Name="Rule43" Data="ErbB2(N!1,bp!0),ErbB4(C!1,Y1188~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB4(C!1,Y1188~p),A(s~pp!0)" ForwardRate="1" />
  89. <Rule Id="75" Name="Rule44" Data="ErbB2(N!1,bp!0),ErbB4(C!1,Y1242~u),A(s~ppp!0)=>ErbB2(N!1,bp!0),ErbB4(C!1,Y1242~p),A(s~pp!0)" ForwardRate="1" />
  90. <Rule Id="76" Name="Rule45" Data="ErbB1(Y992~p)=>ErbB1(Y992~u),Pi()" ForwardRate="1" />
  91. <Rule Id="77" Name="Rule46" Data="ErbB1(Y1068~p)=>ErbB1(Y1068~u),Pi()" ForwardRate="1" />
  92. <Rule Id="78" Name="Rule47" Data="ErbB1(Y1148~p)=>ErbB1(Y1148~u),Pi()" ForwardRate="1" />
  93. <Rule Id="79" Name="Rule48" Data="ErbB2(Y1139~p)=>ErbB2(Y1139~u),Pi()" ForwardRate="1" />
  94. <Rule Id="80" Name="Rule49" Data="ErbB2(Y1196~p)=>ErbB2(Y1196~u),Pi()" ForwardRate="1" />
  95. <Rule Id="81" Name="Rule50" Data="ErbB2(Y1221~p)=>ErbB2(Y1221~u),Pi()" ForwardRate="1" />
  96. <Rule Id="82" Name="ErbB1_RasGAP" Data="ErbB1(Y992~p),RasGAP(SH2)->ErbB1(Y992~p!0),RasGAP(SH2!0)" ForwardRate="1" />
  97. <Rule Id="83" Name="ErbB1_RasGAP_op" Data="ErbB1(Y992~p!0),RasGAP(SH2!0)->ErbB1(Y992~p),RasGAP(SH2)" ForwardRate="1" />
  98. <Rule Id="84" Name="ErbB2_RasGAP" Data="ErbB2(Y1221~p),RasGAP(SH2)->ErbB2(Y1221~p!0),RasGAP(SH2!0)" ForwardRate="1" />
  99. <Rule Id="85" Name="ErbB2_RasGAP_op" Data="ErbB2(Y1221~p!0),RasGAP(SH2!0)->ErbB2(Y1221~p),RasGAP(SH2)" ForwardRate="1" />
  100. <Rule Id="86" Name="ErbB1_Grb2" Data="ErbB1(Y1068~p),Grb2(SH2)->ErbB1(Y1068~p!0),Grb2(SH2!0)" ForwardRate="1" />
  101. <Rule Id="87" Name="ErbB1_Grb2_op" Data="ErbB1(Y1068~p!0),Grb2(SH2!0)->ErbB1(Y1068~p),Grb2(SH2)" ForwardRate="1" />
  102. <Rule Id="88" Name="ErbB2_Grb2" Data="ErbB2(Y1139~p),Grb2(SH2)->ErbB2(Y1139~p!0),Grb2(SH2!0)" ForwardRate="1" />
  103. <Rule Id="89" Name="ErbB2_Grb2_op" Data="ErbB2(Y1139~p!0),Grb2(SH2!0)->ErbB2(Y1139~p),Grb2(SH2)" ForwardRate="1" />
  104. <Rule Id="90" Name="ErbB1_Shc" Data="ErbB1(Y1148~p),Shc(PTB)->ErbB1(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />
  105. <Rule Id="91" Name="ErbB1_Shc_op" Data="ErbB1(Y1148~p!0),Shc(PTB!0)->ErbB1(Y1148~p),Shc(PTB)" ForwardRate="1" />
  106. <Rule Id="92" Name="ErbB2_Shc#1" Data="ErbB2(Y1196~p),Shc(PTB)->ErbB2(Y1196~p!0),Shc(PTB!0)" ForwardRate="1" />
  107. <Rule Id="93" Name="ErbB2_Shc#1_op" Data="ErbB2(Y1196~p!0),Shc(PTB!0)->ErbB2(Y1196~p),Shc(PTB)" ForwardRate="1" />
  108. <Rule Id="94" Name="ErbB2_Shc#2" Data="ErbB2(Y1221~p),Shc(PTB)->ErbB2(Y1221~p!0),Shc(PTB!0)" ForwardRate="1" />
  109. <Rule Id="95" Name="ErbB2_Shc#2_op" Data="ErbB2(Y1221~p!0),Shc(PTB!0)->ErbB2(Y1221~p),Shc(PTB)" ForwardRate="1" />
  110. <Rule Id="96" Name="Shc#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~u)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
  111. <Rule Id="97" Name="Shc#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
  112. <Rule Id="98" Name="Shc#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~u)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
  113. <Rule Id="99" Name="long arm SoS_Ras#1" Data="ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB1(Y1148~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
  114. <Rule Id="100" Name="long arm SoS_Ras#2" Data="ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1196~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
  115. <Rule Id="101" Name="long arm SoS_Ras#3" Data="ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB2(Y1221~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
  116. <Rule Id="102" Name="short arm SoS_Ras#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b),Ras(S1S2~gdp)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b!2),Ras(S1S2~gdp!2)" ForwardRate="1" />
  117. <Rule Id="103" Name="short arm SoS_Ras#2" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b),Ras(S1S2~gdp)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3n!1),SoS(a!1,b!2),Ras(S1S2~gdp!2)" ForwardRate="1" />
  118. <Rule Id="104" Name="direct RasGAP_Ras#1" Data="ErbB1(Y992~p!0),RasGAP(SH2!0,s),Ras(S1S2~gtp)->ErbB1(Y992~p!0),RasGAP(SH2!0,s!1),Ras(S1S2~gtp!1)" ForwardRate="1" />
  119. <Rule Id="105" Name="direct RasGAP_Ras#2" Data="ErbB2(Y1221~p!0),RasGAP(SH2!0,s),Ras(S1S2~gtp)->ErbB2(Y1221~p!0),RasGAP(SH2!0,s!1),Ras(S1S2~gtp!1)" ForwardRate="1" />
  120. <Rule Id="106" Name="Gab1@447#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p)" ForwardRate="1" />
  121. <Rule Id="107" Name="Gab1@472#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p)" ForwardRate="1" />
  122. <Rule Id="108" Name="Gab1@619#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p)" ForwardRate="1" />
  123. <Rule Id="109" Name="Gab1@447#2" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p)" ForwardRate="1" />
  124. <Rule Id="110" Name="Gab1@472#2" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p)" ForwardRate="1" />
  125. <Rule Id="111" Name="Gab1@619#2" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p)" ForwardRate="1" />
  126. <Rule Id="112" Name="short arm PI3K_PI#1" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
  127. <Rule Id="113" Name="short arm PI3K_PI#2" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
  128. <Rule Id="114" Name="short arm PI3K_PI#3" Data="ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB1(Y1068~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
  129. <Rule Id="115" Name="short arm PI3K_PI#4" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y447~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
  130. <Rule Id="116" Name="short arm PI3K_PI#5" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y472~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
  131. <Rule Id="117" Name="short arm PI3K_PI#6" Data="ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s),PI(three~u)->ErbB2(Y1139~p!0),Grb2(SH2!0,SH3c!1),Gab1(PR!1,Y619~p!2),PI3K(SH2!2,s!3),PI(three~u!3)" ForwardRate="1" />
  132. <Rule Id="118" Name="EGFR_p@Y1086" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1086~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1086~p),A(s~pp!0)" ForwardRate="1" />
  133. <Rule Id="119" Name="EGFR_p@Y1173" Data="EGFR(N!1,bp!0),EGFR(C!1,Y1173~u),A(s~ppp!0)=>EGFR(N!1,bp!0),EGFR(C!1,Y1173~p),A(s~pp!0)" ForwardRate="1" />
  134. <Rule Id="120" Name="New Rule" Data="A(x~u)->A(x~p)" ForwardRate="1" />
  135. <Rule Id="121" Name="New Rule_op" Data="A(x~p)->A(x~u)" ForwardRate="1" />
  136. <Rule Id="122" Name="Rule51" Data="A(x~p),B(x1)->A(x~p!0),B(x1!0)" ForwardRate="1" />
  137. <Rule Id="123" Name="Rule52" Data="A(x!0),B(x1!0)->A(x),B(x1)" ForwardRate="1" />
  138. <Rule Id="124" Name="Rule53" Data="A(x!0),B(x1!0,y1~u)->A(x!0),B(x1!0,y1~p)" ForwardRate="1" />
  139. <Rule Id="125" Name="Rule54" Data="A(x~p),B(x2)->A(x~p!0),B(x2!0)" ForwardRate="1" />
  140. <Rule Id="126" Name="Rule55" Data="A(x!0),B(x2!0)->A(x),B(x2)" ForwardRate="1" />
  141. <Rule Id="127" Name="Rule56" Data="A(x!0),B(x2!0,y2~u)->A(x!0),B(x2!0,y2~p)" ForwardRate="1" />
  142. <Rule Id="128" Name="HRG_ErbB3" Data="HRG(r~ext),ErbB3(CR,L~ext)->HRG(r~ext!0),ErbB3(CR,L~ext!0)" ForwardRate="1" />
  143. <Rule Id="129" Name="HRG_ErbB3_op" Data="HRG(r~ext!0),ErbB3(CR,L~ext!0)->HRG(r~ext),ErbB3(CR,L~ext)" ForwardRate="1" />
  144. <Rule Id="130" Name="HRG_ErbB4" Data="HRG(r~ext),ErbB4(CR,L~ext)->HRG(r~ext!0),ErbB4(CR,L~ext!0)" ForwardRate="1" />
  145. <Rule Id="131" Name="HRG_ErbB4_op" Data="HRG(r~ext!0),ErbB4(CR,L~ext!0)->HRG(r~ext),ErbB4(CR,L~ext)" ForwardRate="1" />
  146. <Rule Id="132" Name="Rule57" Data="ErbB3(Y1035~p)=>ErbB3(Y1035~u),Pi()" ForwardRate="1" />
  147. <Rule Id="133" Name="Rule58" Data="ErbB3(Y1178~p)=>ErbB3(Y1178~u),Pi()" ForwardRate="1" />
  148. <Rule Id="134" Name="Rule59" Data="ErbB3(Y1203~p)=>ErbB3(Y1203~u),Pi()" ForwardRate="1" />
  149. <Rule Id="135" Name="Rule60" Data="ErbB3(Y1241~p)=>ErbB3(Y1241~u),Pi()" ForwardRate="1" />
  150. <Rule Id="136" Name="Rule61" Data="ErbB3(Y1257~p)=>ErbB3(Y1257~u),Pi()" ForwardRate="1" />
  151. <Rule Id="137" Name="Rule62" Data="ErbB3(Y1270~p)=>ErbB3(Y1270~u),Pi()" ForwardRate="1" />
  152. <Rule Id="138" Name="Rule63" Data="ErbB3(Y1309~p)=>ErbB3(Y1309~u),Pi()" ForwardRate="1" />
  153. <Rule Id="139" Name="Rule64" Data="ErbB4(Y1056~p)=>ErbB4(Y1056~u),Pi()" ForwardRate="1" />
  154. <Rule Id="140" Name="Rule65" Data="ErbB4(Y1188~p)=>ErbB4(Y1188~u),Pi()" ForwardRate="1" />
  155. <Rule Id="141" Name="Rule66" Data="ErbB4(Y1242~p)=>ErbB4(Y1242~u),Pi()" ForwardRate="1" />
  156. <Rule Id="142" Name="ErbB3_Shc" Data="ErbB3(Y1309~p),Shc(PTB)->ErbB3(Y1309~p!0),Shc(PTB!0)" ForwardRate="1" />
  157. <Rule Id="143" Name="ErbB3_Shc_op" Data="ErbB3(Y1309~p!0),Shc(PTB!0)->ErbB3(Y1309~p),Shc(PTB)" ForwardRate="1" />
  158. <Rule Id="144" Name="Shc#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~u)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p)" ForwardRate="1" />
  159. <Rule Id="145" Name="Shc_op" Data="Shc(Y318~p)=>Shc(Y318~u),Pi()" ForwardRate="1" />
  160. <Rule Id="146" Name="Shc_Grb2" Data="Shc(Y318~p),Grb2(SH2)->Shc(Y318~p!0),Grb2(SH2!0)" ForwardRate="1" />
  161. <Rule Id="147" Name="Shc_Grb2_op" Data="Shc(Y318~p!0),Grb2(SH2!0)->Shc(Y318~p),Grb2(SH2)" ForwardRate="1" />
  162. <Rule Id="148" Name="Grb2_SoS" Data="Grb2(SH3),SoS(SS~u,a)->Grb2(SH3!0),SoS(SS~u,a!0)" ForwardRate="1" />
  163. <Rule Id="149" Name="Grb2_SoS_op" Data="Grb2(SH3!0),SoS(a!0)->Grb2(SH3),SoS(a)" ForwardRate="1" />
  164. <Rule Id="150" Name="long arm SoS_Ras#4" Data="ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b),Ras(S1S2~gdp)->ErbB3(Y1309~p!0),Shc(PTB!0,Y318~p!1),Grb2(SH2!1,SH3n!2),SoS(a!2,b!3),Ras(S1S2~gdp!3)" ForwardRate="1" />
  165. <Rule Id="151" Name="Ras GTP" Data="SoS(b!0),Ras(S1S2~gdp!0)->SoS(b!0),Ras(S1S2~gtp!0)" ForwardRate="1" />
  166. <Rule Id="152" Name="SoS_Ras_op" Data="SoS(b!0),Ras(S1S2!0)->SoS(b),Ras(S1S2)" ForwardRate="1" />
  167. <Rule Id="153" Name="Ras GDP" Data="RasGAP(s!0),Ras(S1S2~gtp!0)->RasGAP(s!0),Ras(S1S2~gdp!0)" ForwardRate="1" />
  168. <Rule Id="154" Name="RasGAP_Ras_op" Data="RasGAP(s!0),Ras(S1S2!0)->RasGAP(s),Ras(S1S2)" ForwardRate="1" />
  169. <Rule Id="155" Name="Grb2_Gab1" Data="Grb2(SH3c),Gab1(PR)->Grb2(SH3c!0),Gab1(PR!0)" ForwardRate="1" />
  170. <Rule Id="156" Name="Grb2_Gab1_op" Data="Grb2(SH3c!0),Gab1(PR!0)->Grb2(SH3c),Gab1(PR)" ForwardRate="1" />
  171. <Rule Id="157" Name="Gab1_PI3K@447" Data="Gab1(Y447~p),PI3K(SH2)->Gab1(Y447~p!0),PI3K(SH2!0)" ForwardRate="1" />
  172. <Rule Id="158" Name="Gab1_PI3K@447_op" Data="Gab1(Y447~p!0),PI3K(SH2!0)->Gab1(Y447~p),PI3K(SH2)" ForwardRate="1" />
  173. <Rule Id="159" Name="Gab1_PI3K@472" Data="Gab1(Y472~p),PI3K(SH2)->Gab1(Y472~p!0),PI3K(SH2!0)" ForwardRate="1" />
  174. <Rule Id="160" Name="Gab1_PI3K@472_op" Data="Gab1(Y472~p!0),PI3K(SH2!0)->Gab1(Y472~p),PI3K(SH2)" ForwardRate="1" />
  175. <Rule Id="161" Name="Gab1_PI3K@619" Data="Gab1(Y619~p),PI3K(SH2)->Gab1(Y619~p!0),PI3K(SH2!0)" ForwardRate="1" />
  176. <Rule Id="162" Name="Gab1_PI3K@619_op" Data="Gab1(Y619~p!0),PI3K(SH2!0)->Gab1(Y619~p),PI3K(SH2)" ForwardRate="1" />
  177. <Rule Id="163" Name="Gab1_Shp2@447" Data="Gab1(Y447~p),Shp2(s)->Gab1(Y447~p!0),Shp2(s!0)" ForwardRate="1" />
  178. <Rule Id="164" Name="Gab1_Shp2@472" Data="Gab1(Y472~p),Shp2(s)->Gab1(Y472~p!0),Shp2(s!0)" ForwardRate="1" />
  179. <Rule Id="165" Name="Gab1_Shp2@619" Data="Gab1(Y619~p),Shp2(s)->Gab1(Y619~p!0),Shp2(s!0)" ForwardRate="1" />
  180. <Rule Id="166" Name="Gab1@447_op" Data="Gab1(Y447~p!0),Shp2(s!0)=>Gab1(Y447~u!0),Shp2(s!0),Pi()" ForwardRate="1" />
  181. <Rule Id="167" Name="Gab1@472_op" Data="Gab1(Y472~p!0),Shp2(s!0)=>Gab1(Y472~u!0),Shp2(s!0),Pi()" ForwardRate="1" />
  182. <Rule Id="168" Name="Gab1@619_op" Data="Gab1(Y619~p!0),Shp2(s!0)=>Gab1(Y619~u!0),Shp2(s!0),Pi()" ForwardRate="1" />
  183. <Rule Id="169" Name="Gab1_Shp2@447_op" Data="Gab1(Y447!0),Shp2(s!0)->Gab1(Y447),Shp2(s)" ForwardRate="1" />
  184. <Rule Id="170" Name="Gab1_Shp2@472_op" Data="Gab1(Y472!0),Shp2(s!0)->Gab1(Y472),Shp2(s)" ForwardRate="1" />
  185. <Rule Id="171" Name="Gab1_Shp2@619_op" Data="Gab1(Y619!0),Shp2(s!0)->Gab1(Y619),Shp2(s)" ForwardRate="1" />
  186. <Rule Id="172" Name="ErbB3_PI3K#1" Data="ErbB3(Y1035~p),PI3K(SH2)->ErbB3(Y1035~p!0),PI3K(SH2!0)" ForwardRate="1" />
  187. <Rule Id="173" Name="ErbB3_PI3K#1_op" Data="ErbB3(Y1035~p!0),PI3K(SH2!0)->ErbB3(Y1035~p),PI3K(SH2)" ForwardRate="1" />
  188. <Rule Id="174" Name="ErbB3_PI3K#2" Data="ErbB3(Y1178~p),PI3K(SH2)->ErbB3(Y1178~p!0),PI3K(SH2!0)" ForwardRate="1" />
  189. <Rule Id="175" Name="ErbB3_PI3K#2_op" Data="ErbB3(Y1178~p!0),PI3K(SH2!0)->ErbB3(Y1178~p),PI3K(SH2)" ForwardRate="1" />
  190. <Rule Id="176" Name="ErbB3_PI3K#3" Data="ErbB3(Y1203~p),PI3K(SH2)->ErbB3(Y1203~p!0),PI3K(SH2!0)" ForwardRate="1" />
  191. <Rule Id="177" Name="ErbB3_PI3K#3_op" Data="ErbB3(Y1203~p!0),PI3K(SH2!0)->ErbB3(Y1203~p),PI3K(SH2)" ForwardRate="1" />
  192. <Rule Id="178" Name="ErbB3_PI3K#4" Data="ErbB3(Y1241~p),PI3K(SH2)->ErbB3(Y1241~p!0),PI3K(SH2!0)" ForwardRate="1" />
  193. <Rule Id="179" Name="ErbB3_PI3K#4_op" Data="ErbB3(Y1241~p!0),PI3K(SH2!0)->ErbB3(Y1241~p),PI3K(SH2)" ForwardRate="1" />
  194. <Rule Id="180" Name="ErbB3_PI3K#5" Data="ErbB3(Y1257~p),PI3K(SH2)->ErbB3(Y1257~p!0),PI3K(SH2!0)" ForwardRate="1" />
  195. <Rule Id="181" Name="ErbB3_PI3K#5_op" Data="ErbB3(Y1257~p!0),PI3K(SH2!0)->ErbB3(Y1257~p),PI3K(SH2)" ForwardRate="1" />
  196. <Rule Id="182" Name="ErbB3_PI3K#6" Data="ErbB3(Y1270~p),PI3K(SH2)->ErbB3(Y1270~p!0),PI3K(SH2!0)" ForwardRate="1" />
  197. <Rule Id="183" Name="ErbB3_PI3K#6_op" Data="ErbB3(Y1270~p!0),PI3K(SH2!0)->ErbB3(Y1270~p),PI3K(SH2)" ForwardRate="1" />
  198. <Rule Id="184" Name="direct PI3K_PI#1" Data="ErbB3(Y1035~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1035~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
  199. <Rule Id="185" Name="direct PI3K_PI#2" Data="ErbB3(Y1178~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1178~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
  200. <Rule Id="186" Name="direct PI3K_PI#3" Data="ErbB3(Y1203~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1203~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
  201. <Rule Id="187" Name="direct PI3K_PI#4" Data="ErbB3(Y1241~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1241~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
  202. <Rule Id="188" Name="direct PI3K_PI#5" Data="ErbB3(Y1257~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1257~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
  203. <Rule Id="189" Name="direct PI3K_PI#6" Data="ErbB3(Y1270~p!0),PI3K(SH2!0,s),PI(three~u)->ErbB3(Y1270~p!0),PI3K(SH2!0,s!1),PI(three~u!1)" ForwardRate="1" />
  204. <Rule Id="190" Name="PI@three" Data="PI3K(s!0),PI(three~u!0)->PI3K(s!0),PI(three~p!0)" ForwardRate="1" />
  205. <Rule Id="191" Name="PI3K_PI_op" Data="PI3K(s!0),PI(three!0)->PI3K(s),PI(three)" ForwardRate="1" />
  206. <Rule Id="192" Name="PTEN_PI" Data="PTEN(s),PI(three~p)->PTEN(s!0),PI(three~p!0)" ForwardRate="1" />
  207. <Rule Id="193" Name="PI@three_op" Data="PTEN(s!0),PI(three~p!0)->PTEN(s!0),PI(three~u!0)" ForwardRate="1" />
  208. <Rule Id="194" Name="PTEN_PI_op" Data="PTEN(s!0),PI(three!0)->PTEN(s),PI(three)" ForwardRate="1" />
  209. <Rule Id="195" Name="PIP3_PDK1" Data="PI(five~p,four~p,three~p),PDK1(PH)->PI(five~p,four~p,three~p!0),PDK1(PH!0)" ForwardRate="1" />
  210. <Rule Id="196" Name="PIP3_PDK1_op" Data="PI(three!0),PDK1(PH!0)->PI(three),PDK1(PH)" ForwardRate="1" />
  211. <Rule Id="197" Name="PIP3_Akt" Data="PI(five~p,four~p,three~p),Akt(PH)->PI(five~p,four~p,three~p!0),Akt(PH!0)" ForwardRate="1" />
  212. <Rule Id="198" Name="PIP3_Akt_op" Data="PI(three!0),Akt(PH!0)->PI(three),Akt(PH)" ForwardRate="1" />
  213. <Rule Id="199" Name="Ras_Raf" Data="Ras(S1S2~gtp),Raf(x~u)->Ras(S1S2~gtp!0),Raf(x~u!0)" ForwardRate="1" />
  214. <Rule Id="200" Name="Raf" Data="Ras(S1S2~gtp!0),Raf(x~u!0)->Ras(S1S2~gtp!0),Raf(x~p!0)" ForwardRate="1" />
  215. <Rule Id="201" Name="Ras_Raf_op" Data="Ras(S1S2~gtp!0),Raf(x!0)->Ras(S1S2~gtp),Raf(x)" ForwardRate="1" />
  216. <Rule Id="202" Name="SoS_ERK" Data="SoS(SS),ERK(T185~p,Y187~p,s)->SoS(SS!0),ERK(T185~p,Y187~p,s!0)" ForwardRate="1" />
  217. <Rule Id="203" Name="SoS_ERK_op" Data="SoS(SS!0),ERK(T185~p,Y187~p,s!0)->SoS(SS),ERK(T185~p,Y187~p,s)" ForwardRate="1" />
  218. <Rule Id="204" Name="SoS@SS" Data="SoS(SS~u!0),ERK(T185~p,Y187~p,s!0)->SoS(SS~p!0),ERK(T185~p,Y187~p,s!0)" ForwardRate="1" />
  219. <Rule Id="205" Name="SoS@SS_op" Data="SoS(SS~p)=>SoS(SS~u),Pi()" ForwardRate="1" />
  220. <Rule Id="206" Name="Rule67" Data="E()=>EGF(r~ext)" ForwardRate="1" />
  221. <Rule Id="207" Name="EGF_EGFRe" Data="EGF(r~ext),EGFR(CR,L~ext)->EGF(r~ext!0),EGFR(CR,L~ext!0)" ForwardRate="1" />
  222. <Rule Id="208" Name="EGF_EGFRi" Data="EGF(r~int),EGFR(CR,L~int)->EGF(r~int!0),EGFR(CR,L~int!0)" ForwardRate="1" />
  223. <Rule Id="209" Name="EGF_EGFR_op" Data="EGF(r!0),EGFR(L!0)->EGF(r),EGFR(L)" ForwardRate="1" />
  224. <Rule Id="210" Name="EGFR_EGFRe" Data="EGFR(C,CR,L~ext!_,N),EGFR(C,CR,L~ext!_,N)->EGFR(C,CR!0,L~ext!_,N),EGFR(C,CR!0,L~ext!_,N)" ForwardRate="1" />
  225. <Rule Id="211" Name="EGFR_EGFRi" Data="EGFR(C,CR,L~int!_,N),EGFR(C,CR,L~int!_,N)->EGFR(C,CR!0,L~int!_,N),EGFR(C,CR!0,L~int!_,N)" ForwardRate="1" />
  226. <Rule Id="212" Name="EGFR_HER2" Data="EGFR(C,CR,L~ext!_,N),HER2(C,CR,N)->EGFR(C,CR!0,L~ext!_,N),HER2(C,CR!0,N)" ForwardRate="1" />
  227. <Rule Id="213" Name="EGFR_HER3" Data="EGFR(C,CR,L~ext!_,N),HER3(C,CR,L~ext!_)->EGFR(C,CR!0,L~ext!_,N),HER3(C,CR!0,L~ext!_)" ForwardRate="1" />
  228. <Rule Id="214" Name="EGFR_HER4" Data="EGFR(C,CR,L~ext!_,N),HER4(C,CR,L~ext!_,N)->EGFR(C,CR!0,L~ext!_,N),HER4(C,CR!0,L~ext!_,N)" ForwardRate="1" />
  229. <Rule Id="215" Name="EGFR_EGFR_op" Data="EGFR(C,CR!0,N),EGFR(C,CR!0,N)->EGFR(C,CR,N),EGFR(C,CR,N)" ForwardRate="1" />
  230. <Rule Id="216" Name="EGFR_HER2_op" Data="EGFR(C,CR!0,N),HER2(C,CR!0,N)->EGFR(C,CR,N),HER2(C,CR,N)" ForwardRate="1" />
  231. <Rule Id="217" Name="EGFR_HER3_op" Data="EGFR(C,CR!0,N),HER3(C,CR!0)->EGFR(C,CR,N),HER3(C,CR)" ForwardRate="1" />
  232. <Rule Id="218" Name="EGFR_HER4_op" Data="EGFR(C,CR!0,N),HER4(C,CR!0,N)->EGFR(C,CR,N),HER4(C,CR,N)" ForwardRate="1" />
  233. <Rule Id="219" Name="11 dimer" Data="EGFR(C,CR!0,N),EGFR(C,CR!0,N)->EGFR(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
  234. <Rule Id="220" Name="11 dimer_op" Data="EGFR(C,CR!1,N!0),EGFR(C!0,CR!1,N)->EGFR(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
  235. <Rule Id="221" Name="21 dimer" Data="HER2(C,CR!0,N),EGFR(C,CR!0,N)->HER2(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
  236. <Rule Id="222" Name="21 dimer_op" Data="HER2(C,CR!1,N!0),EGFR(C!0,CR!1,N)->HER2(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
  237. <Rule Id="223" Name="41 dimer" Data="HER4(C,CR!0,N),EGFR(C,CR!0,N)->HER4(C,CR!1,N!0),EGFR(C!0,CR!1,N)" ForwardRate="1" />
  238. <Rule Id="224" Name="41 dimer_op" Data="HER4(C,CR!1,N!0),EGFR(C!0,CR!1,N)->HER4(C,CR!0,N),EGFR(C,CR!0,N)" ForwardRate="1" />
  239. <Rule Id="225" Name="12 dimer" Data="EGFR(C,CR!0,N),HER2(C,CR!0,N)->EGFR(C,CR!1,N!0),HER2(C!0,CR!1,N)" ForwardRate="1" />
  240. <Rule Id="226" Name="12 dimer_op" Data="EGFR(C,CR!1,N!0),HER2(C!0,CR!1,N)->EGFR(C,CR!0,N),HER2(C,CR!0,N)" ForwardRate="1" />
  241. <Rule Id="227" Name="13 dimer" Data="EGFR(C,CR!0,N),HER3(C,CR!0)->EGFR(C,CR!1,N!0),HER3(C!0,CR!1)" ForwardRate="1" />
  242. <Rule Id="228" Name="13 dimer_op" Data="EGFR(C,CR!1,N!0),HER3(C!0,CR!1)->EGFR(C,CR!0,N),HER3(C,CR!0)" ForwardRate="1" />
  243. <Rule Id="229" Name="14 dimer" Data="EGFR(C,CR!0,N),HER4(C,CR!0,N)->EGFR(C,CR!1,N!0),HER4(C!0,CR!1,N)" ForwardRate="1" />
  244. <Rule Id="230" Name="14 dimer_op" Data="EGFR(C,CR!1,N!0),HER4(C!0,CR!1,N)->EGFR(C,CR!0,N),HER4(C,CR!0,N)" ForwardRate="1" />
  245. <Rule Id="231" Name="EGFR_Inh" Data="EGFR(N!_,bp),Inh1(s)->EGFR(N!_,bp!0),Inh1(s!0)" ForwardRate="1" />
  246. <Rule Id="232" Name="EGFR_Inh_op" Data="EGFR(bp!0),Inh1(s!0)->EGFR(bp),Inh1(s)" ForwardRate="1" />
  247. <Rule Id="233" Name="EGF_mono" Data="EGF(r~ext!0),EGFR(CR,L~ext!0)=>EGF(r~int!0),EGFR(CR,L~int!0)" ForwardRate="1" />
  248. <Rule Id="234" Name="EGF_di" Data="EGF(r~ext!0),EGFR(CR!1,L~ext!0),EGF(r~ext!2),EGFR(CR!1,L~ext!2)=>EGF(r~int!0),EGFR(CR!1,L~int!0),EGF(r~int!2),EGFR(CR!1,L~int!2)" ForwardRate="1" />
  249. <Rule Id="235" Name="Rule68" Data="EGFR(N!0,bp),EGFR(C!0,Y1016~u)->EGFR(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
  250. <Rule Id="236" Name="Rule69" Data="HER2(N!0,bp),EGFR(C!0,Y1016~u)->HER2(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
  251. <Rule Id="237" Name="Rule70" Data="HER4(N!0,bp),EGFR(C!0,Y1016~u)->HER4(N!0,bp),EGFR(C!0,Y1016~p)" ForwardRate="1" />
  252. <Rule Id="238" Name="Rule71" Data="EGFR(N!0,bp),EGFR(C!0,Y1092~u)->EGFR(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
  253. <Rule Id="239" Name="Rule72" Data="HER2(N!0,bp),EGFR(C!0,Y1092~u)->HER2(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
  254. <Rule Id="240" Name="Rule73" Data="HER4(N!0,bp),EGFR(C!0,Y1092~u)->HER4(N!0,bp),EGFR(C!0,Y1092~p)" ForwardRate="1" />
  255. <Rule Id="241" Name="Rule74" Data="EGFR(N!0,bp),EGFR(C!0,Y1172~u)->EGFR(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
  256. <Rule Id="242" Name="Rule75" Data="HER2(N!0,bp),EGFR(C!0,Y1172~u)->HER2(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
  257. <Rule Id="243" Name="Rule76" Data="HER4(N!0,bp),EGFR(C!0,Y1172~u)->HER4(N!0,bp),EGFR(C!0,Y1172~p)" ForwardRate="1" />
  258. <Rule Id="244" Name="Rule77" Data="EGFR(N!0,bp),HER2(C!0,Y1139~u)->EGFR(N!0,bp),HER2(C!0,Y1139~p)" ForwardRate="1" />
  259. <Rule Id="245" Name="Rule78" Data="EGFR(N!0,bp),HER2(C!0,Y1196~u)->EGFR(N!0,bp),HER2(C!0,Y1196~p)" ForwardRate="1" />
  260. <Rule Id="246" Name="Rule79" Data="EGFR(N!0,bp),HER2(C!0,Y1221~u)->EGFR(N!0,bp),HER2(C!0,Y1221~p)" ForwardRate="1" />
  261. <Rule Id="247" Name="Rule80" Data="EGFR(N!0,bp),HER3(C!0,Y1035~u)->EGFR(N!0,bp),HER3(C!0,Y1035~p)" ForwardRate="1" />
  262. <Rule Id="248" Name="Rule81" Data="EGFR(N!0,bp),HER3(C!0,Y1178~u)->EGFR(N!0,bp),HER3(C!0,Y1178~p)" ForwardRate="1" />
  263. <Rule Id="249" Name="Rule82" Data="EGFR(N!0,bp),HER3(C!0,Y1203~u)->EGFR(N!0,bp),HER3(C!0,Y1203~p)" ForwardRate="1" />
  264. <Rule Id="250" Name="Rule83" Data="EGFR(N!0,bp),HER3(C!0,Y1241~u)->EGFR(N!0,bp),HER3(C!0,Y1241~p)" ForwardRate="1" />
  265. <Rule Id="251" Name="Rule84" Data="EGFR(N!0,bp),HER3(C!0,Y1257~u)->EGFR(N!0,bp),HER3(C!0,Y1257~p)" ForwardRate="1" />
  266. <Rule Id="252" Name="Rule85" Data="EGFR(N!0,bp),HER3(C!0,Y1270~u)->EGFR(N!0,bp),HER3(C!0,Y1270~p)" ForwardRate="1" />
  267. <Rule Id="253" Name="Rule86" Data="EGFR(N!0,bp),HER3(C!0,Y1309~u)->EGFR(N!0,bp),HER3(C!0,Y1309~p)" ForwardRate="1" />
  268. <Rule Id="254" Name="Rule87" Data="EGFR(N!0,bp),HER4(C!0,Y1~u)->EGFR(N!0,bp),HER4(C!0,Y1~p)" ForwardRate="1" />
  269. <Rule Id="255" Name="Rule88" Data="EGFR(N!0,bp),HER4(C!0,Y2~u)->EGFR(N!0,bp),HER4(C!0,Y2~p)" ForwardRate="1" />
  270. <Rule Id="256" Name="Rule89" Data="EGFR(N!0,bp),HER4(C!0,Y3~u)->EGFR(N!0,bp),HER4(C!0,Y3~p)" ForwardRate="1" />
  271. <Rule Id="257" Name="Rule90" Data="EGFR(Y1016~p),PTP(s)->EGFR(Y1016~p!0),PTP(s!0)" ForwardRate="1" />
  272. <Rule Id="258" Name="Rule91" Data="EGFR(Y1092~p),PTP(s)->EGFR(Y1092~p!0),PTP(s!0)" ForwardRate="1" />
  273. <Rule Id="259" Name="Rule92" Data="EGFR(Y1172~p),PTP(s)->EGFR(Y1172~p!0),PTP(s!0)" ForwardRate="1" />
  274. <Rule Id="260" Name="Rule93" Data="EGFR(Y1016!0),PTP(s!0)->EGFR(Y1016),PTP(s)" ForwardRate="1" />
  275. <Rule Id="261" Name="Rule94" Data="EGFR(Y1092!0),PTP(s!0)->EGFR(Y1092),PTP(s)" ForwardRate="1" />
  276. <Rule Id="262" Name="Rule95" Data="EGFR(Y1172!0),PTP(s!0)->EGFR(Y1172),PTP(s)" ForwardRate="1" />
  277. <Rule Id="263" Name="Rule96" Data="EGFR(Y1016~p!0),PTP(s!0)->EGFR(Y1016~u!0),PTP(s!0)" ForwardRate="1" />
  278. <Rule Id="264" Name="Rule97" Data="EGFR(Y1092~p!0),PTP(s!0)->EGFR(Y1092~u!0),PTP(s!0)" ForwardRate="1" />
  279. <Rule Id="265" Name="Rule98" Data="EGFR(Y1172~p!0),PTP(s!0)->EGFR(Y1172~u!0),PTP(s!0)" ForwardRate="1" />
  280. <Rule Id="266" Name="deg_EGF" Data="EGF(r~int)->" ForwardRate="1" />
  281. <Rule Id="267" Name="deg_EGFR" Data="EGFR(CR,L~int)->" ForwardRate="1" />
  282. <Rule Id="268" Name="EGFR_RasGAP" Data="EGFR(Y1016~p),RasGAP(SH2~u)=>EGFR(Y1016~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
  283. <Rule Id="269" Name="EGFR_RasGAP_op" Data="EGFR(Y1016~p!0),RasGAP(SH2~rec!0)=>EGFR(Y1016~p),RasGAP(SH2~u)" ForwardRate="1" />
  284. <Rule Id="270" Name="EGFR_Grb2" Data="EGFR(Y1092~p),Grb2(SH2~u)=>EGFR(Y1092~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
  285. <Rule Id="271" Name="EGFR_Grb2_op" Data="EGFR(Y1092~p!0),Grb2(SH2~rec!0)=>EGFR(Y1092~p),Grb2(SH2~u)" ForwardRate="1" />
  286. <Rule Id="272" Name="EGFR_Shc" Data="EGFR(Y1172~p),Shc(PTB~u)=>EGFR(Y1172~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
  287. <Rule Id="273" Name="EGFR_Shc_op" Data="EGFR(Y1172~p!0),Shc(PTB~rec!0)=>EGFR(Y1172~p),Shc(PTB~u)" ForwardRate="1" />
  288. <Rule Id="274" Name="HER2_Grb2" Data="HER2(Y1139~p),Grb2(SH2~u)=>HER2(Y1139~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
  289. <Rule Id="275" Name="HER2_Grb2_op" Data="HER2(Y1139~p!0),Grb2(SH2~rec!0)=>HER2(Y1139~p),Grb2(SH2~u)" ForwardRate="1" />
  290. <Rule Id="276" Name="HER2_Shc#1" Data="HER2(Y1196~p),Shc(PTB~u)=>HER2(Y1196~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
  291. <Rule Id="277" Name="HER2_Shc#1_op" Data="HER2(Y1196~p!0),Shc(PTB~rec!0)=>HER2(Y1196~p),Shc(PTB~u)" ForwardRate="1" />
  292. <Rule Id="278" Name="HER2_RasGAP" Data="HER2(Y1221~p),RasGAP(SH2~u)=>HER2(Y1221~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
  293. <Rule Id="279" Name="HER2_RasGAP_op" Data="HER2(Y1221~p!0),RasGAP(SH2~rec!0)=>HER2(Y1221~p),RasGAP(SH2~u)" ForwardRate="1" />
  294. <Rule Id="280" Name="HER2_Shc#2" Data="HER2(Y1221~p),Shc(PTB~u)=>HER2(Y1221~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
  295. <Rule Id="281" Name="HER2_Shc#2_op" Data="HER2(Y1221~p!0),Shc(PTB~rec!0)=>HER2(Y1221~p),Shc(PTB~u)" ForwardRate="1" />
  296. <Rule Id="282" Name="HER3_PI3K#1" Data="HER3(Y1035~p),PI3K(SH2~u)=>HER3(Y1035~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
  297. <Rule Id="283" Name="HER3_PI3K#1_op" Data="HER3(Y1035~p!0),PI3K(SH2~rec!0)=>HER3(Y1035~p),PI3K(SH2~u)" ForwardRate="1" />
  298. <Rule Id="284" Name="HER3_PI3K#2" Data="HER3(Y1178~p),PI3K(SH2~u)=>HER3(Y1178~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
  299. <Rule Id="285" Name="HER3_PI3K#2_op" Data="HER3(Y1178~p!0),PI3K(SH2~rec!0)=>HER3(Y1178~p),PI3K(SH2~u)" ForwardRate="1" />
  300. <Rule Id="286" Name="HER3_PI3K#3" Data="HER3(Y1203~p),PI3K(SH2~u)=>HER3(Y1203~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
  301. <Rule Id="287" Name="HER3_PI3K#3_op" Data="HER3(Y1203~p!0),PI3K(SH2~rec!0)=>HER3(Y1203~p),PI3K(SH2~u)" ForwardRate="1" />
  302. <Rule Id="288" Name="HER3_PI3K#4" Data="HER3(Y1241~p),PI3K(SH2~u)=>HER3(Y1241~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
  303. <Rule Id="289" Name="HER3_PI3K#4_op" Data="HER3(Y1241~p!0),PI3K(SH2~rec!0)=>HER3(Y1241~p),PI3K(SH2~u)" ForwardRate="1" />
  304. <Rule Id="290" Name="HER3_PI3K#5" Data="HER3(Y1257~p),PI3K(SH2~u)=>HER3(Y1257~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
  305. <Rule Id="291" Name="HER3_PI3K#5_op" Data="HER3(Y1257~p!0),PI3K(SH2~rec!0)=>HER3(Y1257~p),PI3K(SH2~u)" ForwardRate="1" />
  306. <Rule Id="292" Name="HER3_PI3K#6" Data="HER3(Y1270~p),PI3K(SH2~u)=>HER3(Y1270~p!0),PI3K(SH2~rec!0)" ForwardRate="1" />
  307. <Rule Id="293" Name="HER3_PI3K#6_op" Data="HER3(Y1270~p!0),PI3K(SH2~rec!0)=>HER3(Y1270~p),PI3K(SH2~u)" ForwardRate="1" />
  308. <Rule Id="294" Name="HER3_Shc" Data="HER3(Y1309~p),Shc(PTB~u)=>HER3(Y1309~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
  309. <Rule Id="295" Name="HER3_Shc_op" Data="HER3(Y1309~p!0),Shc(PTB~rec!0)=>HER3(Y1309~p),Shc(PTB~u)" ForwardRate="1" />
  310. <Rule Id="296" Name="HER4_RasGAP" Data="HER4(Y1~p),RasGAP(SH2~u)=>HER4(Y1~p!0),RasGAP(SH2~rec!0)" ForwardRate="1" />
  311. <Rule Id="297" Name="HER4_RasGAP_op" Data="HER4(Y1~p!0),RasGAP(SH2~rec!0)=>HER4(Y1~p),RasGAP(SH2~u)" ForwardRate="1" />
  312. <Rule Id="298" Name="HER4_Grb2" Data="HER4(Y2~p),Grb2(SH2~u)=>HER4(Y2~p!0),Grb2(SH2~rec!0)" ForwardRate="1" />
  313. <Rule Id="299" Name="HER4_Grb2_op" Data="HER4(Y2~p!0),Grb2(SH2~rec!0)=>HER4(Y2~p),Grb2(SH2~u)" ForwardRate="1" />
  314. <Rule Id="300" Name="HER4_Shc" Data="HER4(Y3~p),Shc(PTB~u)=>HER4(Y3~p!0),Shc(PTB~rec!0)" ForwardRate="1" />
  315. <Rule Id="301" Name="HER4_Shc_op" Data="HER4(Y3~p!0),Shc(PTB~rec!0)=>HER4(Y3~p),Shc(PTB~u)" ForwardRate="1" />
  316. <Rule Id="302" Name="Shc@Y" Data="Shc(PTB~rec!_,Y~u)->Shc(PTB~rec!_,Y~p)" ForwardRate="1" />
  317. <Rule Id="303" Name="Gab1@48" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48~p)" ForwardRate="1" />
  318. <Rule Id="304" Name="Gab1@317" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317~p)" ForwardRate="1" />
  319. <Rule Id="305" Name="Gab1@447" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447~p)" ForwardRate="1" />
  320. <Rule Id="306" Name="Gab1@472" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472~p)" ForwardRate="1" />
  321. <Rule Id="307" Name="Gab1@619" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619~p)" ForwardRate="1" />
  322. <Rule Id="308" Name="Gab1@657" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y657~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y657~p)" ForwardRate="1" />
  323. <Rule Id="309" Name="Gab1@689" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y689~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y689~p)" ForwardRate="1" />
  324. <Rule Id="310" Name="Gab1@48_op" Data="Gab1(Y48~p)->Gab1(Y48~u)" ForwardRate="1" />
  325. <Rule Id="311" Name="Gab1@317_op" Data="Gab1(Y317~p)->Gab1(Y317~u)" ForwardRate="1" />
  326. <Rule Id="312" Name="Gab1@657_op" Data="Gab1(Y657~p)->Gab1(Y657~u)" ForwardRate="1" />
  327. <Rule Id="313" Name="Gab1@689_op" Data="Gab1(Y689~p)->Gab1(Y689~u)" ForwardRate="1" />
  328. <Rule Id="314" Name="Gab1_Grb2" Data="Gab1(Y48~p),Grb2(SH2)->Gab1(Y48~p!0),Grb2(SH2!0)" ForwardRate="1" />
  329. <Rule Id="315" Name="Gab1_Grb2_op" Data="Gab1(Y48~p!0),Grb2(SH2!0)->Gab1(Y48~p),Grb2(SH2)" ForwardRate="1" />
  330. <Rule Id="316" Name="Gab1_RasGAP" Data="Gab1(Y317~p),RasGAP(SH2)->Gab1(Y317~p!0),RasGAP(SH2!0)" ForwardRate="1" />
  331. <Rule Id="317" Name="Gab1_RasGAP_op" Data="Gab1(Y317~p!0),RasGAP(SH2!0)->Gab1(Y317~p),RasGAP(SH2)" ForwardRate="1" />
  332. <Rule Id="318" Name="Gab1_PI3K@447_op" Data="Gab1(Y447!0),PI3K(SH2!0)->Gab1(Y447),PI3K(SH2)" ForwardRate="1" />
  333. <Rule Id="319" Name="Gab1_PI3K@472_op" Data="Gab1(Y472!0),PI3K(SH2!0)->Gab1(Y472),PI3K(SH2)" ForwardRate="1" />
  334. <Rule Id="320" Name="Gab1_PI3K@619_op" Data="Gab1(Y619!0),PI3K(SH2!0)->Gab1(Y619),PI3K(SH2)" ForwardRate="1" />
  335. <Rule Id="321" Name="Gab1_Shp2#1" Data="Gab1(Y689~p),Shp2(SH2c)->Gab1(Y689~p!0),Shp2(SH2c!0)" ForwardRate="1" />
  336. <Rule Id="322" Name="Gab1_Shp2#2" Data="Gab1(Y657~p,Y689!0),Shp2(SH2c!0,SH2n)->Gab1(Y657~p!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
  337. <Rule Id="323" Name="Gab1_Shp2_op#1" Data="Gab1(Y657!0),Shp2(SH2n!0)->Gab1(Y657),Shp2(SH2n)" ForwardRate="1" />
  338. <Rule Id="324" Name="Gab1_Shp2_op#2" Data="Gab1(Y689!0),Shp2(SH2c!0)->Gab1(Y689),Shp2(SH2c)" ForwardRate="1" />
  339. <Rule Id="325" Name="Rule99" Data="Gab1(Y317~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y317~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
  340. <Rule Id="326" Name="Rule100" Data="Gab1(Y447~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y447~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
  341. <Rule Id="327" Name="Rule101" Data="Gab1(Y472~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y472~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
  342. <Rule Id="328" Name="Rule102" Data="Gab1(Y619~p,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)->Gab1(Y619~u,Y657!1,Y689!0),Shp2(SH2c!0,SH2n!1)" ForwardRate="1" />
  343. <Rule Id="329" Name="PI3K@s Rec" Data="PI3K(SH2~rec!_,s~u)->PI3K(SH2~rec!_,s~p)" ForwardRate="1" />
  344. <Rule Id="330" Name="PI3K@s Gab#1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
  345. <Rule Id="331" Name="PI3K@s Gab#2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
  346. <Rule Id="332" Name="PI3K@s Gab#3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p)" ForwardRate="1" />
  347. <Rule Id="333" Name="PI3K@s_op" Data="PI3K(s~p)->PI3K(s~u)" ForwardRate="1" />
  348. <Rule Id="334" Name="SoS short arm" Data="Grb2(SH2~rec!_,SH3n!0),SoS(GEF,PR!0),Ras(s~gdp)->Grb2(SH2~rec!_,SH3n!0),SoS(GEF!1,PR!0),Ras(s~gdp!1)" ForwardRate="1" />
  349. <Rule Id="335" Name="SoS long arm" Data="Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Shc(PTB~rec!_,Y!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />
  350. <Rule Id="336" Name="SoS vlong arm" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48!1),Grb2(SH2!1,SH3n!2),SoS(GEF,PR!2),Ras(s~gdp)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y48!1),Grb2(SH2!1,SH3n!2),SoS(GEF!3,PR!2),Ras(s~gdp!3)" ForwardRate="1" />
  351. <Rule Id="337" Name="RasGAP no arm" Data="RasGAP(GAP,SH2~rec!_),Ras(s~gtp)->RasGAP(GAP!0,SH2~rec!_),Ras(s~gtp!0)" ForwardRate="1" />
  352. <Rule Id="338" Name="RasGAP long arm" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317!1),RasGAP(GAP,SH2!1),Ras(s~gtp)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y317!1),RasGAP(GAP!2,SH2!1),Ras(s~gtp!2)" ForwardRate="1" />
  353. <Rule Id="339" Name="PI3K no arm" Data="PI3K(SH2~rec!_,s~p),PI(three~u)->PI3K(SH2~rec!_,s~p!0),PI(three~u!0)" ForwardRate="1" />
  354. <Rule Id="340" Name="PI3K long arm #1" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
  355. <Rule Id="341" Name="PI3K long arm #2" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
  356. <Rule Id="342" Name="PI3K long arm #3" Data="Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p),PI(three~u)->Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(SH2!1,s~p!2),PI(three~u!2)" ForwardRate="1" />
  357. <Rule Id="343" Name="intrinsic GDP" Data="Ras(s~gtp)->Ras(s~gdp)" ForwardRate="1" />
  358. <Rule Id="344" Name="PI@five" Data="PI(five~u)->PI(five~p)" ForwardRate="1" />
  359. <Rule Id="345" Name="PI@five_op" Data="SHIP(s!0),PI(five~p!0)->SHIP(s!0),PI(five~u!0)" ForwardRate="1" />
  360. <Rule Id="346" Name="Ras_PI3K no arm" Data="Ras(s~gtp),PI3K(RBD,SH2~rec!_,s~u)->Ras(s~gtp!0),PI3K(RBD!0,SH2~rec!_,s~u)" ForwardRate="1" />
  361. <Rule Id="347" Name="Ras_PI3K long arm #1" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y447!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y447!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
  362. <Rule Id="348" Name="Ras_PI3K long arm #2" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y472!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y472!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
  363. <Rule Id="349" Name="Ras_PI3K long arm #3" Data="Ras(s~gtp),Grb2(SH2~rec!_,SH3c!0),Gab1(PR!0,Y619!1),PI3K(RBD,SH2!1,s~u)->Ras(s~gtp!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PR!1,Y619!2),PI3K(RBD!0,SH2!2,s~u)" ForwardRate="1" />
  364. <Rule Id="350" Name="Ras_PI3K_op" Data="Ras(s!0),PI3K(RBD!0)->Ras(s),PI3K(RBD)" ForwardRate="1" />
  365. <Rule Id="351" Name="PIP3_Gab1" Data="PI(five~p,four~p,three~p),Grb2(SH2~rec!_,SH3c!0),Gab1(PH,PR!0)->PI(five~p,four~p,three~p!0),Grb2(SH2~rec!_,SH3c!1),Gab1(PH!0,PR!1)" ForwardRate="1" />
  366. <Rule Id="352" Name="PIP3_Gab1_op" Data="PI(three!0),Gab1(PH!0)->PI(three),Gab1(PH)" ForwardRate="1" />
  367. <Rule Id="353" Name="PI3K@s Ras" Data="PI3K(RBD!_,s~u)->PI3K(RBD!_,s~p)" ForwardRate="1" />
  368. <Rule Id="354" Name="RasGAP Gab arm" Data="Gab1(PH!_,Y317~p!0),RasGAP(GAP,SH2!0),Ras(s~gtp)->Gab1(PH!_,Y317~p!0),RasGAP(GAP!1,SH2!0),Ras(s~gtp!1)" ForwardRate="1" />
  369. <Rule Id="355" Name="SoS Gab arm #1" Data="Gab1(PH!_,Y48~p!0),Grb2(SH2!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Gab1(PH!_,Y48~p!0),Grb2(SH2!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />
  370. <Rule Id="356" Name="SoS Gab arm #2" Data="Gab1(PH!_,PR!0),Grb2(SH3c!0,SH3n!1),SoS(GEF,PR!1),Ras(s~gdp)->Gab1(PH!_,PR!0),Grb2(SH3c!0,SH3n!1),SoS(GEF!2,PR!1),Ras(s~gdp!2)" ForwardRate="1" />
  371. <Rule Id="357" Name="PI3K Ras arm" Data="PI3K(RBD!_,s~p),PI(three~u)->PI3K(RBD!_,s~p!0),PI(three~u!0)" ForwardRate="1" />
  372. <Rule Id="358" Name="PI3K Gab arm #1" Data="Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y447!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
  373. <Rule Id="359" Name="PI3K Gab arm #2" Data="Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y472!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
  374. <Rule Id="360" Name="PI3K Gab arm #3" Data="Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p),PI(three~u)->Gab1(PH!_,Y619!0),PI3K(SH2!0,s~p!1),PI(three~u!1)" ForwardRate="1" />
  375. <Rule Id="361" Name="ERK_SoS" Data="ERK(T~p,Y~p,s),SoS(S~u)->ERK(T~p,Y~p,s!0),SoS(S~u!0)" ForwardRate="1" />
  376. <Rule Id="362" Name="ERK_SoS_op" Data="ERK(s!0),SoS(S!0)->ERK(s),SoS(S)" ForwardRate="1" />
  377. <Rule Id="363" Name="ERK_Gab1#1" Data="ERK(T~p,Y~p,s),Gab1(S454~u)->ERK(T~p,Y~p,s!0),Gab1(S454~u!0)" ForwardRate="1" />
  378. <Rule Id="364" Name="ERK_Gab1#2" Data="ERK(T~p,Y~p,s),Gab1(T476~u)->ERK(T~p,Y~p,s!0),Gab1(T476~u!0)" ForwardRate="1" />
  379. <Rule Id="365" Name="ERK_Gab1#3" Data="ERK(T~p,Y~p,s),Gab1(S597~u)->ERK(T~p,Y~p,s!0),Gab1(S597~u!0)" ForwardRate="1" />
  380. <Rule Id="366" Name="ERK_Gab1#1_op" Data="ERK(s!0),Gab1(S454!0)->ERK(s),Gab1(S454)" ForwardRate="1" />
  381. <Rule Id="367" Name="ERK_Gab1#2_op" Data="ERK(s!0),Gab1(T476!0)->ERK(s),Gab1(T476)" ForwardRate="1" />
  382. <Rule Id="368" Name="ERK_Gab1#3_op" Data="ERK(s!0),Gab1(S597!0)->ERK(s),Gab1(S597)" ForwardRate="1" />
  383. <Rule Id="369" Name="SoS@S" Data="ERK(s!0),SoS(S~u!0)->ERK(s!0),SoS(S~p!0)" ForwardRate="1" />
  384. <Rule Id="370" Name="SoS@S_op" Data="SoS(S~p)->SoS(S~u)" ForwardRate="1" />
  385. <Rule Id="371" Name="Gab1@454" Data="ERK(s!0),Gab1(S454~u!0)->ERK(s!0),Gab1(S454~p!0)" ForwardRate="1" />
  386. <Rule Id="372" Name="Gab1@476" Data="ERK(s!0),Gab1(T476~u!0)->ERK(s!0),Gab1(T476~p!0)" ForwardRate="1" />
  387. <Rule Id="373" Name="Gab1@597" Data="ERK(s!0),Gab1(S597~u!0)->ERK(s!0),Gab1(S597~p!0)" ForwardRate="1" />
  388. <Rule Id="374" Name="Gab1@454_op" Data="Gab1(S454~p)->Gab1(S454~u)" ForwardRate="1" />
  389. <Rule Id="375" Name="Gab1@476_op" Data="Gab1(T476~p)->Gab1(T476~u)" ForwardRate="1" />
  390. <Rule Id="376" Name="Gab1@597_op" Data="Gab1(S597~p)->Gab1(S597~u)" ForwardRate="1" />
  391. <Rule Id="377" Name="EGFR_Grb2@Y1086_SH2" Data="EGFR(Y1086~p),Grb2(SH2)->EGFR(Y1086~p!0),Grb2(SH2!0)" ForwardRate="1" />
  392. <Rule Id="378" Name="Shc_Src@SH2_S1" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2),Src(S1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2!1),Src(S1!1)" ForwardRate="1" />
  393. <Rule Id="379" Name="Shc_p@Y239" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)" ForwardRate="1" />
  394. <Rule Id="380" Name="Shc_Src_op" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y239~p),Src(S1!1)->PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y239~p),Src(S1)" ForwardRate="1" />
  395. <Rule Id="381" Name="Shc_p@Y240" Data="PI(Five~p!0,four~p),Shc(PTB!0,SH2,Y240~u),Src(S1)=>PI(Five~p!0,four~p),Shc(PTB!0,SH2!1,Y240~p),Src(S1!1)" ForwardRate="1" />
  396. <Rule Id="382" Name="SHP1_EGFR@SH2n_Y1173" Data="Shp1(SH2n),EGFR(Y1173~p)->Shp1(SH2n!0),EGFR(Y1173~p!0)" ForwardRate="1" />
  397. <Rule Id="383" Name="EGFR_u@Y1173" Data="Shp1(SH2n!0),EGFR(Y1173~p!0)->Shp1(SH2n!0),EGFR(Y1173~u!0)" ForwardRate="1" />
  398. <Rule Id="384" Name="EGFR_SHP1_op" Data="Shp1(SH2n!0),EGFR(Y1173~u!0)->Shp1(SH2n),EGFR(Y1173~u)" ForwardRate="1" />
  399. <Rule Id="385" Name="EGFR_Shc@Y1173_PTB" Data="Shc(PTB),EGFR(Y1173~p)->Shc(PTB!0),EGFR(Y1173~p!0)" ForwardRate="1" />
  400. <Rule Id="386" Name="EGFR_Shc@Y1173_SH2" Data="Shc(SH2),EGFR(Y1173~p)->Shc(SH2!0),EGFR(Y1173~p!0)" ForwardRate="1" />
  401. <Rule Id="387" Name="EGFR_Shc@Y992_PTB" Data="Shc(PTB),EGFR(Y992~p)->Shc(PTB!0),EGFR(Y992~p!0)" ForwardRate="1" />
  402. <Rule Id="388" Name="EGFR_Shc@Y992_SH2" Data="Shc(SH2),EGFR(Y992~p)->Shc(SH2!0),EGFR(Y992~p!0)" ForwardRate="1" />
  403. <Rule Id="389" Name="Shc_EGFR@PTB_Y1148" Data="EGFR(Y1148~p),Shc(PTB)->EGFR(Y1148~p!0),Shc(PTB!0)" ForwardRate="1" />
  404. <Rule Id="390" Name="Shc_EGFR@PTB_Y1148_op" Data="EGFR(Y1148~p!0),Shc(PTB!0)->EGFR(Y1148~p),Shc(PTB)" ForwardRate="1" />
  405. <Rule Id="391" Name="Shc_EGFR@SH2_Y1148" Data="EGFR(Y1148~p),Shc(SH2)->EGFR(Y1148~p!0),Shc(SH2!0)" ForwardRate="1" />
  406. <Rule Id="392" Name="Shc_EGFR@SH2_Y1148_op" Data="EGFR(Y1148~p!0),Shc(SH2!0)->EGFR(Y1148~p),Shc(SH2)" ForwardRate="1" />
  407. <Rule Id="393" Name="Shc_EGFR@PTB_Y1173" Data="EGFR(Y1173~p),Shc(PTB)->EGFR(Y1173~p!0),Shc(PTB!0)" ForwardRate="1" />
  408. <Rule Id="394" Name="Shc_EGFR@PTB_Y1173_op" Data="EGFR(Y1173~p!0),Shc(PTB!0)->EGFR(Y1173~p),Shc(PTB)" ForwardRate="1" />
  409. <Rule Id="395" Name="Shc_EGFR@SH2_Y1173" Data="EGFR(Y1173~p),Shc(SH2)->EGFR(Y1173~p!0),Shc(SH2!0)" ForwardRate="1" />
  410. <Rule Id="396" Name="Shc_EGFR@SH2_Y1173_op" Data="EGFR(Y1173~p!0),Shc(SH2!0)->EGFR(Y1173~p),Shc(SH2)" ForwardRate="1" />
  411. <Rule Id="397" Name="Shc_p@Y317" Data="EGFR(Y1148~p!0),Shc(PTB!0,Y317~u)->EGFR(Y1148~p!0),Shc(PTB!0,Y317~p)" ForwardRate="1" />
  412. <Rule Id="398" Name="EGFR_Stat3@Y1068_SH2" Data="Stat3(SH2),EGFR(Y1068~p)->Stat3(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />
  413. <Rule Id="399" Name="EGFR_Stat3@Y1068_SH2_op" Data="Stat3(SH2!0),EGFR(Y1068~p!0)->Stat3(SH2),EGFR(Y1068~p)" ForwardRate="1" />
  414. <Rule Id="400" Name="EGFR_Stat3@Y1086_SH2" Data="Stat3(SH2),EGFR(Y1086~p)->Stat3(SH2!0),EGFR(Y1086~p!0)" ForwardRate="1" />
  415. <Rule Id="401" Name="EGFR_Stat3@Y1086_SH2_op" Data="Stat3(SH2!0),EGFR(Y1086~p!0)->Stat3(SH2),EGFR(Y1086~p)" ForwardRate="1" />
  416. <Rule Id="402" Name="Stat3_p@Y705" Data="Stat3(SH2!0,Y705~u),EGFR(Y1068!0)->Stat3(SH2!0,Y705~p),EGFR(Y1068!0)" ForwardRate="1" />
  417. <Rule Id="403" Name="EGFR_Shc@Y1068_SH2" Data="EGFR(Y1068~p),Shc(SH2)->EGFR(Y1068~p!0),Shc(SH2!0)" ForwardRate="1" />
  418. <Rule Id="404" Name="EGFR_Shc@Y1068_SH2_op" Data="EGFR(Y1068~p!0),Shc(SH2!0)->EGFR(Y1068~p),Shc(SH2)" ForwardRate="1" />
  419. <Rule Id="405" Name="EGFR_Shc@Y1086_SH2" Data="EGFR(Y1086~p),Shc(SH2)->EGFR(Y1086~p!0),Shc(SH2!0)" ForwardRate="1" />
  420. <Rule Id="406" Name="EGFR_Shc@Y1086_SH2_op" Data="EGFR(Y1086~p!0),Shc(SH2!0)->EGFR(Y1086~p),Shc(SH2)" ForwardRate="1" />
  421. <Rule Id="407" Name="EGFR_PLCG1@Y992_SH2" Data="EGFR(Y992~p),PLCG1(SH2)->EGFR(Y992~p!0),PLCG1(SH2!0)" ForwardRate="1" />
  422. <Rule Id="408" Name="EGFR_PLCG1@Y992_SH2_op" Data="EGFR(Y992~p!0),PLCG1(SH2!0)->EGFR(Y992~p),PLCG1(SH2)" ForwardRate="1" />
  423. <Rule Id="409" Name="EGFR_PLCG1@Y1068_SH2" Data="EGFR(Y1068~p),PLCG1(SH2)->EGFR(Y1068~p!0),PLCG1(SH2!0)" ForwardRate="1" />
  424. <Rule Id="410" Name="EGFR_PLCG1@Y1068_SH2_op" Data="EGFR(Y1068~p!0),PLCG1(SH2!0)->EGFR(Y1068~p),PLCG1(SH2)" ForwardRate="1" />
  425. <Rule Id="411" Name="EGFR_PLCG1@Y1086_SH2" Data="EGFR(Y1086~p),PLCG1(SH2)->EGFR(Y1086~p!0),PLCG1(SH2!0)" ForwardRate="1" />
  426. <Rule Id="412" Name="EGFR_PLCG1@Y1086_SH2_op" Data="EGFR(Y1086~p!0),PLCG1(SH2!0)->EGFR(Y1086~p),PLCG1(SH2)" ForwardRate="1" />
  427. <Rule Id="413" Name="EGFR_PLCG1@Y1148_SH2" Data="EGFR(Y1148~p),PLCG1(SH2)->EGFR(Y1148~p!0),PLCG1(SH2!0)" ForwardRate="1" />
  428. <Rule Id="414" Name="EGFR_PLCG1@Y1148_SH2_op" Data="EGFR(Y1148~p!0),PLCG1(SH2!0)->EGFR(Y1148~p),PLCG1(SH2)" ForwardRate="1" />
  429. <Rule Id="415" Name="EGFR_PLCG1@Y1173_SH2" Data="EGFR(Y1173~p),PLCG1(SH2)->EGFR(Y1173~p!0),PLCG1(SH2!0)" ForwardRate="1" />
  430. <Rule Id="416" Name="EGFR_PLCG1@Y1173_SH2_op" Data="EGFR(Y1173~p!0),PLCG1(SH2!0)->EGFR(Y1173~p),PLCG1(SH2)" ForwardRate="1" />
  431. <Rule Id="417" Name="EGFR_Src@Y845_SH2" Data="Src(SH2),EGFR(Y845)->Src(SH2!0),EGFR(Y845!0)" ForwardRate="1" />
  432. <Rule Id="418" Name="EGFR_Src@Y845_SH2_op" Data="Src(SH2!0),EGFR(Y845!0)->Src(SH2),EGFR(Y845)" ForwardRate="1" />
  433. <Rule Id="419" Name="EGFR_p@Y845" Data="Src(SH2!0),EGFR(Y845~u!0)->Src(SH2!0),EGFR(Y845~p!0)" ForwardRate="1" />
  434. <Rule Id="420" Name="EGFR_Eps8@S1_S1" Data="EGFR(S1),Eps8(S1)->EGFR(S1!0),Eps8(S1!0)" ForwardRate="1" />
  435. <Rule Id="421" Name="EGFR_Eps8@S1_S1_op" Data="EGFR(S1!0),Eps8(S1!0)->EGFR(S1),Eps8(S1)" ForwardRate="1" />
  436. <Rule Id="422" Name="Eps8_p@X" Data="EGFR(S1!0),Eps8(S1!0,X~u)->EGFR(S1!0),Eps8(S1!0,X~p)" ForwardRate="1" />
  437. <Rule Id="423" Name="EGFR_PLCG1@Y1173_SH2n" Data="EGFR(Y1173~p),PLCG1(SH2n)->EGFR(Y1173~p!0),PLCG1(SH2n!0)" ForwardRate="1" />
  438. <Rule Id="424" Name="EGFR_PLCG1@Y992_SH2c" Data="EGFR(Y992~p),PLCG1(SH2c)->EGFR(Y992~p!0),PLCG1(SH2c!0)" ForwardRate="1" />
  439. <Rule Id="425" Name="PLCG1_p@Y472" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y472~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y472~p)" ForwardRate="1" />
  440. <Rule Id="426" Name="PLCG1_p@Y771" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y771~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y771~p)" ForwardRate="1" />
  441. <Rule Id="427" Name="PLCG1_p@Y783" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y783~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y783~p)" ForwardRate="1" />
  442. <Rule Id="428" Name="PLCG1_p@Y1254" Data="EGFR(Y1173~p!0),PLCG1(SH2n!0,Y1254~u)->EGFR(Y1173~p!0),PLCG1(SH2n!0,Y1254~p)" ForwardRate="1" />
  443. <Rule Id="429" Name="EGFR_Gab1@S1_S1" Data="Gab1(X~u),EGFR(S1)->Gab1(X~u!0),EGFR(S1!0)" ForwardRate="1" />
  444. <Rule Id="430" Name="Gab1_p@Y627" Data="Gab1(Y627~u!0),EGFR(S1!0)->Gab1(Y627~p!0),EGFR(S1!0)" ForwardRate="1" />
  445. <Rule Id="431" Name="Gab1_EGFR_op" Data="Gab1(Y627~p!0),EGFR(S1!0)->Gab1(Y627~p),EGFR(S1)" ForwardRate="1" />
  446. <Rule Id="432" Name="Gab1_p@Y659" Data="Gab1(Y659~u!0),EGFR(S1!0)->Gab1(Y659~p!0),EGFR(S1!0)" ForwardRate="1" />
  447. <Rule Id="433" Name="Gab1_PIP3@PH" Data="Gab1(PH),PI(five~p,four~p,three~p)->Gab1(PH!0),PI(five~p!0,four~p,three~p)" ForwardRate="1" />
  448. <Rule Id="434" Name="Gab1_SHP2@Y627_SH2n" Data="Gab1(Y627~p),SHP2(SH2n)->Gab1(Y627~p!0),SHP2(SH2n!0)" ForwardRate="1" />
  449. <Rule Id="435" Name="Gab1_SHP2@Y659_SH2c" Data="Gab1(Y659~p),SHP2(SH2c)->Gab1(Y659~p!0),SHP2(SH2c!0)" ForwardRate="1" />
  450. <Rule Id="436" Name="Gab1_u@Y659" Data="Gab1(Y659~p!0),SHP2(SH2c!0)->Gab1(Y659~u!0),SHP2(SH2c!0)" ForwardRate="1" />
  451. <Rule Id="437" Name="Gab1_u@Y627" Data="Gab1(Y627~p!0),SHP2(SH2c!0)->Gab1(Y627~u!0),SHP2(SH2c!0)" ForwardRate="1" />
  452. <Rule Id="438" Name="Gab1_PLCG1@Y307_SH2" Data="Gab1(Y307~p),PLCG1(SH2)->Gab1(Y307~p!0),PLCG1(SH2!0)" ForwardRate="1" />
  453. <Rule Id="439" Name="Gab1_PLCG1@Y373_SH2" Data="Gab1(Y373~p),PLCG1(SH2)->Gab1(Y373~p!0),PLCG1(SH2!0)" ForwardRate="1" />
  454. <Rule Id="440" Name="Gab1_PLCG1@Y407_SH2" Data="Gab1(Y407~p),PLCG1(SH2)->Gab1(Y407~p!0),PLCG1(SH2!0)" ForwardRate="1" />
  455. <Rule Id="441" Name="Akt_PIP2@PH" Data="Akt(PH),PI(four~p,three~p)->Akt(PH!0),PI(four~p!0,three~p)" ForwardRate="1" />
  456. <Rule Id="442" Name="Vav_PIP3@PH" Data="PI(five~p,four~p,three~p),Vav(PH)->PI(five~p!0,four~p,three~p),Vav(PH!0)" ForwardRate="1" />
  457. <Rule Id="443" Name="Vav_PIP3@PH_op" Data="PI(five~p!0,four~p,three~p),Vav(PH!0)->PI(five~p,four~p,three~p),Vav(PH)" ForwardRate="1" />
  458. <Rule Id="444" Name="Vav_Rac@DH_X~u" Data="PI(five~p!0,four~p,three~p),Vav(DH,PH!0,X~p),Rac(X~u)->PI(five~p!0,four~p,three~p),Vav(DH!1,PH!0,X~p),Rac(X~u!1)" ForwardRate="1" />
  459. <Rule Id="445" Name="Vav_Rac@DH_X~u_op" Data="PI(five~p!0,four~p,three~p),Vav(DH!1,PH!0,X~p),Rac(X~u!1)->PI(five~p!0,four~p,three~p),Vav(DH,PH!0,X~p),Rac(X~u)" ForwardRate="1" />
  460. <Rule Id="446" Name="Rac_p@X" Data="Rac(X~gdp!0),Vav(DH!0,PH!1,X~p),PI(five~p!1,four~p,three~p)->Rac(X~gtp!0),Vav(DH!0,PH!1,X~p),PI(five~p!1,four~p,three~p)" ForwardRate="1" />
  461. <Rule Id="447" Name="PIP3_Sos@PH" Data="PI(five~p,four~p,three~p),Sos(PH)->PI(five~p!0,four~p,three~p),Sos(PH!0)" ForwardRate="1" />
  462. <Rule Id="448" Name="Sos_Rac@DH_X~u" Data="PI(five~p!0,four~p,three~p),Sos(DH,PH!0,X~p),Rac(X~u)->PI(five~p!0,four~p,three~p),Sos(DH!1,PH!0,X~p),Rac(X~u!1)" ForwardRate="1" />
  463. <Rule Id="449" Name="Sos_Rac@DH_X~u_op" Data="PI(five~p!0,four~p,three~p),Sos(DH!1,PH!0,X~p),Rac(X~u!1)->PI(five~p!0,four~p,three~p),Sos(DH,PH!0,X~p),Rac(X~u)" ForwardRate="1" />
  464. <Rule Id="450" Name="PIP2_PLD@PH" Data="PI(five~p,four~p),PLD(PH)->PI(five~p!0,four~p),PLD(PH!0)" ForwardRate="1" />
  465. <Rule Id="451" Name="PIP2_PLD@PH_op" Data="PI(five~p!0,four~p),PLD(PH!0)->PI(five~p,four~p),PLD(PH)" ForwardRate="1" />
  466. <Rule Id="452" Name="p85_EGFR@SH2_Y920" Data="p85(SH2),EGFR(Y920~p)->p85(SH2!0),EGFR(Y920~p!0)" ForwardRate="1" />
  467. <Rule Id="453" Name="Rom2_PI3K@PH_S1" Data="Rom2(PH),PI3K(S1)->Rom2(PH!0),PI3K(S1!0)" ForwardRate="1" />
  468. <Rule Id="454" Name="Rom2_PI3K@PH_S1_op" Data="Rom2(PH!0),PI3K(S1!0)->Rom2(PH),PI3K(S1)" ForwardRate="1" />
  469. <Rule Id="455" Name="EGFR_Vav2@Y992_SH2" Data="EGFR(Y992~p),Vav2(SH2)->EGFR(Y992~p!0),Vav2(SH2!0)" ForwardRate="1" />
  470. <Rule Id="456" Name="EGFR_Vav2@Y992_SH2_op" Data="EGFR(Y992~p!0),Vav2(SH2!0)->EGFR(Y992~p),Vav2(SH2)" ForwardRate="1" />
  471. <Rule Id="457" Name="EGFR_Vav@Y1148_SH2" Data="EGFR(Y1148~p),Vav2(SH2)->EGFR(Y1148~p!0),Vav2(SH2!0)" ForwardRate="1" />
  472. <Rule Id="458" Name="EGFR_Vav@Y1148_SH2_op" Data="EGFR(Y1148~p!0),Vav2(SH2!0)->EGFR(Y1148~p),Vav2(SH2)" ForwardRate="1" />
  473. <Rule Id="459" Name="Vav2_p@Y142" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y142~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y142~p)" ForwardRate="1" />
  474. <Rule Id="460" Name="Vav2_p@Y172" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y172~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y172~p)" ForwardRate="1" />
  475. <Rule Id="461" Name="Vav2_p@Y159" Data="EGFR(Y1148~p!0),Vav2(SH2!0,Y159~u)->EGFR(Y1148~p!0),Vav2(SH2!0,Y159~p)" ForwardRate="1" />
  476. <Rule Id="462" Name="Grb2_EGFR@SH2_Y1068" Data="Grb2(SH2),EGFR(Y1068~p)->Grb2(SH2!0),EGFR(Y1068~p!0)" ForwardRate="1" />
  477. <Rule Id="463" Name="Pak1_Grb2@SH3_SBM" Data="Grb2(SH2!0,SH3),EGFR(Y1068~p!0),Pak1(SBM)->Grb2(SH2!1,SH3!0),EGFR(Y1068~p!1),Pak1(SBM!0)" ForwardRate="1" />
  478. <Rule Id="464" Name="Raf1_Ras@CR1_rafts" Data="Raf1(CR1,Y341~p),Ras(rafts)->Raf1(CR1!0,Y341~p),Ras(rafts!0)" ForwardRate="1" />
  479. <Rule Id="465" Name="Raf1_p@S338" Data="Raf1(CR1!0,S338~u,Y341~p),Ras(rafts!0)->Raf1(CR1!0,S338~p,Y341~p),Ras(rafts!0)" ForwardRate="1" />
  480. <Rule Id="466" Name="Ang2_EGFR@r_l" Data="Ang2(r~ext),EGFR(CR,L~ext)=>Ang(r~ext!0),GFR(CR,L~ext!0)" ForwardRate="1" />
  481. <Rule Id="467" Name="Ang2_EGFR@r_l_op" Data="Ang(r~ext!0),GFR(CR,L~ext!0)=>Ang2(r~ext),EGFR(CR,L~ext)" ForwardRate="1" />
  482. <Rule Id="468" Name="EGFR_Clta(int)" Data="EGFR(C,N~ext!0),CLTA(S1!0)->EGFR(C,N~int!0),CLTA(S1!0)" ForwardRate="1" />
  483. <Rule Id="469" Name="Rule103" Data="B(y1~p)->B(y1~u)" ForwardRate="1" />
  484. <Rule Id="470" Name="Rule104" Data="B(y2~p)->B(y2~u)" ForwardRate="1" />
  485. <Rule Id="471" Name="goal" Data="B(y1~p,y2~p,z~u)->B(y1~p,y2~p,z~p)" ForwardRate="1" />
  486. <Rule Id="472" Name="Rule105" Data="ErbB1(N!1,bp!0),ErbB2(C!1,Y1139~u),A(s~ppp!0)=>ErbB1(N!1,bp!0),ErbB2(C!1,Y1139~p),A(s~pp!0)" ForwardRate="1" />
  487. </RuleSet>
  488. <ContactMap Name="Low resolution">
  489. <Agent Name="Shc">
  490. <Site Name="PTB" CanChangeState="true" CanBeBound="true">
  491. <Rule Id="272"/>
  492. <Rule Id="273"/>
  493. <Rule Id="276"/>
  494. <Rule Id="277"/>
  495. <Rule Id="280"/>
  496. <Rule Id="281"/>
  497. <Rule Id="294"/>
  498. <Rule Id="295"/>
  499. <Rule Id="300"/>
  500. <Rule Id="301"/>
  501. </Site>
  502. <Site Name="SH2" CanChangeState="false" CanBeBound="true">
  503. </Site>
  504. <Site Name="Y" CanChangeState="true" CanBeBound="true">
  505. <Rule Id="302"/>
  506. </Site>
  507. <Site Name="Y239" CanChangeState="true" CanBeBound="true">
  508. <Rule Id="379"/>
  509. </Site>
  510. <Site Name="Y240" CanChangeState="true" CanBeBound="true">
  511. <Rule Id="381"/>
  512. </Site>
  513. <Site Name="Y317" CanChangeState="true" CanBeBound="true">
  514. <Rule Id="397"/>
  515. </Site>
  516. <Site Name="Y318" CanChangeState="true" CanBeBound="true">
  517. <Rule Id="96"/>
  518. <Rule Id="97"/>
  519. <Rule Id="98"/>
  520. <Rule Id="144"/>
  521. <Rule Id="145"/>
  522. </Site>
  523. </Agent>
  524. <Agent Name="RasGAP">
  525. <Site Name="GAP" CanChangeState="false" CanBeBound="true">
  526. </Site>
  527. <Site Name="SH2" CanChangeState="true" CanBeBound="true">
  528. <Rule Id="268"/>
  529. <Rule Id="269"/>
  530. <Rule Id="278"/>
  531. <Rule Id="279"/>
  532. <Rule Id="296"/>
  533. <Rule Id="297"/>
  534. </Site>
  535. <Site Name="s" CanChangeState="false" CanBeBound="true">
  536. </Site>
  537. </Agent>
  538. <Agent Name="Grb2">
  539. <Site Name="SH2" CanChangeState="true" CanBeBound="true">
  540. <Rule Id="270"/>
  541. <Rule Id="271"/>
  542. <Rule Id="274"/>
  543. <Rule Id="275"/>
  544. <Rule Id="298"/>
  545. <Rule Id="299"/>
  546. </Site>
  547. <Site Name="SH3" CanChangeState="false" CanBeBound="true">
  548. </Site>
  549. <Site Name="SH3c" CanChangeState="false" CanBeBound="true">
  550. </Site>
  551. <Site Name="SH3n" CanChangeState="false" CanBeBound="true">
  552. </Site>
  553. </Agent>
  554. <Agent Name="ErbB4">
  555. <Site Name="C" CanChangeState="false" CanBeBound="true">
  556. </Site>
  557. <Site Name="CR" CanChangeState="false" CanBeBound="true">
  558. </Site>
  559. <Site Name="L" CanChangeState="true" CanBeBound="true">
  560. </Site>
  561. <Site Name="N" CanChangeState="false" CanBeBound="true">
  562. </Site>
  563. <Site Name="Y1056" CanChangeState="true" CanBeBound="true">
  564. <Rule Id="70"/>
  565. <Rule Id="73"/>
  566. <Rule Id="139"/>
  567. </Site>
  568. <Site Name="Y1188" CanChangeState="true" CanBeBound="true">
  569. <Rule Id="71"/>
  570. <Rule Id="74"/>
  571. <Rule Id="140"/>
  572. </Site>
  573. <Site Name="Y1242" CanChangeState="true" CanBeBound="true">
  574. <Rule Id="72"/>
  575. <Rule Id="75"/>
  576. <Rule Id="141"/>
  577. </Site>
  578. <Site Name="bp" CanChangeState="false" CanBeBound="true">
  579. </Site>
  580. </Agent>
  581. <Agent Name="ErbB3">
  582. <Site Name="C" CanChangeState="false" CanBeBound="true">
  583. </Site>
  584. <Site Name="CR" CanChangeState="false" CanBeBound="true">
  585. </Site>
  586. <Site Name="L" CanChangeState="true" CanBeBound="true">
  587. </Site>
  588. <Site Name="N" CanChangeState="false" CanBeBound="true">
  589. </Site>
  590. <Site Name="Y1035" CanChangeState="true" CanBeBound="true">
  591. <Rule Id="52"/>
  592. <Rule Id="59"/>
  593. <Rule Id="132"/>
  594. </Site>
  595. <Site Name="Y1178" CanChangeState="true" CanBeBound="true">
  596. <Rule Id="53"/>
  597. <Rule Id="60"/>
  598. <Rule Id="133"/>
  599. </Site>
  600. <Site Name="Y1203" CanChangeState="true" CanBeBound="true">
  601. <Rule Id="54"/>
  602. <Rule Id="61"/>
  603. <Rule Id="134"/>
  604. </Site>
  605. <Site Name="Y1241" CanChangeState="true" CanBeBound="true">
  606. <Rule Id="55"/>
  607. <Rule Id="62"/>
  608. <Rule Id="135"/>
  609. </Site>
  610. <Site Name="Y1257" CanChangeState="true" CanBeBound="true">
  611. <Rule Id="56"/>
  612. <Rule Id="63"/>
  613. <Rule Id="136"/>
  614. </Site>
  615. <Site Name="Y1270" CanChangeState="true" CanBeBound="true">
  616. <Rule Id="57"/>
  617. <Rule Id="64"/>
  618. <Rule Id="137"/>
  619. </Site>
  620. <Site Name="Y1309" CanChangeState="true" CanBeBound="true">
  621. <Rule Id="58"/>
  622. <Rule Id="65"/>
  623. <Rule Id="138"/>
  624. </Site>
  625. </Agent>
  626. <Agent Name="ErbB2">
  627. <Site Name="C" CanChangeState="false" CanBeBound="true">
  628. </Site>
  629. <Site Name="CR" CanChangeState="false" CanBeBound="true">
  630. </Site>
  631. <Site Name="L" CanChangeState="true" CanBeBound="true">
  632. </Site>
  633. <Site Name="N" CanChangeState="false" CanBeBound="true">
  634. </Site>
  635. <Site Name="Y1139" CanChangeState="true" CanBeBound="true">
  636. <Rule Id="45"/>
  637. <Rule Id="79"/>
  638. <Rule Id="472"/>
  639. </Site>
  640. <Site Name="Y1196" CanChangeState="true" CanBeBound="true">
  641. <Rule Id="43"/>
  642. <Rule Id="46"/>
  643. <Rule Id="80"/>
  644. </Site>
  645. <Site Name="Y1221" CanChangeState="true" CanBeBound="true">
  646. <Rule Id="44"/>
  647. <Rule Id="47"/>
  648. <Rule Id="81"/>
  649. </Site>
  650. <Site Name="bp" CanChangeState="false" CanBeBound="true">
  651. </Site>
  652. </Agent>
  653. <Agent Name="ErbB1">
  654. <Site Name="C" CanChangeState="false" CanBeBound="true">
  655. </Site>
  656. <Site Nam